STAG1 (stromal antigen 1)

2007-02-01  

Identity

HGNC
LOCATION
3q22.3
LOCUSID
ALIAS
MRD47,SA1,SCC3A
FUSION GENES

Other Information

Locus ID:

NCBI: 10274
MIM: 604358
HGNC: 11354
Ensembl: ENSG00000118007

Variants:

dbSNP: 10274
ClinVar: 10274
TCGA: ENSG00000118007
COSMIC: STAG1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118007ENST00000236698Q8WVM7
ENSG00000118007ENST00000383202Q8WVM7
ENSG00000118007ENST00000434713Q68DW7
ENSG00000118007ENST00000480733C9JJQ0
ENSG00000118007ENST00000483235F8WF82
ENSG00000118007ENST00000487065F8WCB3
ENSG00000118007ENST00000492318H7C595
ENSG00000118007ENST00000629124F8WCB3

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Cell cycleKEGGhsa04110
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA damage response and repair proteinsREACTOMER-HSA-3108214
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
S PhaseREACTOMER-HSA-69242
Establishment of Sister Chromatid CohesionREACTOMER-HSA-2468052
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Mitotic Telophase/CytokinesisREACTOMER-HSA-68884
Cohesin Loading onto ChromatinREACTOMER-HSA-2470946
MeiosisREACTOMER-HSA-1500620
Meiotic synapsisREACTOMER-HSA-1221632

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
185508112008CTCF physically links cohesin to chromatin.238
199362222009Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.151
198226712009Differential regulation of telomere and centromere cohesion by the Scc3 homologues SA1 and SA2, respectively, in human cells.73
243354982014Mutations in the cohesin complex in acute myeloid leukemia: clinical and prognostic implications.44
243240082014Distinct functions of human cohesin-SA1 and cohesin-SA2 in double-strand break repair.24
286919042017Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts.19
153618412004Identification of STAG1 as a key mediator of a p53-dependent apoptotic pathway.16
238749612013Characterization of the interaction between the cohesin subunits Rad21 and SA1/2.16
284305772017Synthetic lethal interaction between the tumour suppressor STAG2 and its paralog STAG1.13
272982592016Functional interplay between SA1 and TRF1 in telomeric DNA binding and DNA-DNA pairing.11

Citation

Dessen P

STAG1 (stromal antigen 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45894/stag1