Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SRSF2 (serine/arginine-rich splicing factor 2)

Identity

Alias_namesSFRS2
splicing factor, arginine/serine-rich 2
serine/arginine-rich splicing factor 2
Alias_symbol (synonym)SC-35
SC35
PR264
SFRS2A
Other aliasSRp30b
HGNC (Hugo) SRSF2
LocusID (NCBI) 6427
Atlas_Id 52737
Location 17q25.1  [Link to chromosome band 17q25]
Location_base_pair Starts at 74730197 and ends at 74733493 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
GPN3 (12q24.11) / SRSF2 (17q25.1)SRSF2 (17q25.1) / SRSF2 (17q25.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  Classification of myelodysplastic syndromes 2015


External links

Nomenclature
HGNC (Hugo)SRSF2   10783
LRG (Locus Reference Genomic)LRG_640
Cards
Entrez_Gene (NCBI)SRSF2  6427  serine/arginine-rich splicing factor 2
AliasesPR264; SC-35; SC35; SFRS2; 
SFRS2A; SRp30b
GeneCards (Weizmann)SRSF2
Ensembl hg19 (Hinxton)ENSG00000161547 [Gene_View]  chr17:74730197-74733493 [Contig_View]  SRSF2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000161547 [Gene_View]  chr17:74730197-74733493 [Contig_View]  SRSF2 [Vega]
ICGC DataPortalENSG00000161547
TCGA cBioPortalSRSF2
AceView (NCBI)SRSF2
Genatlas (Paris)SRSF2
WikiGenes6427
SOURCE (Princeton)SRSF2
Genetics Home Reference (NIH)SRSF2
Genomic and cartography
GoldenPath hg19 (UCSC)SRSF2  -     chr17:74730197-74733493 -  17q25.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SRSF2  -     17q25.1   [Description]    (hg38-Dec_2013)
EnsemblSRSF2 - 17q25.1 [CytoView hg19]  SRSF2 - 17q25.1 [CytoView hg38]
Mapping of homologs : NCBISRSF2 [Mapview hg19]  SRSF2 [Mapview hg38]
OMIM600813   
Gene and transcription
Genbank (Entrez)AK092489 AK093626 AK097069 AK098209 AK123712
RefSeq transcript (Entrez)NM_001195427 NM_003016
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_032905 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)SRSF2
Cluster EST : UnigeneHs.584801 [ NCBI ]
CGAP (NCI)Hs.584801
Alternative Splicing GalleryENSG00000161547
Gene ExpressionSRSF2 [ NCBI-GEO ]   SRSF2 [ EBI - ARRAY_EXPRESS ]   SRSF2 [ SEEK ]   SRSF2 [ MEM ]
Gene Expression Viewer (FireBrowse)SRSF2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6427
GTEX Portal (Tissue expression)SRSF2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ01130   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ01130  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ01130
Splice isoforms : SwissVarQ01130
PhosPhoSitePlusQ01130
Domaine pattern : Prosite (Expaxy)RRM (PS50102)   
Domains : Interpro (EBI)Nucleotide-bd_a/b_plait    RRM_dom   
Domain families : Pfam (Sanger)RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam00076   
Domain families : Smart (EMBL)RRM (SM00360)  
Conserved Domain (NCBI)SRSF2
DMDM Disease mutations6427
Blocks (Seattle)SRSF2
PDB (SRS)2KN4    2LEA    2LEB    2LEC   
PDB (PDBSum)2KN4    2LEA    2LEB    2LEC   
PDB (IMB)2KN4    2LEA    2LEB    2LEC   
PDB (RSDB)2KN4    2LEA    2LEB    2LEC   
Structural Biology KnowledgeBase2KN4    2LEA    2LEB    2LEC   
SCOP (Structural Classification of Proteins)2KN4    2LEA    2LEB    2LEC   
CATH (Classification of proteins structures)2KN4    2LEA    2LEB    2LEC   
SuperfamilyQ01130
Human Protein AtlasENSG00000161547
Peptide AtlasQ01130
HPRD02888
IPIIPI00005978   IPI00746575   IPI01011463   IPI00902967   IPI00385786   IPI01009595   
Protein Interaction databases
DIP (DOE-UCLA)Q01130
IntAct (EBI)Q01130
FunCoupENSG00000161547
BioGRIDSRSF2
STRING (EMBL)SRSF2
ZODIACSRSF2
Ontologies - Pathways
QuickGOQ01130
Ontology : AmiGOnucleotide binding  regulation of alternative mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  transcription corepressor activity  protein binding  nucleus  nucleoplasm  spliceosomal complex  termination of RNA polymerase II transcription  mRNA processing  RNA export from nucleus  mRNA export from nucleus  RNA splicing  PML body  nuclear speck  mRNA 3'-end processing  pre-mRNA binding  poly(A) RNA binding  extracellular exosome  negative regulation of nucleic acid-templated transcription  
Ontology : EGO-EBInucleotide binding  regulation of alternative mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  transcription corepressor activity  protein binding  nucleus  nucleoplasm  spliceosomal complex  termination of RNA polymerase II transcription  mRNA processing  RNA export from nucleus  mRNA export from nucleus  RNA splicing  PML body  nuclear speck  mRNA 3'-end processing  pre-mRNA binding  poly(A) RNA binding  extracellular exosome  negative regulation of nucleic acid-templated transcription  
Pathways : BIOCARTASpliceosomal Assembly [Genes]   
Pathways : KEGGSpliceosome    Herpes simplex infection   
NDEx NetworkSRSF2
Atlas of Cancer Signalling NetworkSRSF2
Wikipedia pathwaysSRSF2
Orthology - Evolution
OrthoDB6427
GeneTree (enSembl)ENSG00000161547
Phylogenetic Trees/Animal Genes : TreeFamSRSF2
HOVERGENQ01130
HOGENOMQ01130
Homologs : HomoloGeneSRSF2
Homology/Alignments : Family Browser (UCSC)SRSF2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSRSF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SRSF2
dbVarSRSF2
ClinVarSRSF2
1000_GenomesSRSF2 
Exome Variant ServerSRSF2
ExAC (Exome Aggregation Consortium)SRSF2 (select the gene name)
Genetic variants : HAPMAP6427
Genomic Variants (DGV)SRSF2 [DGVbeta]
DECIPHER (Syndromes)17:74730197-74733493  ENSG00000161547
CONAN: Copy Number AnalysisSRSF2 
Mutations
ICGC Data PortalSRSF2 
TCGA Data PortalSRSF2 
Broad Tumor PortalSRSF2
OASIS PortalSRSF2 [ Somatic mutations - Copy number]
Cancer Gene: CensusSRSF2 
Somatic Mutations in Cancer : COSMICSRSF2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSRSF2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SRSF2
DgiDB (Drug Gene Interaction Database)SRSF2
DoCM (Curated mutations)SRSF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SRSF2 (select a term)
intoGenSRSF2
Cancer3DSRSF2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600813   
Orphanet
MedgenSRSF2
Genetic Testing Registry SRSF2
NextProtQ01130 [Medical]
TSGene6427
GENETestsSRSF2
Huge Navigator SRSF2 [HugePedia]
snp3D : Map Gene to Disease6427
BioCentury BCIQSRSF2
ClinGenSRSF2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6427
Chemical/Pharm GKB GenePA35699
Clinical trialSRSF2
Miscellaneous
canSAR (ICR)SRSF2 (select the gene name)
Probes
Litterature
PubMed162 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSRSF2
EVEXSRSF2
GoPubMedSRSF2
iHOPSRSF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Mar 14 13:29:12 CET 2017

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