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STAT4 (signal transducer and activator of transcription 4)

Identity

Alias (NCBI)SLEB11
HGNC (Hugo) STAT4
LocusID (NCBI) 6775
Atlas_Id 42430
Location 2q32.2  [Link to chromosome band 2q32]
Location_base_pair Starts at 191029576 and ends at 191150994 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MYO1B (2q32.3) / STAT4 (2q32.2)STAT1 (2q32.2) / STAT4 (2q32.2)STAT4 (2q32.2) / ACKR3 (2q37.3)
MYO1B 2q32.3 / STAT4 2q32.2STAT4 2q32.2 CXCR7

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)STAT4   11365
Cards
Entrez_Gene (NCBI)STAT4    signal transducer and activator of transcription 4
AliasesSLEB11
GeneCards (Weizmann)STAT4
Ensembl hg19 (Hinxton)ENSG00000138378 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138378 [Gene_View]  ENSG00000138378 [Sequence]  chr2:191029576-191150994 [Contig_View]  STAT4 [Vega]
ICGC DataPortalENSG00000138378
TCGA cBioPortalSTAT4
AceView (NCBI)STAT4
Genatlas (Paris)STAT4
SOURCE (Princeton)STAT4
Genetics Home Reference (NIH)STAT4
Genomic and cartography
GoldenPath hg38 (UCSC)STAT4  -     chr2:191029576-191150994 -  2q32.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)STAT4  -     2q32.2   [Description]    (hg19-Feb_2009)
GoldenPathSTAT4 - 2q32.2 [CytoView hg19]  STAT4 - 2q32.2 [CytoView hg38]
ImmunoBaseENSG00000138378
Genome Data Viewer NCBISTAT4 [Mapview hg19]  
OMIM600558   612253   
Gene and transcription
Genbank (Entrez)AB209043 AK299976 AK300868 AK301172 BC016694
RefSeq transcript (Entrez)NM_001243835 NM_003151
Consensus coding sequences : CCDS (NCBI)STAT4
Gene ExpressionSTAT4 [ NCBI-GEO ]   STAT4 [ EBI - ARRAY_EXPRESS ]   STAT4 [ SEEK ]   STAT4 [ MEM ]
Gene Expression Viewer (FireBrowse)STAT4 [ Firebrowse - Broad ]
GenevisibleExpression of STAT4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6775
GTEX Portal (Tissue expression)STAT4
Human Protein AtlasENSG00000138378-STAT4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14765   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14765  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14765
PhosPhoSitePlusQ14765
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)   
Domains : Interpro (EBI)p53-like_TF_DNA-bd    SH2    SH2_dom_sf    STAT    STAT4    STAT4_SH2    STAT_N_sf    STAT_TF_alpha    STAT_TF_coiled-coil    STAT_TF_DNA-bd    STAT_TF_DNA-bd_N    STAT_TF_prot_interaction   
Domain families : Pfam (Sanger)SH2 (PF00017)    STAT_alpha (PF01017)    STAT_bind (PF02864)    STAT_int (PF02865)   
Domain families : Pfam (NCBI)pfam00017    pfam01017    pfam02864    pfam02865   
Domain families : Smart (EMBL)STAT_int (SM00964)  
Conserved Domain (NCBI)STAT4
SuperfamilyQ14765
AlphaFold pdb e-kbQ14765   
Human Protein Atlas [tissue]ENSG00000138378-STAT4 [tissue]
HPRD02779
Protein Interaction databases
DIP (DOE-UCLA)Q14765
IntAct (EBI)Q14765
BioGRIDSTAT4
STRING (EMBL)STAT4
ZODIACSTAT4
Ontologies - Pathways
QuickGOQ14765
Ontology : AmiGOchromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity  protein binding  nucleoplasm  cytosol  regulation of transcription by RNA polymerase II  defense response  receptor signaling pathway via JAK-STAT  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  interleukin-12-mediated signaling pathway  interleukin-21-mediated signaling pathway  interleukin-23-mediated signaling pathway  regulation of cell population proliferation  identical protein binding  response to peptide hormone  positive regulation of transcription by RNA polymerase II  interleukin-35-mediated signaling pathway  
Ontology : EGO-EBIchromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity  protein binding  nucleoplasm  cytosol  regulation of transcription by RNA polymerase II  defense response  receptor signaling pathway via JAK-STAT  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  interleukin-12-mediated signaling pathway  interleukin-21-mediated signaling pathway  interleukin-23-mediated signaling pathway  regulation of cell population proliferation  identical protein binding  response to peptide hormone  positive regulation of transcription by RNA polymerase II  interleukin-35-mediated signaling pathway  
Pathways : BIOCARTAIL12 and Stat4 Dependent Signaling Pathway in Th1 Development [Genes]    NO2-dependent IL 12 Pathway in NK cells [Genes]   
Pathways : KEGGJak-STAT signaling pathway    Hepatitis B    Inflammatory bowel disease (IBD)   
NDEx NetworkSTAT4
Atlas of Cancer Signalling NetworkSTAT4
Wikipedia pathwaysSTAT4
Orthology - Evolution
OrthoDB6775
GeneTree (enSembl)ENSG00000138378
Phylogenetic Trees/Animal Genes : TreeFamSTAT4
Homologs : HomoloGeneSTAT4
Homology/Alignments : Family Browser (UCSC)STAT4
Gene fusions - Rearrangements
Fusion : MitelmanMYO1B/STAT4 [2q32.3/2q32.2]  
Fusion : MitelmanSTAT4/ACKR3 [2q32.2/2q37.3]  
Fusion : QuiverSTAT4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTAT4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STAT4
dbVarSTAT4
ClinVarSTAT4
MonarchSTAT4
1000_GenomesSTAT4 
Exome Variant ServerSTAT4
GNOMAD BrowserENSG00000138378
Varsome BrowserSTAT4
ACMGSTAT4 variants
VarityQ14765
Genomic Variants (DGV)STAT4 [DGVbeta]
DECIPHERSTAT4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSTAT4 
Mutations
ICGC Data PortalSTAT4 
TCGA Data PortalSTAT4 
Broad Tumor PortalSTAT4
OASIS PortalSTAT4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTAT4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSTAT4
Mutations and Diseases : HGMDSTAT4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSTAT4
DgiDB (Drug Gene Interaction Database)STAT4
DoCM (Curated mutations)STAT4
CIViC (Clinical Interpretations of Variants in Cancer)STAT4
Cancer3DSTAT4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600558    612253   
Orphanet703    11710    11709    12394   
DisGeNETSTAT4
MedgenSTAT4
Genetic Testing Registry STAT4
NextProtQ14765 [Medical]
GENETestsSTAT4
Target ValidationSTAT4
Huge Navigator STAT4 [HugePedia]
ClinGenSTAT4
Clinical trials, drugs, therapy
MyCancerGenomeSTAT4
Protein Interactions : CTDSTAT4
Pharm GKB GenePA36185
Pharm GKB PathwaysPA162356267   
PharosQ14765
Clinical trialSTAT4
Miscellaneous
canSAR (ICR)STAT4
HarmonizomeSTAT4
DataMed IndexSTAT4
Probes
Litterature
PubMed267 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSTAT4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:33:32 CEST 2021

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