SRRT (serrate, RNA effector molecule)

2013-05-01  

Identity

HGNC
SRRT
LOCATION
7q22.1
LOCUSID
51593
ALIAS
ARS2,ASR2,serrate
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51593
MIM: 614469
HGNC: 24101
Ensembl: ENSG00000087087

Variants:

dbSNP: 51593
ClinVar: 51593
TCGA: ENSG00000087087
COSMIC: SRRT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000087087ENST00000423692H7C0U8
ENSG00000087087ENST00000431645C9JUL9
ENSG00000087087ENST00000445337A0A0A0MSP6
ENSG00000087087ENST00000448764H7C3A1
ENSG00000087087ENST00000449389H7C1K0
ENSG00000087087ENST00000611405Q9BXP5
ENSG00000087087ENST00000614370A0A087X0F4
ENSG00000087087ENST00000614484Q9BXP5
ENSG00000087087ENST00000618262Q9BXP5
ENSG00000087087ENST00000618411Q9BXP5
ENSG00000087087ENST00000641476A0A286YEP7

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
RNA polymerase II transcribes snRNA genesREACTOMER-HSA-6807505

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
196321822009Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation.80
222443332012Ars2 promotes proper replication-dependent histone mRNA 3' end formation.37
195462342009Interaction of FLASH with arsenite resistance protein 2 is involved in cell cycle progression at S phase.34
180868802008ARS2 is a conserved eukaryotic gene essential for early mammalian development.26
222131452013Ars2 is overexpressed in human cholangiocarcinomas and its depletion increases PTEN and PDCD4 by decreasing microRNA-21.22
289734462017ARS2 is a general suppressor of pervasive transcription.18
176729182007Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.17
100694701999Expression cloning for arsenite-resistance resulted in isolation of tumor-suppressor fau cDNA: possible involvement of the ubiquitin system in arsenic carcinogenesis.15
2640476220162,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-κB, AP-1 and MAPK pathways in human proximal tubular cells.12
297039532018Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting.12

Citation

Dessen P

SRRT (serrate, RNA effector molecule)

Atlas Genet Cytogenet Oncol Haematol. 2013-05-01

Online version: http://atlasgeneticsoncology.org/gene/53328/srrt