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STEAP4 (STEAP4 metalloreductase)

Identity

Alias_namesTNFAIP9
tumor necrosis factor, alpha-induced protein 9
STEAP family member 4
Alias_symbol (synonym)FLJ23153
TIARP
STAMP2
Other aliasSchLAH
HGNC (Hugo) STEAP4
LocusID (NCBI) 79689
Atlas_Id 40604
Location 7q21.12  [Link to chromosome band 7q21]
Location_base_pair Starts at 88276429 and ends at 88306913 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARL17A (17q21.31) / STEAP4 (7q21.12)STEAP4 (7q21.12) / CTNND1 (11q12.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)STEAP4   21923
Cards
Entrez_Gene (NCBI)STEAP4  79689  STEAP4 metalloreductase
AliasesSTAMP2; SchLAH; TIARP; TNFAIP9
GeneCards (Weizmann)STEAP4
Ensembl hg19 (Hinxton)ENSG00000127954 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000127954 [Gene_View]  chr7:88276429-88306913 [Contig_View]  STEAP4 [Vega]
ICGC DataPortalENSG00000127954
TCGA cBioPortalSTEAP4
AceView (NCBI)STEAP4
Genatlas (Paris)STEAP4
WikiGenes79689
SOURCE (Princeton)STEAP4
Genetics Home Reference (NIH)STEAP4
Genomic and cartography
GoldenPath hg38 (UCSC)STEAP4  -     chr7:88276429-88306913 -  7q21.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)STEAP4  -     7q21.12   [Description]    (hg19-Feb_2009)
EnsemblSTEAP4 - 7q21.12 [CytoView hg19]  STEAP4 - 7q21.12 [CytoView hg38]
Mapping of homologs : NCBISTEAP4 [Mapview hg19]  STEAP4 [Mapview hg38]
OMIM611098   
Gene and transcription
Genbank (Entrez)AF423422 AF423423 AK026806 AK027807 AK307644
RefSeq transcript (Entrez)NM_001205315 NM_001205316 NM_024636
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)STEAP4
Cluster EST : UnigeneHs.521008 [ NCBI ]
CGAP (NCI)Hs.521008
Alternative Splicing GalleryENSG00000127954
Gene ExpressionSTEAP4 [ NCBI-GEO ]   STEAP4 [ EBI - ARRAY_EXPRESS ]   STEAP4 [ SEEK ]   STEAP4 [ MEM ]
Gene Expression Viewer (FireBrowse)STEAP4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79689
GTEX Portal (Tissue expression)STEAP4
Human Protein AtlasENSG00000127954-STEAP4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ687X5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ687X5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ687X5
Splice isoforms : SwissVarQ687X5
Catalytic activity : Enzyme1.16.1.- [ Enzyme-Expasy ]   1.16.1.-1.16.1.- [ IntEnz-EBI ]   1.16.1.- [ BRENDA ]   1.16.1.- [ KEGG ]   
PhosPhoSitePlusQ687X5
Domains : Interpro (EBI)Fe3_Rdtase_TM_dom    NAD(P)-bd_dom    P5C_Rdtase_cat_N   
Domain families : Pfam (Sanger)F420_oxidored (PF03807)    Ferric_reduct (PF01794)   
Domain families : Pfam (NCBI)pfam03807    pfam01794   
Conserved Domain (NCBI)STEAP4
DMDM Disease mutations79689
Blocks (Seattle)STEAP4
SuperfamilyQ687X5
Human Protein Atlas [tissue]ENSG00000127954-STEAP4 [tissue]
Peptide AtlasQ687X5
HPRD11637
IPIIPI00745161   IPI00470699   IPI00002856   IPI00925086   
Protein Interaction databases
DIP (DOE-UCLA)Q687X5
IntAct (EBI)Q687X5
FunCoupENSG00000127954
BioGRIDSTEAP4
STRING (EMBL)STEAP4
ZODIACSTEAP4
Ontologies - Pathways
QuickGOQ687X5
Ontology : AmiGOGolgi membrane  endosome  Golgi apparatus  plasma membrane  integral component of plasma membrane  cupric reductase activity  copper ion import  fat cell differentiation  metal ion binding  ferric-chelate reductase (NADPH) activity  iron ion homeostasis  oxidation-reduction process  extracellular exosome  
Ontology : EGO-EBIGolgi membrane  endosome  Golgi apparatus  plasma membrane  integral component of plasma membrane  cupric reductase activity  copper ion import  fat cell differentiation  metal ion binding  ferric-chelate reductase (NADPH) activity  iron ion homeostasis  oxidation-reduction process  extracellular exosome  
NDEx NetworkSTEAP4
Atlas of Cancer Signalling NetworkSTEAP4
Wikipedia pathwaysSTEAP4
Orthology - Evolution
OrthoDB79689
GeneTree (enSembl)ENSG00000127954
Phylogenetic Trees/Animal Genes : TreeFamSTEAP4
HOVERGENQ687X5
HOGENOMQ687X5
Homologs : HomoloGeneSTEAP4
Homology/Alignments : Family Browser (UCSC)STEAP4
Gene fusions - Rearrangements
Tumor Fusion PortalSTEAP4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTEAP4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STEAP4
dbVarSTEAP4
ClinVarSTEAP4
1000_GenomesSTEAP4 
Exome Variant ServerSTEAP4
ExAC (Exome Aggregation Consortium)ENSG00000127954
GNOMAD BrowserENSG00000127954
Genetic variants : HAPMAP79689
Genomic Variants (DGV)STEAP4 [DGVbeta]
DECIPHERSTEAP4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSTEAP4 
Mutations
ICGC Data PortalSTEAP4 
TCGA Data PortalSTEAP4 
Broad Tumor PortalSTEAP4
OASIS PortalSTEAP4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTEAP4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSTEAP4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch STEAP4
DgiDB (Drug Gene Interaction Database)STEAP4
DoCM (Curated mutations)STEAP4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)STEAP4 (select a term)
intoGenSTEAP4
Cancer3DSTEAP4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611098   
Orphanet
DisGeNETSTEAP4
MedgenSTEAP4
Genetic Testing Registry STEAP4
NextProtQ687X5 [Medical]
TSGene79689
GENETestsSTEAP4
Target ValidationSTEAP4
Huge Navigator STEAP4 [HugePedia]
snp3D : Map Gene to Disease79689
BioCentury BCIQSTEAP4
ClinGenSTEAP4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79689
Chemical/Pharm GKB GenePA134874572
Clinical trialSTEAP4
Miscellaneous
canSAR (ICR)STEAP4 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSTEAP4
EVEXSTEAP4
GoPubMedSTEAP4
iHOPSTEAP4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:36:57 CET 2017

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