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SRCAP (Snf2-related CREBBP activator protein)

Identity

Alias_namesSnf2-related CREBBP activator protein
Alias_symbol (synonym)KIAA0309
EAF1
SWR1
DOMO1
HGNC (Hugo) SRCAP
LocusID (NCBI) 10847
Atlas_Id 43068
Location 16p11.2  [Link to chromosome band 16p11]
Location_base_pair Starts at 30710462 and ends at 30751450 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CHSY1 (15q26.3) / SRCAP (16p11.2)SRCAP (16p11.2) / CNP (17q21.2)SRCAP (16p11.2) / RAD52 (12p13.33)
SRCAP (16p11.2) / RPS4Y1 (Yp11.31)SRCAP (16p11.2) / SRCAP (16p11.2)SRCAP (16p11.2) / YWHAZ (8q22.3)
SRCAP (16p11.2) / ZNF524 (19q13.42)USP12 (13q12.13) / SRCAP (16p11.2)SRCAP 16p11.2 / RPS4Y1 Yp11.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SRCAP   16974
Cards
Entrez_Gene (NCBI)SRCAP  10847  Snf2-related CREBBP activator protein
AliasesDOMO1; EAF1; FLHS; SWR1
GeneCards (Weizmann)SRCAP
Ensembl hg19 (Hinxton)ENSG00000080603 [Gene_View]  chr16:30710462-30751450 [Contig_View]  SRCAP [Vega]
Ensembl hg38 (Hinxton)ENSG00000080603 [Gene_View]  chr16:30710462-30751450 [Contig_View]  SRCAP [Vega]
ICGC DataPortalENSG00000080603
TCGA cBioPortalSRCAP
AceView (NCBI)SRCAP
Genatlas (Paris)SRCAP
WikiGenes10847
SOURCE (Princeton)SRCAP
Genetics Home Reference (NIH)SRCAP
Genomic and cartography
GoldenPath hg19 (UCSC)SRCAP  -     chr16:30710462-30751450 +  16p11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SRCAP  -     16p11.2   [Description]    (hg38-Dec_2013)
EnsemblSRCAP - 16p11.2 [CytoView hg19]  SRCAP - 16p11.2 [CytoView hg38]
Mapping of homologs : NCBISRCAP [Mapview hg19]  SRCAP [Mapview hg38]
OMIM136140   611421   
Gene and transcription
Genbank (Entrez)AB621816 AF143946 AK023808 AK025382 AK126463
RefSeq transcript (Entrez)NM_006662
RefSeq genomic (Entrez)NC_000016 NC_018927 NG_032135 NT_187260 NW_004929400
Consensus coding sequences : CCDS (NCBI)SRCAP
Cluster EST : UnigeneHs.620916 [ NCBI ]
CGAP (NCI)Hs.620916
Alternative Splicing GalleryENSG00000080603
Gene ExpressionSRCAP [ NCBI-GEO ]   SRCAP [ EBI - ARRAY_EXPRESS ]   SRCAP [ SEEK ]   SRCAP [ MEM ]
Gene Expression Viewer (FireBrowse)SRCAP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10847
GTEX Portal (Tissue expression)SRCAP
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6ZRS2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6ZRS2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6ZRS2
Splice isoforms : SwissVarQ6ZRS2
Catalytic activity : Enzyme3.6.4.- [ Enzyme-Expasy ]   3.6.4.-3.6.4.- [ IntEnz-EBI ]   3.6.4.- [ BRENDA ]   3.6.4.- [ KEGG ]   
PhosPhoSitePlusQ6ZRS2
Domaine pattern : Prosite (Expaxy)HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    HSA (PS51204)   
Domains : Interpro (EBI)AT_hook-like    AT_hook_DNA-bd_motif    Helicase_ATP-bd    Helicase_C    HSA_dom    P-loop_NTPase    SNF2_N   
Domain families : Pfam (Sanger)Helicase_C (PF00271)    HSA (PF07529)    SNF2_N (PF00176)   
Domain families : Pfam (NCBI)pfam00271    pfam07529    pfam00176   
Domain families : Smart (EMBL)AT_hook (SM00384)  DEXDc (SM00487)  HELICc (SM00490)  
Conserved Domain (NCBI)SRCAP
DMDM Disease mutations10847
Blocks (Seattle)SRCAP
SuperfamilyQ6ZRS2
Human Protein AtlasENSG00000080603
Peptide AtlasQ6ZRS2
HPRD18103
IPIIPI00444046   IPI00009101   IPI00550342   IPI00445167   IPI00926983   
Protein Interaction databases
DIP (DOE-UCLA)Q6ZRS2
IntAct (EBI)Q6ZRS2
FunCoupENSG00000080603
BioGRIDSRCAP
STRING (EMBL)SRCAP
ZODIACSRCAP
Ontologies - Pathways
QuickGOQ6ZRS2
Ontology : AmiGODNA binding  transcription coactivator activity  helicase activity  histone acetyltransferase activity  protein binding  ATP binding  nucleus  Golgi apparatus  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  viral process  histone acetylation  protein complex  perinuclear region of cytoplasm  
Ontology : EGO-EBIDNA binding  transcription coactivator activity  helicase activity  histone acetyltransferase activity  protein binding  ATP binding  nucleus  Golgi apparatus  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  viral process  histone acetylation  protein complex  perinuclear region of cytoplasm  
NDEx NetworkSRCAP
Atlas of Cancer Signalling NetworkSRCAP
Wikipedia pathwaysSRCAP
Orthology - Evolution
OrthoDB10847
GeneTree (enSembl)ENSG00000080603
Phylogenetic Trees/Animal Genes : TreeFamSRCAP
HOVERGENQ6ZRS2
HOGENOMQ6ZRS2
Homologs : HomoloGeneSRCAP
Homology/Alignments : Family Browser (UCSC)SRCAP
Gene fusions - Rearrangements
Fusion : MitelmanSRCAP/RPS4Y1 [16p11.2/Yp11.31]  
Fusion: TCGASRCAP 16p11.2 RPS4Y1 Yp11.31 GBM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSRCAP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SRCAP
dbVarSRCAP
ClinVarSRCAP
1000_GenomesSRCAP 
Exome Variant ServerSRCAP
ExAC (Exome Aggregation Consortium)SRCAP (select the gene name)
Genetic variants : HAPMAP10847
Genomic Variants (DGV)SRCAP [DGVbeta]
DECIPHER (Syndromes)16:30710462-30751450  ENSG00000080603
CONAN: Copy Number AnalysisSRCAP 
Mutations
ICGC Data PortalSRCAP 
TCGA Data PortalSRCAP 
Broad Tumor PortalSRCAP
OASIS PortalSRCAP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSRCAP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSRCAP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SRCAP
DgiDB (Drug Gene Interaction Database)SRCAP
DoCM (Curated mutations)SRCAP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SRCAP (select a term)
intoGenSRCAP
Cancer3DSRCAP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM136140    611421   
Orphanet1966   
MedgenSRCAP
Genetic Testing Registry SRCAP
NextProtQ6ZRS2 [Medical]
TSGene10847
GENETestsSRCAP
Huge Navigator SRCAP [HugePedia]
snp3D : Map Gene to Disease10847
BioCentury BCIQSRCAP
ClinGenSRCAP (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10847
Chemical/Pharm GKB GenePA162404706
Clinical trialSRCAP
Miscellaneous
canSAR (ICR)SRCAP (select the gene name)
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSRCAP
EVEXSRCAP
GoPubMedSRCAP
iHOPSRCAP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Nov 18 19:52:30 CET 2016

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