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STING1 (stimulator of interferon response cGAMP interactor 1)

Identity

Alias (NCBI)ERIS
MITA
MPYS
NET23
SAVI
STING
STING-beta
TMEM173
hMITA
hSTING
HGNC (Hugo) STING1
HGNC Alias symbFLJ38577
NET23
ERIS
MPYS
STING
MITA
HGNC Alias namestimulator of interferon genes
 endoplasmic reticulum IFN stimulator
HGNC Previous nameTMEM173
HGNC Previous nametransmembrane protein 173
LocusID (NCBI) 340061
Atlas_Id 52153
Location 5q31.2  [Link to chromosome band 5q31]
Location_base_pair Starts at 139475533 and ends at 139482758 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute



External links

 

Nomenclature
HGNC (Hugo)STING1   27962
Cards
Entrez_Gene (NCBI)STING1    stimulator of interferon response cGAMP interactor 1
AliasesERIS; MITA; MPYS; NET23; 
SAVI; STING; STING-beta; TMEM173; hMITA; hSTING
GeneCards (Weizmann)STING1
Ensembl hg19 (Hinxton)ENSG00000184584 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000184584 [Gene_View]  ENSG00000184584 [Sequence]  chr5:139475533-139482758 [Contig_View]  STING1 [Vega]
ICGC DataPortalENSG00000184584
TCGA cBioPortalSTING1
AceView (NCBI)STING1
Genatlas (Paris)STING1
SOURCE (Princeton)STING1
Genetics Home Reference (NIH)STING1
Genomic and cartography
GoldenPath hg38 (UCSC)STING1  -     chr5:139475533-139482758 -  5q31.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)STING1  -     5q31.2   [Description]    (hg19-Feb_2009)
GoldenPathSTING1 - 5q31.2 [CytoView hg19]  STING1 - 5q31.2 [CytoView hg38]
ImmunoBaseENSG00000184584
Genome Data Viewer NCBISTING1 [Mapview hg19]  
OMIM612374   615934   
Gene and transcription
Genbank (Entrez)AK095896 AK129800 AK290661 AX775913 BC047779
RefSeq transcript (Entrez)NM_001301738 NM_001367258 NM_198282
Consensus coding sequences : CCDS (NCBI)STING1
Gene ExpressionSTING1 [ NCBI-GEO ]   STING1 [ EBI - ARRAY_EXPRESS ]   STING1 [ SEEK ]   STING1 [ MEM ]
Gene Expression Viewer (FireBrowse)STING1 [ Firebrowse - Broad ]
GenevisibleExpression of STING1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)340061
GTEX Portal (Tissue expression)STING1
Human Protein AtlasENSG00000184584-STING1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86WV6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86WV6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86WV6
PhosPhoSitePlusQ86WV6
Domains : Interpro (EBI)STING    STING_C    STING_C_sf   
Domain families : Pfam (Sanger)TMEM173 (PF15009)   
Domain families : Pfam (NCBI)pfam15009   
Conserved Domain (NCBI)STING1
PDB (RSDB)4EF4    4EF5    4EMT    4EMU    4F5D    4F5E    4F5W    4F5Y    4F9E    4F9G    4KSY    4LOH    4LOI    4QXO    4QXP    4QXQ    4QXR    5BQX    5JEJ    6CFF    6CY7    6DNK    6DXG    6DXL    6MX0    6MX3    6MXE    6NT5    6O8B    6O8C    6RM0    6S26    6S27    6S86    6UKM    6UKU    6UKV    6UKW    6UKX    6UKY    6UKZ    6UL0    6XNP   
PDB Europe4EF4    4EF5    4EMT    4EMU    4F5D    4F5E    4F5W    4F5Y    4F9E    4F9G    4KSY    4LOH    4LOI    4QXO    4QXP    4QXQ    4QXR    5BQX    5JEJ    6CFF    6CY7    6DNK    6DXG    6DXL    6MX0    6MX3    6MXE    6NT5    6O8B    6O8C    6RM0    6S26    6S27    6S86    6UKM    6UKU    6UKV    6UKW    6UKX    6UKY    6UKZ    6UL0    6XNP   
PDB (PDBSum)4EF4    4EF5    4EMT    4EMU    4F5D    4F5E    4F5W    4F5Y    4F9E    4F9G    4KSY    4LOH    4LOI    4QXO    4QXP    4QXQ    4QXR    5BQX    5JEJ    6CFF    6CY7    6DNK    6DXG    6DXL    6MX0    6MX3    6MXE    6NT5    6O8B    6O8C    6RM0    6S26    6S27    6S86    6UKM    6UKU    6UKV    6UKW    6UKX    6UKY    6UKZ    6UL0    6XNP   
