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SSH2 (slingshot protein phosphatase 2)

Identity

Alias (NCBI)SSH-2
SSH-2L
HGNC (Hugo) SSH2
HGNC Alias symbKIAA1725
HGNC Previous nameslingshot homolog 2 (Drosophila)
LocusID (NCBI) 85464
Atlas_Id 53893
Location 17q11.2  [Link to chromosome band 17q11]
Location_base_pair Starts at 29625939 and ends at 29930040 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ABHD15 (17q11.2) / SSH2 (17q11.2)CBX1 (17q21.32) / SSH2 (17q11.2)DAB1 (1p32.2) / SSH2 (17q11.2)
KIAA1109 (4q27) / SSH2 (17q11.2)MED24 (17q21.1) / SSH2 (17q11.2)MYO1D (17q11.2) / SSH2 (17q11.2)
PPP6R3 (11q13.2) / SSH2 (17q11.2)SF3B3 (16q22.1) / SSH2 (17q11.2)SSH2 (17q11.2) / ALG11 (13q14.3)
SSH2 (17q11.2) / BPI (20q11.23)SSH2 (17q11.2) / EFCAB5 (17q11.2)SSH2 (17q11.2) / GOLGA7 (8p11.21)
SSH2 (17q11.2) / LCT (2q21.3)SSH2 (17q11.2) / SSH2 (17q11.2)SSH2 (17q11.2) / SUZ12 (17q11.2)
TANC2 (17q23.2) / SSH2 (17q11.2)SSH2 17q11.2 / SUZ12 17q11.2CBX1 17q21.32 / SSH2 17q11.2
MED24 17q21.1 / SSH2 17q11.2MYO1D 17q11.2 / SSH2 17q11.2PPP6R3 11q13.2 / SSH2 17q11.2
TANC2 17q23.2 / SSH2 17q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SSH2   30580
Cards
Entrez_Gene (NCBI)SSH2    slingshot protein phosphatase 2
AliasesSSH-2; SSH-2L
GeneCards (Weizmann)SSH2
Ensembl hg19 (Hinxton)ENSG00000141298 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000141298 [Gene_View]  ENSG00000141298 [Sequence]  chr17:29625939-29930040 [Contig_View]  SSH2 [Vega]
ICGC DataPortalENSG00000141298
TCGA cBioPortalSSH2
AceView (NCBI)SSH2
Genatlas (Paris)SSH2
SOURCE (Princeton)SSH2
Genetics Home Reference (NIH)SSH2
Genomic and cartography
GoldenPath hg38 (UCSC)SSH2  -     chr17:29625939-29930040 -  17q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SSH2  -     17q11.2   [Description]    (hg19-Feb_2009)
GoldenPathSSH2 - 17q11.2 [CytoView hg19]  SSH2 - 17q11.2 [CytoView hg38]
ImmunoBaseENSG00000141298
Genome Data Viewer NCBISSH2 [Mapview hg19]  
OMIM606779   
Gene and transcription
Genbank (Entrez)AB051512 AB072358 AB072359 AB099290 AF086010
RefSeq transcript (Entrez)NM_001282129 NM_001282130 NM_001282131 NM_033389
Consensus coding sequences : CCDS (NCBI)SSH2
Gene ExpressionSSH2 [ NCBI-GEO ]   SSH2 [ EBI - ARRAY_EXPRESS ]   SSH2 [ SEEK ]   SSH2 [ MEM ]
Gene Expression Viewer (FireBrowse)SSH2 [ Firebrowse - Broad ]
GenevisibleExpression of SSH2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)85464
GTEX Portal (Tissue expression)SSH2
Human Protein AtlasENSG00000141298-SSH2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ76I76   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ76I76  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ76I76
Catalytic activity : Enzyme3.1.3.16 [ Enzyme-Expasy ]   3.1.3.163.1.3.16 [ IntEnz-EBI ]   3.1.3.16 [ BRENDA ]   3.1.3.16 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ76I76
Domaine pattern : Prosite (Expaxy)TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_DUAL (PS50054)   
Domains : Interpro (EBI)DEK_C    Dual-sp_phosphatase_cat-dom    Phosphatase_SSH-like    Prot-tyrosine_phosphatase-like    SSH-N    Tyr_Pase_AS    TYR_PHOSPHATASE_dom    TYR_PHOSPHATASE_DUAL_dom   
Domain families : Pfam (Sanger)DEK_C (PF08766)    DSPc (PF00782)   
Domain families : Pfam (NCBI)pfam08766    pfam00782   
Domain families : Smart (EMBL)DSPc (SM00195)  
Conserved Domain (NCBI)SSH2
PDB (RSDB)2NT2   
PDB Europe2NT2   
PDB (PDBSum)2NT2   
PDB (IMB)2NT2   
Structural Biology KnowledgeBase2NT2   
