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STAT4 (signal transducer and activator of transcription 4)

Identity

HGNC (Hugo) STAT4
LocusID (NCBI) 6775
Atlas_Id 42430
Location 2q32.2  [Link to chromosome band 2q32]
Location_base_pair Starts at 191894302 and ends at 192016322 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
MYO1B (2q32.3) / STAT4 (2q32.2)STAT1 (2q32.2) / STAT4 (2q32.2)STAT4 (2q32.2) / ACKR3 (2q37.3)
MYO1B 2q32.3 / STAT4 2q32.2STAT4 2q32.2 CXCR7

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)STAT4   11365
Cards
Entrez_Gene (NCBI)STAT4  6775  signal transducer and activator of transcription 4
AliasesSLEB11
GeneCards (Weizmann)STAT4
Ensembl hg19 (Hinxton)ENSG00000138378 [Gene_View]  chr2:191894302-192016322 [Contig_View]  STAT4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000138378 [Gene_View]  chr2:191894302-192016322 [Contig_View]  STAT4 [Vega]
ICGC DataPortalENSG00000138378
TCGA cBioPortalSTAT4
AceView (NCBI)STAT4
Genatlas (Paris)STAT4
WikiGenes6775
SOURCE (Princeton)STAT4
Genetics Home Reference (NIH)STAT4
Genomic and cartography
GoldenPath hg19 (UCSC)STAT4  -     chr2:191894302-192016322 -  2q32.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)STAT4  -     2q32.2   [Description]    (hg38-Dec_2013)
EnsemblSTAT4 - 2q32.2 [CytoView hg19]  STAT4 - 2q32.2 [CytoView hg38]
Mapping of homologs : NCBISTAT4 [Mapview hg19]  STAT4 [Mapview hg38]
OMIM600558   612253   
Gene and transcription
Genbank (Entrez)AB209043 AK299976 AK300868 AK301172 BC016694
RefSeq transcript (Entrez)NM_001243835 NM_003151
RefSeq genomic (Entrez)NC_000002 NC_018913 NG_012852 NT_005403 NW_004929305
Consensus coding sequences : CCDS (NCBI)STAT4
Cluster EST : UnigeneHs.735572 [ NCBI ]
CGAP (NCI)Hs.735572
Alternative Splicing GalleryENSG00000138378
Gene ExpressionSTAT4 [ NCBI-GEO ]   STAT4 [ EBI - ARRAY_EXPRESS ]   STAT4 [ SEEK ]   STAT4 [ MEM ]
Gene Expression Viewer (FireBrowse)STAT4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6775
GTEX Portal (Tissue expression)STAT4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14765   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14765  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14765
Splice isoforms : SwissVarQ14765
PhosPhoSitePlusQ14765
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)   
Domains : Interpro (EBI)EF-hand-dom_pair    p53-like_TF_DNA-bd    SH2    STAT_TF_alpha    STAT_TF_coiled-coil    STAT_TF_DNA-bd    STAT_TF_DNA-bd_sub    STAT_TF_prot_interaction   
Domain families : Pfam (Sanger)SH2 (PF00017)    STAT_alpha (PF01017)    STAT_bind (PF02864)    STAT_int (PF02865)   
Domain families : Pfam (NCBI)pfam00017    pfam01017    pfam02864    pfam02865   
Domain families : Smart (EMBL)SH2 (SM00252)  STAT_int (SM00964)  
Conserved Domain (NCBI)STAT4
DMDM Disease mutations6775
Blocks (Seattle)STAT4
SuperfamilyQ14765
Human Protein AtlasENSG00000138378
Peptide AtlasQ14765
HPRD02779
IPIIPI00000106   IPI00917291   IPI00917010   IPI00917466   IPI00916530   
Protein Interaction databases
DIP (DOE-UCLA)Q14765
IntAct (EBI)Q14765
FunCoupENSG00000138378
BioGRIDSTAT4
STRING (EMBL)STAT4
ZODIACSTAT4
Ontologies - Pathways
QuickGOQ14765
Ontology : AmiGORNA polymerase II regulatory region sequence-specific DNA binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleoplasm  cytoplasm  transcription, DNA-templated  regulation of transcription, DNA-templated  JAK-STAT cascade  
Ontology : EGO-EBIRNA polymerase II regulatory region sequence-specific DNA binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleoplasm  cytoplasm  transcription, DNA-templated  regulation of transcription, DNA-templated  JAK-STAT cascade  
Pathways : BIOCARTAIL12 and Stat4 Dependent Signaling Pathway in Th1 Development [Genes]    NO2-dependent IL 12 Pathway in NK cells [Genes]   
Pathways : KEGGJak-STAT signaling pathway    Hepatitis B    Inflammatory bowel disease (IBD)   
NDEx NetworkSTAT4
Atlas of Cancer Signalling NetworkSTAT4
Wikipedia pathwaysSTAT4
Orthology - Evolution
OrthoDB6775
GeneTree (enSembl)ENSG00000138378
Phylogenetic Trees/Animal Genes : TreeFamSTAT4
HOVERGENQ14765
HOGENOMQ14765
Homologs : HomoloGeneSTAT4
Homology/Alignments : Family Browser (UCSC)STAT4
Gene fusions - Rearrangements
Fusion : MitelmanMYO1B/STAT4 [2q32.3/2q32.2]  [t(2;2)(q32;q32)]  
Fusion : MitelmanSTAT4/ACKR3 [2q32.2/2q37.3]  [t(2;2)(q32;q37)]  
Fusion: TCGAMYO1B 2q32.3 STAT4 2q32.2 HNSC
Fusion: TCGASTAT4 2q32.2 CXCR7 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTAT4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STAT4
dbVarSTAT4
ClinVarSTAT4
1000_GenomesSTAT4 
Exome Variant ServerSTAT4
ExAC (Exome Aggregation Consortium)STAT4 (select the gene name)
Genetic variants : HAPMAP6775
Genomic Variants (DGV)STAT4 [DGVbeta]
DECIPHER (Syndromes)2:191894302-192016322  ENSG00000138378
CONAN: Copy Number AnalysisSTAT4 
Mutations
ICGC Data PortalSTAT4 
TCGA Data PortalSTAT4 
Broad Tumor PortalSTAT4
OASIS PortalSTAT4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTAT4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSTAT4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch STAT4
DgiDB (Drug Gene Interaction Database)STAT4
DoCM (Curated mutations)STAT4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)STAT4 (select a term)
intoGenSTAT4
Cancer3DSTAT4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600558    612253   
Orphanet703    11710    11709    12394   
MedgenSTAT4
Genetic Testing Registry STAT4
NextProtQ14765 [Medical]
TSGene6775
GENETestsSTAT4
Huge Navigator STAT4 [HugePedia]
snp3D : Map Gene to Disease6775
BioCentury BCIQSTAT4
ClinGenSTAT4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6775
Chemical/Pharm GKB GenePA36185
Clinical trialSTAT4
Miscellaneous
canSAR (ICR)STAT4 (select the gene name)
Probes
Litterature
PubMed201 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSTAT4
EVEXSTAT4
GoPubMedSTAT4
iHOPSTAT4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:52:49 CET 2016

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