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SSR1 (signal sequence receptor subunit 1)

Identity

Alias_namessignal sequence receptor
Alias_symbol (synonym)TRAPA
Other alias
HGNC (Hugo) SSR1
LocusID (NCBI) 6745
Atlas_Id 42397
Location 6p24.3  [Link to chromosome band 6p24]
Location_base_pair Starts at 7281143 and ends at 7313314 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C5AR1 (19q13.32) / SSR1 (6p24.3)DCN (12q21.33) / SSR1 (6p24.3)RNF165 (18q21.1) / SSR1 (6p24.3)
SSR1 (6p24.3) / AVL9 (7p14.3)SSR1 (6p24.3) / CAGE1 (6p24.3)SSR1 (6p24.3) / DMD (Xp21.2)
SSR1 (6p24.3) / FARS2 (6p25.1)SSR1 (6p24.3) / HPS3 (3q24)SSR1 (6p24.3) / NOTCH2 (1p12)
SSR1 (6p24.3) / PSMA1 (11p15.2)SSR1 (6p24.3) / RBFOX2 (22q12.3)SSR1 (6p24.3) / SRPK2 (7q22.3)
SSR1 (6p24.3) / SSR1 (6p24.3)SSR1 6p24.3 / CAGE1 6p24.3SSR1 6p24.3 / DMD Xp21.2
SSR1 6p24.3 / FARS2 6p25.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  SSR1/CAGE1 (6p24)
t(6;6)(p24;p25) SSR1/FARS2
t(X;6)(p21;p24) SSR1/DMD


External links

Nomenclature
HGNC (Hugo)SSR1   11323
Cards
Entrez_Gene (NCBI)SSR1  6745  signal sequence receptor subunit 1
AliasesTRAPA
GeneCards (Weizmann)SSR1
Ensembl hg19 (Hinxton)ENSG00000124783 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000124783 [Gene_View]  ENSG00000124783 [Sequence]  chr6:7281143-7313314 [Contig_View]  SSR1 [Vega]
ICGC DataPortalENSG00000124783
TCGA cBioPortalSSR1
AceView (NCBI)SSR1
Genatlas (Paris)SSR1
WikiGenes6745
SOURCE (Princeton)SSR1
Genetics Home Reference (NIH)SSR1
Genomic and cartography
GoldenPath hg38 (UCSC)SSR1  -     chr6:7281143-7313314 -  6p24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SSR1  -     6p24.3   [Description]    (hg19-Feb_2009)
EnsemblSSR1 - 6p24.3 [CytoView hg19]  SSR1 - 6p24.3 [CytoView hg38]
Mapping of homologs : NCBISSR1 [Mapview hg19]  SSR1 [Mapview hg38]
OMIM600868   
Gene and transcription
Genbank (Entrez)AF156965 AJ420492 AK024294 AK025753 AK026687
RefSeq transcript (Entrez)NM_001292008 NM_003144
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SSR1
Cluster EST : UnigeneHs.114033 [ NCBI ]
CGAP (NCI)Hs.114033
Alternative Splicing GalleryENSG00000124783
Gene ExpressionSSR1 [ NCBI-GEO ]   SSR1 [ EBI - ARRAY_EXPRESS ]   SSR1 [ SEEK ]   SSR1 [ MEM ]
Gene Expression Viewer (FireBrowse)SSR1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6745
GTEX Portal (Tissue expression)SSR1
Human Protein AtlasENSG00000124783-SSR1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP43307   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP43307  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP43307
Splice isoforms : SwissVarP43307
PhosPhoSitePlusP43307
Domains : Interpro (EBI)TRAP_alpha   
Domain families : Pfam (Sanger)TRAP_alpha (PF03896)   
Domain families : Pfam (NCBI)pfam03896   
Conserved Domain (NCBI)SSR1
DMDM Disease mutations6745
Blocks (Seattle)SSR1
SuperfamilyP43307
Human Protein Atlas [tissue]ENSG00000124783-SSR1 [tissue]
Peptide AtlasP43307
HPRD02924
IPIIPI00301021   IPI00449669   IPI01018736   IPI00946192   IPI00946839   IPI00945633   IPI00946008   IPI00945795   IPI00946676   
Protein Interaction databases
DIP (DOE-UCLA)P43307
IntAct (EBI)P43307
FunCoupENSG00000124783
BioGRIDSSR1
STRING (EMBL)SSR1
ZODIACSSR1
Ontologies - Pathways
QuickGOP43307
Ontology : AmiGOprotein binding  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  cotranslational protein targeting to membrane  positive regulation of cell proliferation  integral component of membrane  IRE1-mediated unfolded protein response  
Ontology : EGO-EBIprotein binding  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  cotranslational protein targeting to membrane  positive regulation of cell proliferation  integral component of membrane  IRE1-mediated unfolded protein response  
Pathways : KEGGProtein processing in endoplasmic reticulum   
NDEx NetworkSSR1
Atlas of Cancer Signalling NetworkSSR1
Wikipedia pathwaysSSR1
Orthology - Evolution
OrthoDB6745
GeneTree (enSembl)ENSG00000124783
Phylogenetic Trees/Animal Genes : TreeFamSSR1
HOVERGENP43307
HOGENOMP43307
Homologs : HomoloGeneSSR1
Homology/Alignments : Family Browser (UCSC)SSR1
Gene fusions - Rearrangements
Fusion : MitelmanSSR1/CAGE1 [6p24.3/6p24.3]  
Fusion : MitelmanSSR1/DMD [6p24.3/Xp21.2]  [t(X;6)(p21;p24)]  
Fusion : MitelmanSSR1/FARS2 [6p24.3/6p25.1]  [t(6;6)(p24;p25)]  
Fusion PortalSSR1 6p24.3 CAGE1 6p24.3 BRCA
Fusion PortalSSR1 6p24.3 DMD Xp21.2 GBM
Fusion PortalSSR1 6p24.3 FARS2 6p25.1 LUAD
Fusion Cancer (Beijing)RNF165 [18q21.1]  -  SSR1 [6p24.3]  [FUSC004338]
Fusion : QuiverSSR1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSSR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SSR1
dbVarSSR1
ClinVarSSR1
1000_GenomesSSR1 
Exome Variant ServerSSR1
ExAC (Exome Aggregation Consortium)ENSG00000124783
GNOMAD BrowserENSG00000124783
Varsome BrowserSSR1
Genetic variants : HAPMAP6745
Genomic Variants (DGV)SSR1 [DGVbeta]
DECIPHERSSR1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSSR1 
Mutations
ICGC Data PortalSSR1 
TCGA Data PortalSSR1 
Broad Tumor PortalSSR1
OASIS PortalSSR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSSR1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSSR1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SSR1
DgiDB (Drug Gene Interaction Database)SSR1
DoCM (Curated mutations)SSR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SSR1 (select a term)
intoGenSSR1
Cancer3DSSR1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600868   
Orphanet
DisGeNETSSR1
MedgenSSR1
Genetic Testing Registry SSR1
NextProtP43307 [Medical]
TSGene6745
GENETestsSSR1
Target ValidationSSR1
Huge Navigator SSR1 [HugePedia]
snp3D : Map Gene to Disease6745
BioCentury BCIQSSR1
ClinGenSSR1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6745
Chemical/Pharm GKB GenePA36147
Clinical trialSSR1
Miscellaneous
canSAR (ICR)SSR1 (select the gene name)
Probes
Litterature
PubMed51 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSSR1
EVEXSSR1
GoPubMedSSR1
iHOPSSR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:42:05 CET 2018

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