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SRPK2 (SRSF protein kinase 2)

Identity

Alias_namesSFRS protein kinase 2
Alias_symbol (synonym)SFRSK2
Other alias
HGNC (Hugo) SRPK2
LocusID (NCBI) 6733
Atlas_Id 42389
Location 7q22.3  [Link to chromosome band 7q22]
Location_base_pair Starts at 104756821 and ends at 104939226 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AREL1 (14q24.3) / SRPK2 (7q22.3)DHX8 (17q21.31) / SRPK2 (7q22.3)SERP1 (3q25.1) / SRPK2 (7q22.3)
SRPK2 (7q22.3) / ATXN7L1 (7q22.3)SRPK2 (7q22.3) / C16orf70 (16q22.1)SRPK2 (7q22.3) / DYNC1I1 (7q21.3)
SRPK2 (7q22.3) / KIAA1324L (7q21.12)SRPK2 (7q22.3) / PUS7 (7q22.3)SRPK2 (7q22.3) / SRPK2 (7q22.3)
SSR1 (6p24.3) / SRPK2 (7q22.3)SRPK2 7q22.3 / ATXN7L1 7q22.3SRPK2 7q22.3 / DYNC1I1 7q21.3
SRPK2 7q22.3 / KIAA1324L 7q21.12SRPK2 7q22.3 / PUS7 7q22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SRPK2   11306
Cards
Entrez_Gene (NCBI)SRPK2  6733  SRSF protein kinase 2
AliasesSFRSK2
GeneCards (Weizmann)SRPK2
Ensembl hg19 (Hinxton)ENSG00000135250 [Gene_View]  chr7:104756821-104939226 [Contig_View]  SRPK2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000135250 [Gene_View]  chr7:104756821-104939226 [Contig_View]  SRPK2 [Vega]
ICGC DataPortalENSG00000135250
TCGA cBioPortalSRPK2
AceView (NCBI)SRPK2
Genatlas (Paris)SRPK2
WikiGenes6733
SOURCE (Princeton)SRPK2
Genetics Home Reference (NIH)SRPK2
Genomic and cartography
GoldenPath hg19 (UCSC)SRPK2  -     chr7:104756821-104939226 -  7q22.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SRPK2  -     7q22.3   [Description]    (hg38-Dec_2013)
EnsemblSRPK2 - 7q22.3 [CytoView hg19]  SRPK2 - 7q22.3 [CytoView hg38]
Mapping of homologs : NCBISRPK2 [Mapview hg19]  SRPK2 [Mapview hg38]
OMIM602980   
Gene and transcription
Genbank (Entrez)AK092977 AK093420 AW086157 AY354201 BC035214
RefSeq transcript (Entrez)NM_001278273 NM_182691 NM_182692
RefSeq genomic (Entrez)NC_000007 NC_018918 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)SRPK2
Cluster EST : UnigeneHs.285197 [ NCBI ]
CGAP (NCI)Hs.285197
Alternative Splicing GalleryENSG00000135250
Gene ExpressionSRPK2 [ NCBI-GEO ]   SRPK2 [ EBI - ARRAY_EXPRESS ]   SRPK2 [ SEEK ]   SRPK2 [ MEM ]
Gene Expression Viewer (FireBrowse)SRPK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6733
GTEX Portal (Tissue expression)SRPK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP78362   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP78362  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP78362
Splice isoforms : SwissVarP78362
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusP78362
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Conserved Domain (NCBI)SRPK2
DMDM Disease mutations6733
Blocks (Seattle)SRPK2
PDB (SRS)2X7G   
PDB (PDBSum)2X7G   
PDB (IMB)2X7G   
PDB (RSDB)2X7G   
Structural Biology KnowledgeBase2X7G   
SCOP (Structural Classification of Proteins)2X7G   
CATH (Classification of proteins structures)2X7G   
SuperfamilyP78362
Human Protein AtlasENSG00000135250
Peptide AtlasP78362
HPRD04280
IPIIPI00333420   IPI00396412   IPI00945288   IPI00946084   IPI00946758   IPI00945069   IPI00946954   IPI00944903   
Protein Interaction databases
DIP (DOE-UCLA)P78362
IntAct (EBI)P78362
FunCoupENSG00000135250
BioGRIDSRPK2
STRING (EMBL)SRPK2
ZODIACSRPK2
Ontologies - Pathways
QuickGOP78362
