Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

SPRY2 (sprouty RTK signaling antagonist 2)

Identity

Alias_namessprouty (Drosophila) homolog 2
sprouty homolog 2 (Drosophila)
Alias_symbol (synonym)hSPRY2
Other aliasIGAN3
HGNC (Hugo) SPRY2
LocusID (NCBI) 10253
Atlas_Id 42381
Location 13q31.1  [Link to chromosome band 13q31]
Location_base_pair Starts at 80335977 and ends at 80340108 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CYP20A1 (2q33.2) / SPRY2 (13q31.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SPRY2   11270
Cards
Entrez_Gene (NCBI)SPRY2  10253  sprouty RTK signaling antagonist 2
AliasesIGAN3; hSPRY2
GeneCards (Weizmann)SPRY2
Ensembl hg19 (Hinxton)ENSG00000136158 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136158 [Gene_View]  chr13:80335977-80340108 [Contig_View]  SPRY2 [Vega]
ICGC DataPortalENSG00000136158
TCGA cBioPortalSPRY2
AceView (NCBI)SPRY2
Genatlas (Paris)SPRY2
WikiGenes10253
SOURCE (Princeton)SPRY2
Genetics Home Reference (NIH)SPRY2
Genomic and cartography
GoldenPath hg38 (UCSC)SPRY2  -     chr13:80335977-80340108 -  13q31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SPRY2  -     13q31.1   [Description]    (hg19-Feb_2009)
EnsemblSPRY2 - 13q31.1 [CytoView hg19]  SPRY2 - 13q31.1 [CytoView hg38]
Mapping of homologs : NCBISPRY2 [Mapview hg19]  SPRY2 [Mapview hg38]
OMIM602466   616818   
Gene and transcription
Genbank (Entrez)AF039843 AK313810 AL713749 AM392994 AM393598
RefSeq transcript (Entrez)NM_001318536 NM_001318537 NM_001318538 NM_005842
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SPRY2
Cluster EST : UnigeneHs.18676 [ NCBI ]
CGAP (NCI)Hs.18676
Alternative Splicing GalleryENSG00000136158
Gene ExpressionSPRY2 [ NCBI-GEO ]   SPRY2 [ EBI - ARRAY_EXPRESS ]   SPRY2 [ SEEK ]   SPRY2 [ MEM ]
Gene Expression Viewer (FireBrowse)SPRY2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10253
GTEX Portal (Tissue expression)SPRY2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43597   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43597  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43597
Splice isoforms : SwissVarO43597
PhosPhoSitePlusO43597
Domaine pattern : Prosite (Expaxy)SPR (PS51227)   
Domains : Interpro (EBI)Sprouty    SPRY2   
Domain families : Pfam (Sanger)Sprouty (PF05210)   
Domain families : Pfam (NCBI)pfam05210   
Conserved Domain (NCBI)SPRY2
DMDM Disease mutations10253
Blocks (Seattle)SPRY2
PDB (SRS)3BUM    3OB1    5HKY    5HKZ   
PDB (PDBSum)3BUM    3OB1    5HKY    5HKZ   
PDB (IMB)3BUM    3OB1    5HKY    5HKZ   
PDB (RSDB)3BUM    3OB1    5HKY    5HKZ   
Structural Biology KnowledgeBase3BUM    3OB1    5HKY    5HKZ   
SCOP (Structural Classification of Proteins)3BUM    3OB1    5HKY    5HKZ   
CATH (Classification of proteins structures)3BUM    3OB1    5HKY    5HKZ   
SuperfamilyO43597
Human Protein AtlasENSG00000136158
Peptide AtlasO43597
HPRD03916
IPIIPI01014320   IPI00012913   
Protein Interaction databases
DIP (DOE-UCLA)O43597
IntAct (EBI)O43597
FunCoupENSG00000136158
BioGRIDSPRY2
STRING (EMBL)SPRY2
ZODIACSPRY2
Ontologies - Pathways
QuickGOO43597
Ontology : AmiGOestablishment of mitotic spindle orientation  protein binding  nucleus  cytosol  cytosol  cytoskeleton  microtubule  plasma membrane  sensory perception of sound  negative regulation of cell proliferation  positive regulation of gene expression  negative regulation of peptidyl-threonine phosphorylation  microtubule cytoskeleton  membrane  protein kinase binding  protein serine/threonine kinase inhibitor activity  positive regulation of cell migration  negative regulation of cell projection organization  ruffle membrane  positive regulation of peptidyl-serine phosphorylation  negative regulation of GTPase activity  negative regulation of fibroblast growth factor receptor signaling pathway  negative regulation of epidermal growth factor receptor signaling pathway  inner ear morphogenesis  negative regulation of apoptotic process  negative regulation of MAP kinase activity  protein serine/threonine kinase activator activity  cell fate commitment  regulation of cell differentiation  negative regulation of Ras protein signal transduction  negative regulation of neurotrophin TRK receptor signaling pathway  positive regulation of protein kinase B signaling  lung growth  bud elongation involved in lung branching  negative regulation of ERK1 and ERK2 cascade  negative regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  positive regulation of protein serine/threonine kinase activity  
