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SRM (spermidine synthase)

Identity

Alias_namesSRML1
Alias_symbol (synonym)SPS1
Other aliasPAPT
SPDSY
HGNC (Hugo) SRM
LocusID (NCBI) 6723
Atlas_Id 74235
Location 1p36.22  [Link to chromosome band 1p36]
Location_base_pair Starts at 11054592 and ends at 11060034 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
SRM (1p36.22) / PPP4R3A (14q32.12)SRM (1p36.22) / RPS9 (19q13.42)ZHX3 (20q12) / SRM (1p36.22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SRM   11296
Cards
Entrez_Gene (NCBI)SRM  6723  spermidine synthase
AliasesPAPT; SPDSY; SPS1; SRML1
GeneCards (Weizmann)SRM
Ensembl hg19 (Hinxton)ENSG00000116649 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000116649 [Gene_View]  chr1:11054592-11060034 [Contig_View]  SRM [Vega]
ICGC DataPortalENSG00000116649
TCGA cBioPortalSRM
AceView (NCBI)SRM
Genatlas (Paris)SRM
WikiGenes6723
SOURCE (Princeton)SRM
Genetics Home Reference (NIH)SRM
Genomic and cartography
GoldenPath hg38 (UCSC)SRM  -     chr1:11054592-11060034 -  1p36.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SRM  -     1p36.22   [Description]    (hg19-Feb_2009)
EnsemblSRM - 1p36.22 [CytoView hg19]  SRM - 1p36.22 [CytoView hg38]
Mapping of homologs : NCBISRM [Mapview hg19]  SRM [Mapview hg38]
OMIM182891   
Gene and transcription
Genbank (Entrez)BC000309 BC033106 EU831469 EU831556 M34338
RefSeq transcript (Entrez)NM_003132
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SRM
Cluster EST : UnigeneHs.76244 [ NCBI ]
CGAP (NCI)Hs.76244
Alternative Splicing GalleryENSG00000116649
Gene ExpressionSRM [ NCBI-GEO ]   SRM [ EBI - ARRAY_EXPRESS ]   SRM [ SEEK ]   SRM [ MEM ]
Gene Expression Viewer (FireBrowse)SRM [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6723
GTEX Portal (Tissue expression)SRM
Protein : pattern, domain, 3D structure
UniProt/SwissProtP19623   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP19623  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP19623
Splice isoforms : SwissVarP19623
Catalytic activity : Enzyme2.5.1.16 [ Enzyme-Expasy ]   2.5.1.162.5.1.16 [ IntEnz-EBI ]   2.5.1.16 [ BRENDA ]   2.5.1.16 [ KEGG ]   
PhosPhoSitePlusP19623
Domaine pattern : Prosite (Expaxy)PABS_1 (PS01330)    PABS_2 (PS51006)   
Domains : Interpro (EBI)PABS    PABS_CS    SAM-dependent_MTases    Spermi_synthase    Spermi_synthase_euk   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)SRM
DMDM Disease mutations6723
Blocks (Seattle)SRM
PDB (SRS)2O05    2O06    2O07    2O0L    3RW9   
PDB (PDBSum)2O05    2O06    2O07    2O0L    3RW9   
PDB (IMB)2O05    2O06    2O07    2O0L    3RW9   
PDB (RSDB)2O05    2O06    2O07    2O0L    3RW9   
Structural Biology KnowledgeBase2O05    2O06    2O07    2O0L    3RW9   
SCOP (Structural Classification of Proteins)2O05    2O06    2O07    2O0L    3RW9   
CATH (Classification of proteins structures)2O05    2O06    2O07    2O0L    3RW9   
SuperfamilyP19623
Human Protein AtlasENSG00000116649
Peptide AtlasP19623
HPRD01692
IPIIPI00292020   
Protein Interaction databases
DIP (DOE-UCLA)P19623
IntAct (EBI)P19623
FunCoupENSG00000116649
BioGRIDSRM
STRING (EMBL)SRM
ZODIACSRM
Ontologies - Pathways
QuickGOP19623
Ontology : AmiGOspermidine synthase activity  spermidine synthase activity  protein binding  cytosol  polyamine metabolic process  spermidine biosynthetic process  spermidine biosynthetic process  identical protein binding  protein homodimerization activity  
Ontology : EGO-EBIspermidine synthase activity  spermidine synthase activity  protein binding  cytosol  polyamine metabolic process  spermidine biosynthetic process  spermidine biosynthetic process  identical protein binding  protein homodimerization activity  
Pathways : KEGGCysteine and methionine metabolism    Arginine and proline metabolism    beta-Alanine metabolism    Glutathione metabolism   
NDEx NetworkSRM
Atlas of Cancer Signalling NetworkSRM
Wikipedia pathwaysSRM
Orthology - Evolution
OrthoDB6723
GeneTree (enSembl)ENSG00000116649
Phylogenetic Trees/Animal Genes : TreeFamSRM
HOVERGENP19623
HOGENOMP19623
Homologs : HomoloGeneSRM
Homology/Alignments : Family Browser (UCSC)SRM
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSRM [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SRM
dbVarSRM
ClinVarSRM
1000_GenomesSRM 
Exome Variant ServerSRM
ExAC (Exome Aggregation Consortium)SRM (select the gene name)
Genetic variants : HAPMAP6723
Genomic Variants (DGV)SRM [DGVbeta]
DECIPHERSRM [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSRM 
Mutations
ICGC Data PortalSRM 
TCGA Data PortalSRM 
Broad Tumor PortalSRM
OASIS PortalSRM [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSRM  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSRM
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SRM
DgiDB (Drug Gene Interaction Database)SRM
DoCM (Curated mutations)SRM (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SRM (select a term)
intoGenSRM
Cancer3DSRM(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM182891   
Orphanet
MedgenSRM
Genetic Testing Registry SRM
NextProtP19623 [Medical]
TSGene6723
GENETestsSRM
Huge Navigator SRM [HugePedia]
snp3D : Map Gene to Disease6723
BioCentury BCIQSRM
ClinGenSRM
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6723
Chemical/Pharm GKB GenePA36120
Clinical trialSRM
Miscellaneous
canSAR (ICR)SRM (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSRM
EVEXSRM
GoPubMedSRM
iHOPSRM
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 11:56:39 CEST 2017

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