STAT4 (signal transducer and activator of transcription 4)

2003-05-01  

Identity

HGNC
LOCATION
2q32.2
LOCUSID
ALIAS
SLEB11
FUSION GENES

Other Information

Locus ID:

NCBI: 6775
MIM: 600558
HGNC: 11365
Ensembl: ENSG00000138378

Variants:

dbSNP: 6775
ClinVar: 6775
TCGA: ENSG00000138378
COSMIC: STAT4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138378ENST00000358470Q14765
ENSG00000138378ENST00000392320Q14765
ENSG00000138378ENST00000409995E9PG69
ENSG00000138378ENST00000413064C9JFG0
ENSG00000138378ENST00000432798C9JM11
ENSG00000138378ENST00000450994E9PBE2
ENSG00000138378ENST00000647167A0A2R8Y693

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Jak-STAT signaling pathwayKEGGko04630
Jak-STAT signaling pathwayKEGGhsa04630
Hepatitis BKEGGhsa05161
Inflammatory bowel disease (IBD)KEGGhsa05321
Inflammatory bowel disease (IBD)KEGGko05321
JAK-STAT signalingKEGGhsa_M00684
JAK-STAT signalingKEGGM00684
Th1 and Th2 cell differentiationKEGGko04658
Th1 and Th2 cell differentiationKEGGhsa04658

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA134992438CAMK1DGenePathwayassociated
PA24684AKT1GenePathwayassociated
PA24685AKT2GenePathwayassociated
PA24686AKT3GenePathwayassociated
PA248NFKB1GenePathwayassociated
PA26048CAMK1GenePathwayassociated
PA26049CAMK1GGenePathwayassociated
PA27749ELK1GenePathwayassociated
PA28212FOSGenePathwayassociated
PA283MAPK8GenePathwayassociated
PA296RELAGenePathwayassociated
PA29988JAK1GenePathwayassociated
PA30006JUNGenePathwayassociated
PA30616MAPK1GenePathwayassociated
PA30622MAPK3GenePathwayassociated
PA31353MYCGenePathwayassociated
PA31600NFKB2GenePathwayassociated
PA337STAT3GenePathwayassociated
PA33759PRKCAGenePathwayassociated
PA33761PRKCBGenePathwayassociated
PA33766PRKCGGenePathwayassociated
PA338STAT5AGenePathwayassociated
PA36042SP1GenePathwayassociated
PA36183STAT1GenePathwayassociated
PA36184STAT2GenePathwayassociated
PA36186STAT5BGenePathwayassociated
PA443434Arthritis, RheumatoidDiseaseClinicalAnnotationassociatedPD
PA449515etanerceptChemicalClinicalAnnotationassociatedPD
PA90CAMK2AGenePathwayassociated
PA91CAMK2BGenePathwayassociated
PA92CAMK2DGenePathwayassociated
PA93CAMK2GGenePathwayassociated

References

Pubmed IDYearTitleCitations
182044462008Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.488
198381932009Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.332
178048422007STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus.313
178048422007STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus.313
203831472010Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus.125
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
191091312009Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-alpha in lupus patients in vivo.92
232423682013Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma.86
191105362009Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus.82
185795782008A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5.64

Citation

Dessen P

STAT4 (signal transducer and activator of transcription 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42430/stat4