Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6707
MIM: 182271
HGNC: 11268
Ensembl: ENSG00000163209
Variants:
dbSNP: 6707
ClinVar: 6707
TCGA: ENSG00000163209
COSMIC: SPRR3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000163209 | ENST00000295367 | Q9UBC9 |
| ENSG00000163209 | ENST00000331860 | Q9UBC9 |
| ENSG00000163209 | ENST00000443178 | B1AN48 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Developmental Biology | REACTOME | R-HSA-1266738 |
| Keratinization | REACTOME | R-HSA-6805567 |
| Formation of the cornified envelope | REACTOME | R-HSA-6809371 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36685674 | 2023 | SPRR3 Contributes to Aggressiveness of Pancreatic Cancer Cells via NF-κB Signaling Pathway. | 0 |
| 36685674 | 2023 | SPRR3 Contributes to Aggressiveness of Pancreatic Cancer Cells via NF-κB Signaling Pathway. | 0 |
| 35126350 | 2021 | Small Proline-Rich Protein 3 Regulates IL-33/ILC2 Axis to Promote Allergic Airway Inflammation. | 8 |
| 35126350 | 2021 | Small Proline-Rich Protein 3 Regulates IL-33/ILC2 Axis to Promote Allergic Airway Inflammation. | 8 |
| 30850686 | 2019 | Fine particulate matter (PM2.5) inhibits ciliogenesis by increasing SPRR3 expression via c-Jun activation in RPE cells and skin keratinocytes. | 12 |
| 30850686 | 2019 | Fine particulate matter (PM2.5) inhibits ciliogenesis by increasing SPRR3 expression via c-Jun activation in RPE cells and skin keratinocytes. | 12 |
| 27304082 | 2017 | Expression of Cornified Envelope Proteins in Skin and Its Relationship with Atopic Dermatitis Phenotype. | 18 |
| 27304082 | 2017 | Expression of Cornified Envelope Proteins in Skin and Its Relationship with Atopic Dermatitis Phenotype. | 18 |
| 23820115 | 2013 | Small proline-rich repeat protein 3 enhances the sensitivity of esophageal cancer cells in response to DNA damage-induced apoptosis. | 12 |
| 23820115 | 2013 | Small proline-rich repeat protein 3 enhances the sensitivity of esophageal cancer cells in response to DNA damage-induced apoptosis. | 12 |
| 22076481 | 2012 | Expression of SPRR3 is associated with tumor cell proliferation in less advanced stages of breast cancer. | 22 |
| 22076481 | 2012 | Expression of SPRR3 is associated with tumor cell proliferation in less advanced stages of breast cancer. | 22 |
| 21490620 | 2011 | Association screening in the Epidermal Differentiation Complex (EDC) identifies an SPRR3 repeat number variant as a risk factor for eczema. | 30 |
| 21777580 | 2011 | Quantitative evaluation of SPRR3 expression in esophageal squamous cell carcinoma by qPCR and its potential use as a biomarker. | 12 |
| 21490620 | 2011 | Association screening in the Epidermal Differentiation Complex (EDC) identifies an SPRR3 repeat number variant as a risk factor for eczema. | 30 |
Citation
Dessen P
SPRR3 (small proline rich protein 3)
Atlas Genet Cytogenet Oncol Haematol. 2008-01-01
Online version: http://atlasgeneticsoncology.org/gene/50003/sprr3
