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ST14 (suppression of tumorigenicity 14)

Identity

Alias_namesPRSS14
suppression of tumorigenicity 14 (colon carcinoma)
Alias_symbol (synonym)SNC19
HAI
MT-SP1
TMPRSS14
Other aliasARCI11
MTSP1
TADG15
HGNC (Hugo) ST14
LocusID (NCBI) 6768
Atlas_Id 42418
Location 11q24.3  [Link to chromosome band 11q24]
Location_base_pair Starts at 130159787 and ends at 130210362 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CYB5A (18q22.3) / ST14 (11q24.3)RNF216 (7p22.1) / ST14 (11q24.3)SOX2-OT (3q26.33) / ST14 (11q24.3)
ST14 (11q24.3) / APLP2 (11q24.3)ST14 (11q24.3) / BARX2 (11q24.3)ST14 (11q24.3) / OTUD5 (Xp11.23)
ST14 (11q24.3) / ST14 (11q24.3)ST14 (11q24.3) / ST7 (7q31.2)RNF216 7p22.1 / ST14 11q24.3
ST14 11q24.3 / APLP2 11q24.3ST14 11q24.3 / BARX2 11q24.3ST14 11q24.3 / ST7 7q31.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  t(3;11)(q26;q24) SOX2-OT/ST14
t(7;11)(p22;q24) RNF216/ST14
t(7;11)(q31;q24) ST14/ST7
ST14/APLP2 (11q24)
ST14/BARX2 (11q24)

