SSH1 (slingshot protein phosphatase 1)

2007-02-01  

Identity

HGNC
LOCATION
12q24.11
LOCUSID
ALIAS
SSH1L
FUSION GENES

Other Information

Locus ID:

NCBI: 54434
MIM: 606778
HGNC: 30579
Ensembl: ENSG00000084112

Variants:

dbSNP: 54434
ClinVar: 54434
TCGA: ENSG00000084112
COSMIC: SSH1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000084112ENST00000326470Q8WYL5
ENSG00000084112ENST00000326495Q8WYL5
ENSG00000084112ENST00000546433H0YHR3
ENSG00000084112ENST00000546697F8W1D9
ENSG00000084112ENST00000548522F8VS18
ENSG00000084112ENST00000551165Q8WYL5

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Regulation of actin cytoskeletonKEGGko04810
Axon guidanceKEGGhsa04360
Regulation of actin cytoskeletonKEGGhsa04810

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
156601332005Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin.94
156710202005Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin.80
151594162004A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia.75
193392772009Reactive oxygen species regulate a slingshot-cofilin activation pathway.75
195676722009Protein kinase D regulates cell migration by direct phosphorylation of the cofilin phosphatase slingshot 1 like.59
178485442007The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes.37
146452192004Phosphoinositide 3-kinase-mediated activation of cofilin phosphatase Slingshot and its role for insulin-induced membrane protrusion.36
128079042003Cell cycle-associated changes in Slingshot phosphatase activity and roles in cytokinesis in animal cells.34
180968212008Dual regulation of cofilin activity by LIM kinase and Slingshot-1L phosphatase controls platelet-derived growth factor-induced migration of human aortic smooth muscle cells.29
188096812008Molecular dissection of the mechanisms of substrate recognition and F-actin-mediated activation of cofilin-phosphatase Slingshot-1.25

Citation

Dessen P

SSH1 (slingshot protein phosphatase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43787/ssh1