Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SSRP1 (structure specific recognition protein 1)

Identity

Alias (NCBI)FACT
FACT80
T160
HGNC (Hugo) SSRP1
HGNC Alias symbFACT80
HGNC Alias namefacilitates chromatin remodeling 80 kDa subunit
LocusID (NCBI) 6749
Atlas_Id 42400
Location 11q12.1  [Link to chromosome band 11q12]
Location_base_pair Starts at 57325989 and ends at 57335892 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CBX1 (17q21.32) / SSRP1 (11q12.1)FBXO34 (14q22.3) / SSRP1 (11q12.1)HEXB (5q13.3) / SSRP1 (11q12.1)
SSRP1 (11q12.1) / EIF3M (11p13)SSRP1 (11q12.1) / FADS2 (11q12.2)SSRP1 (11q12.1) / MED19 (11q12.1)
SSRP1 (11q12.1) / SSRP1 (11q12.1)SSRP1 (11q12.1) / TRMT2A (22q11.21)SSRP1 11q12.1 / MED19 11q12.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  SSRP1/MED19 (11q12)

External links

Nomenclature
HGNC (Hugo)SSRP1   11327
Cards
Entrez_Gene (NCBI)SSRP1  6749  structure specific recognition protein 1
AliasesFACT; FACT80; T160
GeneCards (Weizmann)SSRP1
Ensembl hg19 (Hinxton)ENSG00000149136 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000149136 [Gene_View]  ENSG00000149136 [Sequence]  chr11:57325989-57335892 [Contig_View]  SSRP1 [Vega]
ICGC DataPortalENSG00000149136
TCGA cBioPortalSSRP1
AceView (NCBI)SSRP1
Genatlas (Paris)SSRP1
WikiGenes6749
SOURCE (Princeton)SSRP1
Genetics Home Reference (NIH)SSRP1
Genomic and cartography
GoldenPath hg38 (UCSC)SSRP1  -     chr11:57325989-57335892 -  11q12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SSRP1  -     11q12.1   [Description]    (hg19-Feb_2009)
GoldenPathSSRP1 - 11q12.1 [CytoView hg19]  SSRP1 - 11q12.1 [CytoView hg38]
ImmunoBaseENSG00000149136
genome Data Viewer NCBISSRP1 [Mapview hg19]  
OMIM604328   
Gene and transcription
Genbank (Entrez)AB209132 BC005116 BC091486 M86737
RefSeq transcript (Entrez)NM_003146
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SSRP1
Alternative Splicing GalleryENSG00000149136
Gene ExpressionSSRP1 [ NCBI-GEO ]   SSRP1 [ EBI - ARRAY_EXPRESS ]   SSRP1 [ SEEK ]   SSRP1 [ MEM ]
Gene Expression Viewer (FireBrowse)SSRP1 [ Firebrowse - Broad ]
GenevisibleExpression of SSRP1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6749
GTEX Portal (Tissue expression)SSRP1
Human Protein AtlasENSG00000149136-SSRP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ08945   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ08945  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ08945
Splice isoforms : SwissVarQ08945
PhosPhoSitePlusQ08945
Domaine pattern : Prosite (Expaxy)HMG_BOX_2 (PS50118)   
Domains : Interpro (EBI)DUF1747    HMG_box_dom    HMG_box_dom_sf    PH-like_dom_sf    POB3_N    SSrcognition    SSRP1_dom    SSRP1_sf   
Domain families : Pfam (Sanger)HMG_box (PF00505)    POB3_N (PF17292)    Rtt106 (PF08512)    SSrecog (PF03531)   
Domain families : Pfam (NCBI)pfam00505    pfam17292    pfam08512    pfam03531   
Domain families : Smart (EMBL)HMG (SM00398)  Rtt106 (SM01287)  
Conserved Domain (NCBI)SSRP1
DMDM Disease mutations6749
Blocks (Seattle)SSRP1
PDB (RSDB)4IFS    5UMR    5UMS    5VWE   
PDB Europe4IFS    5UMR    5UMS    5VWE   
PDB (PDBSum)4IFS    5UMR    5UMS    5VWE   
PDB (IMB)4IFS    5UMR    5UMS    5VWE   
Structural Biology KnowledgeBase4IFS    5UMR    5UMS    5VWE   
