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STEAP3 (STEAP3 metalloreductase)

Identity

Alias_namesSTEAP family member 3
Alias_symbol (synonym)TSAP6
dudlin-2
STMP3
Other aliasAHMIO2
dudulin-2
pHyde
HGNC (Hugo) STEAP3
LocusID (NCBI) 55240
Atlas_Id 50919
Location 2q14.2  [Link to chromosome band 2q14]
Location_base_pair Starts at 119223808 and ends at 119265651 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NAB1 (2q32.2) / STEAP3 (2q14.2)STEAP3 (2q14.2) / MT1DP (16q12.2)STEAP3 (2q14.2) / MT1X (16q13)
STEAP3 (2q14.2) / PTK7 (6p21.1)STEAP3 (2q14.2) / SHISA5 (3p21.31)STEAP3 (2q14.2) / SORL1 (11q24.1)
STEAP3 (2q14.2) / STEAP3 (2q14.2)NAB1 2q32.2 / STEAP3 2q14.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)STEAP3   24592
Cards
Entrez_Gene (NCBI)STEAP3  55240  STEAP3 metalloreductase
AliasesAHMIO2; STMP3; TSAP6; dudlin-2; 
dudulin-2; pHyde
GeneCards (Weizmann)STEAP3
Ensembl hg19 (Hinxton)ENSG00000115107 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115107 [Gene_View]  chr2:119223808-119265651 [Contig_View]  STEAP3 [Vega]
ICGC DataPortalENSG00000115107
TCGA cBioPortalSTEAP3
AceView (NCBI)STEAP3
Genatlas (Paris)STEAP3
WikiGenes55240
SOURCE (Princeton)STEAP3
Genetics Home Reference (NIH)STEAP3
Genomic and cartography
GoldenPath hg38 (UCSC)STEAP3  -     chr2:119223808-119265651 +  2q14.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)STEAP3  -     2q14.2   [Description]    (hg19-Feb_2009)
EnsemblSTEAP3 - 2q14.2 [CytoView hg19]  STEAP3 - 2q14.2 [CytoView hg38]
Mapping of homologs : NCBISTEAP3 [Mapview hg19]  STEAP3 [Mapview hg38]
OMIM609671   615234   
Gene and transcription
Genbank (Entrez)AF238864 AF262322 AF423424 AK001691 AK024163
RefSeq transcript (Entrez)NM_001008410 NM_018234 NM_138637 NM_182915
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)STEAP3
Cluster EST : UnigeneHs.647822 [ NCBI ]
CGAP (NCI)Hs.647822
Alternative Splicing GalleryENSG00000115107
Gene ExpressionSTEAP3 [ NCBI-GEO ]   STEAP3 [ EBI - ARRAY_EXPRESS ]   STEAP3 [ SEEK ]   STEAP3 [ MEM ]
Gene Expression Viewer (FireBrowse)STEAP3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55240
GTEX Portal (Tissue expression)STEAP3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ658P3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ658P3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ658P3
Splice isoforms : SwissVarQ658P3
Catalytic activity : Enzyme1.16.1.- [ Enzyme-Expasy ]   1.16.1.-1.16.1.- [ IntEnz-EBI ]   1.16.1.- [ BRENDA ]   1.16.1.- [ KEGG ]   
PhosPhoSitePlusQ658P3
Domains : Interpro (EBI)Fe3_Rdtase_TM_dom    NAD(P)-bd_dom    P5C_Rdtase_cat_N   
Domain families : Pfam (Sanger)F420_oxidored (PF03807)    Ferric_reduct (PF01794)   
Domain families : Pfam (NCBI)pfam03807    pfam01794   
Conserved Domain (NCBI)STEAP3
DMDM Disease mutations55240
Blocks (Seattle)STEAP3
PDB (SRS)2VNS    2VQ3   
PDB (PDBSum)2VNS    2VQ3   
PDB (IMB)2VNS    2VQ3   
PDB (RSDB)2VNS    2VQ3   
Structural Biology KnowledgeBase2VNS    2VQ3   
SCOP (Structural Classification of Proteins)2VNS    2VQ3   
CATH (Classification of proteins structures)2VNS    2VQ3   
SuperfamilyQ658P3
Human Protein AtlasENSG00000115107
Peptide AtlasQ658P3
HPRD10285
