SRPX2 (sushi repeat containing protein X-linked 2)

2009-02-01  

Identity

HGNC
SRPX2
LOCATION
Xq22.1
LOCUSID
27286
ALIAS
BPP,CBPS,PMGX,RESDX,SRPUL

Other Information

Locus ID:

NCBI: 27286
MIM: 300642
HGNC: 30668
Ensembl: ENSG00000102359

Variants:

dbSNP: 27286
ClinVar: 27286
TCGA: ENSG00000102359
COSMIC: SRPX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102359ENST00000373004O60687
ENSG00000102359ENST00000638458A0A1W2PR88
ENSG00000102359ENST00000640282A0A1W2PNZ6
ENSG00000102359ENST00000640889A0A1W2PRB1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
164977222006SRPX2 mutations in disorders of language cortex and cognition.75
241791582013The human language-associated gene SRPX2 regulates synapse formation and vocalization in mice.46
208585962010Molecular networks implicated in speech-related disorders: FOXP2 regulates the SRPX2/uPAR complex.36
190656542009SRPX2 is overexpressed in gastric cancer and promotes cellular migration and adhesion.30
231150502013Non-CpG island promoter hypomethylation and miR-149 regulate the expression of SRPX2 in colorectal cancer.29
187189382008Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR.26
196671182009Sushi repeat protein X-linked 2, a novel mediator of angiogenesis.17
249956712014Analysis of ELP4, SRPX2, and interacting genes in typical and atypical rolandic epilepsy.17
222421482012SRPX2 is a novel chondroitin sulfate proteoglycan that is overexpressed in gastrointestinal cancer.12
202366272010Characterization of SVEP1, KIAA, and SRPX2 in an in vitro cell culture model of endotoxemia.11

Citation

Dessen P

SRPX2 (sushi repeat containing protein X-linked 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-02-01

Online version: http://atlasgeneticsoncology.org/gene/50677/srpx2