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SPSB1 (splA/ryanodine receptor domain and SOCS box containing 1)

Identity

Alias_symbol (synonym)SSB-1
Other aliasSSB1
HGNC (Hugo) SPSB1
LocusID (NCBI) 80176
Atlas_Id 55096
Location 1p36.22  [Link to chromosome band 1p36]
Location_base_pair Starts at 9292882 and ends at 9369531 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CAPZB (1p36.13) / SPSB1 (1p36.22)SORCS2 (4p16.1) / SPSB1 (1p36.22)SPSB1 (1p36.22) / H6PD (1p36.22)
TMEM201 (1p36.22) / SPSB1 (1p36.22)SPSB1 1p36.22 / H6PD 1p36.22TMEM201 1p36.22 / SPSB1 1p36.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SPSB1   30628
Cards
Entrez_Gene (NCBI)SPSB1  80176  splA/ryanodine receptor domain and SOCS box containing 1
AliasesSSB-1; SSB1
GeneCards (Weizmann)SPSB1
Ensembl hg19 (Hinxton)ENSG00000171621 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171621 [Gene_View]  chr1:9292882-9369531 [Contig_View]  SPSB1 [Vega]
ICGC DataPortalENSG00000171621
TCGA cBioPortalSPSB1
AceView (NCBI)SPSB1
Genatlas (Paris)SPSB1
WikiGenes80176
SOURCE (Princeton)SPSB1
Genetics Home Reference (NIH)SPSB1
Genomic and cartography
GoldenPath hg38 (UCSC)SPSB1  -     chr1:9292882-9369531 +  1p36.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SPSB1  -     1p36.22   [Description]    (hg19-Feb_2009)
EnsemblSPSB1 - 1p36.22 [CytoView hg19]  SPSB1 - 1p36.22 [CytoView hg38]
Mapping of homologs : NCBISPSB1 [Mapview hg19]  SPSB1 [Mapview hg38]
OMIM611657   
Gene and transcription
Genbank (Entrez)AB209559 AF131840 AF403026 AK026046 AK130055
RefSeq transcript (Entrez)NM_025106
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SPSB1
Cluster EST : UnigeneHs.738680 [ NCBI ]
CGAP (NCI)Hs.738680
Alternative Splicing GalleryENSG00000171621
Gene ExpressionSPSB1 [ NCBI-GEO ]   SPSB1 [ EBI - ARRAY_EXPRESS ]   SPSB1 [ SEEK ]   SPSB1 [ MEM ]
Gene Expression Viewer (FireBrowse)SPSB1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80176
GTEX Portal (Tissue expression)SPSB1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96BD6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96BD6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96BD6
Splice isoforms : SwissVarQ96BD6
PhosPhoSitePlusQ96BD6
Domaine pattern : Prosite (Expaxy)B302_SPRY (PS50188)    SOCS (PS50225)   
Domains : Interpro (EBI)B30.2/SPRY    ConA-like_dom    SOCS_box    SPRY_dom   
Domain families : Pfam (Sanger)SOCS_box (PF07525)    SPRY (PF00622)   
Domain families : Pfam (NCBI)pfam07525    pfam00622   
Domain families : Smart (EMBL)SOCS_box (SM00969)  SPRY (SM00449)  
Conserved Domain (NCBI)SPSB1
DMDM Disease mutations80176
Blocks (Seattle)SPSB1
PDB (SRS)2JK9    3F2O   
PDB (PDBSum)2JK9    3F2O   
PDB (IMB)2JK9    3F2O   
PDB (RSDB)2JK9    3F2O   
Structural Biology KnowledgeBase2JK9    3F2O   
SCOP (Structural Classification of Proteins)2JK9    3F2O   
CATH (Classification of proteins structures)2JK9    3F2O   
SuperfamilyQ96BD6
Human Protein AtlasENSG00000171621
Peptide AtlasQ96BD6
HPRD18106
IPIIPI00749406   IPI00442828   IPI00853464   
Protein Interaction databases
DIP (DOE-UCLA)Q96BD6
IntAct (EBI)Q96BD6
FunCoupENSG00000171621
BioGRIDSPSB1
STRING (EMBL)SPSB1
ZODIACSPSB1
Ontologies - Pathways
QuickGOQ96BD6
Ontology : AmiGOprotein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  cytosol  intracellular signal transduction  
Ontology : EGO-EBIprotein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  cytosol  intracellular signal transduction  
NDEx NetworkSPSB1
Atlas of Cancer Signalling NetworkSPSB1
Wikipedia pathwaysSPSB1
Orthology - Evolution
OrthoDB80176
GeneTree (enSembl)ENSG00000171621
Phylogenetic Trees/Animal Genes : TreeFamSPSB1
HOVERGENQ96BD6
HOGENOMQ96BD6
Homologs : HomoloGeneSPSB1
Homology/Alignments : Family Browser (UCSC)SPSB1
Gene fusions - Rearrangements
Fusion : MitelmanSPSB1/H6PD [1p36.22/1p36.22]  
Fusion : MitelmanTMEM201/SPSB1 [1p36.22/1p36.22]  [t(1;1)(p36;p36)]  
Fusion: TCGASPSB1 1p36.22 H6PD 1p36.22 THCA
Fusion: TCGATMEM201 1p36.22 SPSB1 1p36.22 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSPSB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SPSB1
dbVarSPSB1
ClinVarSPSB1
1000_GenomesSPSB1 
Exome Variant ServerSPSB1
ExAC (Exome Aggregation Consortium)SPSB1 (select the gene name)
Genetic variants : HAPMAP80176
Genomic Variants (DGV)SPSB1 [DGVbeta]
DECIPHERSPSB1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSPSB1 
Mutations
ICGC Data PortalSPSB1 
TCGA Data PortalSPSB1 
Broad Tumor PortalSPSB1
OASIS PortalSPSB1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSPSB1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSPSB1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SPSB1
DgiDB (Drug Gene Interaction Database)SPSB1
DoCM (Curated mutations)SPSB1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SPSB1 (select a term)
intoGenSPSB1
Cancer3DSPSB1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611657   
Orphanet
MedgenSPSB1
Genetic Testing Registry SPSB1
NextProtQ96BD6 [Medical]
TSGene80176
GENETestsSPSB1
Target ValidationSPSB1
Huge Navigator SPSB1 [HugePedia]
snp3D : Map Gene to Disease80176
BioCentury BCIQSPSB1
ClinGenSPSB1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD80176
Chemical/Pharm GKB GenePA142670871
Clinical trialSPSB1
Miscellaneous
canSAR (ICR)SPSB1 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSPSB1
EVEXSPSB1
GoPubMedSPSB1
iHOPSPSB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Aug 1 17:15:36 CEST 2017

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