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X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

SRY (sex determining region Y)

Identity

Alias (NCBI)SRXX1
SRXY1
TDF
TDY
HGNC (Hugo) SRY
HGNC Alias symbTDF
HGNC Alias nametestis-determining factor
LocusID (NCBI) 6736
Atlas_Id 42392
Location Yp11.2  [Link to chromosome band Yp11]
Location_base_pair Starts at 2786855 and ends at 2787682 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SRY   11311
Cards
Entrez_Gene (NCBI)SRY    sex determining region Y
AliasesSRXX1; SRXY1; TDF; TDY
GeneCards (Weizmann)SRY
Ensembl hg19 (Hinxton)ENSG00000184895 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000184895 [Gene_View]  ENSG00000184895 [Sequence]  chrY:2786855-2787682 [Contig_View]  SRY [Vega]
ICGC DataPortalENSG00000184895
TCGA cBioPortalSRY
AceView (NCBI)SRY
Genatlas (Paris)SRY
SOURCE (Princeton)SRY
Genetics Home Reference (NIH)SRY
Genomic and cartography
GoldenPath hg38 (UCSC)SRY  -     chrY:2786855-2787682 -  Yp11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SRY  -     Yp11.2   [Description]    (hg19-Feb_2009)
GoldenPathSRY - Yp11.2 [CytoView hg19]  SRY - Yp11.2 [CytoView hg38]
ImmunoBaseENSG00000184895
Genome Data Viewer NCBISRY [Mapview hg19]  
OMIM400044   400045   480000   
Gene and transcription
Genbank (Entrez)BC074923 BC074924 L10101 MH972533 MH972534
RefSeq transcript (Entrez)NM_003140
Consensus coding sequences : CCDS (NCBI)SRY
Gene ExpressionSRY [ NCBI-GEO ]   SRY [ EBI - ARRAY_EXPRESS ]   SRY [ SEEK ]   SRY [ MEM ]
Gene Expression Viewer (FireBrowse)SRY [ Firebrowse - Broad ]
GenevisibleExpression of SRY in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6736
GTEX Portal (Tissue expression)SRY
Human Protein AtlasENSG00000184895-SRY [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ05066   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ05066  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ05066
PhosPhoSitePlusQ05066
Domaine pattern : Prosite (Expaxy)HMG_BOX_2 (PS50118)   
Domains : Interpro (EBI)HMG_box_dom    HMG_box_dom_sf    SRY   
Domain families : Pfam (Sanger)HMG_box (PF00505)   
Domain families : Pfam (NCBI)pfam00505   
Domain families : Smart (EMBL)HMG (SM00398)  
Conserved Domain (NCBI)SRY
PDB (RSDB)1HRY    1HRZ    1J46    1J47    2GZK    6EDB   
PDB Europe1HRY    1HRZ    1J46    1J47    2GZK    6EDB   
PDB (PDBSum)1HRY    1HRZ    1J46    1J47    2GZK    6EDB   
PDB (IMB)1HRY    1HRZ    1J46    1J47    2GZK    6EDB   
Structural Biology KnowledgeBase1HRY    1HRZ    1J46    1J47    2GZK    6EDB   
SCOP (Structural Classification of Proteins)1HRY    1HRZ    1J46    1J47    2GZK    6EDB   
CATH (Classification of proteins structures)1HRY    1HRZ    1J46    1J47    2GZK    6EDB   
SuperfamilyQ05066
AlphaFold pdb e-kbQ05066   
Human Protein Atlas [tissue]ENSG00000184895-SRY [tissue]
HPRD08364
Protein Interaction databases
DIP (DOE-UCLA)Q05066
IntAct (EBI)Q05066
BioGRIDSRY
STRING (EMBL)SRY
ZODIACSRY
Ontologies - Pathways
QuickGOQ05066
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  chromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA binding  calmodulin binding  nucleus  nucleus  nucleoplasm  cytoplasm  regulation of transcription, DNA-templated  sex differentiation  transcription factor binding  anatomical structure morphogenesis  positive regulation of gene expression  nuclear speck  cell differentiation  male sex determination  male sex determination  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of male gonad development  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  chromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA binding  calmodulin binding  nucleus  nucleus  nucleoplasm  cytoplasm  regulation of transcription, DNA-templated  sex differentiation  transcription factor binding  anatomical structure morphogenesis  positive regulation of gene expression  nuclear speck  cell differentiation  male sex determination  male sex determination  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of male gonad development  
NDEx NetworkSRY
Atlas of Cancer Signalling NetworkSRY
Wikipedia pathwaysSRY
Orthology - Evolution
OrthoDB6736
GeneTree (enSembl)ENSG00000184895
Phylogenetic Trees/Animal Genes : TreeFamSRY
Homologs : HomoloGeneSRY
Homology/Alignments : Family Browser (UCSC)SRY
Gene fusions - Rearrangements
Fusion : QuiverSRY
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSRY [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SRY
dbVarSRY
ClinVarSRY
MonarchSRY
1000_GenomesSRY 
Exome Variant ServerSRY
GNOMAD BrowserENSG00000184895
Varsome BrowserSRY
ACMGSRY variants
VarityQ05066
Genomic Variants (DGV)SRY [DGVbeta]
DECIPHERSRY [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSRY 
Mutations
ICGC Data PortalSRY 
TCGA Data PortalSRY 
Broad Tumor PortalSRY
OASIS PortalSRY [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSRY  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSRY
Mutations and Diseases : HGMDSRY
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSRY
DgiDB (Drug Gene Interaction Database)SRY
DoCM (Curated mutations)SRY
CIViC (Clinical Interpretations of Variants in Cancer)SRY
Cancer3DSRY
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM400044    400045    480000   
Orphanet1044    1780    2037    19642    5546   
DisGeNETSRY
MedgenSRY
Genetic Testing Registry SRY
NextProtQ05066 [Medical]
GENETestsSRY
Target ValidationSRY
Huge Navigator SRY [HugePedia]
ClinGenSRY (curated)
Clinical trials, drugs, therapy
MyCancerGenomeSRY
Protein Interactions : CTDSRY
Pharm GKB GenePA36135
PharosQ05066
Clinical trialSRY
Miscellaneous
canSAR (ICR)SRY
HarmonizomeSRY
DataMed IndexSRY
Probes
Litterature
PubMed181 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSRY
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:33:12 CEST 2021

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