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SSH2 (slingshot protein phosphatase 2)

Identity

Alias_namesslingshot homolog 2 (Drosophila)
Alias_symbol (synonym)KIAA1725
Other aliasSSH-2
SSH-2L
HGNC (Hugo) SSH2
LocusID (NCBI) 85464
Atlas_Id 53893
Location 17q11.2  [Link to chromosome band 17q11]
Location_base_pair Starts at 27952957 and ends at 28257246 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ABHD15 (17q11.2) / SSH2 (17q11.2)CBX1 (17q21.32) / SSH2 (17q11.2)DAB1 (1p32.2) / SSH2 (17q11.2)
KIAA1109 (4q27) / SSH2 (17q11.2)MED24 (17q21.1) / SSH2 (17q11.2)MYO1D (17q11.2) / SSH2 (17q11.2)
PPP6R3 (11q13.2) / SSH2 (17q11.2)SF3B3 (16q22.1) / SSH2 (17q11.2)SSH2 (17q11.2) / ALG11 (13q14.3)
SSH2 (17q11.2) / BPI (20q11.23)SSH2 (17q11.2) / EFCAB5 (17q11.2)SSH2 (17q11.2) / GOLGA7 (8p11.21)
SSH2 (17q11.2) / LCT (2q21.3)SSH2 (17q11.2) / SSH2 (17q11.2)SSH2 (17q11.2) / SUZ12 (17q11.2)
TANC2 (17q23.2) / SSH2 (17q11.2)SSH2 17q11.2 / SUZ12 17q11.2CBX1 17q21.32 / SSH2 17q11.2
MED24 17q21.1 / SSH2 17q11.2MYO1D 17q11.2 / SSH2 17q11.2PPP6R3 11q13.2 / SSH2 17q11.2
TANC2 17q23.2 / SSH2 17q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SSH2   30580
Cards
Entrez_Gene (NCBI)SSH2  85464  slingshot protein phosphatase 2
AliasesSSH-2; SSH-2L
GeneCards (Weizmann)SSH2
Ensembl hg19 (Hinxton)ENSG00000141298 [Gene_View]  chr17:27952957-28257246 [Contig_View]  SSH2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000141298 [Gene_View]  chr17:27952957-28257246 [Contig_View]  SSH2 [Vega]
ICGC DataPortalENSG00000141298
TCGA cBioPortalSSH2
AceView (NCBI)SSH2
Genatlas (Paris)SSH2
WikiGenes85464
SOURCE (Princeton)SSH2
Genetics Home Reference (NIH)SSH2
Genomic and cartography
GoldenPath hg19 (UCSC)SSH2  -     chr17:27952957-28257246 -  17q11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SSH2  -     17q11.2   [Description]    (hg38-Dec_2013)
EnsemblSSH2 - 17q11.2 [CytoView hg19]  SSH2 - 17q11.2 [CytoView hg38]
Mapping of homologs : NCBISSH2 [Mapview hg19]  SSH2 [Mapview hg38]
OMIM606779   
Gene and transcription
Genbank (Entrez)AB051512 AB072358 AB072359 AB099290 AF484838
RefSeq transcript (Entrez)NM_001282129 NM_001282130 NM_001282131 NM_033389
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)SSH2
Cluster EST : UnigeneHs.654754 [ NCBI ]
CGAP (NCI)Hs.654754
Alternative Splicing GalleryENSG00000141298
Gene ExpressionSSH2 [ NCBI-GEO ]   SSH2 [ EBI - ARRAY_EXPRESS ]   SSH2 [ SEEK ]   SSH2 [ MEM ]
Gene Expression Viewer (FireBrowse)SSH2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)85464
GTEX Portal (Tissue expression)SSH2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ76I76   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ76I76  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ76I76
Splice isoforms : SwissVarQ76I76
Catalytic activity : Enzyme3.1.3.16 [ Enzyme-Expasy ]   3.1.3.163.1.3.16 [ IntEnz-EBI ]   3.1.3.16 [ BRENDA ]   3.1.3.16 [ KEGG ]   
PhosPhoSitePlusQ76I76
Domaine pattern : Prosite (Expaxy)TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_DUAL (PS50054)   
Domains : Interpro (EBI)DEK_C    Dual-sp_phosphatase_cat-dom    DUSP    Homeodomain-like    Prot-tyrosine_phosphatase-like    Tyr_Pase_AS    TYR_PHOSPHATASE_dom    TYR_PHOSPHATASE_DUAL_dom   
Domain families : Pfam (Sanger)DEK_C (PF08766)    DSPc (PF00782)   
Domain families : Pfam (NCBI)pfam08766    pfam00782   
Domain families : Smart (EMBL)DSPc (SM00195)  
Conserved Domain (NCBI)SSH2
DMDM Disease mutations85464
Blocks (Seattle)SSH2
PDB (SRS)2NT2   
PDB (PDBSum)2NT2   
PDB (IMB)2NT2   
PDB (RSDB)2NT2   
Structural Biology KnowledgeBase2NT2   
SCOP (Structural Classification of Proteins)2NT2   
