Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SRGAP2 (SLIT-ROBO Rho GTPase activating protein 2)

Identity

Alias_namesFNBP2
formin binding protein 2
Alias_symbol (synonym)KIAA0456
ARHGAP34
SRGAP2A
Other aliasSRGAP3
HGNC (Hugo) SRGAP2
LocusID (NCBI) 23380
Atlas_Id 43503
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 206205429 and ends at 206464443 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CDKN2A (9p21.3) / SRGAP2 (1q32.1)KLHL20 (1q25.1) / SRGAP2 (1q32.1)MAPKAPK2 (1q32.1) / SRGAP2 (1q32.1)
MGST1 (12p12.3) / SRGAP2 (1q32.1)NGFRAP1 () / SRGAP2 (1q32.1)RFWD2 (1q25.1) / SRGAP2 (1q32.1)
SRGAP2 (1q32.1) / PRPF3 (1q21.2)SRGAP2B (1p11.2) / SRGAP2 (1q32.1)WDR74 (11q12.3) / SRGAP2 (1q32.1)
CDKN2A 9p21.3 / SRGAP2 1q32.1MAPKAPK2 1q32.1 / SRGAP2 1q32.1RFWD2 1q25.1 / SRGAP2 1q32.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SRGAP2   19751
Cards
Entrez_Gene (NCBI)SRGAP2  23380  SLIT-ROBO Rho GTPase activating protein 2
AliasesARHGAP34; FNBP2; SRGAP2A; SRGAP3
GeneCards (Weizmann)SRGAP2
Ensembl hg19 (Hinxton)ENSG00000266028 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000266028 [Gene_View]  chr1:206205429-206464443 [Contig_View]  SRGAP2 [Vega]
ICGC DataPortalENSG00000266028
TCGA cBioPortalSRGAP2
AceView (NCBI)SRGAP2
Genatlas (Paris)SRGAP2
WikiGenes23380
SOURCE (Princeton)SRGAP2
Genetics Home Reference (NIH)SRGAP2
Genomic and cartography
GoldenPath hg38 (UCSC)SRGAP2  -     chr1:206205429-206464443 +  1q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SRGAP2  -     1q32.1   [Description]    (hg19-Feb_2009)
EnsemblSRGAP2 - 1q32.1 [CytoView hg19]  SRGAP2 - 1q32.1 [CytoView hg38]
Mapping of homologs : NCBISRGAP2 [Mapview hg19]  SRGAP2 [Mapview hg38]
OMIM606524   
Gene and transcription
Genbank (Entrez)AB007925 AK000885 AK057565 AK124556 AK293335
RefSeq transcript (Entrez)NM_001042758 NM_001170637 NM_001300952 NM_015326
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SRGAP2
Cluster EST : UnigeneHs.744555 [ NCBI ]
CGAP (NCI)Hs.744555
Alternative Splicing GalleryENSG00000266028
Gene ExpressionSRGAP2 [ NCBI-GEO ]   SRGAP2 [ EBI - ARRAY_EXPRESS ]   SRGAP2 [ SEEK ]   SRGAP2 [ MEM ]
Gene Expression Viewer (FireBrowse)SRGAP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23380
GTEX Portal (Tissue expression)SRGAP2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75044   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75044  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75044
Splice isoforms : SwissVarO75044
PhosPhoSitePlusO75044
Domaine pattern : Prosite (Expaxy)F_BAR (PS51741)    RHOGAP (PS50238)    SH3 (PS50002)   
Domains : Interpro (EBI)F_BAR    FCH_dom    Rho_GTPase_activation_prot    RhoGAP_dom    SH3_domain    srGAP2   
Domain families : Pfam (Sanger)FCH (PF00611)    RhoGAP (PF00620)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam00611    pfam00620    pfam00018   
Domain families : Smart (EMBL)FCH (SM00055)  RhoGAP (SM00324)  SH3 (SM00326)  
Conserved Domain (NCBI)SRGAP2
DMDM Disease mutations23380
Blocks (Seattle)SRGAP2
PDB (SRS)2DL8    4RTT    4RUG   
PDB (PDBSum)2DL8    4RTT    4RUG   
PDB (IMB)2DL8    4RTT    4RUG   
PDB (RSDB)2DL8    4RTT    4RUG   
Structural Biology KnowledgeBase2DL8    4RTT    4RUG   
SCOP (Structural Classification of Proteins)2DL8    4RTT    4RUG   
CATH (Classification of proteins structures)2DL8    4RTT    4RUG   
SuperfamilyO75044
Human Protein AtlasENSG00000266028
Peptide AtlasO75044
HPRD18520
IPIIPI00479125   IPI00478979   IPI00647466   IPI00941205   
Protein Interaction databases
DIP (DOE-UCLA)O75044
IntAct (EBI)O75044
FunCoupENSG00000266028
BioGRIDSRGAP2
STRING (EMBL)SRGAP2
ZODIACSRGAP2
Ontologies - Pathways
QuickGOO75044
