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STAP1 (signal transducing adaptor family member 1)

Identity

Alias_symbol (synonym)STAP-1
BRDG1
Other alias
HGNC (Hugo) STAP1
LocusID (NCBI) 26228
Atlas_Id 838
Location 4q13.2  [Link to chromosome band 4q13]
Location_base_pair Starts at 68424415 and ends at 68473055 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ELMO2 (20q13.12) / STAP1 (4q13.2)UBA6 (4q13.2) / STAP1 (4q13.2)ELMO2 20q13.12 / STAP1 4q13.2
UBA6 4q13.2 / STAP1 4q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)STAP1   24133
Cards
Entrez_Gene (NCBI)STAP1  26228  signal transducing adaptor family member 1
AliasesBRDG1; STAP-1
GeneCards (Weizmann)STAP1
Ensembl hg19 (Hinxton)ENSG00000035720 [Gene_View]  chr4:68424415-68473055 [Contig_View]  STAP1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000035720 [Gene_View]  chr4:68424415-68473055 [Contig_View]  STAP1 [Vega]
ICGC DataPortalENSG00000035720
TCGA cBioPortalSTAP1
AceView (NCBI)STAP1
Genatlas (Paris)STAP1
WikiGenes26228
SOURCE (Princeton)STAP1
Genetics Home Reference (NIH)STAP1
Genomic and cartography
GoldenPath hg19 (UCSC)STAP1  -     chr4:68424415-68473055 +  4q13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)STAP1  -     4q13.2   [Description]    (hg38-Dec_2013)
EnsemblSTAP1 - 4q13.2 [CytoView hg19]  STAP1 - 4q13.2 [CytoView hg38]
Mapping of homologs : NCBISTAP1 [Mapview hg19]  STAP1 [Mapview hg38]
OMIM604298   
Gene and transcription
Genbank (Entrez)AB023483 AI289185 AK313676 BC014958 BE326685
RefSeq transcript (Entrez)NM_001317769 NM_012108
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)STAP1
Cluster EST : UnigeneHs.435579 [ NCBI ]
CGAP (NCI)Hs.435579
Alternative Splicing GalleryENSG00000035720
Gene ExpressionSTAP1 [ NCBI-GEO ]   STAP1 [ EBI - ARRAY_EXPRESS ]   STAP1 [ SEEK ]   STAP1 [ MEM ]
Gene Expression Viewer (FireBrowse)STAP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26228
GTEX Portal (Tissue expression)STAP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9ULZ2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9ULZ2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9ULZ2
Splice isoforms : SwissVarQ9ULZ2
PhosPhoSitePlusQ9ULZ2
Domaine pattern : Prosite (Expaxy)PH_DOMAIN (PS50003)    SH2 (PS50001)   
Domains : Interpro (EBI)PH_dom-like    PH_domain    SH2   
Domain families : Pfam (Sanger)PH (PF00169)    SH2 (PF00017)   
Domain families : Pfam (NCBI)pfam00169    pfam00017   
Domain families : Smart (EMBL)PH (SM00233)  SH2 (SM00252)  
Conserved Domain (NCBI)STAP1
DMDM Disease mutations26228
Blocks (Seattle)STAP1
PDB (SRS)1X1F    3MAZ   
PDB (PDBSum)1X1F    3MAZ   
PDB (IMB)1X1F    3MAZ   
PDB (RSDB)1X1F    3MAZ   
Structural Biology KnowledgeBase1X1F    3MAZ   
SCOP (Structural Classification of Proteins)1X1F    3MAZ   
CATH (Classification of proteins structures)1X1F    3MAZ   
SuperfamilyQ9ULZ2
Human Protein AtlasENSG00000035720
Peptide AtlasQ9ULZ2
HPRD16053
IPIIPI00015876   
Protein Interaction databases
DIP (DOE-UCLA)Q9ULZ2
IntAct (EBI)Q9ULZ2
FunCoupENSG00000035720
BioGRIDSTAP1
STRING (EMBL)STAP1
ZODIACSTAP1
Ontologies - Pathways
QuickGOQ9ULZ2
