| Nomenclature |
|---|
| HGNC (Hugo) | SRF 11291 |
| Cards |
|---|
| Entrez_Gene (NCBI) | SRF 6722 serum response factor |
| Aliases | MCM1 |
| GeneCards (Weizmann) | SRF |
| Ensembl hg19 (Hinxton) | ENSG00000112658 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000112658 [Gene_View] ENSG00000112658 [Sequence] chr6:43171295-43181506 [Contig_View] SRF [Vega] |
| ICGC DataPortal | ENSG00000112658 |
| TCGA cBioPortal | SRF |
| AceView (NCBI) | SRF |
| Genatlas (Paris) | SRF |
| WikiGenes | 6722 |
| SOURCE (Princeton) | SRF |
| Genetics Home Reference (NIH) | SRF |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | SRF - chr6:43171295-43181506 + 6p21.1 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | SRF - 6p21.1 [Description] (hg19-Feb_2009) |
SRF - 6p21.1 [CytoView hg19] SRF - 6p21.1 [CytoView hg38] |
| Mapping of homologs : NCBI | SRF [Mapview hg19] SRF [Mapview hg38] |
| OMIM | 600589 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AB209128 AI085561 AK300467 BC048211 BC052572 |
| RefSeq transcript (Entrez) | NM_001292001 NM_003131 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | SRF |
| Cluster EST : Unigene | Hs.520140 [ NCBI ] |
| CGAP (NCI) | Hs.520140 |
| Alternative Splicing Gallery | ENSG00000112658 |
| Gene Expression | SRF [ NCBI-GEO ] SRF [ EBI - ARRAY_EXPRESS ]
SRF [ SEEK ] SRF [ MEM ] |
| Gene Expression Viewer (FireBrowse) | SRF [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 6722 |
| GTEX Portal (Tissue expression) | SRF |
| Human Protein Atlas | ENSG00000112658-SRF [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P11831 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P11831 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P11831 |
| Splice isoforms : SwissVar | P11831 |
| PhosPhoSitePlus | P11831 |
| Domaine pattern : Prosite (Expaxy) | MADS_BOX_1 (PS00350) MADS_BOX_2 (PS50066) |
| Domains : Interpro (EBI) | MADS_SRF-like TF_MADSbox TF_MADSbox_sf |
| Domain families : Pfam (Sanger) | SRF-TF (PF00319) |
| Domain families : Pfam (NCBI) | pfam00319 |
| Domain families : Smart (EMBL) | MADS (SM00432) |
| Conserved Domain (NCBI) | SRF |
| DMDM Disease mutations | 6722 |
| Blocks (Seattle) | SRF |
| PDB (RSDB) | 1HBX 1K6O 1SRS |
| PDB Europe | 1HBX 1K6O 1SRS |
| PDB (PDBSum) | 1HBX 1K6O 1SRS |
| PDB (IMB) | 1HBX 1K6O 1SRS |
| Structural Biology KnowledgeBase | 1HBX 1K6O 1SRS |
| SCOP (Structural Classification of Proteins) | 1HBX 1K6O 1SRS |
| CATH (Classification of proteins structures) | 1HBX 1K6O 1SRS |
| Superfamily | P11831 |
| Human Protein Atlas [tissue] | ENSG00000112658-SRF [tissue] |
| Peptide Atlas | P11831 |
| HPRD | 02788 |
| IPI | IPI00007879 IPI01016079 IPI00556557 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P11831 |
| IntAct (EBI) | P11831 |
| FunCoup | ENSG00000112658 |
| BioGRID | SRF |
| STRING (EMBL) | SRF |
| ZODIAC | SRF |
| Ontologies - Pathways |
|---|
| QuickGO | P11831 |
| Ontology : AmiGO | nuclear chromatin RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific branching involved in blood vessel morphogenesis response to hypoxia mesoderm formation neuron migration trophectodermal cell differentiation heart looping morphogenesis of an epithelial sheet cell migration involved in sprouting angiogenesis positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation DNA-binding transcription factor activity DNA-binding transcription factor activity protein binding nucleus nucleus nucleoplasm cytoplasm transcription by RNA polymerase II cell-matrix adhesion multicellular organism development heart development long-term memory transcription factor binding transcription factor binding negative regulation of cell proliferation associative learning response to toxic substance response to hormone epithelial structure maintenance positive regulation of transcription via serum response element binding serum response element binding hippocampus development tangential migration from the subventricular zone to the olfactory bulb actin cytoskeleton organization regulation of cell adhesion platelet activation platelet formation negative regulation of cell migration thyroid gland development neuron projection development chromatin DNA binding regulation of water loss via skin response to cytokine response to cytokine megakaryocyte development dorsal aorta morphogenesis mRNA transcription by RNA polymerase II protein homodimerization activity histone deacetylase binding stress fiber assembly sequence-specific DNA binding skin morphogenesis transcription regulatory region DNA binding positive thymic T cell selection sarcomere organization positive regulation of cell differentiation positive regulation of axon extension positive regulation of transcription by RNA polymerase II positive regulation of smooth muscle contraction positive regulation of transcription by glucose muscle cell cellular homeostasis thymus development developmental growth neuron development erythrocyte development positive regulation of DNA-binding transcription factor activity positive regulation of DNA-binding transcription factor activity regulation of smooth muscle cell differentiation positive regulation of filopodium assembly cardiac myofibril assembly angiogenesis involved in wound healing hematopoietic stem cell differentiation positive regulation of transcription initiation from RNA polymerase II promoter long-term synaptic depression face development heart trabecula formation lung morphogenesis bronchus cartilage development trachea cartilage development cardiac vascular smooth muscle cell differentiation eyelid development in camera-type eye lung smooth muscle development RNA polymerase II sequence-specific DNA-binding transcription factor binding bicellular tight junction assembly primary miRNA binding cellular response to glucose stimulus primitive streak formation epithelial cell-cell adhesion cellular senescence negative regulation of amyloid-beta clearance negative regulation of pri-miRNA transcription by RNA polymerase II positive regulation of pri-miRNA transcription by RNA polymerase II |
