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SRF (serum response factor)

Identity

Alias (NCBI)MCM1
HGNC (Hugo) SRF
HGNC Alias symbMCM1
HGNC Alias nameminichromosome maintenance 1 homolog (S. cerevisiae)
 c-fos serum response element-binding transcription factor
LocusID (NCBI) 6722
Atlas_Id 42388
Location 6p21.1  [Link to chromosome band 6p21]
Location_base_pair Starts at 43171269 and ends at 43181506 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SRF (6p21.1) / F5 (1q24.2)SRF (6p21.1) / NCOA2 (8q13.3)SRF (6p21.1) / NEK9 (14q24.3)
SRF 6p21.1 / F5 1q24.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)SRF   11291
Cards
Entrez_Gene (NCBI)SRF    serum response factor
AliasesMCM1
GeneCards (Weizmann)SRF
Ensembl hg19 (Hinxton)ENSG00000112658 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112658 [Gene_View]  ENSG00000112658 [Sequence]  chr6:43171269-43181506 [Contig_View]  SRF [Vega]
ICGC DataPortalENSG00000112658
TCGA cBioPortalSRF
AceView (NCBI)SRF
Genatlas (Paris)SRF
SOURCE (Princeton)SRF
Genetics Home Reference (NIH)SRF
Genomic and cartography
GoldenPath hg38 (UCSC)SRF  -     chr6:43171269-43181506 +  6p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SRF  -     6p21.1   [Description]    (hg19-Feb_2009)
GoldenPathSRF - 6p21.1 [CytoView hg19]  SRF - 6p21.1 [CytoView hg38]
ImmunoBaseENSG00000112658
Genome Data Viewer NCBISRF [Mapview hg19]  
OMIM600589   
Gene and transcription
Genbank (Entrez)AB209128 AI085561 AK300467 BC048211 BC052572
RefSeq transcript (Entrez)NM_001292001 NM_003131
Consensus coding sequences : CCDS (NCBI)SRF
Gene ExpressionSRF [ NCBI-GEO ]   SRF [ EBI - ARRAY_EXPRESS ]   SRF [ SEEK ]   SRF [ MEM ]
Gene Expression Viewer (FireBrowse)SRF [ Firebrowse - Broad ]
GenevisibleExpression of SRF in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6722
GTEX Portal (Tissue expression)SRF
Human Protein AtlasENSG00000112658-SRF [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP11831   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP11831  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP11831
PhosPhoSitePlusP11831
Domaine pattern : Prosite (Expaxy)MADS_BOX_1 (PS00350)    MADS_BOX_2 (PS50066)   
Domains : Interpro (EBI)MADS_SRF-like    TF_MADSbox    TF_MADSbox_sf   
Domain families : Pfam (Sanger)SRF-TF (PF00319)   
Domain families : Pfam (NCBI)pfam00319   
Domain families : Smart (EMBL)MADS (SM00432)  
Conserved Domain (NCBI)SRF
PDB (RSDB)1HBX    1K6O    1SRS   
PDB Europe1HBX    1K6O    1SRS   
PDB (PDBSum)1HBX    1K6O    1SRS   
PDB (IMB)1HBX    1K6O    1SRS   
Structural Biology KnowledgeBase1HBX    1K6O    1SRS   
SCOP (Structural Classification of Proteins)1HBX    1K6O    1SRS   
CATH (Classification of proteins structures)1HBX    1K6O    1SRS   
SuperfamilyP11831
AlphaFold pdb e-kbP11831   
Human Protein Atlas [tissue]ENSG00000112658-SRF [tissue]
HPRD02788
Protein Interaction databases
DIP (DOE-UCLA)P11831
IntAct (EBI)P11831
BioGRIDSRF
STRING (EMBL)SRF
ZODIACSRF
Ontologies - Pathways
QuickGOP11831
Ontology : AmiGOchromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  branching involved in blood vessel morphogenesis  response to hypoxia  mesoderm formation  neuron migration  trophectodermal cell differentiation  heart looping  morphogenesis of an epithelial sheet  cell migration involved in sprouting angiogenesis  positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation  DNA-binding transcription factor activity  DNA-binding transcription factor activity  protein binding  nucleus  nucleoplasm  cytoplasm  regulation of transcription by RNA polymerase II  cell-matrix adhesion  heart development  long-term memory  negative regulation of cell population proliferation  associative learning  response to toxic substance  response to hormone  epithelial structure maintenance  positive regulation of transcription via serum response element binding  serum response element binding  serum response element binding  hippocampus development  tangential migration from the subventricular zone to the olfactory bulb  actin cytoskeleton organization  regulation of cell adhesion  platelet activation  platelet formation  negative regulation of cell migration  thyroid gland development  neuron projection development  chromatin DNA binding  regulation of water loss via skin  response to cytokine  response to cytokine  megakaryocyte development  dorsal aorta morphogenesis  protein homodimerization activity  histone deacetylase binding  stress fiber assembly  skin morphogenesis  positive thymic T cell selection  sarcomere organization  positive regulation of cell differentiation  positive regulation of axon extension  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of smooth muscle contraction  positive regulation of transcription by glucose  muscle cell cellular homeostasis  thymus development  developmental growth  neuron development  erythrocyte development  positive regulation of DNA-binding transcription factor activity  positive regulation of DNA-binding transcription factor activity  regulation of smooth muscle cell differentiation  positive regulation of filopodium assembly  cardiac myofibril assembly  angiogenesis involved in wound healing  hematopoietic stem cell differentiation  positive regulation of transcription initiation from RNA polymerase II promoter  long-term synaptic depression  face development  heart trabecula formation  lung morphogenesis  bronchus cartilage development  trachea cartilage development  cardiac vascular smooth muscle cell differentiation  eyelid development in camera-type eye  lung smooth muscle development  RNA polymerase II-specific DNA-binding transcription factor binding  bicellular tight junction assembly  primary miRNA binding  cellular response to glucose stimulus  primitive streak formation  epithelial cell-cell adhesion  cellular senescence  DNA-binding transcription factor binding  negative regulation of amyloid-beta clearance  negative regulation of pri-miRNA transcription by RNA polymerase II  positive regulation of pri-miRNA transcription by RNA polymerase II  sequence-specific double-stranded DNA binding  
