Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ST8SIA1 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1)

Identity

Alias (NCBI)GD3S
SIAT8
SIAT8-A
SIAT8A
ST8SiaI
HGNC (Hugo) ST8SIA1
HGNC Alias nameST8Sia I
HGNC Previous nameSIAT8
 SIAT8A
HGNC Previous namesialyltransferase 8 (alpha-N-acetylneuraminate: alpha-2,8-sialytransferase, GD3 synthase) A
 ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 1
LocusID (NCBI) 6489
Atlas_Id 45520
Location 12p12.1  [Link to chromosome band 12p12]
Location_base_pair Starts at 22193391 and ends at 22334714 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CARMN (5q32)::ST8SIA1 (12p12.1)MRPL11 (11q13.2)::ST8SIA1 (12p12.1)RAD51AP1 (12p13.32)::ST8SIA1 (12p12.1)
ST8SIA1 (12p12.1)::LMNTD1 (12p12.1)ST8SIA1 (12p12.1)::ST8SIA1 (12p12.1)MRPL11 11q13.2::ST8SIA1 12p12.1
RAD51AP1 12p13.32::ST8SIA1 12p12.1ST8SIA1 12p12.1 IFLTD1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ST8SIA1   10869
Cards
Entrez_Gene (NCBI)ST8SIA1    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
AliasesGD3S; SIAT8; SIAT8-A; SIAT8A; 
ST8SiaI
GeneCards (Weizmann)ST8SIA1
Ensembl hg19 (Hinxton)ENSG00000111728 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111728 [Gene_View]  ENSG00000111728 [Sequence]  chr12:22193391-22334714 [Contig_View]  ST8SIA1 [Vega]
ICGC DataPortalENSG00000111728
TCGA cBioPortalST8SIA1
AceView (NCBI)ST8SIA1
Genatlas (Paris)ST8SIA1
SOURCE (Princeton)ST8SIA1
Genetics Home Reference (NIH)ST8SIA1
Genomic and cartography
GoldenPath hg38 (UCSC)ST8SIA1  -     chr12:22193391-22334714 -  12p12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ST8SIA1  -     12p12.1   [Description]    (hg19-Feb_2009)
GoldenPathST8SIA1 - 12p12.1 [CytoView hg19]  ST8SIA1 - 12p12.1 [CytoView hg38]
ImmunoBaseENSG00000111728
Genome Data Viewer NCBIST8SIA1 [Mapview hg19]  
OMIM601123   
Gene and transcription
Genbank (Entrez)AF088002 AK290941 AK297310 AK315340 AY569975
RefSeq transcript (Entrez)NM_001304450 NM_003034
Consensus coding sequences : CCDS (NCBI)ST8SIA1
Gene ExpressionST8SIA1 [ NCBI-GEO ]   ST8SIA1 [ EBI - ARRAY_EXPRESS ]   ST8SIA1 [ SEEK ]   ST8SIA1 [ MEM ]
Gene Expression Viewer (FireBrowse)ST8SIA1 [ Firebrowse - Broad ]
GenevisibleExpression of ST8SIA1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6489
GTEX Portal (Tissue expression)ST8SIA1
Human Protein AtlasENSG00000111728-ST8SIA1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92185   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92185  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92185
PhosPhoSitePlusQ92185
Domains : Interpro (EBI)Glyco_trans_29    GT29-like_sf    Sialyl_trans   
Domain families : Pfam (Sanger)Glyco_transf_29 (PF00777)   
Domain families : Pfam (NCBI)pfam00777   
Conserved Domain (NCBI)ST8SIA1
SuperfamilyQ92185
AlphaFold pdb e-kbQ92185   
Human Protein Atlas [tissue]ENSG00000111728-ST8SIA1 [tissue]
HPRD03078
Protein Interaction databases
DIP (DOE-UCLA)Q92185
IntAct (EBI)Q92185
BioGRIDST8SIA1
STRING (EMBL)ST8SIA1
ZODIACST8SIA1
Ontologies - Pathways
QuickGOQ92185
Ontology : AmiGOGolgi membrane  alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity  alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity  alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity  protein binding  carbohydrate metabolic process  protein glycosylation  protein glycosylation  N-glycan processing  glycosphingolipid biosynthetic process  positive regulation of cell population proliferation  sialyltransferase activity  oligosaccharide metabolic process  integral component of membrane  cellular response to heat  sialylation  
Ontology : EGO-EBIGolgi membrane  alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity  alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity  alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity  protein binding  carbohydrate metabolic process  protein glycosylation  protein glycosylation  N-glycan processing  glycosphingolipid biosynthetic process  positive regulation of cell population proliferation  sialyltransferase activity  oligosaccharide metabolic process  integral component of membrane  cellular response to heat  sialylation  
Pathways : KEGGKEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES    KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES    KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES   
NDEx NetworkST8SIA1
Atlas of Cancer Signalling NetworkST8SIA1
Wikipedia pathwaysST8SIA1
Orthology - Evolution
OrthoDB6489
GeneTree (enSembl)ENSG00000111728
Phylogenetic Trees/Animal Genes : TreeFamST8SIA1
Homologs : HomoloGeneST8SIA1
Homology/Alignments : Family Browser (UCSC)ST8SIA1
Gene fusions - Rearrangements
Fusion : MitelmanMRPL11::ST8SIA1 [11q13.2/12p12.1]  
Fusion : MitelmanRAD51AP1::ST8SIA1 [12p13.32/12p12.1]  
Fusion : MitelmanST8SIA1::LMNTD1 [12p12.1/12p12.1]  
Fusion : QuiverST8SIA1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerST8SIA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ST8SIA1
dbVarST8SIA1
ClinVarST8SIA1
MonarchST8SIA1
1000_GenomesST8SIA1 
Exome Variant ServerST8SIA1
GNOMAD BrowserENSG00000111728
Varsome BrowserST8SIA1
ACMGST8SIA1 variants
VarityQ92185
Genomic Variants (DGV)ST8SIA1 [DGVbeta]
DECIPHERST8SIA1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisST8SIA1 
Mutations
ICGC Data PortalST8SIA1 
TCGA Data PortalST8SIA1 
Broad Tumor PortalST8SIA1
OASIS PortalST8SIA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICST8SIA1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DST8SIA1
Mutations and Diseases : HGMDST8SIA1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaST8SIA1
DgiDB (Drug Gene Interaction Database)ST8SIA1
DoCM (Curated mutations)ST8SIA1
CIViC (Clinical Interpretations of Variants in Cancer)ST8SIA1
Cancer3DST8SIA1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601123   
Orphanet
DisGeNETST8SIA1
MedgenST8SIA1
Genetic Testing Registry ST8SIA1
NextProtQ92185 [Medical]
GENETestsST8SIA1
Target ValidationST8SIA1
Huge Navigator ST8SIA1 [HugePedia]
ClinGenST8SIA1
Clinical trials, drugs, therapy
MyCancerGenomeST8SIA1
Protein Interactions : CTDST8SIA1
Pharm GKB GenePA35770
PharosQ92185
Clinical trialST8SIA1
Miscellaneous
canSAR (ICR)ST8SIA1
HarmonizomeST8SIA1
ARCHS4ST8SIA1
DataMed IndexST8SIA1
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXST8SIA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 13:01:08 CET 2022

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