SCOP (Structural Classification of Proteins)2NT2   
CATH (Classification of proteins structures)2NT2   
SuperfamilyQ76I76
AlphaFold pdb e-kbQ76I76   
Human Protein Atlas [tissue]ENSG00000141298-SSH2 [tissue]
HPRD09487
Protein Interaction databases
DIP (DOE-UCLA)Q76I76
IntAct (EBI)Q76I76
BioGRIDSSH2
STRING (EMBL)SSH2
ZODIACSSH2
Ontologies - Pathways
QuickGOQ76I76
Ontology : AmiGOactin binding  actin binding  phosphoprotein phosphatase activity  phosphoprotein phosphatase activity  protein tyrosine phosphatase activity  extracellular space  cytoplasm  cytoskeleton  protein dephosphorylation  protein tyrosine/serine/threonine phosphatase activity  actin cytoskeleton organization  actin cytoskeleton organization  negative regulation of actin filament polymerization  peptidyl-tyrosine dephosphorylation  protein serine phosphatase activity  protein threonine phosphatase activity  
Ontology : EGO-EBIactin binding  actin binding  phosphoprotein phosphatase activity  phosphoprotein phosphatase activity  protein tyrosine phosphatase activity  extracellular space  cytoplasm  cytoskeleton  protein dephosphorylation  protein tyrosine/serine/threonine phosphatase activity  actin cytoskeleton organization  actin cytoskeleton organization  negative regulation of actin filament polymerization  peptidyl-tyrosine dephosphorylation  protein serine phosphatase activity  protein threonine phosphatase activity  
Pathways : KEGGRegulation of actin cytoskeleton   
NDEx NetworkSSH2
Atlas of Cancer Signalling NetworkSSH2
Wikipedia pathwaysSSH2
Orthology - Evolution
OrthoDB85464
GeneTree (enSembl)ENSG00000141298
Phylogenetic Trees/Animal Genes : TreeFamSSH2
Homologs : HomoloGeneSSH2
Homology/Alignments : Family Browser (UCSC)SSH2
Gene fusions - Rearrangements
Fusion : MitelmanCBX1/SSH2 [17q21.32/17q11.2]  
Fusion : MitelmanMED24/SSH2 [17q21.1/17q11.2]  
Fusion : MitelmanMYO1D/SSH2 [17q11.2/17q11.2]  
Fusion : MitelmanPPP6R3/SSH2 [11q13.2/17q11.2]  
Fusion : MitelmanTANC2/SSH2 [17q23.2/17q11.2]  
Fusion : QuiverSSH2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSSH2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SSH2
dbVarSSH2
ClinVarSSH2
MonarchSSH2
1000_GenomesSSH2 
Exome Variant ServerSSH2
GNOMAD BrowserENSG00000141298
Varsome BrowserSSH2
ACMGSSH2 variants
VarityQ76I76
Genomic Variants (DGV)SSH2 [DGVbeta]
DECIPHERSSH2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSSH2 
Mutations
ICGC Data PortalSSH2 
TCGA Data PortalSSH2 
Broad Tumor PortalSSH2
OASIS PortalSSH2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSSH2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSSH2
Mutations and Diseases : HGMDSSH2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSSH2
DgiDB (Drug Gene Interaction Database)SSH2
DoCM (Curated mutations)SSH2
CIViC (Clinical Interpretations of Variants in Cancer)SSH2
Cancer3DSSH2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606779   
Orphanet
DisGeNETSSH2
MedgenSSH2
Genetic Testing Registry SSH2
NextProtQ76I76 [Medical]
GENETestsSSH2
Target ValidationSSH2
Huge Navigator SSH2 [HugePedia]
ClinGenSSH2
Clinical trials, drugs, therapy
MyCancerGenomeSSH2
Protein Interactions : CTDSSH2
Pharm GKB GenePA134861867
PharosQ76I76
Clinical trialSSH2
Miscellaneous
canSAR (ICR)SSH2
HarmonizomeSSH2
DataMed IndexSSH2
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSSH2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:33:14 CEST 2021

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