IPIIPI00019350   IPI00411628   IPI00845327   IPI00845307   IPI00386348   IPI00917893   
Protein Interaction databases
DIP (DOE-UCLA)Q658P3
IntAct (EBI)Q658P3
FunCoupENSG00000115107
BioGRIDSTEAP3
STRING (EMBL)STEAP3
ZODIACSTEAP3
Ontologies - Pathways
QuickGOQ658P3
Ontology : AmiGOprotein binding  cytoplasm  multivesicular body  integral component of plasma membrane  apoptotic process  cell cycle  cupric reductase activity  protein secretion  protein secretion  endosome membrane  copper ion import  oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor  transferrin transport  regulation of apoptotic process  metal ion binding  ferric-chelate reductase (NADPH) activity  iron ion homeostasis  oxidation-reduction process  
Ontology : EGO-EBIprotein binding  cytoplasm  multivesicular body  integral component of plasma membrane  apoptotic process  cell cycle  cupric reductase activity  protein secretion  protein secretion  endosome membrane  copper ion import  oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor  transferrin transport  regulation of apoptotic process  metal ion binding  ferric-chelate reductase (NADPH) activity  iron ion homeostasis  oxidation-reduction process  
Pathways : KEGGp53 signaling pathway   
NDEx NetworkSTEAP3
Atlas of Cancer Signalling NetworkSTEAP3
Wikipedia pathwaysSTEAP3
Orthology - Evolution
OrthoDB55240
GeneTree (enSembl)ENSG00000115107
Phylogenetic Trees/Animal Genes : TreeFamSTEAP3
HOVERGENQ658P3
HOGENOMQ658P3
Homologs : HomoloGeneSTEAP3
Homology/Alignments : Family Browser (UCSC)STEAP3
Gene fusions - Rearrangements
Fusion : MitelmanNAB1/STEAP3 [2q32.2/2q14.2]  [t(2;2)(q14;q32)]  
Fusion: TCGANAB1 2q32.2 STEAP3 2q14.2 SKCM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTEAP3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STEAP3
dbVarSTEAP3
ClinVarSTEAP3
1000_GenomesSTEAP3 
Exome Variant ServerSTEAP3
ExAC (Exome Aggregation Consortium)STEAP3 (select the gene name)
Genetic variants : HAPMAP55240
Genomic Variants (DGV)STEAP3 [DGVbeta]
DECIPHERSTEAP3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSTEAP3 
Mutations
ICGC Data PortalSTEAP3 
TCGA Data PortalSTEAP3 
Broad Tumor PortalSTEAP3
OASIS PortalSTEAP3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTEAP3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSTEAP3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch STEAP3
DgiDB (Drug Gene Interaction Database)STEAP3
DoCM (Curated mutations)STEAP3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)STEAP3 (select a term)
intoGenSTEAP3
Cancer3DSTEAP3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609671    615234   
Orphanet21106   
MedgenSTEAP3
Genetic Testing Registry STEAP3
NextProtQ658P3 [Medical]
TSGene55240
GENETestsSTEAP3
Target ValidationSTEAP3
Huge Navigator STEAP3 [HugePedia]
snp3D : Map Gene to Disease55240
BioCentury BCIQSTEAP3
ClinGenSTEAP3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55240
Chemical/Pharm GKB GenePA142670863
Clinical trialSTEAP3
Miscellaneous
canSAR (ICR)STEAP3 (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSTEAP3
EVEXSTEAP3
GoPubMedSTEAP3
iHOPSTEAP3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:57:52 CEST 2017

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