SRSF6 (serine and arginine rich splicing factor 6)

2010-09-01  

Identity

HGNC
LOCATION
20q13.11
LOCUSID
ALIAS
B52,HEL-S-91,SFRS6,SRP55
FUSION GENES

Other Information

Locus ID:

NCBI: 6431
MIM: 601944
HGNC: 10788
Ensembl: ENSG00000124193

Variants:

dbSNP: 6431
ClinVar: 6431
TCGA: ENSG00000124193
COSMIC: SRSF6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124193ENST00000244020Q13247
ENSG00000124193ENST00000483871Q13247
ENSG00000124193ENST00000662078A0A590UK01
ENSG00000124193ENST00000668808A0A590UJP7
ENSG00000124193ENST00000670741A0A590UJK4

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Transcription TerminationREACTOMER-HSA-73856
Cleavage of Growing Transcript in the Termination RegionREACTOMER-HSA-109688
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
mRNA Splicing - Minor PathwayREACTOMER-HSA-72165
mRNA 3'-end processingREACTOMER-HSA-72187
Transport of Mature Transcript to CytoplasmREACTOMER-HSA-72202
Transport of Mature mRNA derived from an Intron-Containing TranscriptREACTOMER-HSA-159236

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
191655272009Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.56
274436062016Long non-coding RNA LINC01133 inhibits epithelial-mesenchymal transition and metastasis in colorectal cancer by interacting with SRSF6.52
231327312013The splicing factor SRSF6 is amplified and is an oncoprotein in lung and colon cancers.44
244409822014Splicing factor SRSF6 promotes hyperplasia of sensitized skin.38
204275422010SRp40 and SRp55 promote the translation of unspliced human immunodeficiency virus type 1 RNA.31
227676022012Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted Tau exon 10 inclusion.24
291140702019SRSF6-regulated alternative splicing that promotes tumour progression offers a therapy target for colorectal cancer.21
125314732003Human transformer 2beta and SRp55 interact with a calcitonin-specific splice enhancer.15
125499142003SRp55 is a regulator of calcitonin/CGRP alternative RNA splicing.14

Citation

Dessen P

SRSF6 (serine and arginine rich splicing factor 6)

Atlas Genet Cytogenet Oncol Haematol. 2010-09-01

Online version: http://atlasgeneticsoncology.org/gene/51664/srsf6