STAU2 (staufen double-stranded RNA binding protein 2)

2001-01-01  

Identity

HGNC
STAU2
LOCATION
8q21.11
LOCUSID
27067
ALIAS
39K2,39K3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 27067
MIM: 605920
HGNC: 11371
Ensembl: ENSG00000040341

Variants:

dbSNP: 27067
ClinVar: 27067
TCGA: ENSG00000040341
COSMIC: STAU2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000040341ENST00000355780Q9NUL3
ENSG00000040341ENST00000517542Q9NUL3
ENSG00000040341ENST00000518502E5RJ67
ENSG00000040341ENST00000518767E5RJN7
ENSG00000040341ENST00000518981E7EVI1
ENSG00000040341ENST00000519961E7EVJ4
ENSG00000040341ENST00000521210Q9NUL3
ENSG00000040341ENST00000521419E5RGT3
ENSG00000040341ENST00000521447E5RFK1
ENSG00000040341ENST00000521451Q9NUL3
ENSG00000040341ENST00000521727E7EPX0
ENSG00000040341ENST00000521736E5RGQ5
ENSG00000040341ENST00000522509Q9NUL3
ENSG00000040341ENST00000522695Q9NUL3
ENSG00000040341ENST00000523533H0YBY0
ENSG00000040341ENST00000523558Q9NUL3
ENSG00000040341ENST00000524104Q9NUL3
ENSG00000040341ENST00000524300Q9NUL3

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
180941222008A genome-wide approach identifies distinct but overlapping subsets of cellular mRNAs associated with Staufen1- and Staufen2-containing ribonucleoprotein complexes.53
121402602002Staufen2 isoforms localize to the somatodendritic domain of neurons and interact with different organelles.49
232638692013Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity.41
215080972011Staufen 2 regulates mGluR long-term depression and Map1b mRNA distribution in hippocampal neurons.30
245208232014Human protein Staufen-2 promotes HIV-1 proliferation by positively regulating RNA export activity of viral protein Rev.5
268434282016The downregulation of the RNA-binding protein Staufen2 in response to DNA damage promotes apoptosis.3

Citation

Dessen P

STAU2 (staufen double-stranded RNA binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2001-01-01

Online version: http://atlasgeneticsoncology.org/gene/78524/stau2