Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SRI (sorcin)

Identity

Alias (NCBI)CP-22
CP22
SCN
V19
HGNC (Hugo) SRI
LocusID (NCBI) 6717
Atlas_Id 45785
Location 7q21.12  [Link to chromosome band 7q21]
Location_base_pair Starts at 88205117 and ends at 88226993 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NPC2 (14q24.3) / SRI (7q21.12)SRI (7q21.12) / DKK1 (10q21.1)SRI (7q21.12) / EMG1 (12p13.31)
SRI (7q21.12) / PTRF (17q21.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SRI   11292
LRG (Locus Reference Genomic)LRG_414
Cards
Entrez_Gene (NCBI)SRI    sorcin
AliasesCP-22; CP22; SCN; V19
GeneCards (Weizmann)SRI
Ensembl hg19 (Hinxton)ENSG00000075142 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000075142 [Gene_View]  ENSG00000075142 [Sequence]  chr7:88205117-88226993 [Contig_View]  SRI [Vega]
ICGC DataPortalENSG00000075142
TCGA cBioPortalSRI
AceView (NCBI)SRI
Genatlas (Paris)SRI
SOURCE (Princeton)SRI
Genetics Home Reference (NIH)SRI
Genomic and cartography
GoldenPath hg38 (UCSC)SRI  -     chr7:88205117-88226993 -  7q21.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SRI  -     7q21.12   [Description]    (hg19-Feb_2009)
GoldenPathSRI - 7q21.12 [CytoView hg19]  SRI - 7q21.12 [CytoView hg38]
ImmunoBaseENSG00000075142
genome Data Viewer NCBISRI [Mapview hg19]  
OMIM182520   
Gene and transcription
Genbank (Entrez)AK129770 AK295225 AK296601 AK310366 AL039198
RefSeq transcript (Entrez)NM_001256891 NM_001256892 NM_003130 NM_198901
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SRI
Alternative Splicing GalleryENSG00000075142
Gene ExpressionSRI [ NCBI-GEO ]   SRI [ EBI - ARRAY_EXPRESS ]   SRI [ SEEK ]   SRI [ MEM ]
Gene Expression Viewer (FireBrowse)SRI [ Firebrowse - Broad ]
GenevisibleExpression of SRI in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6717
GTEX Portal (Tissue expression)SRI
Human Protein AtlasENSG00000075142-SRI [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30626   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP30626  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP30626
Splice isoforms : SwissVarP30626
PhosPhoSitePlusP30626
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)   
Domains : Interpro (EBI)EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom   
Domain families : Pfam (Sanger)EF-hand_6 (PF13405)   
Domain families : Pfam (NCBI)pfam13405   
Domain families : Smart (EMBL)EFh (SM00054)  
Conserved Domain (NCBI)SRI
Blocks (Seattle)SRI
PDB (RSDB)1JUO    2JC2    4U8D    4UPG    4USL    5MRA   
PDB Europe1JUO    2JC2    4U8D    4UPG    4USL    5MRA   
PDB (PDBSum)1JUO    2JC2    4U8D    4UPG    4USL    5MRA   
PDB (IMB)1JUO    2JC2    4U8D    4UPG    4USL    5MRA   
Structural Biology KnowledgeBase1JUO    2JC2    4U8D    4UPG    4USL    5MRA   
SCOP (Structural Classification of Proteins)1JUO    2JC2    4U8D    4UPG    4USL    5MRA   
CATH (Classification of proteins structures)1JUO    2JC2    4U8D    4UPG    4USL    5MRA   
SuperfamilyP30626
Human Protein Atlas [tissue]ENSG00000075142-SRI [tissue]
Peptide AtlasP30626
HPRD01680
IPIIPI00027175   IPI00414264   IPI00925997   IPI00925325   IPI00946099   IPI01013070   
Protein Interaction databases
DIP (DOE-UCLA)P30626
IntAct (EBI)P30626
BioGRIDSRI
STRING (EMBL)SRI
ZODIACSRI
Ontologies - Pathways
QuickGOP30626
Ontology : AmiGOaction potential  protease binding  signaling receptor binding  calcium channel regulator activity  calcium ion binding  protein binding  nucleoplasm  cytoplasm  mitochondrion  endoplasmic reticulum membrane  smooth endoplasmic reticulum  cytosol  calcium ion transport  intracellular sequestering of iron ion  regulation of striated muscle contraction  signal transduction  heart development  muscle organ development  regulation of heart contraction  negative regulation of heart rate  regulation of cell communication by electrical coupling  regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  membrane  sarcoplasmic reticulum  Z disc  T-tubule  sarcoplasmic reticulum membrane  positive regulation of insulin secretion involved in cellular response to glucose stimulus  chromaffin