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SRP14 (signal recognition particle 14)

Identity

Alias_namessignal recognition particle 14kD (homologous Alu RNA-binding protein)
Alias_symbol (synonym)ALURBP
MGC14326
Other alias
HGNC (Hugo) SRP14
LocusID (NCBI) 6727
Atlas_Id 74236
Location 15q15.1  [Link to chromosome band 15q15]
Location_base_pair Starts at 40035690 and ends at 40039202 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NUMB (14q24.2) / SRP14 (15q15.1)SRP14 (15q15.1) / ABCB11 (2q31.1)SRP14 (15q15.1) / C1orf198 (1q42.2)
SRP14 (15q15.1) / EME2 (16p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SRP14   11299
Cards
Entrez_Gene (NCBI)SRP14  6727  signal recognition particle 14
AliasesALURBP
GeneCards (Weizmann)SRP14
Ensembl hg19 (Hinxton)ENSG00000140319 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140319 [Gene_View]  chr15:40035690-40039202 [Contig_View]  SRP14 [Vega]
ICGC DataPortalENSG00000140319
TCGA cBioPortalSRP14
AceView (NCBI)SRP14
Genatlas (Paris)SRP14
WikiGenes6727
SOURCE (Princeton)SRP14
Genetics Home Reference (NIH)SRP14
Genomic and cartography
GoldenPath hg38 (UCSC)SRP14  -     chr15:40035690-40039202 -  15q15.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SRP14  -     15q15.1   [Description]    (hg19-Feb_2009)
EnsemblSRP14 - 15q15.1 [CytoView hg19]  SRP14 - 15q15.1 [CytoView hg38]
Mapping of homologs : NCBISRP14 [Mapview hg19]  SRP14 [Mapview hg38]
OMIM600708   
Gene and transcription
Genbank (Entrez)AB061546 AB451391 BC035495 BC051006 BC071716
RefSeq transcript (Entrez)NM_001309434 NM_003134
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SRP14
Cluster EST : UnigeneHs.533732 [ NCBI ]
CGAP (NCI)Hs.533732
Alternative Splicing GalleryENSG00000140319
Gene ExpressionSRP14 [ NCBI-GEO ]   SRP14 [ EBI - ARRAY_EXPRESS ]   SRP14 [ SEEK ]   SRP14 [ MEM ]
Gene Expression Viewer (FireBrowse)SRP14 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6727
GTEX Portal (Tissue expression)SRP14
Protein : pattern, domain, 3D structure
UniProt/SwissProtP37108   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP37108  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP37108
Splice isoforms : SwissVarP37108
PhosPhoSitePlusP37108
Domains : Interpro (EBI)Signal_recog_particle_SRP14    Signal_recog_particle_SRP9/14   
Domain families : Pfam (Sanger)SRP14 (PF02290)   
Domain families : Pfam (NCBI)pfam02290   
Domain structure : Prodom (Prabi Lyon)Signal_recog_particle_SRP14 (PD009170)   
Conserved Domain (NCBI)SRP14
DMDM Disease mutations6727
Blocks (Seattle)SRP14
PDB (SRS)1E8O    1E8S    1RY1    4UYJ    4UYK    5AOX   
PDB (PDBSum)1E8O    1E8S    1RY1    4UYJ    4UYK    5AOX   
PDB (IMB)1E8O    1E8S    1RY1    4UYJ    4UYK    5AOX   
PDB (RSDB)1E8O    1E8S    1RY1    4UYJ    4UYK    5AOX   
Structural Biology KnowledgeBase1E8O    1E8S    1RY1    4UYJ    4UYK    5AOX   
SCOP (Structural Classification of Proteins)1E8O    1E8S    1RY1    4UYJ    4UYK    5AOX   
CATH (Classification of proteins structures)1E8O    1E8S    1RY1    4UYJ    4UYK    5AOX   
SuperfamilyP37108
Human Protein AtlasENSG00000140319
Peptide AtlasP37108
HPRD02831
IPIIPI00293434   
Protein Interaction databases
DIP (DOE-UCLA)P37108
IntAct (EBI)P37108
FunCoupENSG00000140319
BioGRIDSRP14
STRING (EMBL)SRP14
ZODIACSRP14
Ontologies - Pathways
QuickGOP37108
Ontology : AmiGORNA binding  protein binding  extracellular region  nucleus  cytoplasm  signal recognition particle, endoplasmic reticulum targeting  cytosol  cotranslational protein targeting to membrane  SRP-dependent cotranslational protein targeting to membrane  7S RNA binding  endoplasmic reticulum signal peptide binding  secretory granule lumen  response to drug  neutrophil degranulation  protein targeting to ER  extracellular exosome  ficolin-1-rich granule lumen  
Ontology : EGO-EBIRNA binding  protein binding  extracellular region  nucleus  cytoplasm  signal recognition particle, endoplasmic reticulum targeting  cytosol  cotranslational protein targeting to membrane  SRP-dependent cotranslational protein targeting to membrane  7S RNA binding  endoplasmic reticulum signal peptide binding  secretory granule lumen  response to drug  neutrophil degranulation  protein targeting to ER  extracellular exosome  ficolin-1-rich granule lumen  
Pathways : KEGGProtein export   
NDEx NetworkSRP14
Atlas of Cancer Signalling NetworkSRP14
Wikipedia pathwaysSRP14
Orthology - Evolution
OrthoDB6727
GeneTree (enSembl)ENSG00000140319
Phylogenetic Trees/Animal Genes : TreeFamSRP14
HOVERGENP37108
HOGENOMP37108
Homologs : HomoloGeneSRP14
Homology/Alignments : Family Browser (UCSC)SRP14
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSRP14 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SRP14
dbVarSRP14
ClinVarSRP14
1000_GenomesSRP14 
Exome Variant ServerSRP14
ExAC (Exome Aggregation Consortium)SRP14 (select the gene name)
Genetic variants : HAPMAP6727
Genomic Variants (DGV)SRP14 [DGVbeta]
DECIPHERSRP14 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSRP14 
Mutations
ICGC Data PortalSRP14 
TCGA Data PortalSRP14 
Broad Tumor PortalSRP14
OASIS PortalSRP14 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSRP14  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSRP14
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SRP14
DgiDB (Drug Gene Interaction Database)SRP14
DoCM (Curated mutations)SRP14 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SRP14 (select a term)
intoGenSRP14
Cancer3DSRP14(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600708   
Orphanet
MedgenSRP14
Genetic Testing Registry SRP14
NextProtP37108 [Medical]
TSGene6727
GENETestsSRP14
Target ValidationSRP14
Huge Navigator SRP14 [HugePedia]
snp3D : Map Gene to Disease6727
BioCentury BCIQSRP14
ClinGenSRP14
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6727
Chemical/Pharm GKB GenePA36123
Clinical trialSRP14
Miscellaneous
canSAR (ICR)SRP14 (select the gene name)
Probes
Litterature
PubMed49 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSRP14
EVEXSRP14
GoPubMedSRP14
iHOPSRP14
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:40:29 CEST 2017

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