Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SRSF6 (serine and arginine rich splicing factor 6)

Identity

Alias_namesSFRS6
splicing factor, arginine/serine-rich 6
serine/arginine-rich splicing factor 6
Alias_symbol (synonym)SRP55
B52
Other aliasHEL-S-91
HGNC (Hugo) SRSF6
LocusID (NCBI) 6431
Atlas_Id 51664
Location 20q13.11  [Link to chromosome band 20q13]
Location_base_pair Starts at 43457864 and ends at 43463604 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
JAZF1 (7p15.2) / SRSF6 (20q13.11)SRSF6 (20q13.11) / HMBOX1 (8p21.1)SRSF6 (20q13.11) / SRSF6 (20q13.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SRSF6   10788
Cards
Entrez_Gene (NCBI)SRSF6  6431  serine and arginine rich splicing factor 6
AliasesB52; HEL-S-91; SFRS6; SRP55
GeneCards (Weizmann)SRSF6
Ensembl hg19 (Hinxton)ENSG00000124193 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000124193 [Gene_View]  chr20:43457864-43463604 [Contig_View]  SRSF6 [Vega]
ICGC DataPortalENSG00000124193
TCGA cBioPortalSRSF6
AceView (NCBI)SRSF6
Genatlas (Paris)SRSF6
WikiGenes6431
SOURCE (Princeton)SRSF6
Genetics Home Reference (NIH)SRSF6
Genomic and cartography
GoldenPath hg38 (UCSC)SRSF6  -     chr20:43457864-43463604 +  20q13.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SRSF6  -     20q13.11   [Description]    (hg19-Feb_2009)
EnsemblSRSF6 - 20q13.11 [CytoView hg19]  SRSF6 - 20q13.11 [CytoView hg38]
Mapping of homologs : NCBISRSF6 [Mapview hg19]  SRSF6 [Mapview hg38]
OMIM601944   
Gene and transcription
Genbank (Entrez)AB208976 AB451251 AB451375 AK123171 AK291203
RefSeq transcript (Entrez)NM_006275
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SRSF6
Cluster EST : UnigeneHs.725336 [ NCBI ]
CGAP (NCI)Hs.725336
Alternative Splicing GalleryENSG00000124193
Gene ExpressionSRSF6 [ NCBI-GEO ]   SRSF6 [ EBI - ARRAY_EXPRESS ]   SRSF6 [ SEEK ]   SRSF6 [ MEM ]
Gene Expression Viewer (FireBrowse)SRSF6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6431
GTEX Portal (Tissue expression)SRSF6
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13247   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13247  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13247
Splice isoforms : SwissVarQ13247
PhosPhoSitePlusQ13247
Domaine pattern : Prosite (Expaxy)RRM (PS50102)   
Domains : Interpro (EBI)Nucleotide-bd_a/b_plait    RRM_dom   
Domain families : Pfam (Sanger)RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam00076   
Domain families : Smart (EMBL)RRM (SM00360)  
Conserved Domain (NCBI)SRSF6
DMDM Disease mutations6431
Blocks (Seattle)SRSF6
SuperfamilyQ13247
Human Protein AtlasENSG00000124193
Peptide AtlasQ13247
HPRD09054
IPIIPI00012345   IPI00018203   IPI00215879   IPI00556297   
Protein Interaction databases
DIP (DOE-UCLA)Q13247
IntAct (EBI)Q13247
FunCoupENSG00000124193
BioGRIDSRSF6
STRING (EMBL)SRSF6
ZODIACSRSF6
Ontologies - Pathways
QuickGOQ13247
Ontology : AmiGOalternative mRNA splicing, via spliceosome  regulation of alternative mRNA splicing, via spliceosome  regulation of alternative mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  RNA binding  protein binding  nucleoplasm  termination of RNA polymerase II transcription  mRNA splice site selection  RNA export from nucleus  mRNA export from nucleus  regulation of keratinocyte proliferation  nuclear speck  mRNA 3'-end processing  response to insulin  pre-mRNA binding  negative regulation of keratinocyte differentiation  negative regulation of mRNA splicing, via spliceosome  positive regulation of epithelial cell proliferation involved in lung morphogenesis  negative regulation of cell death  regulation of wound healing  negative regulation of type B pancreatic cell apoptotic process  
Ontology : EGO-EBIalternative mRNA splicing, via spliceosome  regulation of alternative mRNA splicing, via spliceosome  regulation of alternative mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  RNA binding  protein binding  nucleoplasm  termination of RNA polymerase II transcription  mRNA splice site selection  RNA export from nucleus  mRNA export from nucleus  regulation of keratinocyte proliferation  nuclear speck  mRNA 3'-end processing  response to insulin  pre-mRNA binding  negative regulation of keratinocyte differentiation  negative regulation of mRNA splicing, via spliceosome  positive regulation of epithelial cell proliferation involved in lung morphogenesis  negative regulation of cell death  regulation of wound healing  negative regulation of type B pancreatic cell apoptotic process  
Pathways : KEGGSpliceosome    Herpes simplex infection   
NDEx NetworkSRSF6
Atlas of Cancer Signalling NetworkSRSF6
Wikipedia pathwaysSRSF6
Orthology - Evolution
OrthoDB6431
GeneTree (enSembl)ENSG00000124193
Phylogenetic Trees/Animal Genes : TreeFamSRSF6
HOVERGENQ13247
HOGENOMQ13247
Homologs : HomoloGeneSRSF6
Homology/Alignments : Family Browser (UCSC)SRSF6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSRSF6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SRSF6
dbVarSRSF6
ClinVarSRSF6
1000_GenomesSRSF6 
Exome Variant ServerSRSF6
ExAC (Exome Aggregation Consortium)SRSF6 (select the gene name)
Genetic variants : HAPMAP6431
Genomic Variants (DGV)SRSF6 [DGVbeta]
DECIPHERSRSF6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSRSF6 
Mutations
ICGC Data PortalSRSF6 
TCGA Data PortalSRSF6 
Broad Tumor PortalSRSF6
OASIS PortalSRSF6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSRSF6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSRSF6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SRSF6
DgiDB (Drug Gene Interaction Database)SRSF6
DoCM (Curated mutations)SRSF6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SRSF6 (select a term)
intoGenSRSF6
Cancer3DSRSF6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601944   
Orphanet
MedgenSRSF6
Genetic Testing Registry SRSF6
NextProtQ13247 [Medical]
TSGene6431
GENETestsSRSF6
Target ValidationSRSF6
Huge Navigator SRSF6 [HugePedia]
snp3D : Map Gene to Disease6431
BioCentury BCIQSRSF6
ClinGenSRSF6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6431
Chemical/Pharm GKB GenePA35704
Clinical trialSRSF6
Miscellaneous
canSAR (ICR)SRSF6 (select the gene name)
Probes
Litterature
PubMed86 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSRSF6
EVEXSRSF6
GoPubMedSRSF6
iHOPSRSF6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:57:28 CEST 2017

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