CATH (Classification of proteins structures)2NT2   
SuperfamilyQ76I76
Human Protein AtlasENSG00000141298
Peptide AtlasQ76I76
HPRD09487
IPIIPI01009829   IPI00061728   IPI00383249   IPI00655806   IPI00377071   
Protein Interaction databases
DIP (DOE-UCLA)Q76I76
IntAct (EBI)Q76I76
FunCoupENSG00000141298
BioGRIDSSH2
STRING (EMBL)SSH2
ZODIACSSH2
Ontologies - Pathways
QuickGOQ76I76
Ontology : AmiGODNA binding  actin binding  phosphoprotein phosphatase activity  protein tyrosine phosphatase activity  extracellular space  cytoplasm  cytoskeleton  protein dephosphorylation  regulation of actin polymerization or depolymerization  protein tyrosine/serine/threonine phosphatase activity  regulation of lamellipodium assembly  actin cytoskeleton organization  peptidyl-tyrosine dephosphorylation  regulation of axonogenesis  
Ontology : EGO-EBIDNA binding  actin binding  phosphoprotein phosphatase activity  protein tyrosine phosphatase activity  extracellular space  cytoplasm  cytoskeleton  protein dephosphorylation  regulation of actin polymerization or depolymerization  protein tyrosine/serine/threonine phosphatase activity  regulation of lamellipodium assembly  actin cytoskeleton organization  peptidyl-tyrosine dephosphorylation  regulation of axonogenesis  
Pathways : KEGGRegulation of actin cytoskeleton   
NDEx NetworkSSH2
Atlas of Cancer Signalling NetworkSSH2
Wikipedia pathwaysSSH2
Orthology - Evolution
OrthoDB85464
GeneTree (enSembl)ENSG00000141298
Phylogenetic Trees/Animal Genes : TreeFamSSH2
HOVERGENQ76I76
HOGENOMQ76I76
Homologs : HomoloGeneSSH2
Homology/Alignments : Family Browser (UCSC)SSH2
Gene fusions - Rearrangements
Fusion : MitelmanCBX1/SSH2 [17q21.32/17q11.2]  [t(17;17)(q11;q21)]  
Fusion : MitelmanMED24/SSH2 [17q21.1/17q11.2]  [t(17;17)(q11;q21)]  
Fusion : MitelmanMYO1D/SSH2 [17q11.2/17q11.2]  [t(17;17)(q11;q11)]  
Fusion : MitelmanPPP6R3/SSH2 [11q13.2/17q11.2]  [t(11;17)(q13;q11)]  
Fusion : MitelmanTANC2/SSH2 [17q23.2/17q11.2]  [t(17;17)(q11;q23)]  
Fusion: TCGACBX1 17q21.32 SSH2 17q11.2 BRCA
Fusion: TCGAMED24 17q21.1 SSH2 17q11.2 BRCA
Fusion: TCGAMYO1D 17q11.2 SSH2 17q11.2 BRCA
Fusion: TCGAPPP6R3 11q13.2 SSH2 17q11.2 BRCA
Fusion: TCGATANC2 17q23.2 SSH2 17q11.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSSH2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SSH2
dbVarSSH2
ClinVarSSH2
1000_GenomesSSH2 
Exome Variant ServerSSH2
ExAC (Exome Aggregation Consortium)SSH2 (select the gene name)
Genetic variants : HAPMAP85464
Genomic Variants (DGV)SSH2 [DGVbeta]
DECIPHER (Syndromes)17:27952957-28257246  ENSG00000141298
CONAN: Copy Number AnalysisSSH2 
Mutations
ICGC Data PortalSSH2 
TCGA Data PortalSSH2 
Broad Tumor PortalSSH2
OASIS PortalSSH2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSSH2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSSH2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SSH2
DgiDB (Drug Gene Interaction Database)SSH2
DoCM (Curated mutations)SSH2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SSH2 (select a term)
intoGenSSH2
Cancer3DSSH2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606779   
Orphanet
MedgenSSH2
Genetic Testing Registry SSH2
NextProtQ76I76 [Medical]
TSGene85464
GENETestsSSH2
Huge Navigator SSH2 [HugePedia]
snp3D : Map Gene to Disease85464
BioCentury BCIQSSH2
ClinGenSSH2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD85464
Chemical/Pharm GKB GenePA134861867
Clinical trialSSH2
Miscellaneous
canSAR (ICR)SSH2 (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSSH2
EVEXSSH2
GoPubMedSSH2
iHOPSSH2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:29:15 CET 2017

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