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SRGAP2B (SLIT-ROBO Rho GTPase activating protein 2B)

Identity

Alias_namesSRGAP2P2
SLIT-ROBO Rho GTPase activating protein 2 pseudogene 2
SLIT-ROBO Rho GTPase activating protein 2B (pseudogene)
Other aliasSRGAP2L
HGNC (Hugo) SRGAP2B
LocusID (NCBI) 647135
Atlas_Id 74231
Location 1q21.1  [Link to chromosome band 1q21]
Location_base_pair Starts at 144887191 and ends at 145093362 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NUP98 (11p15.4) / SRGAP2B (1p11.2)SRGAP2B (1p11.2) / SRGAP2 (1q32.1)SRGAP2B (1p11.2) / SRGAP2B (1p11.2)
SRGAP2B (1p11.2) / SRGAP2C (1q32.1)TIMP2 (17q25.3) / SRGAP2B (1p11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SRGAP2B   35237
Cards
Entrez_Gene (NCBI)SRGAP2B  647135  SLIT-ROBO Rho GTPase activating protein 2B
AliasesSRGAP2L; SRGAP2P2
GeneCards (Weizmann)SRGAP2B
Ensembl hg19 (Hinxton)ENSG00000196369 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000196369 [Gene_View]  chr1:144887191-145093362 [Contig_View]  SRGAP2B [Vega]
ICGC DataPortalENSG00000196369
TCGA cBioPortalSRGAP2B
AceView (NCBI)SRGAP2B
Genatlas (Paris)SRGAP2B
WikiGenes647135
SOURCE (Princeton)SRGAP2B
Genetics Home Reference (NIH)SRGAP2B
Genomic and cartography
GoldenPath hg38 (UCSC)SRGAP2B  -     chr1:144887191-145093362 -  1q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SRGAP2B  -     1q21.1   [Description]    (hg19-Feb_2009)
EnsemblSRGAP2B - 1q21.1 [CytoView hg19]  SRGAP2B - 1q21.1 [CytoView hg38]
Mapping of homologs : NCBISRGAP2B [Mapview hg19]  SRGAP2B [Mapview hg38]
OMIM614703   
Gene and transcription
Genbank (Entrez)AK025818 BF154710 BQ706477 BY795901 DA326673
RefSeq transcript (Entrez)NM_001271870 NM_001330684
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SRGAP2B
Cluster EST : UnigeneHs.744555 [ NCBI ]
CGAP (NCI)Hs.744555
Alternative Splicing GalleryENSG00000196369
Gene ExpressionSRGAP2B [ NCBI-GEO ]   SRGAP2B [ EBI - ARRAY_EXPRESS ]   SRGAP2B [ SEEK ]   SRGAP2B [ MEM ]
Gene Expression Viewer (FireBrowse)SRGAP2B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)647135
GTEX Portal (Tissue expression)SRGAP2B
Protein : pattern, domain, 3D structure
UniProt/SwissProtP0DMP2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP0DMP2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP0DMP2
Splice isoforms : SwissVarP0DMP2
PhosPhoSitePlusP0DMP2
Domaine pattern : Prosite (Expaxy)F_BAR (PS51741)   
Domains : Interpro (EBI)F_BAR    FCH_dom    srGAP2   
Domain families : Pfam (Sanger)FCH (PF00611)   
Domain families : Pfam (NCBI)pfam00611   
Domain families : Smart (EMBL)FCH (SM00055)  
Conserved Domain (NCBI)SRGAP2B
DMDM Disease mutations647135
Blocks (Seattle)SRGAP2B
SuperfamilyP0DMP2
Human Protein AtlasENSG00000196369
Peptide AtlasP0DMP2
Protein Interaction databases
DIP (DOE-UCLA)P0DMP2
IntAct (EBI)P0DMP2
FunCoupENSG00000196369
BioGRIDSRGAP2B
STRING (EMBL)SRGAP2B
ZODIACSRGAP2B
Ontologies - Pathways
QuickGOP0DMP2
Ontology : AmiGOGTPase activator activity  cytoplasm  nervous system development  negative regulation of cell migration  positive regulation of GTPase activity  Rac GTPase binding  
Ontology : EGO-EBIGTPase activator activity  cytoplasm  nervous system development  negative regulation of cell migration  positive regulation of GTPase activity  Rac GTPase binding  
NDEx NetworkSRGAP2B
Atlas of Cancer Signalling NetworkSRGAP2B
Wikipedia pathwaysSRGAP2B
Orthology - Evolution
OrthoDB647135
GeneTree (enSembl)ENSG00000196369
Phylogenetic Trees/Animal Genes : TreeFamSRGAP2B
HOVERGENP0DMP2
HOGENOMP0DMP2
Homologs : HomoloGeneSRGAP2B
Homology/Alignments : Family Browser (UCSC)SRGAP2B
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSRGAP2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SRGAP2B
dbVarSRGAP2B
ClinVarSRGAP2B
1000_GenomesSRGAP2B 
Exome Variant ServerSRGAP2B
ExAC (Exome Aggregation Consortium)SRGAP2B (select the gene name)
Genetic variants : HAPMAP647135
Genomic Variants (DGV)SRGAP2B [DGVbeta]
DECIPHERSRGAP2B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSRGAP2B 
Mutations
ICGC Data PortalSRGAP2B 
TCGA Data PortalSRGAP2B 
Broad Tumor PortalSRGAP2B
OASIS PortalSRGAP2B [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDSRGAP2B
BioMutasearch SRGAP2B
DgiDB (Drug Gene Interaction Database)SRGAP2B
DoCM (Curated mutations)SRGAP2B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SRGAP2B (select a term)
intoGenSRGAP2B
Cancer3DSRGAP2B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614703   
Orphanet
MedgenSRGAP2B
Genetic Testing Registry SRGAP2B
NextProtP0DMP2 [Medical]
TSGene647135
GENETestsSRGAP2B
Target ValidationSRGAP2B
Huge Navigator SRGAP2B [HugePedia]
snp3D : Map Gene to Disease647135
BioCentury BCIQSRGAP2B
ClinGenSRGAP2B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD647135
Chemical/Pharm GKB GenePA166123739
Clinical trialSRGAP2B
Miscellaneous
canSAR (ICR)SRGAP2B (select the gene name)
Probes
Litterature
PubMed3 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSRGAP2B
EVEXSRGAP2B
GoPubMedSRGAP2B
iHOPSRGAP2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:40:28 CEST 2017

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