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SRGAP2 (SLIT-ROBO Rho GTPase activating protein 2)

Identity

Alias (NCBI)ARHGAP34
FNBP2
SRGAP2A
SRGAP3
HGNC (Hugo) SRGAP2
HGNC Alias symbKIAA0456
ARHGAP34
SRGAP2A
HGNC Previous nameFNBP2
HGNC Previous nameformin binding protein 2
LocusID (NCBI) 23380
Atlas_Id 43503
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 206203541 and ends at 206464436 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDKN2A (9p21.3) / SRGAP2 (1q32.1)KLHL20 (1q25.1) / SRGAP2 (1q32.1)MAPKAPK2 (1q32.1) / SRGAP2 (1q32.1)
MGST1 (12p12.3) / SRGAP2 (1q32.1)NGFRAP1 () / SRGAP2 (1q32.1)RFWD2 (1q25.1) / SRGAP2 (1q32.1)
SRGAP2 (1q32.1) / PRPF3 (1q21.2)SRGAP2B (1p11.2) / SRGAP2 (1q32.1)WDR74 (11q12.3) / SRGAP2 (1q32.1)
CDKN2A 9p21.3 / SRGAP2 1q32.1MAPKAPK2 1q32.1 / SRGAP2 1q32.1RFWD2 1q25.1 / SRGAP2 1q32.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SRGAP2   19751
Cards
Entrez_Gene (NCBI)SRGAP2    SLIT-ROBO Rho GTPase activating protein 2
AliasesARHGAP34; FNBP2; SRGAP2A; SRGAP3
GeneCards (Weizmann)SRGAP2
Ensembl hg19 (Hinxton)ENSG00000266028 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000266028 [Gene_View]  ENSG00000266028 [Sequence]  chr1:206203541-206464436 [Contig_View]  SRGAP2 [Vega]
ICGC DataPortalENSG00000266028
TCGA cBioPortalSRGAP2
AceView (NCBI)SRGAP2
Genatlas (Paris)SRGAP2
SOURCE (Princeton)SRGAP2
Genetics Home Reference (NIH)SRGAP2
Genomic and cartography
GoldenPath hg38 (UCSC)SRGAP2  -     chr1:206203541-206464436 +  1q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SRGAP2  -     1q32.1   [Description]    (hg19-Feb_2009)
GoldenPathSRGAP2 - 1q32.1 [CytoView hg19]  SRGAP2 - 1q32.1 [CytoView hg38]
ImmunoBaseENSG00000266028
Genome Data Viewer NCBISRGAP2 [Mapview hg19]  
OMIM606524   
Gene and transcription
Genbank (Entrez)AB007925 AK000885 AK057565 AK124556 AK293335
RefSeq transcript (Entrez)NM_001042758 NM_001170637 NM_001300952 NM_001377444 NM_001377445 NM_001377446 NM_001377447 NM_015326
Consensus coding sequences : CCDS (NCBI)SRGAP2
Gene ExpressionSRGAP2 [ NCBI-GEO ]   SRGAP2 [ EBI - ARRAY_EXPRESS ]   SRGAP2 [ SEEK ]   SRGAP2 [ MEM ]
Gene Expression Viewer (FireBrowse)SRGAP2 [ Firebrowse - Broad ]
GenevisibleExpression of SRGAP2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23380
GTEX Portal (Tissue expression)SRGAP2
Human Protein AtlasENSG00000266028-SRGAP2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75044   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75044  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75044
PhosPhoSitePlusO75044
Domaine pattern : Prosite (Expaxy)F_BAR (PS51741)    RHOGAP (PS50238)    SH3 (PS50002)   
Domains : Interpro (EBI)AH/BAR_dom_sf    F_BAR    FCH_dom    Rho_GTPase_activation_prot    RhoGAP_dom    SH3-like_dom_sf    SH3_domain    srGAP1/2/3_SH3    srGAP2   
Domain families : Pfam (Sanger)FCH (PF00611)    RhoGAP (PF00620)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam00611    pfam00620    pfam00018   
Domain families : Smart (EMBL)FCH (SM00055)  RhoGAP (SM00324)  SH3 (SM00326)  
Conserved Domain (NCBI)SRGAP2
PDB (RSDB)2DL8    4RTT    4RUG    5I6J    5I6R    5I7D   
PDB Europe2DL8    4RTT    4RUG    5I6J    5I6R    5I7D   
PDB (PDBSum)2DL8    4RTT    4RUG    5I6J    5I6R    5I7D   
PDB (IMB)2DL8    4RTT    4RUG    5I6J    5I6R    5I7D   
Structural Biology KnowledgeBase2DL8    4RTT    4RUG    5I6J    5I6R    5I7D   
SCOP (Structural Classification of Proteins)2DL8    4RTT    4RUG    5I6J    5I6R    5I7D   
CATH (Classification of proteins structures)2DL8    4RTT    4RUG    5I6J    5I6R    5I7D   
SuperfamilyO75044
AlphaFold pdb e-kbO75044   
Human Protein Atlas [tissue]ENSG00000266028-SRGAP2 [tissue]
HPRD18520
Protein Interaction databases
DIP (DOE-UCLA)O75044
IntAct (EBI)O75044
BioGRIDSRGAP2
STRING (EMBL)SRGAP2
ZODIACSRGAP2
Ontologies - Pathways
QuickGOO75044
