SRPK2 (SRSF protein kinase 2)

2003-11-01  

Identity

HGNC
LOCATION
7q22.3
LOCUSID
ALIAS
SFRSK2
FUSION GENES

Other Information

Locus ID:

NCBI: 6733
MIM: 602980
HGNC: 11306
Ensembl: ENSG00000135250

Variants:

dbSNP: 6733
ClinVar: 6733
TCGA: ENSG00000135250
COSMIC: SRPK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135250ENST00000357311P78362
ENSG00000135250ENST00000357311A0A024R704
ENSG00000135250ENST00000393651P78362
ENSG00000135250ENST00000460391C9J2M4
ENSG00000135250ENST00000465072F8WBW4
ENSG00000135250ENST00000465112F8WAV6
ENSG00000135250ENST00000474770H7C521
ENSG00000135250ENST00000477925H7C5L6
ENSG00000135250ENST00000482897C9JWF7
ENSG00000135250ENST00000489828P78362
ENSG00000135250ENST00000489828A0A024R704

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
121340182002Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein.54
184251422008Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome.50
185595002008Serine/arginine protein-specific kinase 2 promotes leukemia cell proliferation by phosphorylating acinus and regulating cyclin A1.36
195924912009Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons.36
280767792017Transcription Dynamics Prevent RNA-Mediated Genomic Instability through SRPK2-Dependent DDX23 Phosphorylation.25
161227762005Suppression of hepatitis B virus replication by SRPK1 and SRPK2 via a pathway independent of the phosphorylation of the viral core protein.20
204983282010Inhibition of hepatitis C virus replication by a specific inhibitor of serine-arginine-rich protein kinase.15
288266722017Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer's Disease.13
262448492015Potential Antileukemia Effect and Structural Analyses of SRPK Inhibition by N-(2-(Piperidin-1-yl)-5-(Trifluoromethyl)Phenyl)Isonicotinamide (SRPIN340).12

Citation

Dessen P

SRPK2 (SRSF protein kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42389/srpk2