SSTR4 (somatostatin receptor 4)

2003-02-01  

Identity

HGNC
LOCATION
20p11.21
LOCUSID
ALIAS
SS-4-R,SS4-R,SS4R

Other Information

Locus ID:

NCBI: 6754
MIM: 182454
HGNC: 11333
Ensembl: ENSG00000132671

Variants:

dbSNP: 6754
ClinVar: 6754
TCGA: ENSG00000132671
COSMIC: SSTR4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132671ENST00000255008P31391

Expression (GTEx)

0
1
2

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
120219202002Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis.45
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
208106042010Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer.34
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
206341972010Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium.25
202337832010A potential inhibitory role for the new truncated variant of somatostatin receptor 5, sst5TMD4, in pituitary adenomas poorly responsive to somatostatin analogs.20
193304522009Acromegaly: correlation between expression of somatostatin receptor subtypes and response to octreotide-lar treatment.16
194268012009C-tail mediated modulation of somatostatin receptor type-4 homo- and heterodimerizations and signaling.11
122104792002Expression of somatostatin receptor subtypes 2 and 4 in human benign prostatic hyperplasia and prostatic cancer.9

Citation

Dessen P

SSTR4 (somatostatin receptor 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42404/sstr4