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SREK1 (splicing regulatory glutamic acid and lysine rich protein 1)

Identity

Alias_namesSFRS12
splicing factor, arginine/serine-rich 12
Alias_symbol (synonym)DKFZp564B176
SRrp86
SRrp508
Other alias
HGNC (Hugo) SREK1
LocusID (NCBI) 140890
Atlas_Id 74227
Location 5q12.3  [Link to chromosome band 5q12]
Location_base_pair Starts at 66144218 and ends at 66183616 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CTNNB1 (3p22.1) / SREK1 (5q12.3)HOMER1 (5q14.1) / SREK1 (5q12.3)IWS1 (2q14.3) / SREK1 (5q12.3)
NFIB (9p23) / SREK1 (5q12.3)SREK1 (5q12.3) / ANKRD12 (18p11.22)SREK1 (5q12.3) / HOMER1 (5q14.1)
SREK1 (5q12.3) / SREK1 (5q12.3)SREK1 (5q12.3) / ST6GAL1 (3q27.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SREK1   17882
Cards
Entrez_Gene (NCBI)SREK1  140890  splicing regulatory glutamic acid and lysine rich protein 1
AliasesSFRS12; SRrp508; SRrp86
GeneCards (Weizmann)SREK1
Ensembl hg19 (Hinxton)ENSG00000153914 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000153914 [Gene_View]  chr5:66144218-66183616 [Contig_View]  SREK1 [Vega]
ICGC DataPortalENSG00000153914
TCGA cBioPortalSREK1
AceView (NCBI)SREK1
Genatlas (Paris)SREK1
WikiGenes140890
SOURCE (Princeton)SREK1
Genetics Home Reference (NIH)SREK1
Genomic and cartography
GoldenPath hg38 (UCSC)SREK1  -     chr5:66144218-66183616 +  5q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SREK1  -     5q12.3   [Description]    (hg19-Feb_2009)
EnsemblSREK1 - 5q12.3 [CytoView hg19]  SREK1 - 5q12.3 [CytoView hg38]
Mapping of homologs : NCBISREK1 [Mapview hg19]  SREK1 [Mapview hg38]
OMIM609268   
Gene and transcription
Genbank (Entrez)AB209694 AF459094 AK091758 AK125893 AK308287
RefSeq transcript (Entrez)NM_001077199 NM_001270492 NM_001270493 NM_001323527 NM_001323529 NM_001323533 NM_001323534 NM_001323535 NM_139168
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SREK1
Cluster EST : UnigeneHs.49367 [ NCBI ]
CGAP (NCI)Hs.49367
Alternative Splicing GalleryENSG00000153914
Gene ExpressionSREK1 [ NCBI-GEO ]   SREK1 [ EBI - ARRAY_EXPRESS ]   SREK1 [ SEEK ]   SREK1 [ MEM ]
Gene Expression Viewer (FireBrowse)SREK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)140890
GTEX Portal (Tissue expression)SREK1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WXA9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WXA9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WXA9
Splice isoforms : SwissVarQ8WXA9
PhosPhoSitePlusQ8WXA9
Domaine pattern : Prosite (Expaxy)RRM (PS50102)   
Domains : Interpro (EBI)Nucleotide-bd_a/b_plait    RRM_dom    Srek1    SREK1_RRM2   
Domain families : Pfam (Sanger)RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam00076   
Domain families : Smart (EMBL)RRM (SM00360)  
Conserved Domain (NCBI)SREK1
DMDM Disease mutations140890
Blocks (Seattle)SREK1
SuperfamilyQ8WXA9
Human Protein AtlasENSG00000153914
Peptide AtlasQ8WXA9
HPRD18043
IPIIPI00103497   IPI00375462   IPI01010042   IPI00974421   IPI00974063   IPI00976211   IPI00977570   
Protein Interaction databases
DIP (DOE-UCLA)Q8WXA9
IntAct (EBI)Q8WXA9
FunCoupENSG00000153914
BioGRIDSREK1
STRING (EMBL)SREK1
ZODIACSREK1
Ontologies - Pathways
QuickGOQ8WXA9
Ontology : AmiGOregulation of alternative mRNA splicing, via spliceosome  RNA binding  protein binding  nucleoplasm  spliceosomal complex  mRNA processing  RNA splicing  nuclear speck  
Ontology : EGO-EBIregulation of alternative mRNA splicing, via spliceosome  RNA binding  protein binding  nucleoplasm  spliceosomal complex  mRNA processing  RNA splicing  nuclear speck  
NDEx NetworkSREK1
Atlas of Cancer Signalling NetworkSREK1
Wikipedia pathwaysSREK1
Orthology - Evolution
OrthoDB140890
GeneTree (enSembl)ENSG00000153914
Phylogenetic Trees/Animal Genes : TreeFamSREK1
HOVERGENQ8WXA9
HOGENOMQ8WXA9
Homologs : HomoloGeneSREK1
Homology/Alignments : Family Browser (UCSC)SREK1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSREK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SREK1
dbVarSREK1
ClinVarSREK1
1000_GenomesSREK1 
Exome Variant ServerSREK1
ExAC (Exome Aggregation Consortium)SREK1 (select the gene name)
Genetic variants : HAPMAP140890
Genomic Variants (DGV)SREK1 [DGVbeta]
DECIPHERSREK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSREK1 
Mutations
ICGC Data PortalSREK1 
TCGA Data PortalSREK1 
Broad Tumor PortalSREK1
OASIS PortalSREK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSREK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSREK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SREK1
DgiDB (Drug Gene Interaction Database)SREK1
DoCM (Curated mutations)SREK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SREK1 (select a term)
intoGenSREK1
Cancer3DSREK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609268   
Orphanet
MedgenSREK1
Genetic Testing Registry SREK1
NextProtQ8WXA9 [Medical]
TSGene140890
GENETestsSREK1
Target ValidationSREK1
Huge Navigator SREK1 [HugePedia]
snp3D : Map Gene to Disease140890
BioCentury BCIQSREK1
ClinGenSREK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD140890
Chemical/Pharm GKB GenePA38255
Clinical trialSREK1
Miscellaneous
canSAR (ICR)SREK1 (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSREK1
EVEXSREK1
GoPubMedSREK1
iHOPSREK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:44:07 CEST 2017

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