Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SRSF4 (serine and arginine rich splicing factor 4)

Identity

Alias_namesSFRS4
splicing factor, arginine/serine-rich 4
serine/arginine-rich splicing factor 4
Alias_symbol (synonym)SRP75
Other alias
HGNC (Hugo) SRSF4
LocusID (NCBI) 6429
Atlas_Id 54670
Location 1p35.3  [Link to chromosome band 1p35]
Location_base_pair Starts at 29147738 and ends at 29182125 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EED (11q14.2) / SRSF4 (1p35.3)LOC100499466 () / SRSF4 (1p35.3)PALLD (4q32.3) / SRSF4 (1p35.3)
RACK1 (5q35.3) / SRSF4 (1p35.3)SRSF4 (1p35.3) / AES (19p13.3)SRSF4 (1p35.3) / SNRNP40 (1p35.2)
TUBB2A (6p25.2) / SRSF4 (1p35.3)USP5 (12p13.31) / SRSF4 (1p35.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]

Solid Tumors TranslocLungAdenocarcID6751 TT_t0101p35p35ID6756


External links

Nomenclature
HGNC (Hugo)SRSF4   10786
Cards
Entrez_Gene (NCBI)SRSF4  6429  serine and arginine rich splicing factor 4
AliasesSFRS4; SRP75
GeneCards (Weizmann)SRSF4
Ensembl hg19 (Hinxton)ENSG00000116350 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000116350 [Gene_View]  ENSG00000116350 [Sequence]  chr1:29147738-29182125 [Contig_View]  SRSF4 [Vega]
ICGC DataPortalENSG00000116350
TCGA cBioPortalSRSF4
AceView (NCBI)SRSF4
Genatlas (Paris)SRSF4
WikiGenes6429
SOURCE (Princeton)SRSF4
Genetics Home Reference (NIH)SRSF4
Genomic and cartography
GoldenPath hg38 (UCSC)SRSF4  -     chr1:29147738-29182125 -  1p35.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SRSF4  -     1p35.3   [Description]    (hg19-Feb_2009)
GoldenPathSRSF4 - 1p35.3 [CytoView hg19]  SRSF4 - 1p35.3 [CytoView hg38]
ImmunoBaseENSG00000116350
Mapping of homologs : NCBISRSF4 [Mapview hg19]  SRSF4 [Mapview hg38]
OMIM601940   
Gene and transcription
Genbank (Entrez)AB209856 AK223444 AK291509 AK293706 AK310528
RefSeq transcript (Entrez)NM_005626
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SRSF4
Cluster EST : UnigeneHs.469970 [ NCBI ]
CGAP (NCI)Hs.469970
Alternative Splicing GalleryENSG00000116350
Gene ExpressionSRSF4 [ NCBI-GEO ]   SRSF4 [ EBI - ARRAY_EXPRESS ]   SRSF4 [ SEEK ]   SRSF4 [ MEM ]
Gene Expression Viewer (FireBrowse)SRSF4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6429
GTEX Portal (Tissue expression)SRSF4
Human Protein AtlasENSG00000116350-SRSF4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ08170   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ08170  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ08170
Splice isoforms : SwissVarQ08170
PhosPhoSitePlusQ08170
Domaine pattern : Prosite (Expaxy)RRM (PS50102)   
Domains : Interpro (EBI)Nucleotide-bd_a/b_plait_sf    RBD_domain_sf    RRM1_SRSF4-like    RRM_dom   
Domain families : Pfam (Sanger)RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam00076   
Domain families : Smart (EMBL)RRM (SM00360)  
Conserved Domain (NCBI)SRSF4
DMDM Disease mutations6429
Blocks (Seattle)SRSF4
SuperfamilyQ08170
Human Protein Atlas [tissue]ENSG00000116350-SRSF4 [tissue]
Peptide AtlasQ08170
HPRD09052
IPIIPI00000015   IPI00908618   IPI01015447   IPI00979480   
Protein Interaction databases
DIP (DOE-UCLA)Q08170
IntAct (EBI)Q08170
FunCoupENSG00000116350
BioGRIDSRSF4
STRING (EMBL)SRSF4
ZODIACSRSF4
Ontologies - Pathways
QuickGOQ08170
Ontology : AmiGORNA splicing, via transesterification reactions  regulation of alternative mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  RNA binding  RNA binding  protein binding  nucleus  nucleoplasm  mRNA processing  RNA export from nucleus  mRNA export from nucleus  RNA splicing  nuclear speck  nuclear speck  mRNA 3'-end processing  response to insulin  mRNA cis splicing, via spliceosome  negative regulation of mRNA splicing, via spliceosome  sequence-specific mRNA binding  
Ontology : EGO-EBIRNA splicing, via transesterification reactions  regulation of alternative mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  RNA binding  RNA binding  protein binding  nucleus  nucleoplasm  mRNA processing  RNA export from nucleus  mRNA export from nucleus  RNA splicing  nuclear speck  nuclear speck  mRNA 3'-end processing  response to insulin  mRNA cis splicing, via spliceosome  negative regulation of mRNA splicing, via spliceosome  sequence-specific mRNA binding  
Pathways : KEGGSpliceosome    Herpes simplex infection   
NDEx NetworkSRSF4
Atlas of Cancer Signalling NetworkSRSF4
Wikipedia pathwaysSRSF4
Orthology - Evolution
OrthoDB6429
GeneTree (enSembl)ENSG00000116350
Phylogenetic Trees/Animal Genes : TreeFamSRSF4
HOGENOMQ08170
Homologs : HomoloGeneSRSF4
Homology/Alignments : Family Browser (UCSC)SRSF4
Gene fusions - Rearrangements
Fusion : MitelmanSRSF4/SNRNP40 [1p35.3/1p35.2]  
Fusion : QuiverSRSF4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSRSF4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SRSF4
dbVarSRSF4
ClinVarSRSF4
1000_GenomesSRSF4 
Exome Variant ServerSRSF4
ExAC (Exome Aggregation Consortium)ENSG00000116350
GNOMAD BrowserENSG00000116350
Varsome BrowserSRSF4
Genetic variants : HAPMAP6429
Genomic Variants (DGV)SRSF4 [DGVbeta]
DECIPHERSRSF4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSRSF4 
Mutations
ICGC Data PortalSRSF4 
TCGA Data PortalSRSF4 
Broad Tumor PortalSRSF4
OASIS PortalSRSF4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSRSF4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSRSF4
Mutations and Diseases : HGMDSRSF4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SRSF4
DgiDB (Drug Gene Interaction Database)SRSF4
DoCM (Curated mutations)SRSF4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SRSF4 (select a term)
intoGenSRSF4
Cancer3DSRSF4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601940   
Orphanet
DisGeNETSRSF4
MedgenSRSF4
Genetic Testing Registry SRSF4
NextProtQ08170 [Medical]
TSGene6429
GENETestsSRSF4
Target ValidationSRSF4
Huge Navigator SRSF4 [HugePedia]
snp3D : Map Gene to Disease6429
BioCentury BCIQSRSF4
ClinGenSRSF4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6429
Chemical/Pharm GKB GenePA35702
Clinical trialSRSF4
Miscellaneous
canSAR (ICR)SRSF4 (select the gene name)
DataMed IndexSRSF4
Probes
Litterature
PubMed76 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSRSF4
EVEXSRSF4
GoPubMedSRSF4
iHOPSRSF4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Aug 26 18:30:34 CEST 2019

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