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STAP1 (signal transducing adaptor family member 1)

Identity

Alias (NCBI)BRDG1
STAP-1
HGNC (Hugo) STAP1
HGNC Alias symbSTAP-1
BRDG1
HGNC Alias nameBCR downstream signaling 1
LocusID (NCBI) 26228
Atlas_Id 838
Location 4q13.2  [Link to chromosome band 4q13]
Location_base_pair Starts at 67558727 and ends at 67607337 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ELMO2 (20q13.12) / STAP1 (4q13.2)UBA6 (4q13.2) / STAP1 (4q13.2)ELMO2 20q13.12 / STAP1 4q13.2
UBA6 4q13.2 / STAP1 4q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)STAP1   24133
Cards
Entrez_Gene (NCBI)STAP1    signal transducing adaptor family member 1
AliasesBRDG1; STAP-1
GeneCards (Weizmann)STAP1
Ensembl hg19 (Hinxton)ENSG00000035720 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000035720 [Gene_View]  ENSG00000035720 [Sequence]  chr4:67558727-67607337 [Contig_View]  STAP1 [Vega]
ICGC DataPortalENSG00000035720
TCGA cBioPortalSTAP1
AceView (NCBI)STAP1
Genatlas (Paris)STAP1
SOURCE (Princeton)STAP1
Genetics Home Reference (NIH)STAP1
Genomic and cartography
GoldenPath hg38 (UCSC)STAP1  -     chr4:67558727-67607337 +  4q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)STAP1  -     4q13.2   [Description]    (hg19-Feb_2009)
GoldenPathSTAP1 - 4q13.2 [CytoView hg19]  STAP1 - 4q13.2 [CytoView hg38]
ImmunoBaseENSG00000035720
Genome Data Viewer NCBISTAP1 [Mapview hg19]  
OMIM604298   
Gene and transcription
Genbank (Entrez)AB023483 AI289185 AK313676 BC014958 BE326685
RefSeq transcript (Entrez)NM_001317769 NM_012108
Consensus coding sequences : CCDS (NCBI)STAP1
Gene ExpressionSTAP1 [ NCBI-GEO ]   STAP1 [ EBI - ARRAY_EXPRESS ]   STAP1 [ SEEK ]   STAP1 [ MEM ]
Gene Expression Viewer (FireBrowse)STAP1 [ Firebrowse - Broad ]
GenevisibleExpression of STAP1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26228
GTEX Portal (Tissue expression)STAP1
Human Protein AtlasENSG00000035720-STAP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9ULZ2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9ULZ2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9ULZ2
PhosPhoSitePlusQ9ULZ2
Domaine pattern : Prosite (Expaxy)PH_DOMAIN (PS50003)    SH2 (PS50001)   
Domains : Interpro (EBI)PH-like_dom_sf    PH_domain    SH2    SH2_dom_sf    STAP1/STAP2    STAP1_SH2   
Domain families : Pfam (Sanger)PH (PF00169)    SH2 (PF00017)   
Domain families : Pfam (NCBI)pfam00169    pfam00017   
Domain families : Smart (EMBL)PH (SM00233)  SH2 (SM00252)  
Conserved Domain (NCBI)STAP1
PDB (RSDB)1X1F    3MAZ   
PDB Europe1X1F    3MAZ   
PDB (PDBSum)1X1F    3MAZ   
PDB (IMB)1X1F    3MAZ   
Structural Biology KnowledgeBase1X1F    3MAZ   
SCOP (Structural Classification of Proteins)1X1F    3MAZ   
CATH (Classification of proteins structures)1X1F    3MAZ   
SuperfamilyQ9ULZ2
AlphaFold pdb e-kbQ9ULZ2   
Human Protein Atlas [tissue]ENSG00000035720-STAP1 [tissue]
HPRD16053
Protein Interaction databases
DIP (DOE-UCLA)Q9ULZ2
IntAct (EBI)Q9ULZ2
BioGRIDSTAP1
STRING (EMBL)STAP1
ZODIACSTAP1
Ontologies - Pathways
QuickGOQ9ULZ2
Ontology : AmiGOphosphotyrosine residue binding  transmembrane receptor protein tyrosine kinase adaptor activity  macrophage colony-stimulating factor receptor binding  protein binding  phospholipid binding  nucleus  nucleoplasm  cytoplasm  mitochondrion  transmembrane receptor protein tyrosine kinase signaling pathway  transmembrane receptor protein tyrosine kinase signaling pathway  positive regulation of gene expression  negative regulation of macrophage chemotaxis  protein kinase binding  protein kinase binding  protein-containing complex  signaling adaptor activity  signaling adaptor activity  negative regulation of phosphorylation  intracellular membrane-bounded organelle  positive regulation of B cell receptor