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STAM2 (signal transducing adaptor molecule 2)

Identity

Alias_namessignal transducing adaptor molecule (SH3 domain and ITAM motif) 2
Alias_symbol (synonym)Hbp
Other aliasSTAM2A
STAM2B
HGNC (Hugo) STAM2
LocusID (NCBI) 10254
Atlas_Id 54047
Location 2q23.3  [Link to chromosome band 2q23]
Location_base_pair Starts at 152116801 and ends at 152175992 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
LARP4B (10p15.3) / STAM2 (2q23.3)STAM2 (2q23.3) / NOSTRIN (2q24.3)STAM2 (2q23.3) / THSD7B (2q22.1)
STAM2 2q23.3 / NOSTRIN 2q24.3STAM2 2q23.3 / THSD7B 2q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)STAM2   11358
Cards
Entrez_Gene (NCBI)STAM2  10254  signal transducing adaptor molecule 2
AliasesHbp; STAM2A; STAM2B
GeneCards (Weizmann)STAM2
Ensembl hg19 (Hinxton)ENSG00000115145 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115145 [Gene_View]  chr2:152116801-152175992 [Contig_View]  STAM2 [Vega]
ICGC DataPortalENSG00000115145
TCGA cBioPortalSTAM2
AceView (NCBI)STAM2
Genatlas (Paris)STAM2
WikiGenes10254
SOURCE (Princeton)STAM2
Genetics Home Reference (NIH)STAM2
Genomic and cartography
GoldenPath hg38 (UCSC)STAM2  -     chr2:152116801-152175992 -  2q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)STAM2  -     2q23.3   [Description]    (hg19-Feb_2009)
EnsemblSTAM2 - 2q23.3 [CytoView hg19]  STAM2 - 2q23.3 [CytoView hg38]
Mapping of homologs : NCBISTAM2 [Mapview hg19]  STAM2 [Mapview hg38]
OMIM606244   
Gene and transcription
Genbank (Entrez)AF042273 AF042274 AK023490 AK292265 AK292847
RefSeq transcript (Entrez)NM_005843
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)STAM2
Cluster EST : UnigeneHs.17200 [ NCBI ]
CGAP (NCI)Hs.17200
Alternative Splicing GalleryENSG00000115145
Gene ExpressionSTAM2 [ NCBI-GEO ]   STAM2 [ EBI - ARRAY_EXPRESS ]   STAM2 [ SEEK ]   STAM2 [ MEM ]
Gene Expression Viewer (FireBrowse)STAM2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10254
GTEX Portal (Tissue expression)STAM2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75886   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75886  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75886
Splice isoforms : SwissVarO75886
PhosPhoSitePlusO75886
Domaine pattern : Prosite (Expaxy)SH3 (PS50002)    UIM (PS50330)    VHS (PS50179)   
Domains : Interpro (EBI)ENTH_VHS    SH3_domain    UIM_dom    VHS_dom   
Domain families : Pfam (Sanger)SH3_1 (PF00018)    UIM (PF02809)    VHS (PF00790)   
Domain families : Pfam (NCBI)pfam00018    pfam02809    pfam00790   
Domain families : Smart (EMBL)SH3 (SM00326)  UIM (SM00726)  VHS (SM00288)  
Conserved Domain (NCBI)STAM2
DMDM Disease mutations10254
Blocks (Seattle)STAM2
PDB (SRS)1X2Q    1X5B    2L0T    5CRV    5IXF   
PDB (PDBSum)1X2Q    1X5B    2L0T    5CRV    5IXF   
PDB (IMB)1X2Q    1X5B    2L0T    5CRV    5IXF   
PDB (RSDB)1X2Q    1X5B    2L0T    5CRV    5IXF   
Structural Biology KnowledgeBase1X2Q    1X5B    2L0T    5CRV    5IXF   
SCOP (Structural Classification of Proteins)1X2Q    1X5B    2L0T    5CRV    5IXF   
CATH (Classification of proteins structures)1X2Q    1X5B    2L0T    5CRV    5IXF   
SuperfamilyO75886
Human Protein AtlasENSG00000115145
Peptide AtlasO75886
HPRD05876
IPIIPI00290542   IPI00607771   
Protein Interaction databases
DIP (DOE-UCLA)O75886
IntAct (EBI)O75886
FunCoupENSG00000115145
BioGRIDSTAM2
STRING (EMBL)STAM2
ZODIACSTAM2
Ontologies - Pathways
QuickGOO75886
Ontology : AmiGOprotein binding  nucleoplasm  cytoplasm  cytosol  cytosol  intracellular protein transport  endosomal transport  macroautophagy  protein deubiquitination  early endosome membrane  ESCRT-0 complex  multivesicular body assembly  negative regulation of epidermal growth factor receptor signaling pathway  intracellular membrane-bounded organelle  membrane organization  
Ontology : EGO-EBIprotein binding  nucleoplasm  cytoplasm  cytosol  cytosol  intracellular protein transport  endosomal transport  macroautophagy  protein deubiquitination  early endosome membrane  ESCRT-0 complex  multivesicular body assembly  negative regulation of epidermal growth factor receptor signaling pathway  intracellular membrane-bounded organelle  membrane organization  
Pathways : KEGGEndocytosis    Jak-STAT signaling pathway   
NDEx NetworkSTAM2
Atlas of Cancer Signalling NetworkSTAM2
Wikipedia pathwaysSTAM2
Orthology - Evolution
OrthoDB10254
GeneTree (enSembl)ENSG00000115145
Phylogenetic Trees/Animal Genes : TreeFamSTAM2
HOVERGENO75886
HOGENOMO75886
Homologs : HomoloGeneSTAM2
Homology/Alignments : Family Browser (UCSC)STAM2
Gene fusions - Rearrangements
Fusion : MitelmanSTAM2/NOSTRIN [2q23.3/2q24.3]  
Fusion : MitelmanSTAM2/THSD7B [2q23.3/2q22.1]  [t(2;2)(q22;q23)]  
Fusion: TCGASTAM2 2q23.3 NOSTRIN 2q24.3 BLCA
Fusion: TCGASTAM2 2q23.3 THSD7B 2q22.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTAM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STAM2
dbVarSTAM2
ClinVarSTAM2
1000_GenomesSTAM2 
Exome Variant ServerSTAM2
ExAC (Exome Aggregation Consortium)STAM2 (select the gene name)
Genetic variants : HAPMAP10254
Genomic Variants (DGV)STAM2 [DGVbeta]
DECIPHERSTAM2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSTAM2 
Mutations
ICGC Data PortalSTAM2 
TCGA Data PortalSTAM2 
Broad Tumor PortalSTAM2
OASIS PortalSTAM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTAM2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSTAM2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch STAM2
DgiDB (Drug Gene Interaction Database)STAM2
DoCM (Curated mutations)STAM2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)STAM2 (select a term)
intoGenSTAM2
Cancer3DSTAM2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606244   
Orphanet
MedgenSTAM2
Genetic Testing Registry STAM2
NextProtO75886 [Medical]
TSGene10254
GENETestsSTAM2
Target ValidationSTAM2
Huge Navigator STAM2 [HugePedia]
snp3D : Map Gene to Disease10254
BioCentury BCIQSTAM2
ClinGenSTAM2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10254
Chemical/Pharm GKB GenePA36180
Clinical trialSTAM2
Miscellaneous
canSAR (ICR)STAM2 (select the gene name)
Probes
Litterature
PubMed70 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSTAM2
EVEXSTAM2
GoPubMedSTAM2
iHOPSTAM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Aug 1 17:15:55 CEST 2017

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