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SRF (serum response factor)

Identity

Alias_symbol (synonym)MCM1
Other alias
HGNC (Hugo) SRF
LocusID (NCBI) 6722
Atlas_Id 42388
Location 6p21.1  [Link to chromosome band 6p21]
Location_base_pair Starts at 43171295 and ends at 43181506 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SRF (6p21.1) / F5 (1q24.2)SRF (6p21.1) / NCOA2 (8q13.3)SRF (6p21.1) / NEK9 (14q24.3)
SRF 6p21.1 / F5 1q24.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  Soft Tissues: Rhabdomyosarcoma
Soft tissue tumors: an overview
t(1;6)(q24;p21) SRF/F5
t(6;8)(p21;q13) SRF/NCOA2
t(6;11)(p21;q13) SRF/RELA


External links

Nomenclature
HGNC (Hugo)SRF   11291
Cards
Entrez_Gene (NCBI)SRF  6722  serum response factor
AliasesMCM1
GeneCards (Weizmann)SRF
Ensembl hg19 (Hinxton)ENSG00000112658 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112658 [Gene_View]  ENSG00000112658 [Sequence]  chr6:43171295-43181506 [Contig_View]  SRF [Vega]
ICGC DataPortalENSG00000112658
TCGA cBioPortalSRF
AceView (NCBI)SRF
Genatlas (Paris)SRF
WikiGenes6722
SOURCE (Princeton)SRF
Genetics Home Reference (NIH)SRF
Genomic and cartography
GoldenPath hg38 (UCSC)SRF  -     chr6:43171295-43181506 +  6p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SRF  -     6p21.1   [Description]    (hg19-Feb_2009)
EnsemblSRF - 6p21.1 [CytoView hg19]  SRF - 6p21.1 [CytoView hg38]
Mapping of homologs : NCBISRF [Mapview hg19]  SRF [Mapview hg38]
OMIM600589   
Gene and transcription
Genbank (Entrez)AB209128 AI085561 AK300467 BC048211 BC052572
RefSeq transcript (Entrez)NM_001292001 NM_003131
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SRF
Cluster EST : UnigeneHs.520140 [ NCBI ]
CGAP (NCI)Hs.520140
Alternative Splicing GalleryENSG00000112658
Gene ExpressionSRF [ NCBI-GEO ]   SRF [ EBI - ARRAY_EXPRESS ]   SRF [ SEEK ]   SRF [ MEM ]
Gene Expression Viewer (FireBrowse)SRF [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6722
GTEX Portal (Tissue expression)SRF
Human Protein AtlasENSG00000112658-SRF [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP11831   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP11831  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP11831
Splice isoforms : SwissVarP11831
PhosPhoSitePlusP11831
Domaine pattern : Prosite (Expaxy)MADS_BOX_1 (PS00350)    MADS_BOX_2 (PS50066)   
Domains : Interpro (EBI)MADS_SRF-like    TF_MADSbox    TF_MADSbox_sf   
Domain families : Pfam (Sanger)SRF-TF (PF00319)   
Domain families : Pfam (NCBI)pfam00319   
Domain families : Smart (EMBL)MADS (SM00432)  
Conserved Domain (NCBI)SRF
DMDM Disease mutations6722
Blocks (Seattle)SRF
PDB (SRS)1HBX    1K6O    1SRS   
PDB (PDBSum)1HBX    1K6O    1SRS   
PDB (IMB)1HBX    1K6O    1SRS   
PDB (RSDB)1HBX    1K6O    1SRS   
Structural Biology KnowledgeBase1HBX    1K6O    1SRS   
SCOP (Structural Classification of Proteins)1HBX    1K6O    1SRS   
CATH (Classification of proteins structures)1HBX    1K6O    1SRS   
SuperfamilyP11831
Human Protein Atlas [tissue]ENSG00000112658-SRF [tissue]
Peptide AtlasP11831
HPRD02788
IPIIPI00007879   IPI01016079   IPI00556557   
Protein Interaction databases
DIP (DOE-UCLA)P11831
IntAct (EBI)P11831
FunCoupENSG00000112658
BioGRIDSRF
STRING (EMBL)SRF
ZODIACSRF
Ontologies - Pathways
QuickGOP11831
Ontology : AmiGOnuclear chromatin  RNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding  transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding  proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  branching involved in blood vessel morphogenesis  response to hypoxia  mesoderm formation  neuron migration  trophectodermal cell differentiation  heart looping  morphogenesis of an epithelial sheet  cell migration involved in sprouting angiogenesis  positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation  DNA-binding transcription factor activity  transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  transcription by RNA polymerase II  cell-matrix adhesion  multicellular organism development  heart development  long-term memory  transcription factor binding  transcription factor binding  negative regulation of cell proliferation  associative learning  response to toxic substance  response to hormone  epithelial structure maintenance  positive regulation of transcription via serum response element binding  serum response element binding  hippocampus development  tangential migration from the subventricular zone to the olfactory bulb  actin cytoskeleton organization  regulation of cell adhesion  platelet activation  platelet formation  negative regulation of cell migration  thyroid gland development  neuron projection development  chromatin DNA binding  regulation of water loss via skin  response to cytokine  response to cytokine  megakaryocyte development  dorsal aorta morphogenesis  mRNA transcription by RNA polymerase II  protein homodimerization activity  histone deacetylase binding  stress fiber assembly  sequence-specific DNA binding  skin morphogenesis  transcription regulatory region DNA binding  positive thymic T cell selection  sarcomere organization  positive regulation of cell differentiation  positive regulation of axon extension  positive regulation of transcription by RNA polymerase II  positive regulation of smooth muscle contraction  positive regulation of transcription by glucose  muscle cell cellular homeostasis  thymus development  developmental growth  neuron development  erythrocyte development  positive regulation of DNA-binding transcription factor activity  regulation of smooth muscle cell differentiation  positive regulation of filopodium assembly  cardiac myofibril assembly  angiogenesis involved in wound healing  hematopoietic stem cell differentiation  positive regulation of transcription initiation from RNA polymerase II promoter  long-term synaptic depression  face development  heart trabecula formation  lung morphogenesis  bronchus cartilage development  trachea cartilage development  cardiac vascular smooth muscle cell differentiation  eyelid development in camera-type eye  lung smooth muscle development  RNA polymerase II sequence-specific DNA-binding transcription factor binding  bicellular tight junction assembly  primary miRNA binding  cellular response to glucose stimulus  primitive streak formation  epithelial cell-cell adhesion  cellular senescence  negative regulation of amyloid-beta clearance  negative regulation of pri-miRNA transcription by RNA polymerase II  positive regulation of pri-miRNA transcription by RNA polymerase II  