PDB (IMB)4EF4    4EF5    4EMT    4EMU    4F5D    4F5E    4F5W    4F5Y    4F9E    4F9G    4KSY    4LOH    4LOI    4QXO    4QXP    4QXQ    4QXR    5BQX    5JEJ    6CFF    6CY7    6DNK    6DXG    6DXL    6MX0    6MX3    6MXE    6NT5    6O8B    6O8C    6RM0    6S26    6S27    6S86    6UKM    6UKU    6UKV    6UKW    6UKX    6UKY    6UKZ    6UL0    6XNP   
Structural Biology KnowledgeBase4EF4    4EF5    4EMT    4EMU    4F5D    4F5E    4F5W    4F5Y    4F9E    4F9G    4KSY    4LOH    4LOI    4QXO    4QXP    4QXQ    4QXR    5BQX    5JEJ    6CFF    6CY7    6DNK    6DXG    6DXL    6MX0    6MX3    6MXE    6NT5    6O8B    6O8C    6RM0    6S26    6S27    6S86    6UKM    6UKU    6UKV    6UKW    6UKX    6UKY    6UKZ    6UL0    6XNP   
SCOP (Structural Classification of Proteins)4EF4    4EF5    4EMT    4EMU    4F5D    4F5E    4F5W    4F5Y    4F9E    4F9G    4KSY    4LOH    4LOI    4QXO    4QXP    4QXQ    4QXR    5BQX    5JEJ    6CFF    6CY7    6DNK    6DXG    6DXL    6MX0    6MX3    6MXE    6NT5    6O8B    6O8C    6RM0    6S26    6S27    6S86    6UKM    6UKU    6UKV    6UKW    6UKX    6UKY    6UKZ    6UL0    6XNP   
CATH (Classification of proteins structures)4EF4    4EF5    4EMT    4EMU    4F5D    4F5E    4F5W    4F5Y    4F9E    4F9G    4KSY    4LOH    4LOI    4QXO    4QXP    4QXQ    4QXR    5BQX    5JEJ    6CFF    6CY7    6DNK    6DXG    6DXL    6MX0    6MX3    6MXE    6NT5    6O8B    6O8C    6RM0    6S26    6S27    6S86    6UKM    6UKU    6UKV    6UKW    6UKX    6UKY    6UKZ    6UL0    6XNP   
SuperfamilyQ86WV6
AlphaFold pdb e-kbQ86WV6   
Human Protein Atlas [tissue]ENSG00000184584-STING1 [tissue]
HPRD14173
Protein Interaction databases
DIP (DOE-UCLA)Q86WV6
IntAct (EBI)Q86WV6
BioGRIDSTING1
STRING (EMBL)STING1
ZODIACSTING1
Ontologies - Pathways
QuickGOQ86WV6
Ontology : AmiGOautophagosome assembly  autophagosome assembly  autophagosome membrane  activation of innate immune response  activation of innate immune response  positive regulation of defense response to virus by host  protein binding  nucleoplasm  mitochondrial outer membrane  endosome  autophagosome  autophagosome  peroxisome  endoplasmic reticulum membrane  endoplasmic reticulum membrane  endoplasmic reticulum membrane  Golgi apparatus  cytosol  plasma membrane  transcription factor binding  positive regulation of macroautophagy  positive regulation of macroautophagy  protein kinase binding  protein kinase binding  integral component of endoplasmic reticulum membrane  cytoplasmic vesicle membrane  secretory granule membrane  ubiquitin protein ligase binding  positive regulation of protein binding  regulation of type I interferon production  positive regulation of type I interferon production  positive regulation of type I interferon production  positive regulation of type I interferon production  positive regulation of interferon-beta production  positive regulation of interferon-beta production  cyclic-di-GMP binding  cyclic-di-GMP binding  cellular response to interferon-beta  identical protein binding  protein homodimerization activity  neutrophil degranulation  innate immune response  innate immune response  innate immune response  positive regulation of transcription by RNA polymerase II  perinuclear region of cytoplasm  regulation of inflammatory response  positive regulation of DNA-binding transcription factor activity  protein complex oligomerization  defense response to virus  defense response to virus  cyclic-GMP-AMP binding  cyclic-GMP-AMP binding  cyclic-GMP-AMP binding  reticulophagy  reticulophagy  cellular response to exogenous dsRNA  cellular response to organic cyclic compound  integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane  
