The signal transducer and activator of transcription STAT5b gene is a new partner of retinoic acid receptor alpha in acute promyelocytic-like leukaemia. |
Arnould C, Philippe C, Bourdon V, Gr goire MJ, Berger R, Jonveaux P. |
Hum Mol Genet. 1999 Sep;8(9):1741-9. |
PMID 10441338 |
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The role of the STAT5 proteins in the proliferation and apoptosis of the CML and AML cells. |
Baskiewicz-Masiuk M, Machalinski B. |
Eur J Haematol. 2004 Jun;72(6):420-9. |
PMID 15128421 |
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A novel role for signal transducer and activator of transcription 5b (STAT5b) in beta1-integrin-mediated human breast cancer cell migration. |
Bernaciak TM, Zareno J, Parsons JT, Silva CM. |
Breast Cancer Res. 2009;11(4):R52. Epub 2009 Jul 24. |
PMID 19630967 |
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A Stat5b transgene is capable of inducing CD8+ lymphoblastic lymphoma in the absence of normal TCR/MHC signaling. |
Bessette K, Lang ML, Fava RA, Grundy M, Heinen J, Horne L, Spolski R, Al-Shami A, Morse HC 3rd, Leonard WJ, Kelly JA. |
Blood. 2008 Jan 1;111(1):344-50. Epub 2007 Sep 21. |
PMID 17890450 |
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Unphosphorylated STATs go nuclear. |
Brown S, Zeidler MP. |
Curr Opin Genet Dev. 2008 Oct;18(5):455-60. Epub 2008 Oct 7. (REVIEW) |
PMID 18840523 |
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STAT proteins: from normal control of cellular events to tumorigenesis. |
Calo V, Migliavacca M, Bazan V, Macaluso M, Buscemi M, Gebbia N, Russo A. |
J Cell Physiol. 2003 Nov;197(2):157-68. (REVIEW) |
PMID 14502555 |
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VEGF, VEGFRs expressions and activated STATs in ovarian epithelial carcinoma. |
Chen H, Ye D, Xie X, Chen B, Lu W. |
Gynecol Oncol. 2004 Sep;94(3):630-5. |
PMID 15350351 |
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Aberrant folding of a mutant Stat5b causes growth hormone insensitivity and proteasomal dysfunction. |
Chia DJ, Subbian E, Buck TM, Hwa V, Rosenfeld RG, Skach WR, Shinde U, Rotwein P. |
J Biol Chem. 2006 Mar 10;281(10):6552-8. Epub 2005 Nov 22. |
PMID 16303763 |
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Roles and regulation of stat family transcription factors in human breast cancer. |
Clevenger CV. |
Am J Pathol. 2004 Nov;165(5):1449-60. (REVIEW) |
PMID 15509516 |
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Serine phosphorylation of STATs. |
Decker T, Kovarik P. |
Oncogene. 2000 May 15;19(21):2628-37. (REVIEW) |
PMID 10851062 |
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STAT5 isoforms regulate colorectal cancer cell apoptosis via reduction of mitochondrial membrane potential and generation of reactive oxygen species. |
Du W, Wang YC, Hong J, Su WY, Lin YW, Lu R, Xiong H, Fang JY. |
J Cell Physiol. 2011 Aug 8. doi: 10.1002/jcp.22977. [Epub ahead of print] |
PMID 21826656 |
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Activation of the signal transducers and activators of transcription signaling pathway by growth hormone (GH) in skin fibroblasts from normal and GH binding protein-positive Laron Syndrome children. |
Freeth JS, Silva CM, Whatmore AJ, Clayton PE. |
Endocrinology. 1998 Jan;139(1):20-8. |
PMID 9421393 |
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Regulation of signal transducer and activator of transcription (STAT) 5b activation by the temporal pattern of growth hormone stimulation. |
Gebert CA, Park SH, Waxman DJ. |
Mol Endocrinol. 1997 Apr;11(4):400-14. |
PMID 9092792 |
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Defective STAT signaling by the leptin receptor in diabetic mice. |
Ghilardi N, Ziegler S, Wiestner A, Stoffel R, Heim MH, Skoda RC. |
Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6231-5. |
PMID 8692797 |
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The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms. |
Gong Y, Ishida-Takahashi R, Villanueva EC, Fingar DC, Munzberg H, Myers MG Jr. |
J Biol Chem. 2007 Oct 19;282(42):31019-27. Epub 2007 Aug 28. |
PMID 17726024 |
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Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription. |
Gouilleux F, Wakao H, Mundt M, Groner B. |
EMBO J. 1994 Sep 15;13(18):4361-9. |
PMID 7925280 |
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Signal transducer and activator of transcription 5b promotes mucosal tolerance in pediatric Crohn's disease and murine colitis. |
Han X, Osuntokun B, Benight N, Loesch K, Frank SJ, Denson LA. |
Am J Pathol. 2006 Dec;169(6):1999-2013. |
PMID 17148664 |
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Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway. |
