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STIM1 (stromal interaction molecule 1)

Identity

Alias_symbol (synonym)GOK
D11S4896E
Other aliasIMD10
STRMK
TAM
TAM1
HGNC (Hugo) STIM1
LocusID (NCBI) 6786
Atlas_Id 42436
Location 11p15.4  [Link to chromosome band 11p15]
Location_base_pair Starts at 3855703 and ends at 4093210 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DLEU2 (13q14.2) / STIM1 (11p15.4)FAM65B (6p22.3) / STIM1 (11p15.4)FAM96A (15q22.31) / STIM1 (11p15.4)
RRM1 (11p15.4) / STIM1 (11p15.4)STIM1 (11p15.4) / DBT (1p21.2)STIM1 (11p15.4) / FITM2 (20q13.12)
STIM1 (11p15.4) / NSD1 (5q35.2)STIM1 (11p15.4) / NUP98 (11p15.4)STIM1 (11p15.4) / STIM1 (11p15.4)
STIM1 (11p15.4) / VAMP2 (17p13.1)STIM1 (11p15.4) / VHL (3p25.3)YAP1 (11q22.1) / STIM1 (11p15.4)
RRM1 11p15.4 / STIM1 11p15.4STIM1 11p15.4 / FITM2 20q13.12STIM1 11p15.4 / NUP98 11p15.4
STIM1 11p15.4 / VHL 3p25.3YAP1 11q22.1 / STIM1 11p15.4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(5;11)(q35;p15) STIM1/NSD1

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 6 ]
  t(3;11)(p25;p15) STIM1/VHL
t(11;11)(p15;p15) RRM1/STIM1
t(11;11)(p15;p15) STIM1/NUP98
t(11;11)(p15;q22) YAP1/STIM1
t(11;15)(p15;q22) FAM96A/STIM1
t(11;20)(p15;q13) STIM1/FITM2

