SPX (spexin hormone)

2014-11-01  

Identity

HGNC
SPX
LOCATION
12p12.1
LOCUSID
80763
ALIAS
C12orf39

Other Information

Locus ID:

NCBI: 80763
HGNC: 28139
Ensembl: ENSG00000134548

Variants:

dbSNP: 80763
ClinVar: 80763
TCGA: ENSG00000134548
COSMIC: SPX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134548ENST00000256969Q9BT56
ENSG00000134548ENST00000535033A0A3B3ISF3
ENSG00000134548ENST00000546199F5GXE5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
245172312014Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III.32
220380512012Peptides derived from the prohormone proNPQ/spexin are potent central modulators of cardiovascular and renal function and nociception.14
291374712018Serum levels of spexin and kisspeptin negatively correlate with obesity and insulin resistance in women.14
262118932015Spexin peptide is expressed in human endocrine and epithelial tissues and reduced after glucose load in type 2 diabetes.13
272182692016Decreased Circulating Levels of Spexin in Obese Children.13
286269422018Effect of obesity and type 2 diabetes, and glucose ingestion on circulating spexin concentration in adolescents.10
191931932009C12ORF39, a novel secreted protein with a typical amidation processing signal.8
302547092018Spexin Levels Are Associated with Metabolic Syndrome Components.6
300316792019Circulating spexin levels are influenced by the presence or absence of gestational diabetes.4
303052422018Spexin: A novel regulator of adipogenesis and fat tissue metabolism.4

Citation

Dessen P

SPX (spexin hormone)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74223/spx