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SRP68 (signal recognition particle 68)

Identity

Alias_namessignal recognition particle 68kD
signal recognition particle 68kDa
Other alias-
HGNC (Hugo) SRP68
LocusID (NCBI) 6730
Atlas_Id 53892
Location 17q25.1  [Link to chromosome band 17q25]
Location_base_pair Starts at 76038775 and ends at 76072526 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ACOX1 (17q25.1) / SRP68 (17q25.1)DNAJA2 (16q11.2) / SRP68 (17q25.1)EVPL (17q25.1) / SRP68 (17q25.1)
FAM178B (2q11.2) / SRP68 (17q25.1)SRP68 (17q25.1) / AP1M2 (19p13.2)SRP68 (17q25.1) / LPO (17q22)
SRP68 (17q25.1) / MIEN1 (17q12)SRP68 (17q25.1) / NEAT1 (11q13.1)SRP68 (17q25.1) / PARP1 (1q42.12)
SRP68 (17q25.1) / RCAN1 (21q22.12)SRP68 (17q25.1) / SRP68 (17q25.1)SRP68 (17q25.1) / URM1 (9q34.11)
TRIM65 (17q25.1) / SRP68 (17q25.1)ACOX1 17q25.1 / SRP68 17q25.1EVPL 17q25.1 / SRP68 17q25.1
SRP68 17q25.1 / AP1M2 19p13.2SRP68 17q25.1 / LPO 17q22SRP68 17q25.1 / RCAN1 21q22.12
SRP68 17q25.1 / URM1 9q34.11TRIM65 17q25.1 / SRP68 17q25.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SRP68   11302
Cards
Entrez_Gene (NCBI)SRP68  6730  signal recognition particle 68
Aliases
GeneCards (Weizmann)SRP68
Ensembl hg19 (Hinxton)ENSG00000167881 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167881 [Gene_View]  chr17:76038775-76072526 [Contig_View]  SRP68 [Vega]
ICGC DataPortalENSG00000167881
TCGA cBioPortalSRP68
AceView (NCBI)SRP68
Genatlas (Paris)SRP68
WikiGenes6730
SOURCE (Princeton)SRP68
Genetics Home Reference (NIH)SRP68
Genomic and cartography
GoldenPath hg38 (UCSC)SRP68  -     chr17:76038775-76072526 -  17q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SRP68  -     17q25.1   [Description]    (hg19-Feb_2009)
EnsemblSRP68 - 17q25.1 [CytoView hg19]  SRP68 - 17q25.1 [CytoView hg38]
Mapping of homologs : NCBISRP68 [Mapview hg19]  SRP68 [Mapview hg38]
OMIM604858   
Gene and transcription
Genbank (Entrez)AF195951 AK002002 AK027320 AK027322 AK074698
RefSeq transcript (Entrez)NM_001260502 NM_001260503 NM_014230
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SRP68
Cluster EST : UnigeneHs.514495 [ NCBI ]
CGAP (NCI)Hs.514495
Alternative Splicing GalleryENSG00000167881
Gene ExpressionSRP68 [ NCBI-GEO ]   SRP68 [ EBI - ARRAY_EXPRESS ]   SRP68 [ SEEK ]   SRP68 [ MEM ]
Gene Expression Viewer (FireBrowse)SRP68 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6730
GTEX Portal (Tissue expression)SRP68
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UHB9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UHB9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UHB9
Splice isoforms : SwissVarQ9UHB9
PhosPhoSitePlusQ9UHB9
Domains : Interpro (EBI)SRP68    TPR-like_helical_dom   
Domain families : Pfam (Sanger)SRP68 (PF16969)   
Domain families : Pfam (NCBI)pfam16969   
Conserved Domain (NCBI)SRP68
DMDM Disease mutations6730
Blocks (Seattle)SRP68
PDB (SRS)4P3E    4P3F    5M72    5M73   
PDB (PDBSum)4P3E    4P3F    5M72    5M73   
PDB (IMB)4P3E    4P3F    5M72    5M73   
PDB (RSDB)4P3E    4P3F    5M72    5M73   
Structural Biology KnowledgeBase4P3E    4P3F    5M72    5M73   
SCOP (Structural Classification of Proteins)4P3E    4P3F    5M72    5M73   
CATH (Classification of proteins structures)4P3E    4P3F    5M72    5M73   
SuperfamilyQ9UHB9
Human Protein AtlasENSG00000167881
Peptide AtlasQ9UHB9
HPRD05331
IPIIPI00168388   IPI00102936   IPI01014848   IPI01010759   IPI01009487   IPI01018053   IPI01015006   IPI00386885   
Protein Interaction databases
DIP (DOE-UCLA)Q9UHB9
IntAct (EBI)Q9UHB9
FunCoupENSG00000167881
BioGRIDSRP68
STRING (EMBL)SRP68
ZODIACSRP68
Ontologies - Pathways
QuickGOQ9UHB9