SCOP (Structural Classification of Proteins)4IFS    5UMR    5UMS    5VWE   
CATH (Classification of proteins structures)4IFS    5UMR    5UMS    5VWE   
SuperfamilyQ08945
Human Protein Atlas [tissue]ENSG00000149136-SSRP1 [tissue]
Peptide AtlasQ08945
HPRD05061
IPIIPI00005154   IPI00556260   IPI00985291   IPI00981139   
Protein Interaction databases
DIP (DOE-UCLA)Q08945
IntAct (EBI)Q08945
FunCoupENSG00000149136
BioGRIDSSRP1
STRING (EMBL)SSRP1
ZODIACSSRP1
Ontologies - Pathways
QuickGOQ08945
Ontology : AmiGOnuclear chromatin  DNA binding  RNA binding  protein binding  nucleoplasm  nucleolus  DNA replication  DNA repair  transcription by RNA polymerase II  transcription elongation from RNA polymerase II promoter  viral process  nucleosome binding  FACT complex  histone binding  regulation of signal transduction by p53 class mediator  regulation of chromatin organization  
Ontology : EGO-EBInuclear chromatin  DNA binding  RNA binding  protein binding  nucleoplasm  nucleolus  DNA replication  DNA repair  transcription by RNA polymerase II  transcription elongation from RNA polymerase II promoter  viral process  nucleosome binding  FACT complex  histone binding  regulation of signal transduction by p53 class mediator  regulation of chromatin organization  
NDEx NetworkSSRP1
Atlas of Cancer Signalling NetworkSSRP1
Wikipedia pathwaysSSRP1
Orthology - Evolution
OrthoDB6749
GeneTree (enSembl)ENSG00000149136
Phylogenetic Trees/Animal Genes : TreeFamSSRP1
HOGENOMQ08945
Homologs : HomoloGeneSSRP1
Homology/Alignments : Family Browser (UCSC)SSRP1
Gene fusions - Rearrangements
Fusion : MitelmanSSRP1/MED19 [11q12.1/11q12.1]  
Fusion PortalSSRP1 11q12.1 MED19 11q12.1 OV
Fusion : QuiverSSRP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSSRP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SSRP1
dbVarSSRP1
ClinVarSSRP1
MonarchSSRP1
1000_GenomesSSRP1 
Exome Variant ServerSSRP1
GNOMAD BrowserENSG00000149136
Varsome BrowserSSRP1
Genetic variants : HAPMAP6749
Genomic Variants (DGV)SSRP1 [DGVbeta]
DECIPHERSSRP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSSRP1 
Mutations
ICGC Data PortalSSRP1 
TCGA Data PortalSSRP1 
Broad Tumor PortalSSRP1
OASIS PortalSSRP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSSRP1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSSRP1
Mutations and Diseases : HGMDSSRP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SSRP1
DgiDB (Drug Gene Interaction Database)SSRP1
DoCM (Curated mutations)SSRP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SSRP1 (select a term)
intoGenSSRP1
Cancer3DSSRP1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604328   
Orphanet
DisGeNETSSRP1
MedgenSSRP1
Genetic Testing Registry SSRP1
NextProtQ08945 [Medical]
TSGene6749
GENETestsSSRP1
Target ValidationSSRP1
Huge Navigator SSRP1 [HugePedia]
snp3D : Map Gene to Disease6749
BioCentury BCIQSSRP1
ClinGenSSRP1
Clinical trials, drugs, therapy
Protein Interactions : CTD6749
Pharm GKB GenePA36151
Clinical trialSSRP1
Miscellaneous
canSAR (ICR)SSRP1 (select the gene name)
HarmonizomeSSRP1
DataMed IndexSSRP1
Probes
Litterature
PubMed175 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSSRP1
EVEXSSRP1
GoPubMedSSRP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:34:26 CEST 2020
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