Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SRGAP2C (SLIT-ROBO Rho GTPase activating protein 2C)

Identity

Alias_namesSRGAP2P1
SLIT-ROBO Rho GTPase activating protein 2 pseudogene 1
Other alias
HGNC (Hugo) SRGAP2C
LocusID (NCBI) 653464
Atlas_Id 74232
Location 1p11.2  [Link to chromosome band 1p11]
Location_base_pair Starts at 121184967 and ends at 121392874 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
SRGAP2B (1p11.2) / SRGAP2C (1q32.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SRGAP2C   30584
Cards
Entrez_Gene (NCBI)SRGAP2C  653464  SLIT-ROBO Rho GTPase activating protein 2C
AliasesSRGAP2P1
GeneCards (Weizmann)SRGAP2C
Ensembl hg19 (Hinxton)ENSG00000171943 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171943 [Gene_View]  chr1:121184967-121392874 [Contig_View]  SRGAP2C [Vega]
ICGC DataPortalENSG00000171943
TCGA cBioPortalSRGAP2C
AceView (NCBI)SRGAP2C
Genatlas (Paris)SRGAP2C
WikiGenes653464
SOURCE (Princeton)SRGAP2C
Genetics Home Reference (NIH)SRGAP2C
Genomic and cartography
GoldenPath hg38 (UCSC)SRGAP2C  -     chr1:121184967-121392874 +  1p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SRGAP2C  -     1p11.2   [Description]    (hg19-Feb_2009)
EnsemblSRGAP2C - 1p11.2 [CytoView hg19]  SRGAP2C - 1p11.2 [CytoView hg38]
Mapping of homologs : NCBISRGAP2C [Mapview hg19]  SRGAP2C [Mapview hg38]
OMIM614704   
Gene and transcription
Genbank (Entrez)BC017972 BC036880 BC112927
RefSeq transcript (Entrez)NM_001271872 NM_001329984
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SRGAP2C
Cluster EST : UnigeneHs.698027 [ NCBI ]
CGAP (NCI)Hs.698027
Alternative Splicing GalleryENSG00000171943
Gene ExpressionSRGAP2C [ NCBI-GEO ]   SRGAP2C [ EBI - ARRAY_EXPRESS ]   SRGAP2C [ SEEK ]   SRGAP2C [ MEM ]
Gene Expression Viewer (FireBrowse)SRGAP2C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)653464
GTEX Portal (Tissue expression)SRGAP2C
Protein : pattern, domain, 3D structure
UniProt/SwissProtP0DJJ0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP0DJJ0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP0DJJ0
Splice isoforms : SwissVarP0DJJ0
PhosPhoSitePlusP0DJJ0
Domaine pattern : Prosite (Expaxy)F_BAR (PS51741)   
Domains : Interpro (EBI)F_BAR    FCH_dom    srGAP2   
Domain families : Pfam (Sanger)FCH (PF00611)   
Domain families : Pfam (NCBI)pfam00611   
Domain families : Smart (EMBL)FCH (SM00055)  
Conserved Domain (NCBI)SRGAP2C
DMDM Disease mutations653464
Blocks (Seattle)SRGAP2C
SuperfamilyP0DJJ0
Human Protein AtlasENSG00000171943
Peptide AtlasP0DJJ0
IPIIPI00174930   
Protein Interaction databases
DIP (DOE-UCLA)P0DJJ0
IntAct (EBI)P0DJJ0
FunCoupENSG00000171943
BioGRIDSRGAP2C
STRING (EMBL)SRGAP2C
ZODIACSRGAP2C
Ontologies - Pathways
QuickGOP0DJJ0
Ontology : AmiGOGTPase activator activity  cytoplasm  extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration  negative regulation of cell migration  protein homodimerization activity  positive regulation of GTPase activity  protein heterodimerization activity  Rac GTPase binding  negative regulation of filopodium assembly  negative regulation of dendritic spine development  positive regulation of neuron migration  
Ontology : EGO-EBIGTPase activator activity  cytoplasm  extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration  negative regulation of cell migration  protein homodimerization activity  positive regulation of GTPase activity  protein heterodimerization activity  Rac GTPase binding  negative regulation of filopodium assembly  negative regulation of dendritic spine development  positive regulation of neuron migration  
NDEx NetworkSRGAP2C
Atlas of Cancer Signalling NetworkSRGAP2C
Wikipedia pathwaysSRGAP2C
Orthology - Evolution
OrthoDB653464
GeneTree (enSembl)ENSG00000171943
Phylogenetic Trees/Animal Genes : TreeFamSRGAP2C
HOVERGENP0DJJ0
HOGENOMP0DJJ0
Homologs : HomoloGeneSRGAP2C
Homology/Alignments : Family Browser (UCSC)SRGAP2C
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSRGAP2C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SRGAP2C
dbVarSRGAP2C
ClinVarSRGAP2C
1000_GenomesSRGAP2C 
Exome Variant ServerSRGAP2C
ExAC (Exome Aggregation Consortium)SRGAP2C (select the gene name)
Genetic variants : HAPMAP653464
Genomic Variants (DGV)SRGAP2C [DGVbeta]
DECIPHERSRGAP2C [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSRGAP2C 
Mutations
ICGC Data PortalSRGAP2C 
TCGA Data PortalSRGAP2C 
Broad Tumor PortalSRGAP2C
OASIS PortalSRGAP2C [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDSRGAP2C
BioMutasearch SRGAP2C
DgiDB (Drug Gene Interaction Database)SRGAP2C
DoCM (Curated mutations)SRGAP2C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SRGAP2C (select a term)
intoGenSRGAP2C
Cancer3DSRGAP2C(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614704   
Orphanet
MedgenSRGAP2C
Genetic Testing Registry SRGAP2C
NextProtP0DJJ0 [Medical]
TSGene653464
GENETestsSRGAP2C
Target ValidationSRGAP2C
Huge Navigator SRGAP2C [HugePedia]
snp3D : Map Gene to Disease653464
BioCentury BCIQSRGAP2C
ClinGenSRGAP2C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD653464
Chemical/Pharm GKB GenePA166049001
Clinical trialSRGAP2C
Miscellaneous
canSAR (ICR)SRGAP2C (select the gene name)
Probes
Litterature
PubMed7 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSRGAP2C
EVEXSRGAP2C
GoPubMedSRGAP2C
iHOPSRGAP2C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:44:08 CEST 2017

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