signaling pathway  positive regulation of B cell receptor signaling pathway  positive regulation of phagocytosis, engulfment  cellular response to lipopolysaccharide  negative regulation of ruffle assembly  negative regulation of macrophage colony-stimulating factor signaling pathway  positive regulation of microglial cell activation  positive regulation of non-membrane spanning protein tyrosine kinase activity  negative regulation of microglial cell migration  positive regulation of microglial cell mediated cytotoxicity  positive regulation of actin cytoskeleton reorganization  
Ontology : EGO-EBIphosphotyrosine residue binding  transmembrane receptor protein tyrosine kinase adaptor activity  macrophage colony-stimulating factor receptor binding  protein binding  phospholipid binding  nucleus  nucleoplasm  cytoplasm  mitochondrion  transmembrane receptor protein tyrosine kinase signaling pathway  transmembrane receptor protein tyrosine kinase signaling pathway  positive regulation of gene expression  negative regulation of macrophage chemotaxis  protein kinase binding  protein kinase binding  protein-containing complex  signaling adaptor activity  signaling adaptor activity  negative regulation of phosphorylation  intracellular membrane-bounded organelle  positive regulation of B cell receptor signaling pathway  positive regulation of B cell receptor signaling pathway  positive regulation of phagocytosis, engulfment  cellular response to lipopolysaccharide  negative regulation of ruffle assembly  negative regulation of macrophage colony-stimulating factor signaling pathway  positive regulation of microglial cell activation  positive regulation of non-membrane spanning protein tyrosine kinase activity  negative regulation of microglial cell migration  positive regulation of microglial cell mediated cytotoxicity  positive regulation of actin cytoskeleton reorganization  
NDEx NetworkSTAP1
Atlas of Cancer Signalling NetworkSTAP1
Wikipedia pathwaysSTAP1
Orthology - Evolution
OrthoDB26228
GeneTree (enSembl)ENSG00000035720
Phylogenetic Trees/Animal Genes : TreeFamSTAP1
Homologs : HomoloGeneSTAP1
Homology/Alignments : Family Browser (UCSC)STAP1
Gene fusions - Rearrangements
Fusion : MitelmanELMO2/STAP1 [20q13.12/4q13.2]  
Fusion : MitelmanUBA6/STAP1 [4q13.2/4q13.2]  
Fusion : QuiverSTAP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTAP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STAP1
dbVarSTAP1
ClinVarSTAP1
MonarchSTAP1
1000_GenomesSTAP1 
Exome Variant ServerSTAP1
GNOMAD BrowserENSG00000035720
Varsome BrowserSTAP1
ACMGSTAP1 variants
VarityQ9ULZ2
Genomic Variants (DGV)STAP1 [DGVbeta]
DECIPHERSTAP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSTAP1 
Mutations
ICGC Data PortalSTAP1 
TCGA Data PortalSTAP1 
Broad Tumor PortalSTAP1
OASIS PortalSTAP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTAP1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSTAP1
Mutations and Diseases : HGMDSTAP1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSTAP1
DgiDB (Drug Gene Interaction Database)STAP1
DoCM (Curated mutations)STAP1
CIViC (Clinical Interpretations of Variants in Cancer)STAP1
Cancer3DSTAP1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604298   
Orphanet
DisGeNETSTAP1
MedgenSTAP1
Genetic Testing Registry STAP1
NextProtQ9ULZ2 [Medical]
GENETestsSTAP1
Target ValidationSTAP1
Huge Navigator STAP1 [HugePedia]
ClinGenSTAP1
Clinical trials, drugs, therapy
MyCancerGenomeSTAP1
Protein Interactions : CTDSTAP1
Pharm GKB GenePA162404948
PharosQ9ULZ2
Clinical trialSTAP1
Miscellaneous
canSAR (ICR)STAP1
HarmonizomeSTAP1
DataMed IndexSTAP1
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSTAP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:33:30 CEST 2021

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