Ontology : EGO-EBIestablishment of mitotic spindle orientation  protein binding  nucleus  cytosol  cytosol  cytoskeleton  microtubule  plasma membrane  sensory perception of sound  negative regulation of cell proliferation  positive regulation of gene expression  negative regulation of peptidyl-threonine phosphorylation  microtubule cytoskeleton  membrane  protein kinase binding  protein serine/threonine kinase inhibitor activity  positive regulation of cell migration  negative regulation of cell projection organization  ruffle membrane  positive regulation of peptidyl-serine phosphorylation  negative regulation of GTPase activity  negative regulation of fibroblast growth factor receptor signaling pathway  negative regulation of epidermal growth factor receptor signaling pathway  inner ear morphogenesis  negative regulation of apoptotic process  negative regulation of MAP kinase activity  protein serine/threonine kinase activator activity  cell fate commitment  regulation of cell differentiation  negative regulation of Ras protein signal transduction  negative regulation of neurotrophin TRK receptor signaling pathway  positive regulation of protein kinase B signaling  lung growth  bud elongation involved in lung branching  negative regulation of ERK1 and ERK2 cascade  negative regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  positive regulation of protein serine/threonine kinase activity  
Pathways : BIOCARTASprouty regulation of tyrosine kinase signals [Genes]   
Pathways : KEGGJak-STAT signaling pathway    MicroRNAs in cancer   
NDEx NetworkSPRY2
Atlas of Cancer Signalling NetworkSPRY2
Wikipedia pathwaysSPRY2
Orthology - Evolution
OrthoDB10253
GeneTree (enSembl)ENSG00000136158
Phylogenetic Trees/Animal Genes : TreeFamSPRY2
HOVERGENO43597
HOGENOMO43597
Homologs : HomoloGeneSPRY2
Homology/Alignments : Family Browser (UCSC)SPRY2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSPRY2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SPRY2
dbVarSPRY2
ClinVarSPRY2
1000_GenomesSPRY2 
Exome Variant ServerSPRY2
ExAC (Exome Aggregation Consortium)SPRY2 (select the gene name)
Genetic variants : HAPMAP10253
Genomic Variants (DGV)SPRY2 [DGVbeta]
DECIPHERSPRY2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSPRY2 
Mutations
ICGC Data PortalSPRY2 
TCGA Data PortalSPRY2 
Broad Tumor PortalSPRY2
OASIS PortalSPRY2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSPRY2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSPRY2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SPRY2
DgiDB (Drug Gene Interaction Database)SPRY2
DoCM (Curated mutations)SPRY2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SPRY2 (select a term)
intoGenSPRY2
Cancer3DSPRY2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602466    616818   
Orphanet
MedgenSPRY2
Genetic Testing Registry SPRY2
NextProtO43597 [Medical]
TSGene10253
GENETestsSPRY2
Target ValidationSPRY2
Huge Navigator SPRY2 [HugePedia]
snp3D : Map Gene to Disease10253
BioCentury BCIQSPRY2
ClinGenSPRY2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10253
Chemical/Pharm GKB GenePA36099
Clinical trialSPRY2
Miscellaneous
canSAR (ICR)SPRY2 (select the gene name)
Probes
Litterature
PubMed155 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSPRY2
EVEXSPRY2
GoPubMedSPRY2
iHOPSPRY2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:57:17 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.