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SPSB4 (splA/ryanodine receptor domain and SOCS box containing 4)

Identity

Alias_symbol (synonym)SSB-4
Other aliasSSB4
HGNC (Hugo) SPSB4
LocusID (NCBI) 92369
Atlas_Id 54667
Location 3q23  [Link to chromosome band 3q23]
Location_base_pair Starts at 141051402 and ends at 141148611 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
SPSB4 (3q23) / SPSB4 (3q23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)SPSB4   30630
Cards
Entrez_Gene (NCBI)SPSB4  92369  splA/ryanodine receptor domain and SOCS box containing 4
AliasesSSB-4; SSB4
GeneCards (Weizmann)SPSB4
Ensembl hg19 (Hinxton)ENSG00000175093 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175093 [Gene_View]  chr3:141051402-141148611 [Contig_View]  SPSB4 [Vega]
ICGC DataPortalENSG00000175093
TCGA cBioPortalSPSB4
AceView (NCBI)SPSB4
Genatlas (Paris)SPSB4
WikiGenes92369
SOURCE (Princeton)SPSB4
Genetics Home Reference (NIH)SPSB4
Genomic and cartography
GoldenPath hg38 (UCSC)SPSB4  -     chr3:141051402-141148611 +  3q23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SPSB4  -     3q23   [Description]    (hg19-Feb_2009)
EnsemblSPSB4 - 3q23 [CytoView hg19]  SPSB4 - 3q23 [CytoView hg38]
Mapping of homologs : NCBISPSB4 [Mapview hg19]  SPSB4 [Mapview hg38]
OMIM611660   
Gene and transcription
Genbank (Entrez)AF086345 AF403029 AK056147 AK056367 BC008324
RefSeq transcript (Entrez)NM_080862
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SPSB4
Cluster EST : UnigeneHs.655112 [ NCBI ]
CGAP (NCI)Hs.655112
Alternative Splicing GalleryENSG00000175093
Gene ExpressionSPSB4 [ NCBI-GEO ]   SPSB4 [ EBI - ARRAY_EXPRESS ]   SPSB4 [ SEEK ]   SPSB4 [ MEM ]
Gene Expression Viewer (FireBrowse)SPSB4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)92369
GTEX Portal (Tissue expression)SPSB4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96A44   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96A44  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96A44
Splice isoforms : SwissVarQ96A44
PhosPhoSitePlusQ96A44
Domaine pattern : Prosite (Expaxy)B302_SPRY (PS50188)    SOCS (PS50225)   
Domains : Interpro (EBI)B30.2/SPRY    ConA-like_dom    SOCS_box    SPRY_dom   
Domain families : Pfam (Sanger)SOCS_box (PF07525)    SPRY (PF00622)   
Domain families : Pfam (NCBI)pfam07525    pfam00622   
Domain families : Smart (EMBL)SOCS_box (SM00969)  SPRY (SM00449)  
Conserved Domain (NCBI)SPSB4
DMDM Disease mutations92369
Blocks (Seattle)SPSB4
PDB (SRS)2V24   
PDB (PDBSum)2V24   
PDB (IMB)2V24   
PDB (RSDB)2V24   
Structural Biology KnowledgeBase2V24   
SCOP (Structural Classification of Proteins)2V24   
CATH (Classification of proteins structures)2V24   
SuperfamilyQ96A44
Human Protein AtlasENSG00000175093
Peptide AtlasQ96A44
HPRD18108
IPIIPI00059238   IPI00983561   IPI00967372   
Protein Interaction databases
DIP (DOE-UCLA)Q96A44
IntAct (EBI)Q96A44
FunCoupENSG00000175093
BioGRIDSPSB4
STRING (EMBL)SPSB4
ZODIACSPSB4
Ontologies - Pathways
QuickGOQ96A44
Ontology : AmiGOprotein binding  cytoplasm  protein ubiquitination  intracellular signal transduction  
Ontology : EGO-EBIprotein binding  cytoplasm  protein ubiquitination  intracellular signal transduction  
NDEx NetworkSPSB4
Atlas of Cancer Signalling NetworkSPSB4
Wikipedia pathwaysSPSB4
Orthology - Evolution
OrthoDB92369
GeneTree (enSembl)ENSG00000175093
Phylogenetic Trees/Animal Genes : TreeFamSPSB4
HOVERGENQ96A44
HOGENOMQ96A44
Homologs : HomoloGeneSPSB4
Homology/Alignments : Family Browser (UCSC)SPSB4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSPSB4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SPSB4
dbVarSPSB4
ClinVarSPSB4
1000_GenomesSPSB4 
Exome Variant ServerSPSB4
ExAC (Exome Aggregation Consortium)SPSB4 (select the gene name)
Genetic variants : HAPMAP92369
Genomic Variants (DGV)SPSB4 [DGVbeta]
DECIPHERSPSB4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSPSB4 
Mutations
ICGC Data PortalSPSB4 
TCGA Data PortalSPSB4 
Broad Tumor PortalSPSB4
OASIS PortalSPSB4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSPSB4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSPSB4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SPSB4
DgiDB (Drug Gene Interaction Database)SPSB4
DoCM (Curated mutations)SPSB4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SPSB4 (select a term)
intoGenSPSB4
Cancer3DSPSB4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611660   
Orphanet
MedgenSPSB4
Genetic Testing Registry SPSB4
NextProtQ96A44 [Medical]
TSGene92369
GENETestsSPSB4
Target ValidationSPSB4
Huge Navigator SPSB4 [HugePedia]
snp3D : Map Gene to Disease92369
BioCentury BCIQSPSB4
ClinGenSPSB4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD92369
Chemical/Pharm GKB GenePA142670874
Clinical trialSPSB4
Miscellaneous
canSAR (ICR)SPSB4 (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSPSB4
EVEXSPSB4
GoPubMedSPSB4
iHOPSPSB4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:32:53 CEST 2017

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