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SRSF5 (serine and arginine rich splicing factor 5)

Identity

Alias_namesSFRS5
splicing factor, arginine/serine-rich 5
serine/arginine-rich splicing factor 5
Alias_symbol (synonym)SRP40
HRS
Other alias
HGNC (Hugo) SRSF5
LocusID (NCBI) 6430
Atlas_Id 74251
Location 14q24.1  [Link to chromosome band 14q24]
Location_base_pair Starts at 69767112 and ends at 69772005 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DUSP4 (8p12) / SRSF5 (14q24.2)HIST1H2BG (6p22.2) / SRSF5 (14q24.2)MRPL51 (12p13.31) / SRSF5 (14q24.2)
PPIG (2q31.1) / SRSF5 (14q24.2)SRSF5 (14q24.2) / HNRNPA2B1 (7p15.2)SRSF5 (14q24.2) / NKAIN2 (6q22.31)
SRSF5 (14q24.2) / SLITRK2 (Xq27.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SRSF5   10787
Cards
Entrez_Gene (NCBI)SRSF5  6430  serine and arginine rich splicing factor 5
AliasesHRS; SFRS5; SRP40
GeneCards (Weizmann)SRSF5
Ensembl hg19 (Hinxton)ENSG00000100650 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100650 [Gene_View]  chr14:69767112-69772005 [Contig_View]  SRSF5 [Vega]
ICGC DataPortalENSG00000100650
TCGA cBioPortalSRSF5
AceView (NCBI)SRSF5
Genatlas (Paris)SRSF5
WikiGenes6430
SOURCE (Princeton)SRSF5
Genetics Home Reference (NIH)SRSF5
Genomic and cartography
GoldenPath hg38 (UCSC)SRSF5  -     chr14:69767112-69772005 +  14q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SRSF5  -     14q24.1   [Description]    (hg19-Feb_2009)
EnsemblSRSF5 - 14q24.1 [CytoView hg19]  SRSF5 - 14q24.1 [CytoView hg38]
Mapping of homologs : NCBISRSF5 [Mapview hg19]  SRSF5 [Mapview hg38]
OMIM600914   
Gene and transcription
Genbank (Entrez)AA640719 AB209804 AB451250 AB451374 AF070562
RefSeq transcript (Entrez)NM_001039465 NM_001320214 NM_006925
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SRSF5
Cluster EST : UnigeneHs.632326 [ NCBI ]
CGAP (NCI)Hs.632326
Alternative Splicing GalleryENSG00000100650
Gene ExpressionSRSF5 [ NCBI-GEO ]   SRSF5 [ EBI - ARRAY_EXPRESS ]   SRSF5 [ SEEK ]   SRSF5 [ MEM ]
Gene Expression Viewer (FireBrowse)SRSF5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6430
GTEX Portal (Tissue expression)SRSF5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13243   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13243  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13243
Splice isoforms : SwissVarQ13243
PhosPhoSitePlusQ13243
Domaine pattern : Prosite (Expaxy)RRM (PS50102)   
Domains : Interpro (EBI)Nucleotide-bd_a/b_plait    RRM_dom   
Domain families : Pfam (Sanger)RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam00076   
Domain families : Smart (EMBL)RRM (SM00360)  
Conserved Domain (NCBI)SRSF5
DMDM Disease mutations6430
Blocks (Seattle)SRSF5
SuperfamilyQ13243
Human Protein AtlasENSG00000100650
Peptide AtlasQ13243
IPIIPI00012341   IPI00221286   IPI00413654   IPI00915825   IPI01009006   IPI01025047   
Protein Interaction databases
DIP (DOE-UCLA)Q13243
IntAct (EBI)Q13243
FunCoupENSG00000100650
BioGRIDSRSF5
STRING (EMBL)SRSF5
ZODIACSRSF5
Ontologies - Pathways
QuickGOQ13243
Ontology : AmiGOmRNA splicing, via spliceosome  RNA binding  protein binding  nucleus  nucleoplasm  nucleolus  cytosol  termination of RNA polymerase II transcription  mRNA splice site selection  mRNA processing  RNA export from nucleus  mRNA export from nucleus  response to wounding  nuclear speck  mRNA 3'-end processing  cellular response to insulin stimulus  positive regulation of RNA splicing  protein kinase B binding  RS domain binding  regulation of cell cycle  liver regeneration  
Ontology : EGO-EBImRNA splicing, via spliceosome  RNA binding  protein binding  nucleus  nucleoplasm  nucleolus  cytosol  termination of RNA polymerase II transcription  mRNA splice site selection  mRNA processing  RNA export from nucleus  mRNA export from nucleus  response to wounding  nuclear speck  mRNA 3'-end processing  cellular response to insulin stimulus  positive regulation of RNA splicing  protein kinase B binding  RS domain binding  regulation of cell cycle  liver regeneration  
Pathways : KEGGSpliceosome    Herpes simplex infection   
NDEx NetworkSRSF5
Atlas of Cancer Signalling NetworkSRSF5
Wikipedia pathwaysSRSF5
Orthology - Evolution
OrthoDB6430
GeneTree (enSembl)ENSG00000100650
Phylogenetic Trees/Animal Genes : TreeFamSRSF5
HOVERGENQ13243
HOGENOMQ13243
Homologs : HomoloGeneSRSF5
Homology/Alignments : Family Browser (UCSC)SRSF5
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSRSF5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SRSF5
dbVarSRSF5
ClinVarSRSF5
1000_GenomesSRSF5 
Exome Variant ServerSRSF5
ExAC (Exome Aggregation Consortium)SRSF5 (select the gene name)
Genetic variants : HAPMAP6430
Genomic Variants (DGV)SRSF5 [DGVbeta]
DECIPHERSRSF5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSRSF5 
Mutations
ICGC Data PortalSRSF5 
TCGA Data PortalSRSF5 
Broad Tumor PortalSRSF5
OASIS PortalSRSF5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSRSF5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSRSF5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SRSF5
DgiDB (Drug Gene Interaction Database)SRSF5
DoCM (Curated mutations)SRSF5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SRSF5 (select a term)
intoGenSRSF5
Cancer3DSRSF5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600914   
Orphanet
MedgenSRSF5
Genetic Testing Registry SRSF5
NextProtQ13243 [Medical]
TSGene6430
GENETestsSRSF5
Target ValidationSRSF5
Huge Navigator SRSF5 [HugePedia]
snp3D : Map Gene to Disease6430
BioCentury BCIQSRSF5
ClinGenSRSF5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6430
Chemical/Pharm GKB GenePA35703
Clinical trialSRSF5
Miscellaneous
canSAR (ICR)SRSF5 (select the gene name)
Probes
Litterature
PubMed71 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSRSF5
EVEXSRSF5
GoPubMedSRSF5
iHOPSRSF5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:44:12 CEST 2017

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