SRI (sorcin)

2007-02-01 Affiliation

Identity

HGNC

SRI

LOCATION

7q21.12

LOCUSID

6717

ALIAS

CP-22,CP22,SCN,V19

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6717
MIM: 182520
HGNC: 11292
Ensembl: ENSG00000075142

Variants:

dbSNP: 6717
ClinVar: 6717
TCGA: ENSG00000075142
COSMIC: SRI

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000075142	ENST00000265729	P30626
ENSG00000075142	ENST00000394641	P30626
ENSG00000075142	ENST00000419179	B4DHQ6
ENSG00000075142	ENST00000431660	P30626
ENSG00000075142	ENST00000457606	E9PG82
ENSG00000075142	ENST00000490437	C9J0K6

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Hemostasis	REACTOME	R-HSA-109582
Platelet homeostasis	REACTOME	R-HSA-418346
Platelet calcium homeostasis	REACTOME	R-HSA-418360
Reduction of cytosolic Ca++ levels	REACTOME	R-HSA-418359
Muscle contraction	REACTOME	R-HSA-397014
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptides	REACTOME	R-HSA-425393
Sodium/Calcium exchangers	REACTOME	R-HSA-425561
Ion channel transport	REACTOME	R-HSA-983712
Ion transport by P-type ATPases	REACTOME	R-HSA-936837
Stimuli-sensing channels	REACTOME	R-HSA-2672351
Cardiac conduction	REACTOME	R-HSA-5576891
Ion homeostasis	REACTOME	R-HSA-5578775

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
20647321	2010	Mitochondrial chaperone Trap1 and the calcium binding protein Sorcin interact and protect cells against apoptosis induced by antiblastic agents.	44
22052463	2011	Sorcin induces a drug-resistant phenotype in human colorectal cancer by modulating Ca(2+) homeostasis.	25
16320026	2006	Identification of histological markers for malignant glioma by genome-wide expression analysis: dynein, alpha-PIX and sorcin.	20
25197934	2014	Sorcin, a calcium binding protein involved in the multidrug resistance mechanisms in cancer cells.	18
19885748	2010	Upregulation of soluble resistance-related calcium-binding protein (sorcin) in gastric cancer.	15
21109982	2011	Overexpression of sorcin results in multidrug resistance in gastric cancer cells with up-regulation of P-gp.	15
22338092	2012	Glucose-induced nuclear shuttling of ChREBP is mediated by sorcin and Ca(2+) ions in pancreatic β-cells.	15
24013575	2013	Inhibition of sorcin reverses multidrug resistance of K562/A02 cells and MCF-7/A02 cells via regulating apoptosis-related proteins.	13
24427308	2014	Sorcin links calcium signaling to vesicle trafficking, regulates Polo-like kinase 1 and is necessary for mitosis.	13

Citation

Dessen P

SRI (sorcin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45785/sri