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SREK1 (splicing regulatory glutamic acid and lysine rich protein 1)

Identity

Alias (NCBI)SFRS12
SRrp508
SRrp86
HGNC (Hugo) SREK1
HGNC Alias symbDKFZp564B176
SRrp86
SRrp508
HGNC Alias nameserine-arginine-rich splicing regulatory protein 508
HGNC Previous nameSFRS12
HGNC Previous namesplicing factor, arginine/serine-rich 12
LocusID (NCBI) 140890
Atlas_Id 74227
Location 5q12.3  [Link to chromosome band 5q12]
Location_base_pair Starts at 66144835 and ends at 66183616 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CTNNB1 (3p22.1) / SREK1 (5q12.3)HOMER1 (5q14.1) / SREK1 (5q12.3)IWS1 (2q14.3) / SREK1 (5q12.3)
NFIB (9p23) / SREK1 (5q12.3)SREK1 (5q12.3) / ANKRD12 (18p11.22)SREK1 (5q12.3) / HOMER1 (5q14.1)
SREK1 (5q12.3) / SREK1 (5q12.3)SREK1 (5q12.3) / ST6GAL1 (3q27.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SREK1   17882
Cards
Entrez_Gene (NCBI)SREK1    splicing regulatory glutamic acid and lysine rich protein 1
AliasesSFRS12; SRrp508; SRrp86
GeneCards (Weizmann)SREK1
Ensembl hg19 (Hinxton)ENSG00000153914 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000153914 [Gene_View]  ENSG00000153914 [Sequence]  chr5:66144835-66183616 [Contig_View]  SREK1 [Vega]
ICGC DataPortalENSG00000153914
TCGA cBioPortalSREK1
AceView (NCBI)SREK1
Genatlas (Paris)SREK1
SOURCE (Princeton)SREK1
Genetics Home Reference (NIH)SREK1
Genomic and cartography
GoldenPath hg38 (UCSC)SREK1  -     chr5:66144835-66183616 +  5q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SREK1  -     5q12.3   [Description]    (hg19-Feb_2009)
GoldenPathSREK1 - 5q12.3 [CytoView hg19]  SREK1 - 5q12.3 [CytoView hg38]
ImmunoBaseENSG00000153914
Genome Data Viewer NCBISREK1 [Mapview hg19]  
OMIM609268   
Gene and transcription
Genbank (Entrez)AB209694 AF459094 AK091758 AK125893 AK308287
RefSeq transcript (Entrez)NM_001077199 NM_001270492 NM_001270493 NM_001323527 NM_001323529 NM_001323533 NM_001323534 NM_001323535 NM_139168
Consensus coding sequences : CCDS (NCBI)SREK1
Gene ExpressionSREK1 [ NCBI-GEO ]   SREK1 [ EBI - ARRAY_EXPRESS ]   SREK1 [ SEEK ]   SREK1 [ MEM ]
Gene Expression Viewer (FireBrowse)SREK1 [ Firebrowse - Broad ]
GenevisibleExpression of SREK1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)140890
GTEX Portal (Tissue expression)SREK1
Human Protein AtlasENSG00000153914-SREK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WXA9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WXA9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WXA9
PhosPhoSitePlusQ8WXA9
Domaine pattern : Prosite (Expaxy)RRM (PS50102)   
Domains : Interpro (EBI)Nucleotide-bd_a/b_plait_sf    RBD_domain_sf    RRM_dom    SREK1_RRM2   
Domain families : Pfam (Sanger)RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam00076   
Domain families : Smart (EMBL)RRM (SM00360)  
Conserved Domain (NCBI)SREK1
SuperfamilyQ8WXA9
AlphaFold pdb e-kbQ8WXA9   
Human Protein Atlas [tissue]ENSG00000153914-SREK1 [tissue]
HPRD18043
Protein Interaction databases
DIP (DOE-UCLA)Q8WXA9
IntAct (EBI)Q8WXA9
BioGRIDSREK1
STRING (EMBL)SREK1
ZODIACSREK1
Ontologies - Pathways
QuickGOQ8WXA9
Ontology : AmiGORNA binding  RNA binding  protein binding  nucleoplasm  nucleoplasm  spliceosomal complex  mRNA processing  RNA splicing  nuclear speck  
Ontology : EGO-EBIRNA binding  RNA binding  protein binding  nucleoplasm  nucleoplasm  spliceosomal complex  mRNA processing  RNA splicing  nuclear speck  
NDEx NetworkSREK1
Atlas of Cancer Signalling NetworkSREK1
Wikipedia pathwaysSREK1
Orthology - Evolution
OrthoDB140890
GeneTree (enSembl)ENSG00000153914
Phylogenetic Trees/Animal Genes : TreeFamSREK1
Homologs : HomoloGeneSREK1
Homology/Alignments : Family Browser (UCSC)SREK1
Gene fusions - Rearrangements
Fusion : QuiverSREK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSREK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SREK1
dbVarSREK1
ClinVarSREK1
MonarchSREK1
1000_GenomesSREK1 
Exome Variant ServerSREK1
GNOMAD BrowserENSG00000153914
Varsome BrowserSREK1
ACMGSREK1 variants
VarityQ8WXA9
Genomic Variants (DGV)SREK1 [DGVbeta]
DECIPHERSREK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSREK1 
Mutations
ICGC Data PortalSREK1 
TCGA Data PortalSREK1 
Broad Tumor PortalSREK1
OASIS PortalSREK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSREK1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSREK1
Mutations and Diseases : HGMDSREK1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSREK1
DgiDB (Drug Gene Interaction Database)SREK1
DoCM (Curated mutations)SREK1
CIViC (Clinical Interpretations of Variants in Cancer)SREK1
Cancer3DSREK1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609268   
Orphanet
DisGeNETSREK1
MedgenSREK1
Genetic Testing Registry SREK1
NextProtQ8WXA9 [Medical]
GENETestsSREK1
Target ValidationSREK1
Huge Navigator SREK1 [HugePedia]
ClinGenSREK1
Clinical trials, drugs, therapy
MyCancerGenomeSREK1
Protein Interactions : CTDSREK1
Pharm GKB GenePA38255
PharosQ8WXA9
Clinical trialSREK1
Miscellaneous
canSAR (ICR)SREK1
HarmonizomeSREK1
DataMed IndexSREK1
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSREK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:24:09 CEST 2021

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