ST6GAL2 (ST6 beta-galactoside alpha-2,6-sialyltransferase 2)

2014-11-01  

Identity

HGNC
ST6GAL2
LOCATION
2q12.3
LOCUSID
84620
ALIAS
SIAT2,ST6GalII
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84620
MIM: 608472
HGNC: 10861
Ensembl: ENSG00000144057

Variants:

dbSNP: 84620
ClinVar: 84620
TCGA: ENSG00000144057
COSMIC: ST6GAL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144057ENST00000361686Q96JF0
ENSG00000144057ENST00000361803H7BY52
ENSG00000144057ENST00000409087Q96JF0
ENSG00000144057ENST00000409382Q96JF0
ENSG00000144057ENST00000419159C9JIK2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
N-Glycan biosynthesisKEGGko00510
Other types of O-glycan biosynthesisKEGGko00514
N-Glycan biosynthesisKEGGhsa00510
Other types of O-glycan biosynthesisKEGGhsa00514
Metabolic pathwaysKEGGhsa01100
N-glycan biosynthesis, complex typeKEGGhsa_M00075
N-glycan biosynthesis, complex typeKEGGM00075
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinREACTOMER-HSA-446193
Synthesis of substrates in N-glycan biosythesisREACTOMER-HSA-446219
Sialic acid metabolismREACTOMER-HSA-4085001

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
198502832010Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches.27
126033282003Identification and functional expression of a second human beta-galactoside alpha2,6-sialyltransferase, ST6Gal II.16
197685372010Transcriptional regulation of the human ST6GAL2 gene in cerebral cortex and neuronal cells.15
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12

Citation

Dessen P

ST6GAL2 (ST6 beta-galactoside alpha-2,6-sialyltransferase 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74270/st6gal2