Ontology : AmiGORNA binding  signal recognition particle binding  protein binding  nucleolus  endoplasmic reticulum  signal recognition particle, endoplasmic reticulum targeting  cytosol  cytosol  ribosome  focal adhesion  SRP-dependent cotranslational protein targeting to membrane  7S RNA binding  protein domain specific binding  endoplasmic reticulum signal peptide binding  response to drug  ribosome binding  protein targeting to ER  signal recognition particle  
Ontology : EGO-EBIRNA binding  signal recognition particle binding  protein binding  nucleolus  endoplasmic reticulum  signal recognition particle, endoplasmic reticulum targeting  cytosol  cytosol  ribosome  focal adhesion  SRP-dependent cotranslational protein targeting to membrane  7S RNA binding  protein domain specific binding  endoplasmic reticulum signal peptide binding  response to drug  ribosome binding  protein targeting to ER  signal recognition particle  
Pathways : KEGGProtein export   
NDEx NetworkSRP68
Atlas of Cancer Signalling NetworkSRP68
Wikipedia pathwaysSRP68
Orthology - Evolution
OrthoDB6730
GeneTree (enSembl)ENSG00000167881
Phylogenetic Trees/Animal Genes : TreeFamSRP68
HOVERGENQ9UHB9
HOGENOMQ9UHB9
Homologs : HomoloGeneSRP68
Homology/Alignments : Family Browser (UCSC)SRP68
Gene fusions - Rearrangements
Fusion : MitelmanACOX1/SRP68 [17q25.1/17q25.1]  [t(17;17)(q25;q25)]  
Fusion : MitelmanEVPL/SRP68 [17q25.1/17q25.1]  [t(17;17)(q25;q25)]  
Fusion : MitelmanSRP68/AP1M2 [17q25.1/19p13.2]  [t(17;19)(q25;p13)]  
Fusion : MitelmanSRP68/LPO [17q25.1/17q22]  [t(17;17)(q22;q25)]  
Fusion : MitelmanSRP68/MIEN1 [17q25.1/17q12]  [del(17)(q12q25)]  
Fusion : MitelmanSRP68/RCAN1 [17q25.1/21q22.12]  [t(17;21)(q25;q22)]  
Fusion : MitelmanSRP68/URM1 [17q25.1/9q34.11]  [t(9;17)(q34;q25)]  
Fusion : MitelmanTRIM65/SRP68 [17q25.1/17q25.1]  [t(17;17)(q25;q25)]  
Fusion: TCGAACOX1 17q25.1 SRP68 17q25.1 BLCA LUAD
Fusion: TCGAEVPL 17q25.1 SRP68 17q25.1 OV
Fusion: TCGASRP68 17q25.1 AP1M2 19p13.2 GBM
Fusion: TCGASRP68 17q25.1 LPO 17q22 BRCA
Fusion: TCGASRP68 17q25.1 RCAN1 21q22.12 LUAD
Fusion: TCGASRP68 17q25.1 URM1 9q34.11 GBM
Fusion: TCGATRIM65 17q25.1 SRP68 17q25.1 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSRP68 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SRP68
dbVarSRP68
ClinVarSRP68
1000_GenomesSRP68 
Exome Variant ServerSRP68
ExAC (Exome Aggregation Consortium)SRP68 (select the gene name)
Genetic variants : HAPMAP6730
Genomic Variants (DGV)SRP68 [DGVbeta]
DECIPHERSRP68 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSRP68 
Mutations
ICGC Data PortalSRP68 
TCGA Data PortalSRP68 
Broad Tumor PortalSRP68
OASIS PortalSRP68 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSRP68  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSRP68
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SRP68
DgiDB (Drug Gene Interaction Database)SRP68
DoCM (Curated mutations)SRP68 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SRP68 (select a term)
intoGenSRP68
Cancer3DSRP68(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604858   
Orphanet
MedgenSRP68
Genetic Testing Registry SRP68
NextProtQ9UHB9 [Medical]
TSGene6730
GENETestsSRP68
Target ValidationSRP68
Huge Navigator SRP68 [HugePedia]
snp3D : Map Gene to Disease6730
BioCentury BCIQSRP68
ClinGenSRP68
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6730
Chemical/Pharm GKB GenePA36126
Clinical trialSRP68
Miscellaneous
canSAR (ICR)SRP68 (select the gene name)
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSRP68
EVEXSRP68
GoPubMedSRP68
iHOPSRP68
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:57:24 CEST 2017

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