Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

SRP68 (signal recognition particle 68)

Identity

Alias (NCBI)-
HGNC (Hugo) SRP68
HGNC Previous namesignal recognition particle 68kD
 signal recognition particle 68kDa
LocusID (NCBI) 6730
Atlas_Id 53892
Location 17q25.1  [Link to chromosome band 17q25]
Location_base_pair Starts at 76038785 and ends at 76072517 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACOX1 (17q25.1) / SRP68 (17q25.1)DNAJA2 (16q11.2) / SRP68 (17q25.1)EVPL (17q25.1) / SRP68 (17q25.1)
FAM178B (2q11.2) / SRP68 (17q25.1)SRP68 (17q25.1) / AP1M2 (19p13.2)SRP68 (17q25.1) / LPO (17q22)
SRP68 (17q25.1) / MIEN1 (17q12)SRP68 (17q25.1) / NEAT1 (11q13.1)SRP68 (17q25.1) / PARP1 (1q42.12)
SRP68 (17q25.1) / RCAN1 (21q22.12)SRP68 (17q25.1) / SRP68 (17q25.1)SRP68 (17q25.1) / URM1 (9q34.11)
TRIM65 (17q25.1) / SRP68 (17q25.1)ACOX1 17q25.1 / SRP68 17q25.1EVPL 17q25.1 / SRP68 17q25.1
SRP68 17q25.1 / AP1M2 19p13.2SRP68 17q25.1 / LPO 17q22SRP68 17q25.1 / RCAN1 21q22.12
SRP68 17q25.1 / URM1 9q34.11TRIM65 17q25.1 / SRP68 17q25.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SRP68   11302
Cards
Entrez_Gene (NCBI)SRP68    signal recognition particle 68
Aliases
GeneCards (Weizmann)SRP68
Ensembl hg19 (Hinxton)ENSG00000167881 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167881 [Gene_View]  ENSG00000167881 [Sequence]  chr17:76038785-76072517 [Contig_View]  SRP68 [Vega]
ICGC DataPortalENSG00000167881
TCGA cBioPortalSRP68
AceView (NCBI)SRP68
Genatlas (Paris)SRP68
SOURCE (Princeton)SRP68
Genetics Home Reference (NIH)SRP68
Genomic and cartography
GoldenPath hg38 (UCSC)SRP68  -     chr17:76038785-76072517 -  17q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SRP68  -     17q25.1   [Description]    (hg19-Feb_2009)
GoldenPathSRP68 - 17q25.1 [CytoView hg19]  SRP68 - 17q25.1 [CytoView hg38]
ImmunoBaseENSG00000167881
Genome Data Viewer NCBISRP68 [Mapview hg19]  
OMIM604858   
Gene and transcription
Genbank (Entrez)AF195951 AK002002 AK027320 AK027322 AK074698
RefSeq transcript (Entrez)NM_001260502 NM_001260503 NM_014230
Consensus coding sequences : CCDS (NCBI)SRP68
Gene ExpressionSRP68 [ NCBI-GEO ]   SRP68 [ EBI - ARRAY_EXPRESS ]   SRP68 [ SEEK ]   SRP68 [ MEM ]
Gene Expression Viewer (FireBrowse)SRP68 [ Firebrowse - Broad ]
GenevisibleExpression of SRP68 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6730
GTEX Portal (Tissue expression)SRP68
Human Protein AtlasENSG00000167881-SRP68 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UHB9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UHB9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UHB9
PhosPhoSitePlusQ9UHB9
Domains : Interpro (EBI)SRP68    SRP68-RBD    SRP68_N_sf   
Domain families : Pfam (Sanger)SRP68 (PF16969)   
Domain families : Pfam (NCBI)pfam16969   
Conserved Domain (NCBI)SRP68
PDB (RSDB)4P3E    4P3F    5M72    5M73    5WRV   
PDB Europe4P3E    4P3F    5M72    5M73    5WRV   
PDB (PDBSum)4P3E    4P3F    5M72    5M73    5WRV   
PDB (IMB)4P3E    4P3F    5M72    5M73    5WRV   
Structural Biology KnowledgeBase4P3E    4P3F    5M72    5M73    5WRV   
SCOP (Structural Classification of Proteins)4P3E    4P3F    5M72    5M73    5WRV   
CATH (Classification of proteins structures)4P3E    4P3F    5M72    5M73    5WRV   
SuperfamilyQ9UHB9
AlphaFold pdb e-kbQ9UHB9   
Human Protein Atlas [tissue]ENSG00000167881-SRP68 [tissue]
HPRD05331
Protein Interaction databases
DIP (DOE-UCLA)Q9UHB9
