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STAT5A (signal transducer and activator of transcription 5A)

Identity

Alias_namesSTAT5
Alias_symbol (synonym)MGF
Other alias
HGNC (Hugo) STAT5A
LocusID (NCBI) 6776
Atlas_Id 42431
Location 17q21.2  [Link to chromosome band 17q21]
Location_base_pair Starts at 42287867 and ends at 42311942 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ATP6V0A1 (17q21.2) / STAT5A (17q21.2)MED4 (13q14.2) / STAT5A (17q21.2)RAB40B (17q25.3) / STAT5A (17q21.2)
STAT5A (17q21.2) / ARNTL2 (12p11.23)STAT5A (17q21.2) / BCL6 (3q27.3)STAT5A (17q21.2) / RAB40B (17q25.3)
STAT5A (17q21.2) / RARA (17q21.2)ZNF14 (19p13.11) / STAT5A (17q21.2)ATP6V0A1 17q21.2 / STAT5A 17q21.2
STAT5A 17q21.2 / ARNTL2 12p11.23ZNF14 19p13.11 / STAT5A 17q21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  ins(12;8)(p13;q11q21) ETV6/LYN


External links

Nomenclature
HGNC (Hugo)STAT5A   11366
Cards
Entrez_Gene (NCBI)STAT5A  6776  signal transducer and activator of transcription 5A
AliasesMGF; STAT5
GeneCards (Weizmann)STAT5A
Ensembl hg19 (Hinxton)ENSG00000126561 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000126561 [Gene_View]  chr17:42287867-42311942 [Contig_View]  STAT5A [Vega]
ICGC DataPortalENSG00000126561
TCGA cBioPortalSTAT5A
AceView (NCBI)STAT5A
Genatlas (Paris)STAT5A
WikiGenes6776
SOURCE (Princeton)STAT5A
Genetics Home Reference (NIH)STAT5A
Genomic and cartography
GoldenPath hg38 (UCSC)STAT5A  -     chr17:42287867-42311942 +  17q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)STAT5A  -     17q21.2   [Description]    (hg19-Feb_2009)
EnsemblSTAT5A - 17q21.2 [CytoView hg19]  STAT5A - 17q21.2 [CytoView hg38]
Mapping of homologs : NCBISTAT5A [Mapview hg19]  STAT5A [Mapview hg38]
OMIM601511   
Gene and transcription
Genbank (Entrez)AB208972 AK291650 AK301457 AK310632 AK310713
RefSeq transcript (Entrez)NM_001288718 NM_001288719 NM_001288720 NM_003152
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)STAT5A
Cluster EST : UnigeneHs.437058 [ NCBI ]
CGAP (NCI)Hs.437058
Alternative Splicing GalleryENSG00000126561
Gene ExpressionSTAT5A [ NCBI-GEO ]   STAT5A [ EBI - ARRAY_EXPRESS ]   STAT5A [ SEEK ]   STAT5A [ MEM ]
Gene Expression Viewer (FireBrowse)STAT5A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6776
GTEX Portal (Tissue expression)STAT5A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP42229   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP42229  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP42229
Splice isoforms : SwissVarP42229
PhosPhoSitePlusP42229
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)   
Domains : Interpro (EBI)EF-hand-dom_pair    p53-like_TF_DNA-bd    SH2    STAT    STAT_TF_alpha    STAT_TF_coiled-coil    STAT_TF_DNA-bd    STAT_TF_DNA-bd_sub    STAT_TF_prot_interaction   
Domain families : Pfam (Sanger)SH2 (PF00017)    STAT_alpha (PF01017)    STAT_bind (PF02864)    STAT_int (PF02865)   
Domain families : Pfam (NCBI)pfam00017    pfam01017    pfam02864    pfam02865   
Domain families : Smart (EMBL)SH2 (SM00252)  STAT_int (SM00964)  
Conserved Domain (NCBI)STAT5A
DMDM Disease mutations6776
Blocks (Seattle)STAT5A
SuperfamilyP42229
Human Protein AtlasENSG00000126561
Peptide AtlasP42229
HPRD03301
IPIIPI00030783   IPI01010362   IPI01012667   IPI00878538   
Protein Interaction databases
DIP (DOE-UCLA)P42229
IntAct (EBI)P42229
FunCoupENSG00000126561
BioGRIDSTAT5A
STRING (EMBL)STAT5A
ZODIACSTAT5A
Ontologies - Pathways
QuickGOP42229
