ST14 (ST14 transmembrane serine protease matriptase)

2003-02-01  

Identity

HGNC
LOCATION
11q24.3
LOCUSID
ALIAS
ARCI11,CAP3,HAI,MT-SP1,MTSP1,PRSS14,SNC19,TADG15,TMPRSS14
FUSION GENES

Other Information

Locus ID:

NCBI: 6768
MIM: 606797
HGNC: 11344
Ensembl: ENSG00000149418

Variants:

dbSNP: 6768
ClinVar: 6768
TCGA: ENSG00000149418
COSMIC: ST14

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149418ENST00000278742Q9Y5Y6

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Developmental BiologyREACTOMER-HSA-1266738
KeratinizationREACTOMER-HSA-6805567
Formation of the cornified envelopeREACTOMER-HSA-6809371

References

Pubmed IDYearTitleCitations
161032202005Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation.90
201424892010Membrane-anchored serine protease matriptase regulates epithelial barrier formation and permeability in the intestine.74
127387782003The activation of matriptase requires its noncatalytic domains, serine protease domain, and its cognate inhibitor.68
174565942007The macrophage-stimulating protein pathway promotes metastasis in a mouse model for breast cancer and predicts poor prognosis in humans.64
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
172739672007Autosomal recessive ichthyosis with hypotrichosis caused by a mutation in ST14, encoding type II transmembrane serine protease matriptase.55
173894012007Coordinate expression and functional profiling identify an extracellular proteolytic signaling pathway.54
171310552006Matriptase and its putative role in cancer.53
210987082010A novel signaling axis of matriptase/PDGF-D/ß-PDGFR in human prostate cancer.50
187137502008Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activity.47

Citation

Dessen P

ST14 (ST14 transmembrane serine protease matriptase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42418/st14