SRGAP2 (SLIT-ROBO Rho GTPase activating protein 2)

2006-10-01  

Identity

HGNC
SRGAP2
LOCATION
1q32.1
LOCUSID
23380
ALIAS
ARHGAP34,FNBP2,SRGAP2A,SRGAP3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23380
MIM: 606524
HGNC: 19751
Ensembl: ENSG00000266028

Variants:

dbSNP: 23380
ClinVar: 23380
TCGA: ENSG00000266028
COSMIC: SRGAP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000266028ENST00000419187E9PDX4
ENSG00000266028ENST00000572793A0A075B743
ENSG00000266028ENST00000573034O75044
ENSG00000266028ENST00000579225A0A075B7C8
ENSG00000266028ENST00000604010A0A075B7E9
ENSG00000266028ENST00000604925A0A075B7E6
ENSG00000266028ENST00000605476Q5VZB4
ENSG00000266028ENST00000605610A0A075B7B5
ENSG00000266028ENST00000624873B7ZM87

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Signaling by Robo receptorREACTOMER-HSA-376176
Inactivation of Cdc42 and RacREACTOMER-HSA-428543

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
225599432012Evolution of human-specific neural SRGAP2 genes by incomplete segmental duplication.119
225599442012Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation.104
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
211484822011Bi-modal regulation of a formin by srGAP2.24
208106532010srGAP2 arginine methylation regulates cell migration and cell spreading through promoting dimerization.20
238928962013Rapid and accurate large-scale genotyping of duplicated genes and discovery of interlocus gene conversions.19
273738322016SRGAP2 and Its Human-Specific Paralog Co-Regulate the Development of Excitatory and Inhibitory Synapses.14
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
289125602017The SRGAP2 SNPs, their haplotypes and G × E interactions on serum lipid traits.11

Citation

Dessen P

SRGAP2 (SLIT-ROBO Rho GTPase activating protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43503/srgap2