Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SRGN (serglycin)

Identity

Alias (NCBI)PPG
PRG
PRG1
HGNC (Hugo) SRGN
HGNC Alias symbPPG
HGNC Alias nameserglycin proteoglycan
HGNC Previous namePRG
 PRG1
HGNC Previous nameproteoglycan 1, secretory granule
LocusID (NCBI) 5552
Atlas_Id 52326
Location 10q22.1  [Link to chromosome band 10q22]
Location_base_pair Starts at 69088103 and ends at 69104804 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SPACA6 (19q13.41) / SRGN (10q22.1)SRGN (10q22.1) / ALAS1 (3p21.2)SRGN (10q22.1) / SGPL1 (10q22.1)
SRGN (10q22.1) / SRGN (10q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)SRGN   9361
Cards
Entrez_Gene (NCBI)SRGN  5552  serglycin
AliasesPPG; PRG; PRG1
GeneCards (Weizmann)SRGN
Ensembl hg19 (Hinxton)ENSG00000122862 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000122862 [Gene_View]  ENSG00000122862 [Sequence]  chr10:69088103-69104804 [Contig_View]  SRGN [Vega]
ICGC DataPortalENSG00000122862
TCGA cBioPortalSRGN
AceView (NCBI)SRGN
Genatlas (Paris)SRGN
WikiGenes5552
SOURCE (Princeton)SRGN
Genetics Home Reference (NIH)SRGN
Genomic and cartography
GoldenPath hg38 (UCSC)SRGN  -     chr10:69088103-69104804 +  10q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SRGN  -     10q22.1   [Description]    (hg19-Feb_2009)
GoldenPathSRGN - 10q22.1 [CytoView hg19]  SRGN - 10q22.1 [CytoView hg38]
ImmunoBaseENSG00000122862
genome Data Viewer NCBISRGN [Mapview hg19]  
OMIM177040   
Gene and transcription
Genbank (Entrez)AI347627 AK311873 BC015516 BC022313 BG057351
RefSeq transcript (Entrez)NM_001321053 NM_001321054 NM_002727
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SRGN
Alternative Splicing GalleryENSG00000122862
Gene ExpressionSRGN [ NCBI-GEO ]   SRGN [ EBI - ARRAY_EXPRESS ]   SRGN [ SEEK ]   SRGN [ MEM ]
Gene Expression Viewer (FireBrowse)SRGN [ Firebrowse - Broad ]
GenevisibleExpression of SRGN in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5552
GTEX Portal (Tissue expression)SRGN
Human Protein AtlasENSG00000122862-SRGN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10124   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP10124  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP10124
Splice isoforms : SwissVarP10124
PhosPhoSitePlusP10124
Domains : Interpro (EBI)Serglycin   
Domain families : Pfam (Sanger)Serglycin (PF04360)   
Domain families : Pfam (NCBI)pfam04360   
Conserved Domain (NCBI)SRGN
DMDM Disease mutations5552
Blocks (Seattle)SRGN
SuperfamilyP10124
Human Protein Atlas [tissue]ENSG00000122862-SRGN [tissue]
Peptide AtlasP10124
HPRD01513
IPIIPI00019372   
Protein Interaction databases
DIP (DOE-UCLA)P10124
IntAct (EBI)P10124
FunCoupENSG00000122862
BioGRIDSRGN
STRING (EMBL)SRGN
ZODIACSRGN
Ontologies - Pathways
QuickGOP10124
Ontology : AmiGOplatelet degranulation  protein binding  extracellular region  extracellular space  Golgi apparatus  granzyme-mediated apoptotic signaling pathway  protein processing  secretory granule  negative regulation of bone mineralization  negative regulation of bone mineralization  platelet alpha granule lumen  biomineral tissue development  secretory granule organization  mast cell secretory granule organization  T cell secretory granule organization  maintenance of protease location in mast cell secretory granule  maintenance of granzyme B location in T cell secretory granule  mast cell granule  negative regulation of cytokine secretion  modulation of chemical synaptic transmission  Schaffer collateral - CA1 synapse  glutamatergic synapse  postsynaptic specialization, intracellular component  regulation of postsynapse organization  
Ontology : EGO-EBIplatelet degranulation  protein binding  extracellular region  extracellular space  Golgi apparatus  granzyme-mediated apoptotic signaling pathway  protein processing  secretory granule  negative regulation of bone mineralization  negative regulation of bone mineralization  platelet alpha granule lumen  biomineral tissue development  secretory granule organization  mast cell secretory granule organization  T cell secretory granule organization  maintenance of protease location in mast cell secretory granule  maintenance of granzyme B location in T cell secretory granule  mast cell granule  negative regulation of cytokine secretion  modulation of chemical synaptic transmission  Schaffer collateral - CA1 synapse  glutamatergic synapse  postsynaptic specialization, intracellular component  regulation of postsynapse organization  
NDEx NetworkSRGN
Atlas of Cancer Signalling NetworkSRGN
Wikipedia pathwaysSRGN
Orthology - Evolution
OrthoDB5552
GeneTree (enSembl)ENSG00000122862
Phylogenetic Trees/Animal Genes : TreeFamSRGN
HOGENOMP10124
Homologs : HomoloGeneSRGN
Homology/Alignments : Family Browser (UCSC)SRGN
Gene fusions - Rearrangements
Fusion : QuiverSRGN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSRGN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SRGN
dbVarSRGN
ClinVarSRGN
MonarchSRGN
1000_GenomesSRGN 
Exome Variant ServerSRGN
GNOMAD BrowserENSG00000122862
Varsome BrowserSRGN
Genetic variants : HAPMAP5552
Genomic Variants (DGV)SRGN [DGVbeta]
DECIPHERSRGN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSRGN 
Mutations
ICGC Data PortalSRGN 
TCGA Data PortalSRGN 
Broad Tumor PortalSRGN
OASIS PortalSRGN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSRGN  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSRGN
Mutations and Diseases : HGMDSRGN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SRGN
DgiDB (Drug Gene Interaction Database)SRGN
DoCM (Curated mutations)SRGN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SRGN (select a term)
intoGenSRGN
Cancer3DSRGN(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM177040   
Orphanet
DisGeNETSRGN
MedgenSRGN
Genetic Testing Registry SRGN
NextProtP10124 [Medical]
TSGene5552
GENETestsSRGN
Target ValidationSRGN
Huge Navigator SRGN [HugePedia]
snp3D : Map Gene to Disease5552
BioCentury BCIQSRGN
ClinGenSRGN
Clinical trials, drugs, therapy
Protein Interactions : CTD5552
Pharm GKB GenePA33733
Clinical trialSRGN
Miscellaneous
canSAR (ICR)SRGN (select the gene name)
HarmonizomeSRGN
DataMed IndexSRGN
Probes
Litterature
PubMed63 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSRGN
EVEXSRGN
GoPubMedSRGN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:34:18 CEST 2020

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