Ontology : AmiGOlamellipodium assembly involved in ameboidal cell migration  GTPase activator activity  GTPase activator activity  protein binding  nucleoplasm  cytoplasm  cytosol  cytosol  cytosol  plasma membrane  signal transduction  postsynaptic density  extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration  lamellipodium  negative regulation of cell migration  small GTPase binding  substrate adhesion-dependent cell spreading  identical protein binding  protein homodimerization activity  positive regulation of GTPase activity  positive regulation of GTPase activity  dendritic spine head  postsynaptic membrane  phagocytic vesicle  filopodium assembly  neuron projection morphogenesis  actin filament severing  regulation of small GTPase mediated signal transduction  negative regulation of cell death  dendritic spine development  negative regulation of neuron migration  
Ontology : EGO-EBIlamellipodium assembly involved in ameboidal cell migration  GTPase activator activity  GTPase activator activity  protein binding  nucleoplasm  cytoplasm  cytosol  cytosol  cytosol  plasma membrane  signal transduction  postsynaptic density  extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration  lamellipodium  negative regulation of cell migration  small GTPase binding  substrate adhesion-dependent cell spreading  identical protein binding  protein homodimerization activity  positive regulation of GTPase activity  positive regulation of GTPase activity  dendritic spine head  postsynaptic membrane  phagocytic vesicle  filopodium assembly  neuron projection morphogenesis  actin filament severing  regulation of small GTPase mediated signal transduction  negative regulation of cell death  dendritic spine development  negative regulation of neuron migration  
Pathways : KEGGAxon guidance   
NDEx NetworkSRGAP2
Atlas of Cancer Signalling NetworkSRGAP2
Wikipedia pathwaysSRGAP2
Orthology - Evolution
OrthoDB23380
GeneTree (enSembl)ENSG00000266028
Phylogenetic Trees/Animal Genes : TreeFamSRGAP2
Homologs : HomoloGeneSRGAP2
Homology/Alignments : Family Browser (UCSC)SRGAP2
Gene fusions - Rearrangements
Fusion : MitelmanCDKN2A/SRGAP2 [9p21.3/1q32.1]  
Fusion : MitelmanMAPKAPK2/SRGAP2 [1q32.1/1q32.1]  
Fusion : MitelmanRFWD2/SRGAP2 [1q25.1/1q32.1]  
Fusion : MitelmanSRGAP2/PRPF3 [1q32.1/1q21.2]  
Fusion : QuiverSRGAP2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSRGAP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SRGAP2
dbVarSRGAP2
ClinVarSRGAP2
MonarchSRGAP2
1000_GenomesSRGAP2 
Exome Variant ServerSRGAP2
GNOMAD BrowserENSG00000266028
Varsome BrowserSRGAP2
ACMGSRGAP2 variants
VarityO75044
Genomic Variants (DGV)SRGAP2 [DGVbeta]
DECIPHERSRGAP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSRGAP2 
Mutations
ICGC Data PortalSRGAP2 
TCGA Data PortalSRGAP2 
Broad Tumor PortalSRGAP2
OASIS PortalSRGAP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSRGAP2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSRGAP2
Mutations and Diseases : HGMDSRGAP2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSRGAP2
DgiDB (Drug Gene Interaction Database)SRGAP2
DoCM (Curated mutations)SRGAP2
CIViC (Clinical Interpretations of Variants in Cancer)SRGAP2
Cancer3DSRGAP2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606524   
Orphanet
DisGeNETSRGAP2
MedgenSRGAP2
Genetic Testing Registry SRGAP2
NextProtO75044 [Medical]
GENETestsSRGAP2
Target ValidationSRGAP2
Huge Navigator SRGAP2 [HugePedia]
ClinGenSRGAP2
Clinical trials, drugs, therapy
MyCancerGenomeSRGAP2
Protein Interactions : CTDSRGAP2
Pharm GKB GenePA164742513
PharosO75044
Clinical trialSRGAP2
Miscellaneous
canSAR (ICR)SRGAP2
HarmonizomeSRGAP2
DataMed IndexSRGAP2
Probes
Litterature
PubMed61 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSRGAP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:33:07 CEST 2021

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