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STAT4 (signal transducer and activator of transcription 4)

Identity

Other namesSLEB11
HGNC (Hugo) STAT4
LocusID (NCBI) 6775
Location 2q32.2
Location_base_pair Starts at 191894302 and ends at 192016322 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)STAT4   11365
Cards
Entrez_Gene (NCBI)STAT4  6775  signal transducer and activator of transcription 4
GeneCards (Weizmann)STAT4
Ensembl (Hinxton)ENSG00000138378 [Gene_View]  chr2:191894302-192016322 [Contig_View]  STAT4 [Vega]
ICGC DataPortalENSG00000138378
cBioPortalSTAT4
AceView (NCBI)STAT4
Genatlas (Paris)STAT4
WikiGenes6775
SOURCE (Princeton)NM_001243835 NM_003151
Genomic and cartography
GoldenPath (UCSC)STAT4  -  2q32.2   chr2:191894302-192016322 -  2q32.2   [Description]    (hg19-Feb_2009)
EnsemblSTAT4 - 2q32.2 [CytoView]
Mapping of homologs : NCBISTAT4 [Mapview]
OMIM600558   612253   
Gene and transcription
Genbank (Entrez)AB209043 AK299976 AK300868 AK301172 BC016694
RefSeq transcript (Entrez)NM_001243835 NM_003151
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NG_012852 NT_005403 NW_001838863 NW_004929305
Consensus coding sequences : CCDS (NCBI)STAT4
Cluster EST : UnigeneHs.735572 [ NCBI ]
CGAP (NCI)Hs.735572
Alternative Splicing : Fast-db (Paris)GSHG0018232
Alternative Splicing GalleryENSG00000138378
Gene ExpressionSTAT4 [ NCBI-GEO ]     STAT4 [ SEEK ]   STAT4 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14765 (Uniprot)
NextProtQ14765  [Medical]
With graphics : InterProQ14765
Splice isoforms : SwissVarQ14765 (Swissvar)
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)   
Domains : Interpro (EBI)EF-hand-dom_pair [organisation]   p53-like_TF_DNA-bd [organisation]   SH2 [organisation]   STAT [organisation]   STAT_TF_alpha [organisation]   STAT_TF_coiled-coil [organisation]   STAT_TF_DNA-bd [organisation]   STAT_TF_DNA-bd_sub [organisation]   STAT_TF_prot_interaction [organisation]  
Related proteins : CluSTrQ14765
Domain families : Pfam (Sanger)SH2 (PF00017)    STAT_alpha (PF01017)    STAT_bind (PF02864)    STAT_int (PF02865)   
Domain families : Pfam (NCBI)pfam00017    pfam01017    pfam02864    pfam02865   
Domain families : Smart (EMBL)SH2 (SM00252)  STAT_int (SM00964)  
DMDM Disease mutations6775
Blocks (Seattle)Q14765
Human Protein AtlasENSG00000138378 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ14765
HPRD02779
IPIIPI00000106   IPI00917291   IPI00917010   IPI00917466   IPI00916530   
Protein Interaction databases
DIP (DOE-UCLA)Q14765
IntAct (EBI)Q14765
FunCoupENSG00000138378
BioGRIDSTAT4
InParanoidQ14765
Interologous Interaction database Q14765
IntegromeDBSTAT4
STRING (EMBL)STAT4
Ontologies - Pathways
Ontology : AmiGOsequence-specific DNA binding transcription factor activity  signal transducer activity  calcium ion binding  nucleus  nucleolus  cytoplasm  transcription, DNA-templated  protein phosphorylation  JAK-STAT cascade  cell proliferation  cytokine-mediated signaling pathway  sequence-specific DNA binding  positive regulation of transcription from RNA polymerase II promoter  
Ontology : EGO-EBIsequence-specific DNA binding transcription factor activity  signal transducer activity  calcium ion binding  nucleus  nucleolus  cytoplasm  transcription, DNA-templated  protein phosphorylation  JAK-STAT cascade  cell proliferation  cytokine-mediated signaling pathway  sequence-specific DNA binding  positive regulation of transcription from RNA polymerase II promoter  
Pathways : BIOCARTAIL12 and Stat4 Dependent Signaling Pathway in Th1 Development [Genes]    NO2-dependent IL 12 Pathway in NK cells [Genes]   
Pathways : KEGGJak-STAT signaling pathway    Hepatitis B    Inflammatory bowel disease (IBD)   
Protein Interaction DatabaseSTAT4
Wikipedia pathwaysSTAT4
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)STAT4
snp3D : Map Gene to Disease6775
SNP (GeneSNP Utah)STAT4
SNP : HGBaseSTAT4
Genetic variants : HAPMAPSTAT4
Exome VariantSTAT4
1000_GenomesSTAT4 
ICGC programENSG00000138378 
Somatic Mutations in Cancer : COSMICSTAT4 
CONAN: Copy Number AnalysisSTAT4 
Mutations and Diseases : HGMDSTAT4
Genomic VariantsSTAT4  STAT4 [DGVbeta]
dbVarSTAT4
ClinVarSTAT4
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM600558    612253   
MedgenSTAT4
GENETestsSTAT4
Disease Genetic AssociationSTAT4
Huge Navigator STAT4 [HugePedia]  STAT4 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneSTAT4
Homology/Alignments : Family Browser (UCSC)STAT4
Phylogenetic Trees/Animal Genes : TreeFamSTAT4
Chemical/Protein Interactions : CTD6775
Chemical/Pharm GKB GenePA36185
Clinical trialSTAT4
Cancer Resource (Charite)ENSG00000138378
Other databases
Probes
Litterature
PubMed171 Pubmed reference(s) in Entrez
CoreMineSTAT4
iHOPSTAT4
OncoSearchSTAT4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jul 26 14:49:03 CEST 2014

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