Ontology : EGO-EBInuclear chromatin  RNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding  transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding  proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  branching involved in blood vessel morphogenesis  response to hypoxia  mesoderm formation  neuron migration  trophectodermal cell differentiation  heart looping  morphogenesis of an epithelial sheet  cell migration involved in sprouting angiogenesis  positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation  DNA-binding transcription factor activity  transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  transcription by RNA polymerase II  cell-matrix adhesion  multicellular organism development  heart development  long-term memory  transcription factor binding  transcription factor binding  negative regulation of cell proliferation  associative learning  response to toxic substance  response to hormone  epithelial structure maintenance  positive regulation of transcription via serum response element binding  serum response element binding  hippocampus development  tangential migration from the subventricular zone to the olfactory bulb  actin cytoskeleton organization  regulation of cell adhesion  platelet activation  platelet formation  negative regulation of cell migration  thyroid gland development  neuron projection development  chromatin DNA binding  regulation of water loss via skin  response to cytokine  response to cytokine  megakaryocyte development  dorsal aorta morphogenesis  mRNA transcription by RNA polymerase II  protein homodimerization activity  histone deacetylase binding  stress fiber assembly  sequence-specific DNA binding  skin morphogenesis  transcription regulatory region DNA binding  positive thymic T cell selection  sarcomere organization  positive regulation of cell differentiation  positive regulation of axon extension  positive regulation of transcription by RNA polymerase II  positive regulation of smooth muscle contraction  positive regulation of transcription by glucose  muscle cell cellular homeostasis  thymus development  developmental growth  neuron development  erythrocyte development  positive regulation of DNA-binding transcription factor activity  regulation of smooth muscle cell differentiation  positive regulation of filopodium assembly  cardiac myofibril assembly  angiogenesis involved in wound healing  hematopoietic stem cell differentiation  positive regulation of transcription initiation from RNA polymerase II promoter  long-term synaptic depression  face development  heart trabecula formation  lung morphogenesis  bronchus cartilage development  trachea cartilage development  cardiac vascular smooth muscle cell differentiation  eyelid development in camera-type eye  lung smooth muscle development  RNA polymerase II sequence-specific DNA-binding transcription factor binding  bicellular tight junction assembly  primary miRNA binding  cellular response to glucose stimulus  primitive streak formation  epithelial cell-cell adhesion  cellular senescence  negative regulation of amyloid-beta clearance  negative regulation of pri-miRNA transcription by RNA polymerase II  positive regulation of pri-miRNA transcription by RNA polymerase II  
Pathways : KEGGMAPK signaling pathway    HTLV-I infection    Viral carcinogenesis   
NDEx NetworkSRF
Atlas of Cancer Signalling NetworkSRF
Wikipedia pathwaysSRF
Orthology - Evolution
OrthoDB6722
GeneTree (enSembl)ENSG00000112658
Phylogenetic Trees/Animal Genes : TreeFamSRF
HOVERGENP11831
HOGENOMP11831
Homologs : HomoloGeneSRF
Homology/Alignments : Family Browser (UCSC)SRF
Gene fusions - Rearrangements
Fusion : MitelmanSRF/F5 [6p21.1/1q24.2]  
Fusion : MitelmanSRF/NCOA2 [6p21.1/8q13.3]  [t(6;8)(p21;q13)]  
Fusion PortalSRF 6p21.1 F5 1q24.2 BRCA
Fusion : QuiverSRF
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSRF [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SRF
dbVarSRF
ClinVarSRF
1000_GenomesSRF 
Exome Variant ServerSRF
ExAC (Exome Aggregation Consortium)ENSG00000112658
GNOMAD BrowserENSG00000112658
Varsome BrowserSRF
Genetic variants : HAPMAP6722
Genomic Variants (DGV)SRF [DGVbeta]
DECIPHERSRF [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSRF 
Mutations
ICGC Data PortalSRF 
TCGA Data PortalSRF 
Broad Tumor PortalSRF
OASIS PortalSRF [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSRF  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSRF
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SRF
DgiDB (Drug Gene Interaction Database)SRF
DoCM (Curated mutations)SRF (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SRF (select a term)
intoGenSRF
Cancer3DSRF(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600589   
Orphanet
DisGeNETSRF
MedgenSRF
Genetic Testing Registry SRF
NextProtP11831 [Medical]
TSGene6722
GENETestsSRF
Target ValidationSRF
Huge Navigator SRF [HugePedia]
snp3D : Map Gene to Disease6722
BioCentury BCIQSRF
ClinGenSRF
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6722
Chemical/Pharm GKB GenePA36116
Clinical trialSRF
Miscellaneous
canSAR (ICR)SRF (select the gene name)
Probes
Litterature
PubMed196 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSRF
EVEXSRF
GoPubMedSRF
iHOPSRF
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:41:52 CET 2018

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