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X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

SRY (sex determining region Y)

Identity

Alias_symbol (synonym)TDF
Other aliasSRXX1
SRXY1
TDY
HGNC (Hugo) SRY
LocusID (NCBI) 6736
Atlas_Id 42392
Location Yp11.2  [Link to chromosome band Yp11]
Location_base_pair Starts at 2786855 and ends at 2787741 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SRY   11311
Cards
Entrez_Gene (NCBI)SRY  6736  sex determining region Y
AliasesSRXX1; SRXY1; TDF; TDY
GeneCards (Weizmann)SRY
Ensembl hg19 (Hinxton)ENSG00000184895 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000184895 [Gene_View]  chrY:2786855-2787741 [Contig_View]  SRY [Vega]
ICGC DataPortalENSG00000184895
TCGA cBioPortalSRY
AceView (NCBI)SRY
Genatlas (Paris)SRY
WikiGenes6736
SOURCE (Princeton)SRY
Genetics Home Reference (NIH)SRY
Genomic and cartography
GoldenPath hg38 (UCSC)SRY  -     chrY:2786855-2787741 -  Yp11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SRY  -     Yp11.2   [Description]    (hg19-Feb_2009)
EnsemblSRY - Yp11.2 [CytoView hg19]  SRY - Yp11.2 [CytoView hg38]
Mapping of homologs : NCBISRY [Mapview hg19]  SRY [Mapview hg38]
OMIM400044   400045   480000   
Gene and transcription
Genbank (Entrez)BC074923 BC074924 EU446863 L10101 S53156
RefSeq transcript (Entrez)NM_003140
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SRY
Cluster EST : UnigeneHs.1992 [ NCBI ]
CGAP (NCI)Hs.1992
Alternative Splicing GalleryENSG00000184895
Gene ExpressionSRY [ NCBI-GEO ]   SRY [ EBI - ARRAY_EXPRESS ]   SRY [ SEEK ]   SRY [ MEM ]
Gene Expression Viewer (FireBrowse)SRY [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6736
GTEX Portal (Tissue expression)SRY
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ05066   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ05066  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ05066
Splice isoforms : SwissVarQ05066
PhosPhoSitePlusQ05066
Domaine pattern : Prosite (Expaxy)HMG_BOX_2 (PS50118)   
Domains : Interpro (EBI)HMG_box_dom    SRY   
Domain families : Pfam (Sanger)HMG_box (PF00505)   
Domain families : Pfam (NCBI)pfam00505   
Domain families : Smart (EMBL)HMG (SM00398)  
Conserved Domain (NCBI)SRY
DMDM Disease mutations6736
Blocks (Seattle)SRY
PDB (SRS)1HRY    1HRZ    1J46    1J47    2GZK   
PDB (PDBSum)1HRY    1HRZ    1J46    1J47    2GZK   
PDB (IMB)1HRY    1HRZ    1J46    1J47    2GZK   
PDB (RSDB)1HRY    1HRZ    1J46    1J47    2GZK   
Structural Biology KnowledgeBase1HRY    1HRZ    1J46    1J47    2GZK   
SCOP (Structural Classification of Proteins)1HRY    1HRZ    1J46    1J47    2GZK   
CATH (Classification of proteins structures)1HRY    1HRZ    1J46    1J47    2GZK   
SuperfamilyQ05066
Human Protein AtlasENSG00000184895
Peptide AtlasQ05066
HPRD08364
IPIIPI00011568   IPI00956692   IPI01013243   IPI01012788   IPI00385239   IPI00385240   
Protein Interaction databases
DIP (DOE-UCLA)Q05066
IntAct (EBI)Q05066
FunCoupENSG00000184895
BioGRIDSRY
STRING (EMBL)SRY
ZODIACSRY
Ontologies - Pathways
QuickGOQ05066
Ontology : AmiGODNA binding  transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding  calmodulin binding  nucleus  nucleus  nucleoplasm  cytoplasm  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  sex differentiation  transcription factor binding  nuclear speck  cell differentiation  male sex determination  positive regulation of transcription, DNA-templated  positive regulation of male gonad development  
Ontology : EGO-EBIDNA binding  transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding  calmodulin binding  nucleus  nucleus  nucleoplasm  cytoplasm  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  sex differentiation  transcription factor binding  nuclear speck  cell differentiation  male sex determination  positive regulation of transcription, DNA-templated  positive regulation of male gonad development  
NDEx NetworkSRY
Atlas of Cancer Signalling NetworkSRY
Wikipedia pathwaysSRY
Orthology - Evolution
OrthoDB6736
GeneTree (enSembl)ENSG00000184895
Phylogenetic Trees/Animal Genes : TreeFamSRY
HOVERGENQ05066
HOGENOMQ05066
Homologs : HomoloGeneSRY
Homology/Alignments : Family Browser (UCSC)SRY
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSRY [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SRY
dbVarSRY
ClinVarSRY
1000_GenomesSRY 
Exome Variant ServerSRY
ExAC (Exome Aggregation Consortium)SRY (select the gene name)
Genetic variants : HAPMAP6736
Genomic Variants (DGV)SRY [DGVbeta]
DECIPHERSRY [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSRY 
Mutations
ICGC Data PortalSRY 
TCGA Data PortalSRY 
Broad Tumor PortalSRY
OASIS PortalSRY [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSRY  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSRY
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SRY
DgiDB (Drug Gene Interaction Database)SRY
DoCM (Curated mutations)SRY (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SRY (select a term)
intoGenSRY
Cancer3DSRY(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM400044    400045    480000   
Orphanet1044    1780    2037    19642    5546   
MedgenSRY
Genetic Testing Registry SRY
NextProtQ05066 [Medical]
TSGene6736
GENETestsSRY
Target ValidationSRY
Huge Navigator SRY [HugePedia]
snp3D : Map Gene to Disease6736
BioCentury BCIQSRY
ClinGenSRY (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6736
Chemical/Pharm GKB GenePA36135
Clinical trialSRY
Miscellaneous
canSAR (ICR)SRY (select the gene name)
Probes
Litterature
PubMed167 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSRY
EVEXSRY
GoPubMedSRY
iHOPSRY
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:08:32 CEST 2017

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