Ontology : AmiGOspliceosomal complex assembly  magnesium ion binding  angiogenesis  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleolus  cytoplasm  protein phosphorylation  positive regulation of cell proliferation  RNA splicing  positive regulation of gene expression  cell differentiation  nuclear speck organization  intracellular signal transduction  positive regulation of neuron apoptotic process  poly(A) RNA binding  positive regulation of viral genome replication  negative regulation of viral genome replication  innate immune response  positive regulation of cell cycle  regulation of mRNA splicing, via spliceosome  14-3-3 protein binding  
Ontology : EGO-EBIspliceosomal complex assembly  magnesium ion binding  angiogenesis  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleolus  cytoplasm  protein phosphorylation  positive regulation of cell proliferation  RNA splicing  positive regulation of gene expression  cell differentiation  nuclear speck organization  intracellular signal transduction  positive regulation of neuron apoptotic process  poly(A) RNA binding  positive regulation of viral genome replication  negative regulation of viral genome replication  innate immune response  positive regulation of cell cycle  regulation of mRNA splicing, via spliceosome  14-3-3 protein binding  
NDEx NetworkSRPK2
Atlas of Cancer Signalling NetworkSRPK2
Wikipedia pathwaysSRPK2
Orthology - Evolution
OrthoDB6733
GeneTree (enSembl)ENSG00000135250
Phylogenetic Trees/Animal Genes : TreeFamSRPK2
HOVERGENP78362
HOGENOMP78362
Homologs : HomoloGeneSRPK2
Homology/Alignments : Family Browser (UCSC)SRPK2
Gene fusions - Rearrangements
Fusion : MitelmanSRPK2/ATXN7L1 [7q22.3/7q22.3]  
Fusion : MitelmanSRPK2/DYNC1I1 [7q22.3/7q21.3]  [t(7;7)(q21;q22)]  
Fusion : MitelmanSRPK2/KIAA1324L [7q22.3/7q21.12]  [t(7;7)(q21;q22)]  
Fusion : MitelmanSRPK2/PUS7 [7q22.3/7q22.3]  [t(7;7)(q22;q22)]  
Fusion: TCGASRPK2 7q22.3 ATXN7L1 7q22.3 HNSC
Fusion: TCGASRPK2 7q22.3 DYNC1I1 7q21.3 LUAD
Fusion: TCGASRPK2 7q22.3 KIAA1324L 7q21.12 HNSC
Fusion: TCGASRPK2 7q22.3 PUS7 7q22.3 BRCA THCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSRPK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SRPK2
dbVarSRPK2
ClinVarSRPK2
1000_GenomesSRPK2 
Exome Variant ServerSRPK2
ExAC (Exome Aggregation Consortium)SRPK2 (select the gene name)
Genetic variants : HAPMAP6733
Genomic Variants (DGV)SRPK2 [DGVbeta]
DECIPHER (Syndromes)7:104756821-104939226  ENSG00000135250
CONAN: Copy Number AnalysisSRPK2 
Mutations
ICGC Data PortalSRPK2 
TCGA Data PortalSRPK2 
Broad Tumor PortalSRPK2
OASIS PortalSRPK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSRPK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSRPK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SRPK2
DgiDB (Drug Gene Interaction Database)SRPK2
DoCM (Curated mutations)SRPK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SRPK2 (select a term)
intoGenSRPK2
Cancer3DSRPK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602980   
Orphanet
MedgenSRPK2
Genetic Testing Registry SRPK2
NextProtP78362 [Medical]
TSGene6733
GENETestsSRPK2
Huge Navigator SRPK2 [HugePedia]
snp3D : Map Gene to Disease6733
BioCentury BCIQSRPK2
ClinGenSRPK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6733
Chemical/Pharm GKB GenePA36130
Clinical trialSRPK2
Miscellaneous
canSAR (ICR)SRPK2 (select the gene name)
Probes
Litterature
PubMed51 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSRPK2
EVEXSRPK2
GoPubMedSRPK2
iHOPSRPK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:20:51 CEST 2017

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