Ontology : AmiGOphosphotyrosine binding  transmembrane receptor protein tyrosine kinase adaptor activity  SH3/SH2 adaptor activity  macrophage colony-stimulating factor receptor binding  protein binding  phospholipid binding  nucleus  cytoplasm  mitochondrion  transmembrane receptor protein tyrosine kinase signaling pathway  positive regulation of gene expression  negative regulation of macrophage chemotaxis  protein kinase binding  negative regulation of phosphorylation  protein complex  positive regulation of B cell receptor signaling pathway  positive regulation of phagocytosis, engulfment  cellular response to lipopolysaccharide  negative regulation of ruffle assembly  negative regulation of macrophage colony-stimulating factor signaling pathway  positive regulation of microglial cell activation  positive regulation of non-membrane spanning protein tyrosine kinase activity  negative regulation of microglial cell migration  positive regulation of microglial cell mediated cytotoxicity  positive regulation of actin cytoskeleton reorganization  
Ontology : EGO-EBIphosphotyrosine binding  transmembrane receptor protein tyrosine kinase adaptor activity  SH3/SH2 adaptor activity  macrophage colony-stimulating factor receptor binding  protein binding  phospholipid binding  nucleus  cytoplasm  mitochondrion  transmembrane receptor protein tyrosine kinase signaling pathway  positive regulation of gene expression  negative regulation of macrophage chemotaxis  protein kinase binding  negative regulation of phosphorylation  protein complex  positive regulation of B cell receptor signaling pathway  positive regulation of phagocytosis, engulfment  cellular response to lipopolysaccharide  negative regulation of ruffle assembly  negative regulation of macrophage colony-stimulating factor signaling pathway  positive regulation of microglial cell activation  positive regulation of non-membrane spanning protein tyrosine kinase activity  negative regulation of microglial cell migration  positive regulation of microglial cell mediated cytotoxicity  positive regulation of actin cytoskeleton reorganization  
NDEx NetworkSTAP1
Atlas of Cancer Signalling NetworkSTAP1
Wikipedia pathwaysSTAP1
Orthology - Evolution
OrthoDB26228
GeneTree (enSembl)ENSG00000035720
Phylogenetic Trees/Animal Genes : TreeFamSTAP1
HOVERGENQ9ULZ2
HOGENOMQ9ULZ2
Homologs : HomoloGeneSTAP1
Homology/Alignments : Family Browser (UCSC)STAP1
Gene fusions - Rearrangements
Fusion : MitelmanELMO2/STAP1 [20q13.12/4q13.2]  [t(4;20)(q13;q13)]  
Fusion : MitelmanUBA6/STAP1 [4q13.2/4q13.2]  [t(4;4)(q13;q13)]  
Fusion: TCGAELMO2 20q13.12 STAP1 4q13.2 BRCA
Fusion: TCGAUBA6 4q13.2 STAP1 4q13.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTAP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STAP1
dbVarSTAP1
ClinVarSTAP1
1000_GenomesSTAP1 
Exome Variant ServerSTAP1
ExAC (Exome Aggregation Consortium)STAP1 (select the gene name)
Genetic variants : HAPMAP26228
Genomic Variants (DGV)STAP1 [DGVbeta]
DECIPHER (Syndromes)4:68424415-68473055  ENSG00000035720
CONAN: Copy Number AnalysisSTAP1 
Mutations
ICGC Data PortalSTAP1 
TCGA Data PortalSTAP1 
Broad Tumor PortalSTAP1
OASIS PortalSTAP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTAP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSTAP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch STAP1
DgiDB (Drug Gene Interaction Database)STAP1
DoCM (Curated mutations)STAP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)STAP1 (select a term)
intoGenSTAP1
Cancer3DSTAP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604298   
Orphanet
MedgenSTAP1
Genetic Testing Registry STAP1
NextProtQ9ULZ2 [Medical]
TSGene26228
GENETestsSTAP1
Huge Navigator STAP1 [HugePedia]
snp3D : Map Gene to Disease26228
BioCentury BCIQSTAP1
ClinGenSTAP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26228
Chemical/Pharm GKB GenePA162404948
Clinical trialSTAP1
Miscellaneous
canSAR (ICR)STAP1 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSTAP1
EVEXSTAP1
GoPubMedSTAP1
iHOPSTAP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:21:10 CEST 2017

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