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ST3GAL1 (ST3 beta-galactoside alpha-2,3-sialyltransferase 1)

Identity

Alias_namesSIAT4A
sialyltransferase 4A (beta-galactosidase alpha-2
Alias_symbol (synonym)ST3O
SIATFL
ST3GalA.1
Other aliasGal-NAc6S
ST3GalA
ST3GalIA
ST3GalIA,1
HGNC (Hugo) ST3GAL1
LocusID (NCBI) 6482
Atlas_Id 51334
Location 8q24.22  [Link to chromosome band 8q24]
Location_base_pair Starts at 133454848 and ends at 133571940 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AES (19p13.3) / ST3GAL1 (8q24.22)HNRNPL (19q13.2) / ST3GAL1 (8q24.22)HTR4 (5q32) / ST3GAL1 (8q24.22)
MTSS1 (8q24.13) / ST3GAL1 (8q24.22)NDRG1 (8q24.22) / ST3GAL1 (8q24.22)NEMF (14q21.3) / ST3GAL1 (8q24.22)
NPNT (4q24) / ST3GAL1 (8q24.22)ST3GAL1 (8q24.22) / COL22A1 (8q24.23)ST3GAL1 (8q24.22) / ST3GAL1 (8q24.22)
MTSS1 8q24.13 / ST3GAL1 8q24.22NDRG1 8q24.22 / ST3GAL1 8q24.22ST3GAL1 8q24.22 / COL22A1 8q24.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ST3GAL1   10862
Cards
Entrez_Gene (NCBI)ST3GAL1  6482  ST3 beta-galactoside alpha-2,3-sialyltransferase 1
AliasesGal-NAc6S; SIAT4A; SIATFL; ST3GalA; 
ST3GalA.1; ST3GalIA; ST3GalIA,1; ST3O
GeneCards (Weizmann)ST3GAL1
Ensembl hg19 (Hinxton)ENSG00000008513 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000008513 [Gene_View]  chr8:133454848-133571940 [Contig_View]  ST3GAL1 [Vega]
ICGC DataPortalENSG00000008513
TCGA cBioPortalST3GAL1
AceView (NCBI)ST3GAL1
Genatlas (Paris)ST3GAL1
WikiGenes6482
SOURCE (Princeton)ST3GAL1
Genetics Home Reference (NIH)ST3GAL1
Genomic and cartography
GoldenPath hg38 (UCSC)ST3GAL1  -     chr8:133454848-133571940 -  8q24.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ST3GAL1  -     8q24.22   [Description]    (hg19-Feb_2009)
EnsemblST3GAL1 - 8q24.22 [CytoView hg19]  ST3GAL1 - 8q24.22 [CytoView hg38]
Mapping of homologs : NCBIST3GAL1 [Mapview hg19]  ST3GAL1 [Mapview hg38]
OMIM607187   
Gene and transcription
Genbank (Entrez)AF059321 AK093867 AK311319 AL709325 AL833743
RefSeq transcript (Entrez)NM_003033 NM_173344
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ST3GAL1
Cluster EST : UnigeneHs.374257 [ NCBI ]
CGAP (NCI)Hs.374257
Alternative Splicing GalleryENSG00000008513
Gene ExpressionST3GAL1 [ NCBI-GEO ]   ST3GAL1 [ EBI - ARRAY_EXPRESS ]   ST3GAL1 [ SEEK ]   ST3GAL1 [ MEM ]
Gene Expression Viewer (FireBrowse)ST3GAL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6482
GTEX Portal (Tissue expression)ST3GAL1
Human Protein AtlasENSG00000008513-ST3GAL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ11201   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ11201  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ11201
Splice isoforms : SwissVarQ11201
Catalytic activity : Enzyme2.4.99.4 [ Enzyme-Expasy ]   2.4.99.42.4.99.4 [ IntEnz-EBI ]   2.4.99.4 [ BRENDA ]   2.4.99.4 [ KEGG ]   
PhosPhoSitePlusQ11201
Domains : Interpro (EBI)Glyco_trans_29    Sialyl_trans   
Domain families : Pfam (Sanger)Glyco_transf_29 (PF00777)   
Domain families : Pfam (NCBI)pfam00777   
Conserved Domain (NCBI)ST3GAL1
DMDM Disease mutations6482
Blocks (Seattle)ST3GAL1
SuperfamilyQ11201
Human Protein Atlas [tissue]ENSG00000008513-ST3GAL1 [tissue]
Peptide AtlasQ11201
HPRD06219
IPIIPI00009629   IPI00983429   IPI00976740   IPI00985299   IPI00979786   IPI00982119   
Protein Interaction databases
DIP (DOE-UCLA)Q11201
IntAct (EBI)Q11201
FunCoupENSG00000008513
BioGRIDST3GAL1
STRING (EMBL)ST3GAL1
ZODIACST3GAL1
Ontologies - Pathways
QuickGOQ11201