External links

Nomenclature
HGNC (Hugo)ST14   11344
Cards
Entrez_Gene (NCBI)ST14  6768  suppression of tumorigenicity 14
AliasesARCI11; HAI; MT-SP1; MTSP1; 
PRSS14; SNC19; TADG15; TMPRSS14
GeneCards (Weizmann)ST14
Ensembl hg19 (Hinxton)ENSG00000149418 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000149418 [Gene_View]  ENSG00000149418 [Sequence]  chr11:130159787-130210362 [Contig_View]  ST14 [Vega]
ICGC DataPortalENSG00000149418
TCGA cBioPortalST14
AceView (NCBI)ST14
Genatlas (Paris)ST14
WikiGenes6768
SOURCE (Princeton)ST14
Genetics Home Reference (NIH)ST14
Genomic and cartography
GoldenPath hg38 (UCSC)ST14  -     chr11:130159787-130210362 +  11q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ST14  -     11q24.3   [Description]    (hg19-Feb_2009)
EnsemblST14 - 11q24.3 [CytoView hg19]  ST14 - 11q24.3 [CytoView hg38]
Mapping of homologs : NCBIST14 [Mapview hg19]  ST14 [Mapview hg38]
OMIM602400   606797   
Gene and transcription
Genbank (Entrez)AB030036 AF057145 AF118224 AF133086 AK302454
RefSeq transcript (Entrez)NM_021978
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ST14
Cluster EST : UnigeneHs.504315 [ NCBI ]
CGAP (NCI)Hs.504315
Alternative Splicing GalleryENSG00000149418
Gene ExpressionST14 [ NCBI-GEO ]   ST14 [ EBI - ARRAY_EXPRESS ]   ST14 [ SEEK ]   ST14 [ MEM ]
Gene Expression Viewer (FireBrowse)ST14 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6768
GTEX Portal (Tissue expression)ST14
Human Protein AtlasENSG00000149418-ST14 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y5Y6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y5Y6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y5Y6
Splice isoforms : SwissVarQ9Y5Y6
Catalytic activity : Enzyme3.4.21.109 [ Enzyme-Expasy ]   3.4.21.1093.4.21.109 [ IntEnz-EBI ]   3.4.21.109 [ BRENDA ]   3.4.21.109 [ KEGG ]   
PhosPhoSitePlusQ9Y5Y6
Domaine pattern : Prosite (Expaxy)CUB (PS01180)    LDLRA_1 (PS01209)    LDLRA_2 (PS50068)    SEA (PS50024)    TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)CUB_dom    LDL_receptor-like_sf    LDLR_class-A_CS    LDrepeatLR_classA_rpt    Peptidase_S1_PA    Peptidase_S1A_matripase    SEA_dom    SEA_dom_sf    Sperma_CUB_dom_sf    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)CUB (PF00431)    Ldl_recept_a (PF00057)    SEA (PF01390)    Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00431    pfam00057    pfam01390    pfam00089   
Domain families : Smart (EMBL)CUB (SM00042)  LDLa (SM00192)  Tryp_SPc (SM00020)  
Conserved Domain (NCBI)ST14
DMDM Disease mutations6768
Blocks (Seattle)ST14
PDB (RSDB)1EAW    1EAX    2FMV    2GV6    2GV7    3BN9    3NCL    3NPS    3P8F    3P8G    3SO3    4IS5    4ISL    4ISN    4ISO    4JYT    4JZ1    4JZI    4O97    4O9V    4R0I    5LYO   
PDB Europe1EAW    1EAX    2FMV    2GV6    2GV7    3BN9    3NCL    3NPS    3P8F    3P8G    3SO3    4IS5    4ISL    4ISN    4ISO    4JYT    4JZ1    4JZI    4O97    4O9V    4R0I    5LYO   
PDB (PDBSum)1EAW    1EAX    2FMV    2GV6    2GV7    3BN9    3NCL    3NPS    3P8F    3P8G    3SO3    4IS5    4ISL    4ISN    4ISO    4JYT    4JZ1    4JZI    4O97    4O9V    4R0I    5LYO   
PDB (IMB)1EAW    1EAX    2FMV    2GV6    2GV7    3BN9    3NCL    3NPS    3P8F    3P8G    3SO3    4IS5    4ISL    4ISN    4ISO    4JYT    4JZ1    4JZI    4O97    4O9V    4R0I    5LYO   
Structural Biology KnowledgeBase1EAW    1EAX    2FMV    2GV6    2GV7    3BN9    3NCL    3NPS    3P8F    3P8G    3SO3    4IS5    4ISL    4ISN    4ISO    4JYT    4JZ1    4JZI    4O97    4O9V    4R0I    5LYO   
SCOP (Structural Classification of Proteins)1EAW    1EAX    2FMV    2GV6    2GV7    3BN9    3NCL    3NPS    3P8F    3P8G    3SO3    4IS5    4ISL    4ISN    4ISO    4JYT    4JZ1    4JZI    4O97    4O9V    4R0I    5LYO   
CATH (Classification of proteins structures)1EAW    1EAX    2FMV    2GV6    2GV7    3BN9    3NCL    3NPS    3P8F    3P8G    3SO3    4IS5    4ISL    4ISN    4ISO    4JYT    4JZ1    4JZI    4O97    4O9V    4R0I    5LYO   
SuperfamilyQ9Y5Y6
Human Protein Atlas [tissue]ENSG00000149418-ST14 [tissue]
Peptide AtlasQ9Y5Y6
HPRD06005
IPIIPI00001922   IPI00985102   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y5Y6
IntAct (EBI)Q9Y5Y6
FunCoupENSG00000149418
BioGRIDST14
STRING (EMBL)ST14
ZODIACST14
Ontologies - Pathways
QuickGOQ9Y5Y6
Ontology : AmiGOneural tube closure  endopeptidase activity  serine-type endopeptidase activity  extracellular space  plasma membrane  integral component of plasma membrane  proteolysis  serine-type peptidase activity  basolateral plasma membrane  extrinsic component of plasma membrane  keratinocyte differentiation  keratinocyte differentiation  epithelial cell morphogenesis involved in placental branching  cornification  
Ontology : EGO-EBIneural tube closure  endopeptidase activity  serine-type endopeptidase activity  extracellular space  plasma membrane  integral component of plasma membrane  proteolysis  serine-type peptidase activity  basolateral plasma membrane  extrinsic component of plasma membrane  keratinocyte differentiation  keratinocyte differentiation  epithelial cell morphogenesis involved in placental branching  cornification  
Pathways : KEGGMicroRNAs in cancer   
NDEx NetworkST14
Atlas of Cancer Signalling NetworkST14
Wikipedia pathwaysST14
Orthology - Evolution
OrthoDB6768
GeneTree (enSembl)ENSG00000149418
Phylogenetic Trees/Animal Genes : TreeFamST14
HOGENOMQ9Y5Y6
Homologs : HomoloGeneST14
Homology/Alignments : Family Browser (UCSC)ST14
Gene fusions - Rearrangements
Fusion : MitelmanRNF216/ST14 [7p22.1/11q24.3]  [t(7;11)(p22;q24)]  
Fusion : MitelmanST14/APLP2 [11q24.3/11q24.3]  [t(11;11)(q24;q24)]  
Fusion : MitelmanST14/BARX2 [11q24.3/11q24.3]  [t(11;11)(q24;q24)]  
Fusion : MitelmanST14/ST7 [11q24.3/7q31.2]  [t(7;11)(q31;q24)]  
Fusion PortalRNF216 7p22.1 ST14 11q24.3 BRCA
Fusion PortalST14 11q24.3 APLP2 11q24.3 PRAD
Fusion PortalST14 11q24.3 BARX2 11q24.3 BRCA
Fusion PortalST14 11q24.3 ST7 7q31.2 BRCA
Fusion : QuiverST14
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerST14 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ST14
dbVarST14
ClinVarST14
1000_GenomesST14 
Exome Variant ServerST14
ExAC (Exome Aggregation Consortium)ENSG00000149418
GNOMAD BrowserENSG00000149418
Varsome BrowserST14
Genetic variants : HAPMAP6768
Genomic Variants (DGV)ST14 [DGVbeta]
DECIPHERST14 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisST14 
Mutations
ICGC Data PortalST14 
TCGA Data PortalST14 
Broad Tumor PortalST14
OASIS PortalST14 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICST14  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDST14
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ST14
DgiDB (Drug Gene Interaction Database)ST14
DoCM (Curated mutations)ST14 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ST14 (select a term)
intoGenST14
Cancer3DST14(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602400    606797   
Orphanet12109   
DisGeNETST14
MedgenST14
Genetic Testing Registry ST14
NextProtQ9Y5Y6 [Medical]
TSGene6768
GENETestsST14
Target ValidationST14
Huge Navigator ST14 [HugePedia]
snp3D : Map Gene to Disease6768
BioCentury BCIQST14
ClinGenST14
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6768
Chemical/Pharm GKB GenePA36168
Clinical trialST14
Miscellaneous
canSAR (ICR)ST14 (select the gene name)
DataMed IndexST14
Probes
Litterature
PubMed119 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineST14
EVEXST14
GoPubMedST14
iHOPST14
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Feb 14 16:59:47 CET 2019
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