SPRR2A (small proline rich protein 2A)

2013-03-01 Affiliation

Identity

HGNC

SPRR2A

LOCATION

1q21.3

LOCUSID

6700

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6700
MIM: 182267
HGNC: 11261
Ensembl: ENSG00000241794

Variants:

dbSNP: 6700
ClinVar: 6700
TCGA: ENSG00000241794
COSMIC: SPRR2A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000241794	ENST00000392653	P35326

Expression (GTEx)

500

1000

1500

2000

2500

3000

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Developmental Biology	REACTOME	R-HSA-1266738
Keratinization	REACTOME	R-HSA-6805567
Formation of the cornified envelope	REACTOME	R-HSA-6809371

References

Pubmed ID	Year	Title	Citations
18643845	2009	Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families.	16
18155796	2008	Small proline-rich proteins (SPRR) function as SH3 domain ligands, increase resistance to injury and are associated with epithelial-mesenchymal transition (EMT) in cholangiocytes.	14
24123265	2014	Small proline rich protein 2a in benign and malignant liver disease.	10
28859701	2017	RNA sequencing and pathway analysis identify tumor necrosis factor alpha driven small proline-rich protein dysregulation in chronic rhinosinusitis.	7
22731250	2012	SPRR2A enhances p53 deacetylation through HDAC1 and down regulates p21 promoter activity.	5
23728799	2013	SPRR2A expression in cholangiocarcinoma increases local tumor invasiveness but prevents metastasis.	3
30108165	2018	Comprehensive Genomic Profiling of Patient-matched Head and Neck Cancer Cells: A Preclinical Pipeline for Metastatic and Recurrent Disease.	3

Citation

Dessen P

SPRR2A (small proline rich protein 2A)

Atlas Genet Cytogenet Oncol Haematol. 2013-03-01

Online version: http://atlasgeneticsoncology.org/gene/53219/sprr2a