Ontology : EGO-EBIchromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  branching involved in blood vessel morphogenesis  response to hypoxia  mesoderm formation  neuron migration  trophectodermal cell differentiation  heart looping  morphogenesis of an epithelial sheet  cell migration involved in sprouting angiogenesis  positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation  DNA-binding transcription factor activity  DNA-binding transcription factor activity  protein binding  nucleus  nucleoplasm  cytoplasm  regulation of transcription by RNA polymerase II  cell-matrix adhesion  heart development  long-term memory  negative regulation of cell population proliferation  associative learning  response to toxic substance  response to hormone  epithelial structure maintenance  positive regulation of transcription via serum response element binding  serum response element binding  serum response element binding  hippocampus development  tangential migration from the subventricular zone to the olfactory bulb  actin cytoskeleton organization  regulation of cell adhesion  platelet activation  platelet formation  negative regulation of cell migration  thyroid gland development  neuron projection development  chromatin DNA binding  regulation of water loss via skin  response to cytokine  response to cytokine  megakaryocyte development  dorsal aorta morphogenesis  protein homodimerization activity  histone deacetylase binding  stress fiber assembly  skin morphogenesis  positive thymic T cell selection  sarcomere organization  positive regulation of cell differentiation  positive regulation of axon extension  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of smooth muscle contraction  positive regulation of transcription by glucose  muscle cell cellular homeostasis  thymus development  developmental growth  neuron development  erythrocyte development  positive regulation of DNA-binding transcription factor activity  positive regulation of DNA-binding transcription factor activity  regulation of smooth muscle cell differentiation  positive regulation of filopodium assembly  cardiac myofibril assembly  angiogenesis involved in wound healing  hematopoietic stem cell differentiation  positive regulation of transcription initiation from RNA polymerase II promoter  long-term synaptic depression  face development  heart trabecula formation  lung morphogenesis  bronchus cartilage development  trachea cartilage development  cardiac vascular smooth muscle cell differentiation  eyelid development in camera-type eye  lung smooth muscle development  RNA polymerase II-specific DNA-binding transcription factor binding  bicellular tight junction assembly  primary miRNA binding  cellular response to glucose stimulus  primitive streak formation  epithelial cell-cell adhesion  cellular senescence  DNA-binding transcription factor binding  negative regulation of amyloid-beta clearance  negative regulation of pri-miRNA transcription by RNA polymerase II  positive regulation of pri-miRNA transcription by RNA polymerase II  sequence-specific double-stranded DNA binding  
Pathways : BIOCARTAPDGF Signaling Pathway [Genes]    Insulin Signaling Pathway [Genes]    EGF Signaling Pathway [Genes]    Growth Hormone Signaling Pathway [Genes]    Hop Pathway in Cardiac Development [Genes]    IL 6 signaling pathway [Genes]    Role of MAL in Rho-Mediated Activation of SRF [Genes]    IGF-1 Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    HTLV-I infection    Viral carcinogenesis   
NDEx NetworkSRF
Atlas of Cancer Signalling NetworkSRF
Wikipedia pathwaysSRF
Orthology - Evolution
OrthoDB6722
GeneTree (enSembl)ENSG00000112658
Phylogenetic Trees/Animal Genes : TreeFamSRF
Homologs : HomoloGeneSRF
Homology/Alignments : Family Browser (UCSC)SRF
Gene fusions - Rearrangements
Fusion : MitelmanSRF/F5 [6p21.1/1q24.2]  
Fusion : MitelmanSRF/NCOA2 [6p21.1/8q13.3]  
Fusion : QuiverSRF
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSRF [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SRF
dbVarSRF
ClinVarSRF
MonarchSRF
1000_GenomesSRF 
Exome Variant ServerSRF
GNOMAD BrowserENSG00000112658
Varsome BrowserSRF
ACMGSRF variants
VarityP11831
Genomic Variants (DGV)SRF [DGVbeta]
DECIPHERSRF [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSRF 
Mutations
ICGC Data PortalSRF 
TCGA Data PortalSRF 
Broad Tumor PortalSRF
OASIS PortalSRF [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSRF  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSRF
Mutations and Diseases : HGMDSRF
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSRF
DgiDB (Drug Gene Interaction Database)SRF
DoCM (Curated mutations)SRF
CIViC (Clinical Interpretations of Variants in Cancer)SRF
Cancer3DSRF
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600589   
Orphanet
DisGeNETSRF
MedgenSRF
Genetic Testing Registry SRF
NextProtP11831 [Medical]
GENETestsSRF
Target ValidationSRF
Huge Navigator SRF [HugePedia]
ClinGenSRF
Clinical trials, drugs, therapy
MyCancerGenomeSRF
Protein Interactions : CTDSRF
Pharm GKB GenePA36116
PharosP11831
Clinical trialSRF
Miscellaneous
canSAR (ICR)SRF
HarmonizomeSRF
DataMed IndexSRF
Probes
Litterature
PubMed212 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSRF
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:33:06 CEST 2021
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