Heim MH, Kerr IM, Stark GR, Darnell JE Jr. |
Science. 1995 Mar 3;267(5202):1347-9. |
PMID 7871432 |
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A functional DNA binding domain is required for growth hormone-induced nuclear accumulation of Stat5B. |
Herrington J, Rui L, Luo G, Yu-Lee LY, Carter-Su C. |
J Biol Chem. 1999 Feb 19;274(8):5138-45. |
PMID 9988763 |
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Cooperative and redundant effects of STAT5 and Ras signaling in BCR/ABL transformed hematopoietic cells. |
Hoover RR, Gerlach MJ, Koh EY, Daley GQ. |
Oncogene. 2001 Sep 13;20(41):5826-35. |
PMID 11593388 |
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Growth hormone insensitivity and severe short stature in siblings: a novel mutation at the exon 13-intron 13 junction of the STAT5b gene. |
Hwa V, Camacho-Hubner C, Little BM, David A, Metherell LA, El-Khatib N, Savage MO, Rosenfeld RG. |
Horm Res. 2007;68(5):218-24. Epub 2007 Mar 28. |
PMID 17389811 |
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Constitutive nuclear import of latent and activated STAT5a by its coiled coil domain. |
Iyer J, Reich NC. |
FASEB J. 2008 Feb;22(2):391-400. Epub 2007 Sep 10. |
PMID 17846080 |
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Novel activation of STAT5b in response to epidermal growth factor. |
Kloth MT, Catling AD, Silva CM. |
J Biol Chem. 2002 Mar 8;277(10):8693-701. Epub 2001 Dec 20. |
PMID 11751923 |
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STAT5b, a Mediator of Synergism between c-Src and the Epidermal Growth Factor Receptor. |
Kloth MT, Laughlin KK, Biscardi JS, Boerner JL, Parsons SJ, Silva CM. |
J Biol Chem. 2003 Jan 17;278(3):1671-9. Epub 2002 Nov 11. |
PMID 12429742 |
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Constitutive activation of signal transducer and activator of transcription 5 contributes to tumor growth, epithelial-mesenchymal transition, and resistance to epidermal growth factor receptor targeting. |
Koppikar P, Lui VW, Man D, Xi S, Chai RL, Nelson E, Tobey AB, Grandis JR. |
Clin Cancer Res. 2008 Dec 1;14(23):7682-90. |
PMID 19047094 |
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Signal transducer and activator of transcription 5a/b: Biomarker and therapeutic target in prostate and breast cancer. |
Koptyra M, Gupta S, Talati P, Nevalainen MT. |
Int J Biochem Cell Biol. 2011 Oct;43(10):1417-21. Epub 2011 Jun 17. |
PMID 21704724 |
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Signal transducers and activators of transcription 5b activation enhances hepatocellular carcinoma aggressiveness through induction of epithelial-mesenchymal transition. |
Lee TK, Man K, Poon RT, Lo CM, Yuen AP, Ng IO, Ng KT, Leonard W, Fan ST. |
Cancer Res. 2006 Oct 15;66(20):9948-56. |
PMID 17047057 |
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Stats: transcriptional control and biological impact. |
Levy DE, Darnell JE Jr. |
Nat Rev Mol Cell Biol. 2002 Sep;3(9):651-62. (REVIEW) |
PMID 12209125 |
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Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells. |
Lin JX, Mietz J, Modi WS, John S, Leonard WJ. |
J Biol Chem. 1996 May 3;271(18):10738-44. |
PMID 8631883 |
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Stat5a is mandatory for adult mammary gland development and lactogenesis. |
Liu X, Robinson GW, Wagner KU, Garrett L, Wynshaw-Boris A, Hennighausen L. |
Genes Dev. 1997 Jan 15;11(2):179-86. |
PMID 9009201 |
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Autocrine/paracrine erythropoietin signalling promotes JAK/STAT-dependent proliferation of human cervical cancer cells. |
Lopez TV, Lappin TR, Maxwell P, Shi Z, Lopez-Marure R, Aguilar C, Rocha-Zavaleta L. |
Int J Cancer. 2011 Jan 20. doi: 10.1002/ijc.25935. [Epub ahead of print] |
PMID 21442620 |
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Deletion of the carboxyl-terminal transactivation domain of MGF-Stat5 results in sustained DNA binding and a dominant negative phenotype. |
Moriggl R, Gouilleux-Gruart V, Jahne R, Berchtold S, Gartmann C, Liu X, Hennighausen L, Sotiropoulos A, Groner B, Gouilleux F. |
Mol Cell Biol. 1996 Oct;16(10):5691-700. |
PMID 8816482 |
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Nuclear translocation of the transcription factor STAT5 in the rat brain after systemic leptin administration. |
Mutze J, Roth J, Gerstberger R, Hubschle T. |
Neurosci Lett. 2007 May 7;417(3):286-91. Epub 2007 Mar 2. |
PMID 17353091 |
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STAT5b deficiency: an unsuspected cause of growth failure, immunodeficiency, and severe pulmonary disease. |
Nadeau K, Hwa V, Rosenfeld RG. |
J Pediatr. 2011 May;158(5):701-8. Epub 2011 Mar 17. (REVIEW) |
PMID 21414633 |
