Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

SRP54 (signal recognition particle 54kDa)

Identity

Alias_namessignal recognition particle 54kDa
Other alias-
HGNC (Hugo) SRP54
LocusID (NCBI) 6729
Atlas_Id 51107
Location 14q13.2  [Link to chromosome band 14q13]
Location_base_pair Starts at 35452104 and ends at 35498773 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ATP5S (14q21.3) / SRP54 (14q13.2)IBTK (6q14.1) / SRP54 (14q13.2)SRP54 (14q13.2) / CCDC175 (14q23.1)
SRP54 (14q13.2) / CRTAP (3p22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SRP54   11301
Cards
Entrez_Gene (NCBI)SRP54  6729  signal recognition particle 54kDa
Aliases
GeneCards (Weizmann)SRP54
Ensembl hg19 (Hinxton)ENSG00000100883 [Gene_View]  chr14:35452104-35498773 [Contig_View]  SRP54 [Vega]
Ensembl hg38 (Hinxton)ENSG00000100883 [Gene_View]  chr14:35452104-35498773 [Contig_View]  SRP54 [Vega]
ICGC DataPortalENSG00000100883
TCGA cBioPortalSRP54
AceView (NCBI)SRP54
Genatlas (Paris)SRP54
WikiGenes6729
SOURCE (Princeton)SRP54
Genetics Home Reference (NIH)SRP54
Genomic and cartography
GoldenPath hg19 (UCSC)SRP54  -     chr14:35452104-35498773 +  14q13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SRP54  -     14q13.2   [Description]    (hg38-Dec_2013)
EnsemblSRP54 - 14q13.2 [CytoView hg19]  SRP54 - 14q13.2 [CytoView hg38]
Mapping of homologs : NCBISRP54 [Mapview hg19]  SRP54 [Mapview hg38]
OMIM604857   
Gene and transcription
Genbank (Entrez)AK293319 AK300824 AK312853 BC000652 BC003389
RefSeq transcript (Entrez)NM_001146282 NM_003136
RefSeq genomic (Entrez)NC_000014 NC_018925 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)SRP54
Cluster EST : UnigeneHs.167535 [ NCBI ]
CGAP (NCI)Hs.167535
Alternative Splicing GalleryENSG00000100883
Gene ExpressionSRP54 [ NCBI-GEO ]   SRP54 [ EBI - ARRAY_EXPRESS ]   SRP54 [ SEEK ]   SRP54 [ MEM ]
Gene Expression Viewer (FireBrowse)SRP54 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6729
GTEX Portal (Tissue expression)SRP54
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61011   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP61011  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61011
Splice isoforms : SwissVarP61011
PhosPhoSitePlusP61011
Domaine pattern : Prosite (Expaxy)SRP54 (PS00300)   
Domains : Interpro (EBI)AAA+_ATPase    P-loop_NTPase    Signal_recog_particl_SRP54_hlx    Signal_recog_particle_SRP54_M    SRP54    SRP54_euk    SRP54_GTPase_dom   
Domain families : Pfam (Sanger)SRP54 (PF00448)    SRP54_N (PF02881)    SRP_SPB (PF02978)   
Domain families : Pfam (NCBI)pfam00448    pfam02881    pfam02978   
Domain families : Smart (EMBL)AAA (SM00382)  SRP54 (SM00962)  SRP54_N (SM00963)  
Conserved Domain (NCBI)SRP54
DMDM Disease mutations6729
Blocks (Seattle)SRP54
PDB (SRS)1MFQ    1QB2   
PDB (PDBSum)1MFQ    1QB2   
PDB (IMB)1MFQ    1QB2   
PDB (RSDB)1MFQ    1QB2   
Structural Biology KnowledgeBase1MFQ    1QB2   
SCOP (Structural Classification of Proteins)1MFQ    1QB2   
CATH (Classification of proteins structures)1MFQ    1QB2   
SuperfamilyP61011
Human Protein AtlasENSG00000100883
Peptide AtlasP61011
HPRD05330
IPIIPI00009822   IPI01026241   IPI01026576   IPI01026447   IPI01025877   IPI00929464   
Protein Interaction databases
DIP (DOE-UCLA)P61011
IntAct (EBI)P61011
FunCoupENSG00000100883
BioGRIDSRP54
STRING (EMBL)SRP54
ZODIACSRP54
Ontologies - Pathways
QuickGOP61011
Ontology : AmiGOGTPase activity  protein binding  GTP binding  nucleus  nucleolus  nucleolus  cytoplasm  signal recognition particle, endoplasmic reticulum targeting  cytosol  SRP-dependent cotranslational protein targeting to membrane  SRP-dependent cotranslational protein targeting to membrane  SRP-dependent cotranslational protein targeting to membrane, translocation  SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition  drug binding  metabolic process  7S RNA binding  nuclear speck  GDP binding  endoplasmic reticulum signal peptide binding  response to drug  ribonucleoprotein complex binding  poly(A) RNA binding  protein targeting to ER  
Ontology : EGO-EBIGTPase activity  protein binding  GTP binding  nucleus  nucleolus  nucleolus  cytoplasm  signal recognition particle, endoplasmic reticulum targeting  cytosol  SRP-dependent cotranslational protein targeting to membrane  SRP-dependent cotranslational protein targeting to membrane  SRP-dependent cotranslational protein targeting to membrane, translocation  SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition  drug binding  metabolic process  7S RNA binding  nuclear speck  GDP binding  endoplasmic reticulum signal peptide binding  response to drug  ribonucleoprotein complex binding  poly(A) RNA binding  protein targeting to ER  
Pathways : KEGGProtein export   
NDEx NetworkSRP54
Atlas of Cancer Signalling NetworkSRP54
Wikipedia pathwaysSRP54
Orthology - Evolution
OrthoDB6729
GeneTree (enSembl)ENSG00000100883
Phylogenetic Trees/Animal Genes : TreeFamSRP54
HOVERGENP61011
HOGENOMP61011
Homologs : HomoloGeneSRP54
Homology/Alignments : Family Browser (UCSC)SRP54
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSRP54 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SRP54
dbVarSRP54
ClinVarSRP54
1000_GenomesSRP54 
Exome Variant ServerSRP54
ExAC (Exome Aggregation Consortium)SRP54 (select the gene name)
Genetic variants : HAPMAP6729
Genomic Variants (DGV)SRP54 [DGVbeta]
DECIPHER (Syndromes)14:35452104-35498773  ENSG00000100883
CONAN: Copy Number AnalysisSRP54 
Mutations
ICGC Data PortalSRP54 
TCGA Data PortalSRP54 
Broad Tumor PortalSRP54
OASIS PortalSRP54 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSRP54  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSRP54
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SRP54
DgiDB (Drug Gene Interaction Database)SRP54
DoCM (Curated mutations)SRP54 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SRP54 (select a term)
intoGenSRP54
Cancer3DSRP54(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604857   
Orphanet
MedgenSRP54
Genetic Testing Registry SRP54
NextProtP61011 [Medical]
TSGene6729
GENETestsSRP54
Huge Navigator SRP54 [HugePedia]
snp3D : Map Gene to Disease6729
BioCentury BCIQSRP54
ClinGenSRP54
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6729
Chemical/Pharm GKB GenePA36125
Clinical trialSRP54
Miscellaneous
canSAR (ICR)SRP54 (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSRP54
EVEXSRP54
GoPubMedSRP54
iHOPSRP54
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:29:08 CET 2017

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.