Ontology : AmiGOlamellipodium assembly involved in ameboidal cell migration  GTPase activator activity  GTPase activator activity  GTPase activator activity  protein binding  nucleus  cytoplasm  cytosol  cytosol  plasma membrane  signal transduction  cell proliferation  postsynaptic density  extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration  lamellipodium  cell junction  substrate adhesion-dependent cell spreading  protein homodimerization activity  positive regulation of GTPase activity  positive regulation of GTPase activity  dendritic spine head  postsynaptic membrane  phagocytic vesicle  filopodium assembly  Rac GTPase binding  neuron projection morphogenesis  actin filament severing  regulation of small GTPase mediated signal transduction  negative regulation of cell death  dendritic spine development  negative regulation of neuron migration  
Ontology : EGO-EBIlamellipodium assembly involved in ameboidal cell migration  GTPase activator activity  GTPase activator activity  GTPase activator activity  protein binding  nucleus  cytoplasm  cytosol  cytosol  plasma membrane  signal transduction  cell proliferation  postsynaptic density  extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration  lamellipodium  cell junction  substrate adhesion-dependent cell spreading  protein homodimerization activity  positive regulation of GTPase activity  positive regulation of GTPase activity  dendritic spine head  postsynaptic membrane  phagocytic vesicle  filopodium assembly  Rac GTPase binding  neuron projection morphogenesis  actin filament severing  regulation of small GTPase mediated signal transduction  negative regulation of cell death  dendritic spine development  negative regulation of neuron migration  
Pathways : KEGGAxon guidance   
NDEx NetworkSRGAP2
Atlas of Cancer Signalling NetworkSRGAP2
Wikipedia pathwaysSRGAP2
Orthology - Evolution
OrthoDB23380
GeneTree (enSembl)ENSG00000266028
Phylogenetic Trees/Animal Genes : TreeFamSRGAP2
HOVERGENO75044
HOGENOMO75044
Homologs : HomoloGeneSRGAP2
Homology/Alignments : Family Browser (UCSC)SRGAP2
Gene fusions - Rearrangements
Fusion : MitelmanCDKN2A/SRGAP2 [9p21.3/1q32.1]  [t(1;9)(q32;p21)]  
Fusion : MitelmanMAPKAPK2/SRGAP2 [1q32.1/1q32.1]  [t(1;1)(q32;q32)]  
Fusion : MitelmanRFWD2/SRGAP2 [1q25.1/1q32.1]  [t(1;1)(q25;q32)]  
Fusion : MitelmanSRGAP2/PRPF3 [1q32.1/1q21.2]  [t(1;1)(q21;q32)]  
Fusion: TCGACDKN2A 9p21.3 SRGAP2 1q32.1 LUSC
Fusion: TCGAMAPKAPK2 1q32.1 SRGAP2 1q32.1 HNSC
Fusion: TCGARFWD2 1q25.1 SRGAP2 1q32.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSRGAP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SRGAP2
dbVarSRGAP2
ClinVarSRGAP2
1000_GenomesSRGAP2 
Exome Variant ServerSRGAP2
ExAC (Exome Aggregation Consortium)SRGAP2 (select the gene name)
Genetic variants : HAPMAP23380
Genomic Variants (DGV)SRGAP2 [DGVbeta]
DECIPHERSRGAP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSRGAP2 
Mutations
ICGC Data PortalSRGAP2 
TCGA Data PortalSRGAP2 
Broad Tumor PortalSRGAP2
OASIS PortalSRGAP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSRGAP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSRGAP2
BioMutasearch SRGAP2
DgiDB (Drug Gene Interaction Database)SRGAP2
DoCM (Curated mutations)SRGAP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SRGAP2 (select a term)
intoGenSRGAP2
Cancer3DSRGAP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606524   
Orphanet
MedgenSRGAP2
Genetic Testing Registry SRGAP2
NextProtO75044 [Medical]
TSGene23380
GENETestsSRGAP2
Target ValidationSRGAP2
Huge Navigator SRGAP2 [HugePedia]
snp3D : Map Gene to Disease23380
BioCentury BCIQSRGAP2
ClinGenSRGAP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23380
Chemical/Pharm GKB GenePA164742513
Clinical trialSRGAP2
Miscellaneous
canSAR (ICR)SRGAP2 (select the gene name)
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSRGAP2
EVEXSRGAP2
GoPubMedSRGAP2
iHOPSRGAP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:57:23 CEST 2017

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