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SPRY4 (sprouty RTK signaling antagonist 4)

Identity

Alias_namessprouty homolog 4 (Drosophila)
Other aliasHH17
HGNC (Hugo) SPRY4
LocusID (NCBI) 81848
Atlas_Id 43800
Location 5q31.3  [Link to chromosome band 5q31]
Location_base_pair Starts at 142310427 and ends at 142325055 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MAGI1 (3p14.1) / SPRY4 (5q31.3)PRSS23 (11q14.2) / SPRY4 (5q31.3)SPRY4 (5q31.3) / RNASET2 (6q27)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SPRY4   15533
Cards
Entrez_Gene (NCBI)SPRY4  81848  sprouty RTK signaling antagonist 4
AliasesHH17
GeneCards (Weizmann)SPRY4
Ensembl hg19 (Hinxton)ENSG00000187678 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000187678 [Gene_View]  chr5:142310427-142325055 [Contig_View]  SPRY4 [Vega]
ICGC DataPortalENSG00000187678
TCGA cBioPortalSPRY4
AceView (NCBI)SPRY4
Genatlas (Paris)SPRY4
WikiGenes81848
SOURCE (Princeton)SPRY4
Genetics Home Reference (NIH)SPRY4
Genomic and cartography
GoldenPath hg38 (UCSC)SPRY4  -     chr5:142310427-142325055 -  5q31.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SPRY4  -     5q31.3   [Description]    (hg19-Feb_2009)
EnsemblSPRY4 - 5q31.3 [CytoView hg19]  SPRY4 - 5q31.3 [CytoView hg38]
Mapping of homologs : NCBISPRY4 [Mapview hg19]  SPRY4 [Mapview hg38]
OMIM146110   607984   615266   
Gene and transcription
Genbank (Entrez)AF227516 AF251060 AK096464 AK226147 BC125095
RefSeq transcript (Entrez)NM_001127496 NM_001293289 NM_001293290 NM_030964
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SPRY4
Cluster EST : UnigeneHs.323308 [ NCBI ]
CGAP (NCI)Hs.323308
Alternative Splicing GalleryENSG00000187678
Gene ExpressionSPRY4 [ NCBI-GEO ]   SPRY4 [ EBI - ARRAY_EXPRESS ]   SPRY4 [ SEEK ]   SPRY4 [ MEM ]
Gene Expression Viewer (FireBrowse)SPRY4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)81848
GTEX Portal (Tissue expression)SPRY4
Human Protein AtlasENSG00000187678-SPRY4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9C004   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9C004  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9C004
Splice isoforms : SwissVarQ9C004
PhosPhoSitePlusQ9C004
Domaine pattern : Prosite (Expaxy)SPR (PS51227)   
Domains : Interpro (EBI)Sprouty    SPRY4   
Domain families : Pfam (Sanger)Sprouty (PF05210)   
Domain families : Pfam (NCBI)pfam05210   
Conserved Domain (NCBI)SPRY4
DMDM Disease mutations81848
Blocks (Seattle)SPRY4
PDB (SRS)3BUN   
PDB (PDBSum)3BUN   
PDB (IMB)3BUN   
PDB (RSDB)3BUN   
Structural Biology KnowledgeBase3BUN   
SCOP (Structural Classification of Proteins)3BUN   
CATH (Classification of proteins structures)3BUN   
SuperfamilyQ9C004
Human Protein Atlas [tissue]ENSG00000187678-SPRY4 [tissue]
Peptide AtlasQ9C004
HPRD10466
IPIIPI00895795   IPI00221316   IPI00000526   IPI00307426   
Protein Interaction databases
DIP (DOE-UCLA)Q9C004
IntAct (EBI)Q9C004
FunCoupENSG00000187678
BioGRIDSPRY4
STRING (EMBL)SPRY4
ZODIACSPRY4
Ontologies - Pathways
QuickGOQ9C004
Ontology : AmiGOprotein binding  cytoplasm  focal adhesion  multicellular organism development  ruffle membrane  negative regulation of ERK1 and ERK2 cascade  
Ontology : EGO-EBIprotein binding  cytoplasm  focal adhesion  multicellular organism development  ruffle membrane  negative regulation of ERK1 and ERK2 cascade  
Pathways : BIOCARTASprouty regulation of tyrosine kinase signals [Genes]   
Pathways : KEGGJak-STAT signaling pathway   
NDEx NetworkSPRY4
Atlas of Cancer Signalling NetworkSPRY4
Wikipedia pathwaysSPRY4
Orthology - Evolution
OrthoDB81848
GeneTree (enSembl)ENSG00000187678
Phylogenetic Trees/Animal Genes : TreeFamSPRY4
HOVERGENQ9C004
HOGENOMQ9C004
Homologs : HomoloGeneSPRY4
Homology/Alignments : Family Browser (UCSC)SPRY4
Gene fusions - Rearrangements
Tumor Fusion PortalSPRY4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSPRY4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SPRY4
dbVarSPRY4
ClinVarSPRY4
1000_GenomesSPRY4 
Exome Variant ServerSPRY4
ExAC (Exome Aggregation Consortium)ENSG00000187678
GNOMAD BrowserENSG00000187678
Genetic variants : HAPMAP81848
Genomic Variants (DGV)SPRY4 [DGVbeta]
DECIPHERSPRY4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSPRY4 
Mutations
ICGC Data PortalSPRY4 
TCGA Data PortalSPRY4 
Broad Tumor PortalSPRY4
OASIS PortalSPRY4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSPRY4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSPRY4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SPRY4
DgiDB (Drug Gene Interaction Database)SPRY4
DoCM (Curated mutations)SPRY4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SPRY4 (select a term)
intoGenSPRY4
Cancer3DSPRY4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM146110    607984    615266   
Orphanet3249    22312    8668   
DisGeNETSPRY4
MedgenSPRY4
Genetic Testing Registry SPRY4
NextProtQ9C004 [Medical]
TSGene81848
GENETestsSPRY4
Target ValidationSPRY4
Huge Navigator SPRY4 [HugePedia]
snp3D : Map Gene to Disease81848
BioCentury BCIQSPRY4
ClinGenSPRY4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD81848
Chemical/Pharm GKB GenePA37975
Clinical trialSPRY4
Miscellaneous
canSAR (ICR)SPRY4 (select the gene name)
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSPRY4
EVEXSPRY4
GoPubMedSPRY4
iHOPSPRY4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:36:22 CET 2017

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