Ontology : AmiGOallantoin metabolic process  positive regulation of endothelial cell proliferation  DNA binding  transcription factor activity, sequence-specific DNA binding  protein tyrosine kinase activity  signal transducer activity  protein binding  nucleoplasm  nucleoplasm  cytosol  cytosol  citrate metabolic process  2-oxoglutarate metabolic process  succinate metabolic process  oxaloacetate metabolic process  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  isoleucine metabolic process  valine metabolic process  creatine metabolic process  fatty acid metabolic process  JAK-STAT cascade  lactation  peptidyl-tyrosine phosphorylation  taurine metabolic process  prolactin signaling pathway  regulation of multicellular organism growth  positive regulation of blood vessel endothelial cell migration  creatinine metabolic process  JAK-STAT cascade involved in growth hormone signaling pathway  
Ontology : EGO-EBIallantoin metabolic process  positive regulation of endothelial cell proliferation  DNA binding  transcription factor activity, sequence-specific DNA binding  protein tyrosine kinase activity  signal transducer activity  protein binding  nucleoplasm  nucleoplasm  cytosol  cytosol  citrate metabolic process  2-oxoglutarate metabolic process  succinate metabolic process  oxaloacetate metabolic process  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  isoleucine metabolic process  valine metabolic process  creatine metabolic process  fatty acid metabolic process  JAK-STAT cascade  lactation  peptidyl-tyrosine phosphorylation  taurine metabolic process  prolactin signaling pathway  regulation of multicellular organism growth  positive regulation of blood vessel endothelial cell migration  creatinine metabolic process  JAK-STAT cascade involved in growth hormone signaling pathway  
Pathways : BIOCARTA [Genes]   
Pathways : KEGG   
NDEx NetworkSTAT5A
Atlas of Cancer Signalling NetworkSTAT5A
Wikipedia pathwaysSTAT5A
Orthology - Evolution
OrthoDB6776
GeneTree (enSembl)ENSG00000126561
Phylogenetic Trees/Animal Genes : TreeFamSTAT5A
HOVERGENP42229
HOGENOMP42229
Homologs : HomoloGeneSTAT5A
Homology/Alignments : Family Browser (UCSC)STAT5A
Gene fusions - Rearrangements
Fusion : MitelmanATP6V0A1/STAT5A [17q21.2/17q21.2]  [t(17;17)(q21;q21)]  
Fusion : MitelmanSTAT5A/ARNTL2 [17q21.2/12p11.23]  [t(12;17)(p11;q21)]  
Fusion : MitelmanZNF14/STAT5A [19p13.11/17q21.2]  [t(17;19)(q21;p13)]  
Fusion: TCGAATP6V0A1 17q21.2 STAT5A 17q21.2 BLCA
Fusion: TCGASTAT5A 17q21.2 ARNTL2 12p11.23 LUAD
Fusion: TCGAZNF14 19p13.11 STAT5A 17q21.2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTAT5A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STAT5A
dbVarSTAT5A
ClinVarSTAT5A
1000_GenomesSTAT5A 
Exome Variant ServerSTAT5A
ExAC (Exome Aggregation Consortium)STAT5A (select the gene name)
Genetic variants : HAPMAP6776
Genomic Variants (DGV)STAT5A [DGVbeta]
DECIPHERSTAT5A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSTAT5A 
Mutations
ICGC Data PortalSTAT5A 
TCGA Data PortalSTAT5A 
Broad Tumor PortalSTAT5A
OASIS PortalSTAT5A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTAT5A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSTAT5A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch STAT5A
DgiDB (Drug Gene Interaction Database)STAT5A
DoCM (Curated mutations)STAT5A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)STAT5A (select a term)
intoGenSTAT5A
Cancer3DSTAT5A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601511   
Orphanet
MedgenSTAT5A
Genetic Testing Registry STAT5A
NextProtP42229 [Medical]
TSGene6776
GENETestsSTAT5A
Target ValidationSTAT5A
Huge Navigator STAT5A [HugePedia]
snp3D : Map Gene to Disease6776
BioCentury BCIQSTAT5A
ClinGenSTAT5A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6776
Chemical/Pharm GKB GenePA338
Clinical trialSTAT5A
Miscellaneous
canSAR (ICR)STAT5A (select the gene name)
Probes
Litterature
PubMed311 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSTAT5A
EVEXSTAT5A
GoPubMedSTAT5A
iHOPSTAT5A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:15:56 CEST 2017

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