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STEAP4 (STEAP4 metalloreductase)

Identity

Alias (NCBI)STAMP2
SchLAH
TIARP
TNFAIP9
HGNC (Hugo) STEAP4
HGNC Alias symbFLJ23153
TIARP
STAMP2
SchLAH
HGNC Alias nameseven chromosome locus associated with HCC
HGNC Previous nameTNFAIP9
HGNC Previous nametumor necrosis factor, alpha-induced protein 9
 STEAP family member 4
LocusID (NCBI) 79689
Atlas_Id 40604
Location 7q21.12  [Link to chromosome band 7q21]
Location_base_pair Starts at 88270896 and ends at 88306894 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARL17A (17q21.31) / STEAP4 (7q21.12)STEAP4 (7q21.12) / CTNND1 (11q12.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)STEAP4   21923
Cards
Entrez_Gene (NCBI)STEAP4    STEAP4 metalloreductase
AliasesSTAMP2; SchLAH; TIARP; TNFAIP9
GeneCards (Weizmann)STEAP4
Ensembl hg19 (Hinxton)ENSG00000127954 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000127954 [Gene_View]  ENSG00000127954 [Sequence]  chr7:88270896-88306894 [Contig_View]  STEAP4 [Vega]
ICGC DataPortalENSG00000127954
TCGA cBioPortalSTEAP4
AceView (NCBI)STEAP4
Genatlas (Paris)STEAP4
SOURCE (Princeton)STEAP4
Genetics Home Reference (NIH)STEAP4
Genomic and cartography
GoldenPath hg38 (UCSC)STEAP4  -     chr7:88270896-88306894 -  7q21.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)STEAP4  -     7q21.12   [Description]    (hg19-Feb_2009)
GoldenPathSTEAP4 - 7q21.12 [CytoView hg19]  STEAP4 - 7q21.12 [CytoView hg38]
ImmunoBaseENSG00000127954
Genome Data Viewer NCBISTEAP4 [Mapview hg19]  
OMIM611098   
Gene and transcription
Genbank (Entrez)AF423422 AF423423 AK026806 AK027807 AK307644
RefSeq transcript (Entrez)NM_001205315 NM_001205316 NM_024636
Consensus coding sequences : CCDS (NCBI)STEAP4
Gene ExpressionSTEAP4 [ NCBI-GEO ]   STEAP4 [ EBI - ARRAY_EXPRESS ]   STEAP4 [ SEEK ]   STEAP4 [ MEM ]
Gene Expression Viewer (FireBrowse)STEAP4 [ Firebrowse - Broad ]
GenevisibleExpression of STEAP4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79689
GTEX Portal (Tissue expression)STEAP4
Human Protein AtlasENSG00000127954-STEAP4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ687X5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ687X5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ687X5
PhosPhoSitePlusQ687X5
Domains : Interpro (EBI)Fe3_Rdtase_TM_dom    NAD(P)-bd_dom_sf    P5C_Rdtase_cat_N   
Domain families : Pfam (Sanger)F420_oxidored (PF03807)    Ferric_reduct (PF01794)   
Domain families : Pfam (NCBI)pfam03807    pfam01794   
Conserved Domain (NCBI)STEAP4
PDB (RSDB)6HCY    6HD1   
PDB Europe6HCY    6HD1   
PDB (PDBSum)6HCY    6HD1   
PDB (IMB)6HCY    6HD1   
Structural Biology KnowledgeBase6HCY    6HD1   
SCOP (Structural Classification of Proteins)6HCY    6HD1   
CATH (Classification of proteins structures)6HCY    6HD1   
SuperfamilyQ687X5
AlphaFold pdb e-kbQ687X5   
Human Protein Atlas [tissue]ENSG00000127954-STEAP4 [tissue]
HPRD11637
Protein Interaction databases
DIP (DOE-UCLA)Q687X5
IntAct (EBI)Q687X5
BioGRIDSTEAP4
STRING (EMBL)STEAP4
ZODIACSTEAP4
Ontologies - Pathways
QuickGOQ687X5
Ontology : AmiGOGolgi membrane  nucleoplasm  endosome  plasma membrane  plasma membrane  plasma membrane  cupric reductase activity  electron transfer activity  copper ion import  integral component of membrane  heme binding  electron transport chain  early endosome membrane  iron import into cell  fat cell differentiation  metal ion binding  ferric-chelate reductase (NADPH) activity  ferric-chelate reductase (NADPH) activity  extracellular exosome  protein homotrimerization  FAD binding  
Ontology : EGO-EBIGolgi membrane  nucleoplasm  endosome  plasma membrane  plasma membrane  plasma membrane  cupric reductase activity  electron transfer activity  copper ion import  integral component of membrane  heme binding  electron transport chain  early endosome membrane  iron import into cell  fat cell differentiation  metal ion binding  ferric-chelate reductase (NADPH) activity  ferric-chelate reductase (NADPH) activity  extracellular exosome  protein homotrimerization  FAD binding  
NDEx NetworkSTEAP4
Atlas of Cancer Signalling NetworkSTEAP4
Wikipedia pathwaysSTEAP4
Orthology - Evolution
OrthoDB79689
GeneTree (enSembl)ENSG00000127954
Phylogenetic Trees/Animal Genes : TreeFamSTEAP4
Homologs : HomoloGeneSTEAP4
Homology/Alignments : Family Browser (UCSC)STEAP4
Gene fusions - Rearrangements
Fusion : QuiverSTEAP4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTEAP4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STEAP4
dbVarSTEAP4
ClinVarSTEAP4
MonarchSTEAP4
1000_GenomesSTEAP4 
Exome Variant ServerSTEAP4
GNOMAD BrowserENSG00000127954
Varsome BrowserSTEAP4
ACMGSTEAP4 variants
VarityQ687X5
Genomic Variants (DGV)STEAP4 [DGVbeta]
DECIPHERSTEAP4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSTEAP4 
Mutations
ICGC Data PortalSTEAP4 
TCGA Data PortalSTEAP4 
Broad Tumor PortalSTEAP4
OASIS PortalSTEAP4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTEAP4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSTEAP4
Mutations and Diseases : HGMDSTEAP4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSTEAP4
DgiDB (Drug Gene Interaction Database)STEAP4
DoCM (Curated mutations)STEAP4
CIViC (Clinical Interpretations of Variants in Cancer)STEAP4
Cancer3DSTEAP4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611098   
Orphanet
DisGeNETSTEAP4
MedgenSTEAP4
Genetic Testing Registry STEAP4
NextProtQ687X5 [Medical]
GENETestsSTEAP4
Target ValidationSTEAP4
Huge Navigator STEAP4 [HugePedia]
ClinGenSTEAP4
Clinical trials, drugs, therapy
MyCancerGenomeSTEAP4
Protein Interactions : CTDSTEAP4
Pharm GKB GenePA134874572
PharosQ687X5
Clinical trialSTEAP4
Miscellaneous
canSAR (ICR)STEAP4
HarmonizomeSTEAP4
DataMed IndexSTEAP4
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSTEAP4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:33:34 CEST 2021

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