SRP72 (signal recognition particle 72)

2016-12-01  

Identity

HGNC
LOCATION
4q12
LOCUSID
ALIAS
BMFF,BMFS1,HEL103
FUSION GENES

Other Information

Locus ID:

NCBI: 6731
MIM: 602122
HGNC: 11303
Ensembl: ENSG00000174780

Variants:

dbSNP: 6731
ClinVar: 6731
TCGA: ENSG00000174780
COSMIC: SRP72

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174780ENST00000504757R4GNC1
ENSG00000174780ENST00000505314D6RDY6
ENSG00000174780ENST00000510663O76094
ENSG00000174780ENST00000642900O76094
ENSG00000174780ENST00000642900V9HWK0

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Protein exportKEGGko03060
Protein exportKEGGhsa03060
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
SRP-dependent cotranslational protein targeting to membraneREACTOMER-HSA-1799339
Gene ExpressionREACTOMER-HSA-74160

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
225415602012Exome sequencing identifies autosomal-dominant SRP72 mutations associated with familial aplasia and myelodysplasia.31
207292132010Inhibitors of MAPK pathway ERK1/2 or p38 prevent the IL-1{beta}-induced up-regulation of SRP72 autoantigen in Jurkat cells.10
155888162005Identification of an RNA-binding domain in human SRP72.9
166722322006Protein SRP68 of human signal recognition particle: identification of the RNA and SRP72 binding domains.9
184410462008The 5e motif of eukaryotic signal recognition particle RNA contains a conserved adenosine for the binding of SRP72.7
278996662017Structures of human SRP72 complexes provide insights into SRP RNA remodeling and ribosome interaction.7
230480282012A novel histone H4 arginine 3 methylation-sensitive histone H4 binding activity and transcriptional regulatory function for signal recognition particle subunits SRP68 and SRP72.6
210737482010Identification of amino acid residues in protein SRP72 required for binding to a kinked 5e motif of the human signal recognition particle RNA.5
283695292017Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation.2
284941882017Depletion of signal recognition particle 72kDa increases radiosensitivity.1

Citation

Dessen P

SRP72 (signal recognition particle 72)

Atlas Genet Cytogenet Oncol Haematol. 2016-12-01

Online version: http://atlasgeneticsoncology.org/gene/56663/srp72