Ontology : EGO-EBIautophagosome assembly  autophagosome assembly  autophagosome membrane  activation of innate immune response  activation of innate immune response  positive regulation of defense response to virus by host  protein binding  nucleoplasm  mitochondrial outer membrane  endosome  autophagosome  autophagosome  peroxisome  endoplasmic reticulum membrane  endoplasmic reticulum membrane  endoplasmic reticulum membrane  Golgi apparatus  cytosol  plasma membrane  transcription factor binding  positive regulation of macroautophagy  positive regulation of macroautophagy  protein kinase binding  protein kinase binding  integral component of endoplasmic reticulum membrane  cytoplasmic vesicle membrane  secretory granule membrane  ubiquitin protein ligase binding  positive regulation of protein binding  regulation of type I interferon production  positive regulation of type I interferon production  positive regulation of type I interferon production  positive regulation of type I interferon production  positive regulation of interferon-beta production  positive regulation of interferon-beta production  cyclic-di-GMP binding  cyclic-di-GMP binding  cellular response to interferon-beta  identical protein binding  protein homodimerization activity  neutrophil degranulation  innate immune response  innate immune response  innate immune response  positive regulation of transcription by RNA polymerase II  perinuclear region of cytoplasm  regulation of inflammatory response  positive regulation of DNA-binding transcription factor activity  protein complex oligomerization  defense response to virus  defense response to virus  cyclic-GMP-AMP binding  cyclic-GMP-AMP binding  cyclic-GMP-AMP binding  reticulophagy  reticulophagy  cellular response to exogenous dsRNA  cellular response to organic cyclic compound  integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane  
NDEx NetworkSTING1
Atlas of Cancer Signalling NetworkSTING1
Wikipedia pathwaysSTING1
Orthology - Evolution
OrthoDB340061
GeneTree (enSembl)ENSG00000184584
Phylogenetic Trees/Animal Genes : TreeFamSTING1
Homologs : HomoloGeneSTING1
Homology/Alignments : Family Browser (UCSC)STING1
Gene fusions - Rearrangements
Fusion : QuiverSTING1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTING1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STING1
dbVarSTING1
ClinVarSTING1
MonarchSTING1
1000_GenomesSTING1 
Exome Variant ServerSTING1
GNOMAD BrowserENSG00000184584
Varsome BrowserSTING1
ACMGSTING1 variants
VarityQ86WV6
Genomic Variants (DGV)STING1 [DGVbeta]
DECIPHERSTING1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSTING1 
Mutations
ICGC Data PortalSTING1 
TCGA Data PortalSTING1 
Broad Tumor PortalSTING1
OASIS PortalSTING1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDSTING1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSTING1
DgiDB (Drug Gene Interaction Database)STING1
DoCM (Curated mutations)STING1
CIViC (Clinical Interpretations of Variants in Cancer)STING1
Cancer3DSTING1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612374    615934   
Orphanet23209   
DisGeNETSTING1
MedgenSTING1
Genetic Testing Registry STING1
NextProtQ86WV6 [Medical]
GENETestsSTING1
Target ValidationSTING1
Huge Navigator STING1 [HugePedia]
ClinGenSTING1
Clinical trials, drugs, therapy
MyCancerGenomeSTING1
Protein Interactions : CTDSTING1
PharosQ86WV6
Clinical trialSTING1
Miscellaneous
canSAR (ICR)STING1
HarmonizomeSTING1
DataMed IndexSTING1
Probes
Litterature
PubMed241 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSTING1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:33:34 CEST 2021

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