STEAP3 (STEAP3 metalloreductase)

2009-05-01  

Identity

HGNC
LOCATION
2q14.2
LOCUSID
ALIAS
AHMIO2,STMP3,TSAP6,dudlin-2,dudulin-2,pHyde
FUSION GENES

Other Information

Locus ID:

NCBI: 55240
MIM: 609671
HGNC: 24592
Ensembl: ENSG00000115107

Variants:

dbSNP: 55240
ClinVar: 55240
TCGA: ENSG00000115107
COSMIC: STEAP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115107ENST00000393106Q658P3
ENSG00000115107ENST00000393106A0A024RAD7
ENSG00000115107ENST00000393107Q658P3
ENSG00000115107ENST00000393107A0A024RAD7
ENSG00000115107ENST00000393110Q658P3
ENSG00000115107ENST00000409811B8ZZX6

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
p53 signaling pathwayKEGGko04115
p53 signaling pathwayKEGGhsa04115
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Iron uptake and transportREACTOMER-HSA-917937
Transferrin endocytosis and recyclingREACTOMER-HSA-917977
TP53 Regulates Transcription of Cell Death GenesREACTOMER-HSA-5633008
TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseREACTOMER-HSA-6803204
FerroptosisKEGGko04216
FerroptosisKEGGhsa04216

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
153194362004TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway.58
126067222003The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase.24
184959272008Structure of the membrane proximal oxidoreductase domain of human Steap3, the dominant ferrireductase of the erythroid transferrin cycle.24
218714512011Human STEAP3 maintains tumor growth under hypoferric condition.9
226240352012Exosome-related multi-pass transmembrane protein TSAP6 is a target of rhomboid protease RHBDD1-induced proteolysis.9
266753502016Human STEAP3 mutations with no phenotypic red cell changes.3
192365082009Down-regulated expression of the TSAP6 protein in liver is associated with a transition from cirrhosis to hepatocellular carcinoma.2
278258122017TSAP6 is a novel candidate marker of poor survival in metastatic high-grade serous carcinoma.2
283039162017Copper transporters are responsible for copper isotopic fractionation in eukaryotic cells.2

Citation

Dessen P

STEAP3 (STEAP3 metalloreductase)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50919/steap3