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Role of signal transducer and activator of transcription 5 in nucleophosmin/ anaplastic lymphoma kinase-mediated malignant transformation of lymphoid cells. |
Nieborowska-Skorska M, Slupianek A, Xue L, Zhang Q, Raghunath PN, Hoser G, Wasik MA, Morris SW, Skorski T. |
Cancer Res. 2001 Sep 1;61(17):6517-23. |
PMID 11522649 |
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Serine phosphorylation of GH-activated signal transducer and activator of transcription 5a (STAT5a) and STAT5b: impact on STAT5 transcriptional activity. |
Park SH, Yamashita H, Rui H, Waxman DJ. |
Mol Endocrinol. 2001 Dec;15(12):2157-71. |
PMID 11731617 |
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Loss of nuclear localized and tyrosine phosphorylated Stat5 in breast cancer predicts poor clinical outcome and increased risk of antiestrogen therapy failure. |
Peck AR, Witkiewicz AK, Liu C, Stringer GA, Klimowicz AC, Pequignot E, Freydin B, Tran TH, Yang N, Rosenberg AL, Hooke JA, Kovatich AJ, Nevalainen MT, Shriver CD, Hyslop T, Sauter G, Rimm DL, Magliocco AM, Rui H. |
J Clin Oncol. 2011 Jun 20;29(18):2448-58. Epub 2011 May 16. |
PMID 21576635 |
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Differential expression of STAT5 and Bcl-xL, and high expression of Neu and STAT3 in non-small-cell lung carcinoma. |
Sanchez-Ceja SG, Reyes-Maldonado E, Vazquez-Manriquez ME, Lopez-Luna JJ, Belmont A, Gutierrez-Castellanos S. |
Lung Cancer. 2006 Nov;54(2):163-8. Epub 2006 Sep 7. |
PMID 16959370 |
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Characterization and cloning of STAT5 from IM-9 cells and its activation by growth hormone. |
Silva CM, Lu H, Day RN. |
Mol Endocrinol. 1996 May;10(5):508-18. |
PMID 8732682 |
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Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis. |
Silva CM. |
Oncogene. 2004 Oct 18;23(48):8017-23. (REVIEW) |
PMID 15489919 |
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The role of signal transducer and activator of transcription factors in leukemogenesis. |
Sternberg DW, Gilliland DG. |
J Clin Oncol. 2004 Jan 15;22(2):361-71. (REVIEW) |
PMID 14722044 |
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STAT 5a expression in the breast is maintained in secretory carcinoma, in contrast to other histologic types. |
Strauss BL, Bratthauer GL, Tavassoli FA. |
Hum Pathol. 2006 May;37(5):586-92. |
PMID 16647957 |
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Stat5 promotes homotypic adhesion and inhibits invasive characteristics of human breast cancer cells. |
Sultan AS, Xie J, LeBaron MJ, Ealley EL, Nevalainen MT, Rui H. |
Oncogene. 2005 Jan 27;24(5):746-60. |
PMID 15592524 |
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Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. |
Teglund S, McKay C, Schuetz E, van Deursen JM, Stravopodis D, Wang D, Brown M, Bodner S, Grosveld G, Ihle JN. |
Cell. 1998 May 29;93(5):841-50. |
PMID 9630227 |
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Constitutively active Stat5b in CD4+ T cells inhibits graft-versus-host disease lethality associated with increased regulatory T-cell potency and decreased T effector cell responses. |
Vogtenhuber C, Bucher C, Highfill SL, Koch LK, Goren E, Panoskaltsis-Mortari A, Taylor PA, Farrar MA, Blazar BR. |
Blood. 2010 Jul 22;116(3):466-74. Epub 2010 May 4. |
PMID 20442366 |
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Modulation of signal transducer and activator of transcription 5b activity in breast cancer cells by mutation of tyrosines within the transactivation domain. |
Weaver AM, Silva CM. |
Mol Endocrinol. 2006 Oct;20(10):2392-405. Epub 2006 Jun 13. |
PMID 16772534 |
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Nucleocytoplasmic shuttling of signal transducers. |
Xu L, Massague J. |
Nat Rev Mol Cell Biol. 2004 Mar;5(3):209-19. (REVIEW) |
PMID 14991001 |
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Naturally occurring dominant-negative Stat5 suppresses transcriptional activity of estrogen receptors and induces apoptosis in T47D breast cancer cells. |
Yamashita H, Iwase H, Toyama T, Fujii Y. |
Oncogene. 2003 Mar 20;22(11):1638-52. |
PMID 12642867 |
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Stat5B shuttles between cytoplasm and nucleus in a cytokine-dependent and -independent manner. |
Zeng R, Aoki Y, Yoshida M, Arai K, Watanabe S. |
J Immunol. 2002 May 1;168(9):4567-75. |
PMID 11971004 |
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STAT5 activation by BCR-Abl contributes to transformation of K562 leukemia cells. |
de Groot RP, Raaijmakers JA, Lammers JW, Jove R, Koenderman L. |
Blood. 1999 Aug 1;94(3):1108-12. |
PMID 10419904 |
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