| Ontology : EGO-EBI | nuclear chromatin RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific branching involved in blood vessel morphogenesis response to hypoxia mesoderm formation neuron migration trophectodermal cell differentiation heart looping morphogenesis of an epithelial sheet cell migration involved in sprouting angiogenesis positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation DNA-binding transcription factor activity DNA-binding transcription factor activity protein binding nucleus nucleus nucleoplasm cytoplasm transcription by RNA polymerase II cell-matrix adhesion multicellular organism development heart development long-term memory transcription factor binding transcription factor binding negative regulation of cell proliferation associative learning response to toxic substance response to hormone epithelial structure maintenance positive regulation of transcription via serum response element binding serum response element binding hippocampus development tangential migration from the subventricular zone to the olfactory bulb actin cytoskeleton organization regulation of cell adhesion platelet activation platelet formation negative regulation of cell migration thyroid gland development neuron projection development chromatin DNA binding regulation of water loss via skin response to cytokine response to cytokine megakaryocyte development dorsal aorta morphogenesis mRNA transcription by RNA polymerase II protein homodimerization activity histone deacetylase binding stress fiber assembly sequence-specific DNA binding skin morphogenesis transcription regulatory region DNA binding positive thymic T cell selection sarcomere organization positive regulation of cell differentiation positive regulation of axon extension positive regulation of transcription by RNA polymerase II positive regulation of smooth muscle contraction positive regulation of transcription by glucose muscle cell cellular homeostasis thymus development developmental growth neuron development erythrocyte development positive regulation of DNA-binding transcription factor activity positive regulation of DNA-binding transcription factor activity regulation of smooth muscle cell differentiation positive regulation of filopodium assembly cardiac myofibril assembly angiogenesis involved in wound healing hematopoietic stem cell differentiation positive regulation of transcription initiation from RNA polymerase II promoter long-term synaptic depression face development heart trabecula formation lung morphogenesis bronchus cartilage development trachea cartilage development cardiac vascular smooth muscle cell differentiation eyelid development in camera-type eye lung smooth muscle development RNA polymerase II sequence-specific DNA-binding transcription factor binding bicellular tight junction assembly primary miRNA binding cellular response to glucose stimulus primitive streak formation epithelial cell-cell adhesion cellular senescence negative regulation of amyloid-beta clearance negative regulation of pri-miRNA transcription by RNA polymerase II positive regulation of pri-miRNA transcription by RNA polymerase II |
| Pathways : KEGG | MAPK signaling pathway HTLV-I infection Viral carcinogenesis |
| NDEx Network | SRF |
| Atlas of Cancer Signalling Network | SRF |
| Wikipedia pathways | SRF |
| Orthology - Evolution |
|---|
| OrthoDB | 6722 |
| GeneTree (enSembl) | ENSG00000112658 |
| Phylogenetic Trees/Animal Genes : TreeFam | SRF |
| HOGENOM | P11831 |
| Homologs : HomoloGene | SRF |
| Homology/Alignments : Family Browser (UCSC) | SRF |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | SRF/F5 [6p21.1/1q24.2] |
| Fusion : Mitelman | SRF/NCOA2 [6p21.1/8q13.3] [t(6;8)(p21;q13)] |
| Fusion Portal | SRF 6p21.1 F5 1q24.2 BRCA |
| Fusion : Quiver | SRF |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | SRF [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | SRF |
| dbVar | SRF |
| ClinVar | SRF |
| 1000_Genomes | SRF |
| Exome Variant Server | SRF |
| ExAC (Exome Aggregation Consortium) | ENSG00000112658 |
| GNOMAD Browser | ENSG00000112658 |
| Varsome Browser | SRF |
| Genetic variants : HAPMAP | 6722 |
| Genomic Variants (DGV) | SRF [DGVbeta] |
| DECIPHER | SRF [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | SRF |
| Mutations |
|---|
| ICGC Data Portal | SRF |
| TCGA Data Portal | SRF |
| Broad Tumor Portal | SRF |
| OASIS Portal | SRF [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | SRF [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | SRF |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search SRF |
| DgiDB (Drug Gene Interaction Database) | SRF |
| DoCM (Curated mutations) | SRF (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | SRF (select a term) |
| intoGen | SRF |
| Cancer3D | SRF(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 600589 |
| Orphanet | |
| DisGeNET | SRF |
| Medgen | SRF |
| Genetic Testing Registry | SRF
|
| NextProt | P11831 [Medical] |
| TSGene | 6722 |
| GENETests | SRF |
| Target Validation | SRF |
| Huge Navigator |
SRF [HugePedia] |
| snp3D : Map Gene to Disease | 6722 |
| BioCentury BCIQ | SRF |
| ClinGen | SRF |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 6722 |
| Chemical/Pharm GKB Gene | PA36116 |
| Clinical trial | SRF |
| Miscellaneous |
|---|
| canSAR (ICR) | SRF (select the gene name) |
| DataMed Index | SRF |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 196 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | SRF |
| EVEX | SRF |
| GoPubMed | SRF |
| iHOP | SRF |