granule membrane  cytoplasmic sequestering of transcription factor  axon terminus  ion channel binding  dendritic spine neck  protein heterodimerization activity  positive regulation of release of sequestered calcium ion into cytosol  regulation of calcium ion transport  negative regulation of cardiac muscle contraction  negative regulation of ryanodine-sensitive calcium-release channel activity  extracellular exosome  extracellular exosome  repressing transcription factor binding  regulation of cardiac muscle cell contraction  regulation of relaxation of muscle  regulation of high voltage-gated calcium channel activity  regulation of cell communication by electrical coupling involved in cardiac conduction  negative regulation of transcription regulatory region DNA binding  
Ontology : EGO-EBIaction potential  protease binding  signaling receptor binding  calcium channel regulator activity  calcium ion binding  protein binding  nucleoplasm  cytoplasm  mitochondrion  endoplasmic reticulum membrane  smooth endoplasmic reticulum  cytosol  calcium ion transport  intracellular sequestering of iron ion  regulation of striated muscle contraction  signal transduction  heart development  muscle organ development  regulation of heart contraction  negative regulation of heart rate  regulation of cell communication by electrical coupling  regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  membrane  sarcoplasmic reticulum  Z disc  T-tubule  sarcoplasmic reticulum membrane  positive regulation of insulin secretion involved in cellular response to glucose stimulus  chromaffin granule membrane  cytoplasmic sequestering of transcription factor  axon terminus  ion channel binding  dendritic spine neck  protein heterodimerization activity  positive regulation of release of sequestered calcium ion into cytosol  regulation of calcium ion transport  negative regulation of cardiac muscle contraction  negative regulation of ryanodine-sensitive calcium-release channel activity  extracellular exosome  extracellular exosome  repressing transcription factor binding  regulation of cardiac muscle cell contraction  regulation of relaxation of muscle  regulation of high voltage-gated calcium channel activity  regulation of cell communication by electrical coupling involved in cardiac conduction  negative regulation of transcription regulatory region DNA binding  
NDEx NetworkSRI
Atlas of Cancer Signalling NetworkSRI
Wikipedia pathwaysSRI
Orthology - Evolution
OrthoDB6717
GeneTree (enSembl)ENSG00000075142
Phylogenetic Trees/Animal Genes : TreeFamSRI
HOGENOMP30626
Homologs : HomoloGeneSRI
Homology/Alignments : Family Browser (UCSC)SRI
Gene fusions - Rearrangements
Fusion : QuiverSRI
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSRI [hg38]
dbVarSRI
ClinVarSRI
MonarchSRI
1000_GenomesSRI 
Exome Variant ServerSRI
GNOMAD BrowserENSG00000075142
Varsome BrowserSRI
Genomic Variants (DGV)SRI [DGVbeta]
DECIPHERSRI [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSRI 
Mutations
ICGC Data PortalSRI 
TCGA Data PortalSRI 
Broad Tumor PortalSRI
OASIS PortalSRI [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSRI  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSRI
Mutations and Diseases : HGMDSRI
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SRI
DgiDB (Drug Gene Interaction Database)SRI
DoCM (Curated mutations)SRI (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SRI (select a term)
intoGenSRI
Cancer3DSRI(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM182520   
Orphanet
DisGeNETSRI
MedgenSRI
Genetic Testing Registry SRI
NextProtP30626 [Medical]
GENETestsSRI
Target ValidationSRI
Huge Navigator SRI [HugePedia]
ClinGenSRI
Clinical trials, drugs, therapy
MyCancerGenomeSRI
Protein Interactions : CTD
Pharm GKB GenePA36117
PharosP30626
Clinical trialSRI
Miscellaneous
canSAR (ICR)SRI (select the gene name)
HarmonizomeSRI
DataMed IndexSRI
Probes
Litterature
PubMed83 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSRI
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:39:14 CET 2021
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