SREBF2 (sterol regulatory element binding transcription factor 2)

2003-08-01  

Identity

HGNC
LOCATION
22q13.2
LOCUSID
ALIAS
SREBP-2,SREBP2,bHLHd2
FUSION GENES

Other Information

Locus ID:

NCBI: 6721
MIM: 600481
HGNC: 11290
Ensembl: ENSG00000198911

Variants:

dbSNP: 6721
ClinVar: 6721
TCGA: ENSG00000198911
COSMIC: SREBF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198911ENST00000361204Q12772
ENSG00000198911ENST00000361204A0A024R1Q0
ENSG00000198911ENST00000424354G3V0I8
ENSG00000198911ENST00000435061H0Y7E5
ENSG00000198911ENST00000612482A0A087X1T2

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Regulation of cholesterol biosynthesis by SREBP (SREBF)REACTOMER-HSA-1655829
Activation of gene expression by SREBF (SREBP)REACTOMER-HSA-2426168
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of white adipocyte differentiationREACTOMER-HSA-381340

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
204668822010MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis.345
205668752010miR-33 links SREBP-2 induction to repression of sterol transporters.212
190417662008Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance.167
207328772010Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation.143
150263652004Dysregulation of sterol response element-binding proteins and downstream effectors in prostate cancer during progression to androgen independence.97
192310102009Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH.94
150851962004Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis.93
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
179214362008Sterol-dependent regulation of proprotein convertase subtilisin/kexin type 9 expression by sterol-regulatory element binding protein-2.77
238381632013Sterol regulatory element binding protein 2 activation of NLRP3 inflammasome in endothelium mediates hemodynamic-induced atherosclerosis susceptibility.75

Citation

Dessen P

SREBF2 (sterol regulatory element binding transcription factor 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42387/srebf2