Ontology : AmiGOGolgi membrane  beta-galactoside (CMP) alpha-2,3-sialyltransferase activity  beta-galactoside (CMP) alpha-2,3-sialyltransferase activity  beta-galactoside (CMP) alpha-2,3-sialyltransferase activity  N-acetylneuraminate metabolic process  cellular protein modification process  protein phosphorylation  protein N-linked glycosylation  oligosaccharide metabolic process  membrane  O-glycan processing  keratan sulfate biosynthetic process  protein N-linked glycosylation via asparagine  integral component of Golgi membrane  Golgi cisterna membrane  extracellular exosome  sialylation  
Ontology : EGO-EBIGolgi membrane  beta-galactoside (CMP) alpha-2,3-sialyltransferase activity  beta-galactoside (CMP) alpha-2,3-sialyltransferase activity  beta-galactoside (CMP) alpha-2,3-sialyltransferase activity  N-acetylneuraminate metabolic process  cellular protein modification process  protein phosphorylation  protein N-linked glycosylation  oligosaccharide metabolic process  membrane  O-glycan processing  keratan sulfate biosynthetic process  protein N-linked glycosylation via asparagine  integral component of Golgi membrane  Golgi cisterna membrane  extracellular exosome  sialylation  
Pathways : KEGGMucin type O-Glycan biosynthesis    Glycosaminoglycan biosynthesis - keratan sulfate    Glycosphingolipid biosynthesis - globo series    Glycosphingolipid biosynthesis - ganglio series   
NDEx NetworkST3GAL1
Atlas of Cancer Signalling NetworkST3GAL1
Wikipedia pathwaysST3GAL1
Orthology - Evolution
OrthoDB6482
GeneTree (enSembl)ENSG00000008513
Phylogenetic Trees/Animal Genes : TreeFamST3GAL1
HOVERGENQ11201
HOGENOMQ11201
Homologs : HomoloGeneST3GAL1
Homology/Alignments : Family Browser (UCSC)ST3GAL1
Gene fusions - Rearrangements
Fusion : MitelmanMTSS1/ST3GAL1 [8q24.13/8q24.22]  [t(8;8)(q24;q24)]  
Fusion : MitelmanNDRG1/ST3GAL1 [8q24.22/8q24.22]  [t(8;8)(q24;q24)]  
Fusion : MitelmanST3GAL1/COL22A1 [8q24.22/8q24.23]  [t(8;8)(q24;q24)]  
Fusion: TCGA_MDACCMTSS1 8q24.13 ST3GAL1 8q24.22 BRCA
Fusion: TCGA_MDACCNDRG1 8q24.22 ST3GAL1 8q24.22 KIRC
Fusion: TCGA_MDACCST3GAL1 8q24.22 COL22A1 8q24.23 BRCA
Tumor Fusion PortalST3GAL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerST3GAL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ST3GAL1
dbVarST3GAL1
ClinVarST3GAL1
1000_GenomesST3GAL1 
Exome Variant ServerST3GAL1
ExAC (Exome Aggregation Consortium)ENSG00000008513
GNOMAD BrowserENSG00000008513
Genetic variants : HAPMAP6482
Genomic Variants (DGV)ST3GAL1 [DGVbeta]
DECIPHERST3GAL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisST3GAL1 
Mutations
ICGC Data PortalST3GAL1 
TCGA Data PortalST3GAL1 
Broad Tumor PortalST3GAL1
OASIS PortalST3GAL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICST3GAL1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDST3GAL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ST3GAL1
DgiDB (Drug Gene Interaction Database)ST3GAL1
DoCM (Curated mutations)ST3GAL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ST3GAL1 (select a term)
intoGenST3GAL1
Cancer3DST3GAL1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607187   
Orphanet
DisGeNETST3GAL1
MedgenST3GAL1
Genetic Testing Registry ST3GAL1
NextProtQ11201 [Medical]
TSGene6482
GENETestsST3GAL1
Target ValidationST3GAL1
Huge Navigator ST3GAL1 [HugePedia]
snp3D : Map Gene to Disease6482
BioCentury BCIQST3GAL1
ClinGenST3GAL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6482
Chemical/Pharm GKB GenePA35764
Clinical trialST3GAL1
Miscellaneous
canSAR (ICR)ST3GAL1 (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineST3GAL1
EVEXST3GAL1
GoPubMedST3GAL1
iHOPST3GAL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:36:48 CET 2017

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