External links

Nomenclature
HGNC (Hugo)STIM1   11386
LRG (Locus Reference Genomic)LRG_164
Cards
Entrez_Gene (NCBI)STIM1  6786  stromal interaction molecule 1
AliasesD11S4896E; GOK; IMD10; STRMK; 
TAM; TAM1
GeneCards (Weizmann)STIM1
Ensembl hg19 (Hinxton)ENSG00000167323 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167323 [Gene_View]  ENSG00000167323 [Sequence]  chr11:3855703-4093210 [Contig_View]  STIM1 [Vega]
ICGC DataPortalENSG00000167323
TCGA cBioPortalSTIM1
AceView (NCBI)STIM1
Genatlas (Paris)STIM1
WikiGenes6786
SOURCE (Princeton)STIM1
Genetics Home Reference (NIH)STIM1
Genomic and cartography
GoldenPath hg38 (UCSC)STIM1  -     chr11:3855703-4093210 +  11p15.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)STIM1  -     11p15.4   [Description]    (hg19-Feb_2009)
EnsemblSTIM1 - 11p15.4 [CytoView hg19]  STIM1 - 11p15.4 [CytoView hg38]
Mapping of homologs : NCBISTIM1 [Mapview hg19]  STIM1 [Mapview hg38]
OMIM160565   605921   612783   
Gene and transcription
Genbank (Entrez)AK057599 AK098480 AK310510 AK314928 BC019905
RefSeq transcript (Entrez)NM_001277961 NM_001277962 NM_003156
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)STIM1
Cluster EST : UnigeneHs.657794 [ NCBI ]
CGAP (NCI)Hs.657794
Alternative Splicing GalleryENSG00000167323
Gene ExpressionSTIM1 [ NCBI-GEO ]   STIM1 [ EBI - ARRAY_EXPRESS ]   STIM1 [ SEEK ]   STIM1 [ MEM ]
Gene Expression Viewer (FireBrowse)STIM1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6786
GTEX Portal (Tissue expression)STIM1
Human Protein AtlasENSG00000167323-STIM1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13586   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13586  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13586
Splice isoforms : SwissVarQ13586
PhosPhoSitePlusQ13586
Domaine pattern : Prosite (Expaxy)SAM_DOMAIN (PS50105)   
Domains : Interpro (EBI)SAM    SAM/pointed    SOAR    STM1   
Domain families : Pfam (Sanger)SAM_2 (PF07647)    SOAR (PF16533)   
Domain families : Pfam (NCBI)pfam07647    pfam16533   
Domain families : Smart (EMBL)SAM (SM00454)  
Conserved Domain (NCBI)STIM1
DMDM Disease mutations6786
Blocks (Seattle)STIM1
PDB (SRS)2K60    2MAJ    2MAK    3TEQ    4O9B   
PDB (PDBSum)2K60    2MAJ    2MAK    3TEQ    4O9B   
PDB (IMB)2K60    2MAJ    2MAK    3TEQ    4O9B   
PDB (RSDB)2K60    2MAJ    2MAK    3TEQ    4O9B   
Structural Biology KnowledgeBase2K60    2MAJ    2MAK    3TEQ    4O9B   
SCOP (Structural Classification of Proteins)2K60    2MAJ    2MAK    3TEQ    4O9B   
CATH (Classification of proteins structures)2K60    2MAJ    2MAK    3TEQ    4O9B   
SuperfamilyQ13586
Human Protein Atlas [tissue]ENSG00000167323-STIM1 [tissue]
Peptide AtlasQ13586
HPRD05803
IPIIPI00299063   IPI00977315   IPI00981150   IPI00981522   IPI00983477   IPI00975506   IPI00985282   IPI00976172   IPI00976954   IPI00977517   IPI00976850   IPI00984650   
Protein Interaction databases
DIP (DOE-UCLA)Q13586
IntAct (EBI)Q13586
FunCoupENSG00000167323
BioGRIDSTIM1
STRING (EMBL)STIM1
ZODIACSTIM1
Ontologies - Pathways
QuickGOQ13586
Ontology : AmiGOprotease binding  store-operated calcium entry  calcium channel regulator activity  calcium ion binding  detection of calcium ion  protein binding  endoplasmic reticulum  endoplasmic reticulum membrane  microtubule  plasma membrane  integral component of plasma membrane  cellular calcium ion homeostasis  integral component of endoplasmic reticulum membrane  activation of store-operated calcium channel activity  cortical endoplasmic reticulum  cortical endoplasmic reticulum  sarcoplasmic reticulum membrane  identical protein binding  positive regulation of angiogenesis  microtubule plus-end binding  regulation of calcium ion transport  enamel mineralization  regulation of cardiac conduction  regulation of store-operated calcium entry  
Ontology : EGO-EBIprotease binding  store-operated calcium entry  calcium channel regulator activity  calcium ion binding  detection of calcium ion  protein binding  endoplasmic reticulum  endoplasmic reticulum membrane  microtubule  plasma membrane  integral component of plasma membrane  cellular calcium ion homeostasis  integral component of endoplasmic reticulum membrane  activation of store-operated calcium channel activity  cortical endoplasmic reticulum  cortical endoplasmic reticulum  sarcoplasmic reticulum membrane  identical protein binding  positive regulation of angiogenesis  microtubule plus-end binding  regulation of calcium ion transport  enamel mineralization  regulation of cardiac conduction  regulation of store-operated calcium entry  
NDEx NetworkSTIM1
Atlas of Cancer Signalling NetworkSTIM1
Wikipedia pathwaysSTIM1
Orthology - Evolution
OrthoDB6786
GeneTree (enSembl)ENSG00000167323
Phylogenetic Trees/Animal Genes : TreeFamSTIM1
HOVERGENQ13586
HOGENOMQ13586
Homologs : HomoloGeneSTIM1
Homology/Alignments : Family Browser (UCSC)STIM1
Gene fusions - Rearrangements
Fusion : MitelmanFAM96A/STIM1 [15q22.31/11p15.4]  [t(11;15)(p15;q22)]  
Fusion : MitelmanRRM1/STIM1 [11p15.4/11p15.4]  [t(11;11)(p15;p15)]  
Fusion : MitelmanSTIM1/FITM2 [11p15.4/20q13.12]  [t(11;20)(p15;q13)]  
Fusion : MitelmanSTIM1/NSD1 [11p15.4/5q35.2]  [t(5;11)(q35;p15)]  
Fusion : MitelmanSTIM1/NUP98 [11p15.4/11p15.4]  [t(11;11)(p15;p15)]  
Fusion : MitelmanSTIM1/VHL [11p15.4/3p25.3]  [t(3;11)(p25;p15)]  
Fusion : MitelmanYAP1/STIM1 [11q22.1/11p15.4]  [t(11;11)(p15;q22)]  
Fusion PortalRRM1 11p15.4 STIM1 11p15.4 BRCA
Fusion PortalSTIM1 11p15.4 FITM2 20q13.12 BRCA
Fusion PortalSTIM1 11p15.4 NUP98 11p15.4 LUAD
Fusion PortalSTIM1 11p15.4 VHL 3p25.3 LUSC
Fusion PortalYAP1 11q22.1 STIM1 11p15.4 BRCA
Fusion : QuiverSTIM1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTIM1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STIM1
dbVarSTIM1
ClinVarSTIM1
1000_GenomesSTIM1 
Exome Variant ServerSTIM1
ExAC (Exome Aggregation Consortium)ENSG00000167323
GNOMAD BrowserENSG00000167323
Genetic variants : HAPMAP6786
Genomic Variants (DGV)STIM1 [DGVbeta]
DECIPHERSTIM1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSTIM1 
Mutations
ICGC Data PortalSTIM1 
TCGA Data PortalSTIM1 
Broad Tumor PortalSTIM1
OASIS PortalSTIM1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTIM1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSTIM1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch STIM1
DgiDB (Drug Gene Interaction Database)STIM1
DoCM (Curated mutations)STIM1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)STIM1 (select a term)
intoGenSTIM1
Cancer3DSTIM1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM160565    605921    612783   
Orphanet590    2388    21582   
DisGeNETSTIM1
MedgenSTIM1
Genetic Testing Registry STIM1
NextProtQ13586 [Medical]
TSGene6786
GENETestsSTIM1
Target ValidationSTIM1
Huge Navigator STIM1 [HugePedia]
snp3D : Map Gene to Disease6786
BioCentury BCIQSTIM1
ClinGenSTIM1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6786
Chemical/Pharm GKB GenePA36195
Clinical trialSTIM1
Miscellaneous
canSAR (ICR)STIM1 (select the gene name)
Probes
Litterature
PubMed320 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSTIM1
EVEXSTIM1
GoPubMedSTIM1
iHOPSTIM1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:52:16 CEST 2018
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