IntAct (EBI)Q9UHB9
BioGRIDSRP68
STRING (EMBL)SRP68
ZODIACSRP68
Ontologies - Pathways
QuickGOQ9UHB9
Ontology : AmiGORNA binding  signal recognition particle binding  signal recognition particle binding  protein binding  nucleolus  endoplasmic reticulum  signal recognition particle, endoplasmic reticulum targeting  signal recognition particle, endoplasmic reticulum targeting  cytosol  cytosol  ribosome  focal adhesion  SRP-dependent cotranslational protein targeting to membrane  7S RNA binding  protein domain specific binding  endoplasmic reticulum signal peptide binding  response to drug  ribosome binding  signal recognition particle  
Ontology : EGO-EBIRNA binding  signal recognition particle binding  signal recognition particle binding  protein binding  nucleolus  endoplasmic reticulum  signal recognition particle, endoplasmic reticulum targeting  signal recognition particle, endoplasmic reticulum targeting  cytosol  cytosol  ribosome  focal adhesion  SRP-dependent cotranslational protein targeting to membrane  7S RNA binding  protein domain specific binding  endoplasmic reticulum signal peptide binding  response to drug  ribosome binding  signal recognition particle  
Pathways : KEGGProtein export   
NDEx NetworkSRP68
Atlas of Cancer Signalling NetworkSRP68
Wikipedia pathwaysSRP68
Orthology - Evolution
OrthoDB6730
GeneTree (enSembl)ENSG00000167881
Phylogenetic Trees/Animal Genes : TreeFamSRP68
Homologs : HomoloGeneSRP68
Homology/Alignments : Family Browser (UCSC)SRP68
Gene fusions - Rearrangements
Fusion : MitelmanACOX1/SRP68 [17q25.1/17q25.1]  
Fusion : MitelmanEVPL/SRP68 [17q25.1/17q25.1]  
Fusion : MitelmanSRP68/AP1M2 [17q25.1/19p13.2]  
Fusion : MitelmanSRP68/LPO [17q25.1/17q22]  
Fusion : MitelmanSRP68/MIEN1 [17q25.1/17q12]  
Fusion : MitelmanSRP68/RCAN1 [17q25.1/21q22.12]  
Fusion : MitelmanSRP68/URM1 [17q25.1/9q34.11]  
Fusion : MitelmanTRIM65/SRP68 [17q25.1/17q25.1]  
Fusion : QuiverSRP68
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSRP68 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SRP68
dbVarSRP68
ClinVarSRP68
MonarchSRP68
1000_GenomesSRP68 
Exome Variant ServerSRP68
GNOMAD BrowserENSG00000167881
Varsome BrowserSRP68
ACMGSRP68 variants
VarityQ9UHB9
Genomic Variants (DGV)SRP68 [DGVbeta]
DECIPHERSRP68 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSRP68 
Mutations
ICGC Data PortalSRP68 
TCGA Data PortalSRP68 
Broad Tumor PortalSRP68
OASIS PortalSRP68 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSRP68  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSRP68
Mutations and Diseases : HGMDSRP68
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSRP68
DgiDB (Drug Gene Interaction Database)SRP68
DoCM (Curated mutations)SRP68
CIViC (Clinical Interpretations of Variants in Cancer)SRP68
Cancer3DSRP68
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604858   
Orphanet
DisGeNETSRP68
MedgenSRP68
Genetic Testing Registry SRP68
NextProtQ9UHB9 [Medical]
GENETestsSRP68
Target ValidationSRP68
Huge Navigator SRP68 [HugePedia]
ClinGenSRP68
Clinical trials, drugs, therapy
MyCancerGenomeSRP68
Protein Interactions : CTDSRP68
Pharm GKB GenePA36126
PharosQ9UHB9
Clinical trialSRP68
Miscellaneous
canSAR (ICR)SRP68
HarmonizomeSRP68
DataMed IndexSRP68
Probes
Litterature
PubMed88 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSRP68
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:33:08 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.